Neuroplastic changes in resting-state functional connectivity after stroke rehabilitation

Most neuroimaging research in stroke rehabilitation mainly focuses on the neural mechanisms underlying the natural history of post-stroke recovery. However, connectivity mapping from resting-state fMRI is well suited for different neurological conditions and provides a promising method to explore pl...

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Published inFrontiers in human neuroscience Vol. 9; p. 546
Main Authors Fan, Yang-teng, Wu, Ching-yi, Liu, Ho-ling, Lin, Keh-chung, Wai, Yau-yau, Chen, Yao-liang
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 06.10.2015
Frontiers Media S.A
Subjects
Activities of daily living
Brain mapping
Brain research
Cerebral hemispheres
Cortex (motor)
fMRI
functional connectivity
Functional magnetic resonance imaging
Medicine
Motor Cortex
Motor task performance
Neural networks
Neuroimaging
Neuroplasticity
Neuroscience
Occupational therapy
Recovery of function
Rehabilitation
robot
Robots
Stroke
Taiwan
robot
fMRI
rehabilitation
functional connectivity
motor cortex
stroke
Online AccessGet full text
ISSN1662-5161
1662-5161
DOI10.3389/fnhum.2015.00546

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Abstract Most neuroimaging research in stroke rehabilitation mainly focuses on the neural mechanisms underlying the natural history of post-stroke recovery. However, connectivity mapping from resting-state fMRI is well suited for different neurological conditions and provides a promising method to explore plastic changes for treatment-induced recovery from stroke. We examined the changes in resting-state functional connectivity (RS-FC) of the ipsilesional primary motor cortex (M1) in 10 post-acute stroke patients before and immediately after 4 weeks of robot-assisted bilateral arm therapy (RBAT). Motor performance, functional use of the affected arm, and daily function improved in all participants. Reduced interhemispheric RS-FC between the ipsilesional and contralesional M1 (M1-M1) and the contralesional-lateralized connections were noted before treatment. In contrast, greater M1-M1 functional connectivity and disturbed resting-state networks were observed after RBAT relative to pre-treatment. Increased changes in M1-M1 RS-FC after RBAT were coupled with better motor and functional improvements. Mediation analysis showed the pre-to-post difference in M1-M1 RS-FC was a significant mediator for the relationship between motor and functional recovery. These results show neuroplastic changes and functional recoveries induced by RBAT in post-acute stroke survivors and suggest that interhemispheric functional connectivity in the motor cortex may be a neurobiological marker for recovery after stroke rehabilitation.
AbstractList Most neuroimaging research in stroke rehabilitation mainly focuses on the neural mechanisms underlying the natural history of post-stroke recovery. However, connectivity mapping from resting-state fMRI is well suited for different neurological conditions and provides a promising method to explore plastic changes for treatment-induced recovery from stroke. We examined the changes in resting-state functional connectivity (RS-FC) of the ipsilesional primary motor cortex (M1) in 10 post-acute stroke patients before and immediately after 4 weeks of robot-assisted bilateral arm therapy (RBAT). Motor performance, functional use of the affected arm, and daily function improved in all participants. Reduced interhemispheric RS-FC between the ipsilesional and contralesional M1 (M1-M1) and the contralesional-lateralized connections were noted before treatment. In contrast, greater M1-M1 functional connectivity and disturbed resting-state networks were observed after RBAT relative to pre-treatment. Increased changes in M1-M1 RS-FC after RBAT were coupled with better motor and functional improvements. Mediation analysis showed the pre-to-post difference in M1-M1 RS-FC was a significant mediator for the relationship between motor and functional recovery. These results show neuroplastic changes and functional recoveries induced by RBAT in post-acute stroke survivors and suggest that interhemispheric functional connectivity in the motor cortex may be a neurobiological marker for recovery after stroke rehabilitation.Most neuroimaging research in stroke rehabilitation mainly focuses on the neural mechanisms underlying the natural history of post-stroke recovery. However, connectivity mapping from resting-state fMRI is well suited for different neurological conditions and provides a promising method to explore plastic changes for treatment-induced recovery from stroke. We examined the changes in resting-state functional connectivity (RS-FC) of the ipsilesional primary motor cortex (M1) in 10 post-acute stroke patients before and immediately after 4 weeks of robot-assisted bilateral arm therapy (RBAT). Motor performance, functional use of the affected arm, and daily function improved in all participants. Reduced interhemispheric RS-FC between the ipsilesional and contralesional M1 (M1-M1) and the contralesional-lateralized connections were noted before treatment. In contrast, greater M1-M1 functional connectivity and disturbed resting-state networks were observed after RBAT relative to pre-treatment. Increased changes in M1-M1 RS-FC after RBAT were coupled with better motor and functional improvements. Mediation analysis showed the pre-to-post difference in M1-M1 RS-FC was a significant mediator for the relationship between motor and functional recovery. These results show neuroplastic changes and functional recoveries induced by RBAT in post-acute stroke survivors and suggest that interhemispheric functional connectivity in the motor cortex may be a neurobiological marker for recovery after stroke rehabilitation.
