Identification of airway mucosal type 2 inflammation by using clinical biomarkers in asthmatic patients - Silkoff, Philip E.; Laviolette, Michel; Singh, Dave; FitzGerald, J. Mark; Kelsen, Steven; Backer, Vibeke; Porsbjerg, Celeste M.; Girodet, Pierre-Olivier; Berger, Patrick; Kline, Joel N.; Chupp, Geoffrey; Susulic, Vedrana S.; et al. (Journal of allergy and clinical immunology, 2017)
Keywords: Adolescent; Adult; airway mucosal gene expression; Allergy and Immunology; Asthma; Asthma - blood; Asthma - immunology; Asthma - metabolism; Asthma - physiopathology; Biomarkers; Biomarkers - blood; Biomarkers - metabolism; Biopsy; CCL17 protein; Cell Adhesion Molecules - immunology; Cell Line; Cell lines; Chemokine CCL17 - blood; Chemokine CCL17 - immunology; Chemokine CCL26; Chemokines; Chemokines, CC - blood; Chemokines, CC - immunology; Cytokines; Eosinophils - immunology; Female; Gene Expression; Humans; Inflammation; Interleukin 13; Interleukin-13 - genetics; Interleukin-13 - immunology; Kinases; Leukocyte Count; Leukocytes (eosinophilic); Male; Middle Aged; Mucosa; Nitric oxide; Nitric Oxide - metabolism; phenotypes; Population studies; Respiratory Function Tests; Respiratory Mucosa - immunology; Respiratory tract; Severity of Illness Index; Smooth muscle; type 2 inflammation; Young Adult; Feno; sIgE; SERPINB2; spEOS; airway mucosal gene expression; biomarkers; IVS; bEOS; Asthma; sCCL26; sCCL17; phenotypes; ADEPT; FDR; NPV; PPV; ICS; CLCA1; type 2 inflammation; Blood eosinophil; Fraction of exhaled nitric oxide; Sputum eosinophil; Serum CCL26; F eno; Inhaled corticosteroid; Negative predictive values; In vitro signature; False discovery rate; Calcium-activated chloride channel regulator 1; Positive predictive value; Serpin peptidase inhibitor, clade B, member 2 (also known as plasminogen activator inhibitor 2); Serum IgE; Serum CCL17; Airways Disease Endotyping for Personalized Therapeutics