Most neuroimaging research in stroke rehabilitation mainly focuses on the neural mechanisms underlying the natural history of post-stroke recovery. However, connectivity mapping from resting-state fMRI is well suited for different neurological conditions and provides a promising method to explore plastic changes for treatment-induced recovery from stroke. We examined the changes in resting-state functional connectivity (RS-FC) of the ipsilesional primary motor cortex (M1) in 10 post-acute stroke patients before and immediately after 4 weeks of robot-assisted bilateral arm therapy (RBAT). Motor performance, functional use of the affected arm, and daily function improved in all participants. Reduced interhemispheric RS-FC between the ipsilesional and contralesional M1 (M1-M1) and the contralesional-lateralized connections were noted before treatment. In contrast, greater M1-M1 functional connectivity and disturbed resting-state networks were observed after RBAT relative to pre-treatment. Increased changes in M1-M1 RS-FC after RBAT were coupled with better motor and functional improvements. Mediation analysis showed the pre-to-post difference in M1-M1 RS-FC was a significant mediator for the relationship between motor and functional recovery. These results show neuroplastic changes and functional recoveries induced by RBAT in post-acute stroke survivors and suggest that interhemispheric functional connectivity in the motor cortex may be a neurobiological marker for recovery after stroke rehabilitation.
Author Wu, Ching-yi
Chen, Yao-liang
Liu, Ho-ling
Wai, Yau-yau
Fan, Yang-teng
Lin, Keh-chung
AuthorAffiliation 5 Department of Medical Imaging and Radiological Sciences, Chang Gung University Taoyuan, Taiwan
4 Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center Houston, TX, USA
3 Healthy Aging Research Center, Chang Gung University Taoyuan, Taiwan
7 Department of Diagnostic Radiology, Chang Gung Memorial Hospital Keelung, Taiwan
2 Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung University Taoyuan, Taiwan
6 Department of Physical Medicine and Rehabilitation, Division of Occupational Therapy, National Taiwan University Hospital Taipei, Taiwan
8 MRI Center, Chang Gung Memorial Hospital Taoyuan, Taiwan
1 School of Occupational Therapy, College of Medicine, National Taiwan University and Division of Occupational Therapy, Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital Taipei, Taiwan
AuthorAffiliation_xml – name: 1 School of Occupational Therapy, College of Medicine, National Taiwan University and Division of Occupational Therapy, Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital Taipei, Taiwan
– name: 3 Healthy Aging Research Center, Chang Gung University Taoyuan, Taiwan
– name: 4 Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center Houston, TX, USA
– name: 2 Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung University Taoyuan, Taiwan
– name: 8 MRI Center, Chang Gung Memorial Hospital Taoyuan, Taiwan
– name: 5 Department of Medical Imaging and Radiological Sciences, Chang Gung University Taoyuan, Taiwan
– name: 6 Department of Physical Medicine and Rehabilitation, Division of Occupational Therapy, National Taiwan University Hospital Taipei, Taiwan
– name: 7 Department of Diagnostic Radiology, Chang Gung Memorial Hospital Keelung, Taiwan
Author_xml – sequence: 1
  givenname: Yang-teng
  surname: Fan
  fullname: Fan, Yang-teng
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  givenname: Ching-yi
  surname: Wu
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– sequence: 3
  givenname: Ho-ling
  surname: Liu
  fullname: Liu, Ho-ling
– sequence: 4
  givenname: Keh-chung
  surname: Lin
  fullname: Lin, Keh-chung
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  surname: Wai
  fullname: Wai, Yau-yau
– sequence: 6
  givenname: Yao-liang
  surname: Chen
  fullname: Chen, Yao-liang
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26557065$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1161/strokeaha.112.658807
10.1016/j.neuroimage.2009.05.043
10.1109/icorr.2013.6650506
10.1093/brain/awq043
10.1177/1545968308331148
10.1002/mrm.1910350312
10.1097/wco.0000000000000150
10.3389/fnhum.2015.00120
10.1186/s12883-014-0236-6
10.1016/j.ijpsycho.2006.03.011
10.1007/s00415-014-7345-4
10.1186/1743-0003-10-35
10.3389/fneng.2014.00025
10.1177/0269215511416383
10.1186/1743-0003-11-111
10.3389/fnsys.2010.00013
10.1177/1545968309345268
10.1177/1545968314522349
10.2340/1650197771331
10.1016/j.neuroimage.2012.02.070
10.1682/jrrd.2005.04.0075
10.1177/1073858413491147
10.1109/iembs.2011.6091843
10.1073/pnas.95.15.8939
10.1161/01.str.0000177865.37334.ce
10.1093/scan/nst101
10.2340/16501977-0928
10.1161/strokeaha.108.530584
10.3233/RNN-2004-00282
10.1177/1545968312445910
10.1038/35094500
10.1177/1545968311405675
10.1113/jphysiol.2012.243469
10.3389/fnhum.2014.01037
10.1212/01.wnl.0000148726.45458.a9
10.1109/embc.2012.6346981
10.1523/jneurosci.3662-11.2012
10.1038/nrn2735
10.1161/strokeaha.113.003537
10.2340/165019771994263115119
10.1161/strokeaha.110.596155
10.1007/s00221-008-1276-1
10.1007/springerreference_183334
10.1177/1545968312457827
10.1177/1545968305276663
10.1002/hbm.460020107
10.1097/mrr.0b013e32834d330a
10.1056/NEJMoa0911341
10.1002/mrm.1910340409
10.1161/01.str.0000071761.36075.a6
10.3389/fneur.2013.00178
10.1212/wnl.0b013e31825f25e7
10.1016/j.neuroimage.2012.02.018
10.1146/annurev.neuro.29.051605.112819
10.1126/science.1169896
10.1002/ana.21905
10.1016/s0014-4886(89)80005-6
10.1310/tsr1604-270
10.1016/j.neuroimage.2011.10.023
10.1310/tsr18s01-599
10.1007/s11065-005-6252-y
10.1371/journal.pone.0084729
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Copyright 2015. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright © 2015 Fan, Wu, Liu, Lin, Wai and Chen. 2015 Fan, Wu, Liu, Lin, Wai and Chen
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Keywords robot
fMRI
rehabilitation
functional connectivity
motor cortex
stroke
Language English
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Reviewed by: Martin Lotze, University of Greifswald, Germany; Erin Burke Quinlan, University of California, Irvine, USA
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References Lo (B37) 2010; 362
Horwitz (B27) 1998; 95
Waller (B57) 2014; 14
Housman (B28) 2009; 23
Rehme (B44) 2013; 591
Basteris (B2) 2014; 11
Friston (B17) 1996; 35
Puh (B42) 2007; 63
Calautti (B6) 2003; 34
Fan (B15) 2014; 9
Friston (B16) 1994; 2
Manson (B39) 2008; 187
Hsieh (B31) 2012; 43
Van Delden (B52) 2012; 44
Van Essen (B53) 2012; 62
Golestani (B19) 2013; 27
James (B33) 2009; 16
Park (B41) 2011; 42
Arya (B1) 2011; 18
Teng (B50) 1987; 48
Hughes (B32) 2015; 9
Hamilton (B24) 1994; 26
Saleh (B46) 2012
Simkins (B48) 2013; 3
Dijkhuizen (B13) 2014; 27
Fugl-Meyer (B18) 1975; 7
Hesse (B26) 2005; 36
Granziera (B20) 2012; 79
Wager (B56) 2009; 47
van Meer (B54) 2012
Wu (B62) 2013; 10
Grefkes (B21) 2014; 20
Carter (B8) 2012; 62
Hsieh (B29) 2014; 261
Bosnell (B5) 2011; 25
Chen (B10) 2013; 4
Hsieh (B30) 2009; 40
Wei (B59) 2011; 34
Stinear (B49) 2014; 45
De Santis (B11) 2014; 8
Rehme (B45) 2012; 59
Bloom (B4) 2005; 15
Biswal (B3) 1995; 34
Murphy (B40) 2009; 10
Gusnard (B22) 2001; 2
Dromerick (B14) 2006; 43
Hanlon (B25) 2005; 64
Liao (B35) 2012; 26
Desmurget (B12) 2009; 324
Varkuti (B55) 2013; 27
Urbin (B51) 2014; 28
Wang (B58) 2010; 133
Yan (B64) 2010; 4
Hamilton (B23) 1987
Xu (B63) 2014; 9
Carter (B7) 2010; 67
Young (B65) 2014; 7
Raichle (B43) 2006; 29
Wolf (B60) 1989; 104
Kwakkel (B34) 2004; 22
Wolf (B61) 2005; 19
Lin (B36) 2010; 24
Sergi (B47) 2011
16109908 - Stroke. 2005 Sep;36(9):1960-6
24416273 - PLoS One. 2014 Jan 08;9(1):e84729
19237734 - Neurorehabil Neural Repair. 2009 Jun;23 (5):505-14
22044987 - Int J Rehabil Res. 2011 Dec;34(4):349-56
25333606 - Curr Opin Neurol. 2014 Dec;27(6):637-43
19423830 - Science. 2009 May 8;324(5928):811-3
22645108 - Neurorehabil Neural Repair. 2013 Jan;27(1):53-62
23090951 - J Physiol. 2013 Jan 1;591(1):17-31
24748465 - J Neurol. 2014 May;261(5):1037-45
23366942 - Conf Proc IEEE Eng Med Biol Soc. 2012;2012:4559-62
1135616 - Scand J Rehabil Med. 1975;7(1):13-31
20354002 - Brain. 2010 Apr;133(Pt 4):1224-38
3611032 - J Clin Psychiatry. 1987 Aug;48(8):314-8
9671783 - Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8939-44
15642913 - Neurology. 2005 Jan 11;64(1):114-20
25012864 - J Neuroeng Rehabil. 2014 Jul 10;11:111
22995440 - Neurorehabil Neural Repair. 2013 Feb;27(2):153-63
24178916 - Stroke. 2014 Jan;45(1):205-10
8699946 - Magn Reson Med. 1996 Mar;35(3):346-55
19740732 - Top Stroke Rehabil. 2009 Jul-Aug;16(4):270-81
19228851 - Stroke. 2009 Apr;40(4):1386-91
8524021 - Magn Reson Med. 1995 Oct;34(4):537-41
22023742 - Neuroimage. 2012 Feb 1;59(3):2771-82
22120029 - Top Stroke Rehabil. 2011 Oct;18 Suppl 1:599-610
22366334 - Neuroimage. 2012 Oct 1;62(4):2222-31
12738893 - Stroke. 2003 Jun;34(6):1553-66
2707361 - Exp Neurol. 1989 May;104(2):125-32
19888284 - Nat Rev Neurosci. 2009 Dec;10(12):861-72
16093410 - Neurorehabil Neural Repair. 2005 Sep;19(3):194-205
22895994 - Stroke. 2012 Oct;43(10 ):2729-34
22266762 - J Rehabil Med. 2012 Feb;44(2):106-17
21646444 - Neurorehabil Neural Repair. 2011 Sep;25(7):607-16
22722626 - Neurology. 2012 Jul 3;79(1):39-46
23587106 - J Neuroeng Rehabil. 2013 Apr 12;10 :35
19729583 - Neurorehabil Neural Repair. 2010 Jan;24(1):42-51
22414990 - Neuroimage. 2012 Oct 1;62(4):2271-80
17041825 - J Rehabil Res Dev. 2006 May-Jun;43(3):401-8
24553104 - Neurorehabil Neural Repair. 2014 Oct;28(8):761-9
18236036 - Exp Brain Res. 2008 May;187(1):25-31
25784872 - Front Hum Neurosci. 2015 Mar 02;9:120
21441147 - Stroke. 2011 May;42(5):1357-62
22457497 - J Neurosci. 2012 Mar 28;32(13):4495-507
20400552 - N Engl J Med. 2010 May 13;362(19):1772-83
16814889 - Int J Psychophysiol. 2007 Feb;63(2):173-80
23774218 - Neuroscientist. 2014 Feb;20(1):56-70
20373348 - Ann Neurol. 2010 Mar;67(3):365-75
20577591 - Front Syst Neurosci. 2010 May 14;4:13
16211466 - Neuropsychol Rev. 2005 Jun;15(2):59-71
15502272 - Restor Neurol Neurosci. 2004;22(3-5):281-99
25494635 - BMC Neurol. 2014 Dec 14;14 :236
21840917 - Clin Rehabil. 2012 Feb;26(2):111-20
24187321 - IEEE Int Conf Rehabil Robot. 2013 Jun;2013:6650506
25601833 - Front Hum Neurosci. 2015 Jan 05;8:1037
16776593 - Annu Rev Neurosci. 2006;29:449-76
24223571 - Front Neurol. 2013 Nov 07;4:178
25071547 - Front Neuroeng. 2014 Jul 08;7:25
19465137 - Neuroimage. 2009 Sep;47(3):821-35
7801060 - Scand J Rehabil Med. 1994 Sep;26(3):115-9
11584306 - Nat Rev Neurosci. 2001 Oct;2(10 ):685-94
22256066 - Conf Proc IEEE Eng Med Biol Soc. 2011;2011:7470-3
23929944 - Soc Cogn Affect Neurosci. 2014 Aug;9(8):1203-13
References_xml – volume: 43
  start-page: 2729
  year: 2012
  ident: B31
  article-title: Dose-response relationship of robot-assisted stroke motor rehabilitation the impact of initial motor status
  publication-title: Stroke.
  doi: 10.1161/strokeaha.112.658807
– volume: 47
  start-page: 821
  year: 2009
  ident: B56
  article-title: Brain mediators of cardiovascular responses to social threat: part I: Reciprocal dorsal and ventral sub-regions of the medial prefrontal cortex and heart-rate reactivity
  publication-title: Neuroimage.
  doi: 10.1016/j.neuroimage.2009.05.043
– volume: 3
  start-page: 6650506
  year: 2013
  ident: B48
  article-title: Robotic unilateral and bilateral upper-limb movement training for stroke survivors afflicted by chronic hemiparesis
  publication-title: IEEE. Int. Conf. Rehabil. Robot.
  doi: 10.1109/icorr.2013.6650506
– volume: 133
  start-page: 1224
  year: 2010
  ident: B58
  article-title: Dynamic functional reorganization of the motor execution network after stroke
  publication-title: Brain.
  doi: 10.1093/brain/awq043
– volume: 23
  start-page: 505
  year: 2009
  ident: B28
  article-title: A randomized controlled trial of gravity-supported, computer-enhanced arm exercise for individuals with severe hemiparesis
  publication-title: Neurorehabil. Neural Repair.
  doi: 10.1177/1545968308331148
– volume: 35
  start-page: 346
  year: 1996
  ident: B17
  article-title: Movement-related effects in fMRI time-series
  publication-title: Magn. Reson. Med.
  doi: 10.1002/mrm.1910350312
– volume: 27
  start-page: 637
  year: 2014
  ident: B13
  article-title: Assessment and modulation of resting-state neural networks after stroke
  publication-title: Curr. Opin. Neurol.
  doi: 10.1097/wco.0000000000000150
– volume: 9
  start-page: 120
  year: 2015
  ident: B32
  article-title: Upper extremity proprioception in healthy aging and stroke populations and the effects of therapist-and robot-based rehabilitation therapies on proprioceptive function
  publication-title: Front. Hum. Neurosci.
  doi: 10.3389/fnhum.2015.00120
– volume: 14
  start-page: 236
  year: 2014
  ident: B57
  article-title: Sequencing bilateral and unilateral task-oriented training versus task oriented training alone to improve arm function in individuals with chronic stroke
  publication-title: BMC. Neurol.
  doi: 10.1186/s12883-014-0236-6
– volume: 63
  start-page: 173
  year: 2007
  ident: B42
  article-title: Increased cognitive load during simple and complex motor tasks in acute stage after stroke
  publication-title: Int. J. Psychophysiol.
  doi: 10.1016/j.ijpsycho.2006.03.011
– volume: 261
  start-page: 1037
  year: 2014
  ident: B29
  article-title: Sequential combination of robot-assisted therapy and constraint-induced therapy in stroke rehabilitation: a randomized controlled trial
  publication-title: J. Neurol.
  doi: 10.1007/s00415-014-7345-4
– volume: 10
  start-page: 35
  year: 2013
  ident: B62
  article-title: Unilateral versus bilateral robot-assisted rehabilitation on arm-trunk control and functions post stroke: a randomized controlled trial
  publication-title: J. Neuroeng. Rehabil.
  doi: 10.1186/1743-0003-10-35
– volume: 7
  start-page: 25
  year: 2014
  ident: B65
  article-title: Changes in functional connectivity correlate with behavioral gains in stroke patients after therapy using a brain-computer interface device
  publication-title: Front. Neuroeng.
  doi: 10.3389/fneng.2014.00025
– volume: 26
  start-page: 111
  year: 2012
  ident: B35
  article-title: Effects of robot-assisted upper limb rehabilitation on daily function and real-world arm activity in patients with chronic stroke: a randomized controlled trial
  publication-title: Clin. Rehabil.
  doi: 10.1177/0269215511416383
– volume: 11
  start-page: 111
  year: 2014
  ident: B2
  article-title: Training modalities in robot-mediated upper limb rehabilitation in stroke: a framework for classification based on a systematic review
  publication-title: J. Neuroeng. Rehabil.
  doi: 10.1186/1743-0003-11-111
– volume: 4
  start-page: 13
  year: 2010
  ident: B64
  article-title: DPARSF: a MATLAB toolbox for “pipeline” data analysis of resting-state fMRI
  publication-title: Front. Syst. Neurosci.
  doi: 10.3389/fnsys.2010.00013
– volume: 24
  start-page: 42
  year: 2010
  ident: B36
  article-title: The effects of bilateral arm training on motor control and functional performance in chronic stroke: a randomized controlled study
  publication-title: Neurorehabil. Neural. Repair.
  doi: 10.1177/1545968309345268
– volume: 28
  start-page: 761
  year: 2014
  ident: B51
  article-title: Resting-state functional connectivity and its association with multiple domains of upper-extremity function in chronic stroke
  publication-title: Neurorehabil. Neural. Repair.
  doi: 10.1177/1545968314522349
– volume: 7
  start-page: 13
  year: 1975
  ident: B18
  article-title: The post-stroke hemiplegic patient. 1. a method for evaluation of physical performance
  publication-title: Scand. J. Rehabil. Med.
  doi: 10.2340/1650197771331
– volume: 62
  start-page: 2271
  year: 2012
  ident: B8
  article-title: Why use a connectivity-based approach to study stroke and recovery of function?
  publication-title: Neuroimage.
  doi: 10.1016/j.neuroimage.2012.02.070
– volume: 43
  start-page: 401
  year: 2006
  ident: B14
  article-title: Relationships between upper-limb functional limitation and self-reported disability 3 months after stroke
  publication-title: J. Rehabil. Res. Dev.
  doi: 10.1682/jrrd.2005.04.0075
– volume: 20
  start-page: 56
  year: 2014
  ident: B21
  article-title: Cortical reorganization after stroke: how much and how functional?
  publication-title: Neuroscientist.
  doi: 10.1177/1073858413491147
– start-page: 7470
  year: 2011
  ident: B47
  article-title: Predicting efficacy of robot-aided rehabilitation in chronic stroke patients using an MRI-compatible robotic device
  publication-title: Conf. Proc. IEEE. Eng. Med. Biol. Soc. 2011.
  doi: 10.1109/iembs.2011.6091843
– volume: 95
  start-page: 8939
  year: 1998
  ident: B27
  article-title: Functional connectivity of the angular gyrus in normal reading and dyslexia
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.95.15.8939
– volume: 36
  start-page: 1960
  year: 2005
  ident: B26
  article-title: Computerized arm training improves the motor control of the severely affected arm after stroke: a single-blinded randomized trial in two centers
  publication-title: Stroke.
  doi: 10.1161/01.str.0000177865.37334.ce
– volume: 9
  start-page: 1203
  year: 2014
  ident: B15
  article-title: Empathic arousal and social understanding in individuals with autism: evidence from fMRI and ERP measurements
  publication-title: Soc. Cogn. Affect. Neurosci.
  doi: 10.1093/scan/nst101
– volume: 44
  start-page: 106
  year: 2012
  ident: B52
  article-title: Unilateral versus bilateral upper limb exercise therapy after stroke: a systematic review
  publication-title: J. Rehabil. Medicine.
  doi: 10.2340/16501977-0928
– volume: 40
  start-page: 1386
  year: 2009
  ident: B30
  article-title: Responsiveness and validity of three outcome measures of motor function after stroke rehabilitation
  publication-title: Stroke.
  doi: 10.1161/strokeaha.108.530584
– volume: 22
  start-page: 281
  year: 2004
  ident: B34
  article-title: Understanding the pattern of functional recovery after stroke: facts and theories
  publication-title: Restorat. Neurol. Neurosci.
  doi: 10.3233/RNN-2004-00282
– volume: 27
  start-page: 53
  year: 2013
  ident: B55
  article-title: Resting state changes in functional connectivity correlate with movement recovery for BCI and robot-assisted upper-extremity training after stroke
  publication-title: Neurorehabil. Neural. Repair.
  doi: 10.1177/1545968312445910
– volume: 2
  start-page: 685
  year: 2001
  ident: B22
  article-title: Searching for a baseline: functional imaging and the resting human brain
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/35094500
– volume: 25
  start-page: 607
  year: 2011
  ident: B5
  article-title: Motor practice promotes increased activity in brain regions structurally disconnected after subcortical stroke
  publication-title: Neurorehabil. Neural Repair.
  doi: 10.1177/1545968311405675
– volume: 591
  start-page: 17
  year: 2013
  ident: B44
  article-title: Cerebral network disorders after stroke: evidence from imaging-based connectivity analyses of active and resting brain states in humans
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2012.243469
– volume: 8
  start-page: 1037
  year: 2014
  ident: B11
  article-title: Robot-assisted training of the kinesthetic sense: enhancing proprioception after stroke
  publication-title: Front. Hum. Neurosci.
  doi: 10.3389/fnhum.2014.01037
– volume: 64
  start-page: 114
  year: 2005
  ident: B25
  article-title: New brain networks are active after right MCA stroke when moving the ipsilesional arm
  publication-title: Neurology.
  doi: 10.1212/01.wnl.0000148726.45458.a9
– start-page: 4559
  year: 2012
  ident: B46
  article-title: Resting state functional connectivity and task-related effective connectivity changes after upper extremity rehabilitation: a pilot study
  publication-title: Conf. Proc. IEEE. Eng. Med. Biol. Soc. 2012.
  doi: 10.1109/embc.2012.6346981
– start-page: 4495
  year: 2012
  ident: B54
  article-title: Extent of bilateral neuronal network reorganization and functional recovery in relation to stroke severity
  publication-title: J. Neurosci. 32
  doi: 10.1523/jneurosci.3662-11.2012
– volume: 10
  start-page: 861
  year: 2009
  ident: B40
  article-title: Plasticity during stroke recovery: from synapse to behavior
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn2735
– volume: 45
  start-page: 205
  year: 2014
  ident: B49
  article-title: Bilateral priming accelerates recovery of upper limb function after stroke: a randomized controlled trial
  publication-title: Stroke.
  doi: 10.1161/strokeaha.113.003537
– volume: 26
  start-page: 115
  year: 1994
  ident: B24
  article-title: Interrater reliability of the 7-level functional independence measure (FIM)
  publication-title: Scand. J. Rehabil. Med.
  doi: 10.2340/165019771994263115119
– volume: 42
  start-page: 1357
  year: 2011
  ident: B41
  article-title: Longitudinal changes of resting-state functional connectivity during motor recovery after stroke
  publication-title: Stroke.
  doi: 10.1161/strokeaha.110.596155
– volume: 187
  start-page: 25
  year: 2008
  ident: B39
  article-title: Impairment of movement-associated brain deactivation in multiple sclerosis: further evidence for a functional pathology of interhemispheric neuronal inhibition
  publication-title: Exp. Brain. Res.
  doi: 10.1007/s00221-008-1276-1
– volume: 48
  start-page: 314
  year: 1987
  ident: B50
  article-title: The Modified Mini-Mental State (3MS) examination
  publication-title: J. Clin. Psychiatry.
  doi: 10.1007/springerreference_183334
– volume: 27
  start-page: 153
  year: 2013
  ident: B19
  article-title: Longitudinal evaluation of resting-state FMRI after acute stroke with hemiparesis
  publication-title: Neurorehabil. Neural Repair.
  doi: 10.1177/1545968312457827
– volume: 19
  start-page: 194
  year: 2005
  ident: B61
  article-title: The EXCITE trial: attributes of the Wolf Motor Function Test in patients with subacute stroke
  publication-title: Neurorehabil. Neural. Repair.
  doi: 10.1177/1545968305276663
– volume: 2
  start-page: 56
  year: 1994
  ident: B16
  article-title: Functional and effective connectivity in neuroimaging: A synthesis
  publication-title: Hum. Brain Mapp.
  doi: 10.1002/hbm.460020107
– volume: 34
  start-page: 349
  year: 2011
  ident: B59
  article-title: The responsiveness and correlation between Fugl-Meyer Assessment, Motor Status Scale and the Action Research Arm Test in chronic stroke with upper-extremity rehabilitation robotic training
  publication-title: Int. J. Rehabil. Res.
  doi: 10.1097/mrr.0b013e32834d330a
– volume: 362
  start-page: 1772
  year: 2010
  ident: B37
  article-title: Robot-assisted therapy for long-term upper-limb impairment after stroke
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa0911341
– volume: 34
  start-page: 537
  year: 1995
  ident: B3
  article-title: Functional connectivity in the motor cortex of resting human brain using echo-planar MRI
  publication-title: Magn. Reson. Med.
  doi: 10.1002/mrm.1910340409
– volume: 34
  start-page: 1553
  year: 2003
  ident: B6
  article-title: Functional neuroimaging studies of motor recovery after stroke in adults: a review
  publication-title: Stroke.
  doi: 10.1161/01.str.0000071761.36075.a6
– volume: 4
  start-page: 178
  year: 2013
  ident: B10
  article-title: Resting state interhemispheric motor connectivity and white matter integrity correlate with motor impairment in chronic stroke
  publication-title: Front. Neurol.
  doi: 10.3389/fneur.2013.00178
– volume: 79
  start-page: 39
  year: 2012
  ident: B20
  article-title: A new early and automated MRI-based predictor of motor improvement after stroke
  publication-title: Neurology.
  doi: 10.1212/wnl.0b013e31825f25e7
– volume: 62
  start-page: 2222
  year: 2012
  ident: B53
  article-title: The Human Connectome Project: a data acquisition perspective
  publication-title: Neuroimage.
  doi: 10.1016/j.neuroimage.2012.02.018
– volume: 29
  start-page: 449
  year: 2006
  ident: B43
  article-title: Brain work and brain imaging
  publication-title: Annu. Rev. Neurosci.
  doi: 10.1146/annurev.neuro.29.051605.112819
– volume: 324
  start-page: 811
  year: 2009
  ident: B12
  article-title: Movement intention after parietal cortex stimulation in humans
  publication-title: Science.
  doi: 10.1126/science.1169896
– volume: 67
  start-page: 365
  year: 2010
  ident: B7
  article-title: Resting interhemispheric functional magnetic resonance imaging connectivity predicts performance after stroke
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.21905
– volume: 104
  start-page: 125
  year: 1989
  ident: B60
  article-title: Forced use of hemiplegic upper extremities to reverse the effect of learned nonuse among chronic stroke and head-injured patients
  publication-title: Exp. Neurol.
  doi: 10.1016/s0014-4886(89)80005-6
– volume-title: Rehabilitation outcomes: Analysis and measurement
  year: 1987
  ident: B23
  article-title: A uniform national data system for medical rehabilitation
– volume: 16
  start-page: 270
  year: 2009
  ident: B33
  article-title: Changes in resting state effective connectivity in the motor network following rehabilitation of upper extremity poststroke paresis
  publication-title: Top Stroke Rehabil.
  doi: 10.1310/tsr1604-270
– volume: 59
  start-page: 2771
  year: 2012
  ident: B45
  article-title: Activation likelihood estimation meta-analysis of motor-related neural activity after stroke
  publication-title: Neuroimage.
  doi: 10.1016/j.neuroimage.2011.10.023
– volume: 18
  start-page: 599
  year: 2011
  ident: B1
  article-title: Estimating the minimal clinically important difference of an upper extremity recovery measure in subacute stroke patients
  publication-title: Top Stroke Rehabil.
  doi: 10.1310/tsr18s01-599
– volume: 15
  start-page: 59
  year: 2005
  ident: B4
  article-title: The role of the corpus callosum in interhemispheric transfer of information: excitation or inhibition?
  publication-title: Neuropsychol. Rev.
  doi: 10.1007/s11065-005-6252-y
– volume: 9
  start-page: e84729
  year: 2014
  ident: B63
  article-title: Contribution of the resting-state functional connectivity of the contralesional primary sensorimotor cortex to motor recovery after subcortical stroke
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0084729
– reference: 23366942 - Conf Proc IEEE Eng Med Biol Soc. 2012;2012:4559-62
– reference: 2707361 - Exp Neurol. 1989 May;104(2):125-32
– reference: 9671783 - Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8939-44
– reference: 23090951 - J Physiol. 2013 Jan 1;591(1):17-31
– reference: 20400552 - N Engl J Med. 2010 May 13;362(19):1772-83
– reference: 21441147 - Stroke. 2011 May;42(5):1357-62
– reference: 22120029 - Top Stroke Rehabil. 2011 Oct;18 Suppl 1:599-610
– reference: 25071547 - Front Neuroeng. 2014 Jul 08;7:25
– reference: 17041825 - J Rehabil Res Dev. 2006 May-Jun;43(3):401-8
– reference: 25333606 - Curr Opin Neurol. 2014 Dec;27(6):637-43
– reference: 16211466 - Neuropsychol Rev. 2005 Jun;15(2):59-71
– reference: 19729583 - Neurorehabil Neural Repair. 2010 Jan;24(1):42-51
– reference: 18236036 - Exp Brain Res. 2008 May;187(1):25-31
– reference: 23774218 - Neuroscientist. 2014 Feb;20(1):56-70
– reference: 22722626 - Neurology. 2012 Jul 3;79(1):39-46
– reference: 22457497 - J Neurosci. 2012 Mar 28;32(13):4495-507
– reference: 21840917 - Clin Rehabil. 2012 Feb;26(2):111-20
– reference: 25601833 - Front Hum Neurosci. 2015 Jan 05;8:1037
– reference: 22414990 - Neuroimage. 2012 Oct 1;62(4):2271-80
– reference: 19888284 - Nat Rev Neurosci. 2009 Dec;10(12):861-72
– reference: 22995440 - Neurorehabil Neural Repair. 2013 Feb;27(2):153-63
– reference: 25784872 - Front Hum Neurosci. 2015 Mar 02;9:120
– reference: 16776593 - Annu Rev Neurosci. 2006;29:449-76
– reference: 22023742 - Neuroimage. 2012 Feb 1;59(3):2771-82
– reference: 1135616 - Scand J Rehabil Med. 1975;7(1):13-31
– reference: 16814889 - Int J Psychophysiol. 2007 Feb;63(2):173-80
– reference: 24748465 - J Neurol. 2014 May;261(5):1037-45
– reference: 19465137 - Neuroimage. 2009 Sep;47(3):821-35
– reference: 19237734 - Neurorehabil Neural Repair. 2009 Jun;23 (5):505-14
– reference: 24553104 - Neurorehabil Neural Repair. 2014 Oct;28(8):761-9
– reference: 22645108 - Neurorehabil Neural Repair. 2013 Jan;27(1):53-62
– reference: 24223571 - Front Neurol. 2013 Nov 07;4:178
– reference: 24178916 - Stroke. 2014 Jan;45(1):205-10
– reference: 8699946 - Magn Reson Med. 1996 Mar;35(3):346-55
– reference: 19740732 - Top Stroke Rehabil. 2009 Jul-Aug;16(4):270-81
– reference: 8524021 - Magn Reson Med. 1995 Oct;34(4):537-41
– reference: 20577591 - Front Syst Neurosci. 2010 May 14;4:13
– reference: 15642913 - Neurology. 2005 Jan 11;64(1):114-20
– reference: 15502272 - Restor Neurol Neurosci. 2004;22(3-5):281-99
– reference: 7801060 - Scand J Rehabil Med. 1994 Sep;26(3):115-9
– reference: 22256066 - Conf Proc IEEE Eng Med Biol Soc. 2011;2011:7470-3
– reference: 16093410 - Neurorehabil Neural Repair. 2005 Sep;19(3):194-205
– reference: 11584306 - Nat Rev Neurosci. 2001 Oct;2(10 ):685-94
– reference: 20373348 - Ann Neurol. 2010 Mar;67(3):365-75
– reference: 24187321 - IEEE Int Conf Rehabil Robot. 2013 Jun;2013:6650506
– reference: 12738893 - Stroke. 2003 Jun;34(6):1553-66
– reference: 24416273 - PLoS One. 2014 Jan 08;9(1):e84729
– reference: 19423830 - Science. 2009 May 8;324(5928):811-3
– reference: 22895994 - Stroke. 2012 Oct;43(10 ):2729-34
– reference: 22266762 - J Rehabil Med. 2012 Feb;44(2):106-17
– reference: 21646444 - Neurorehabil Neural Repair. 2011 Sep;25(7):607-16
– reference: 16109908 - Stroke. 2005 Sep;36(9):1960-6
– reference: 22366334 - Neuroimage. 2012 Oct 1;62(4):2222-31
– reference: 20354002 - Brain. 2010 Apr;133(Pt 4):1224-38
– reference: 25494635 - BMC Neurol. 2014 Dec 14;14 :236
– reference: 19228851 - Stroke. 2009 Apr;40(4):1386-91
– reference: 22044987 - Int J Rehabil Res. 2011 Dec;34(4):349-56
– reference: 3611032 - J Clin Psychiatry. 1987 Aug;48(8):314-8
– reference: 23929944 - Soc Cogn Affect Neurosci. 2014 Aug;9(8):1203-13
– reference: 25012864 - J Neuroeng Rehabil. 2014 Jul 10;11:111
– reference: 23587106 - J Neuroeng Rehabil. 2013 Apr 12;10 :35
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Snippet Most neuroimaging research in stroke rehabilitation mainly focuses on the neural mechanisms underlying the natural history of post-stroke recovery. However,...
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StartPage 546
SubjectTerms Activities of daily living
Brain mapping
Brain research
Cerebral hemispheres
Cortex (motor)
fMRI
functional connectivity
Functional magnetic resonance imaging
Medicine
Motor Cortex
Motor task performance
Neural networks
Neuroimaging
Neuroplasticity
Neuroscience
Occupational therapy
Recovery of function
Rehabilitation
robot
Robots
Stroke
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Title Neuroplastic changes in resting-state functional connectivity after stroke rehabilitation
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