An Increase in Cellular Size Variance Contributes to the Increase in Ultrasound Backscatter During Cell Death
This study aims to explain the contribution of changes in cellular size variance (CSV) to increases in ultrasound-integrated backscatter (UIB) measured from cell samples undergoing cell death. A Monte Carlo algorithm was used to compare simulations of 2D distributions of cells, uniform (CSV = 0) ver...
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| Published in | Ultrasound in medicine & biology Vol. 36; no. 9; pp. 1546 - 1558 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Elsevier Inc
01.09.2010
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0301-5629 1879-291X 1879-291X |
| DOI | 10.1016/j.ultrasmedbio.2010.05.025 |
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| Abstract | This study aims to explain the contribution of changes in cellular size variance (CSV) to increases in ultrasound-integrated backscatter (UIB) measured from cell samples undergoing cell death. A Monte Carlo algorithm was used to compare simulations of 2D distributions of cells, uniform (CSV = 0)
versus heterogeneous (CSV > 0) and the same mean cellular size (
M
¯
). UIB increased in arrangements with heterogeneous cellular sizes from 3.6dB (
M
¯
= 20 μm, CSV = 0 μm/CSV = 18 μm) to 5.6 dB (
M
¯
=10 μm, CSV = 0 μm/CSV = 8 μm). Experimentally, UIB (10 to 30 MHz) was measured from cell samples of four tumor cell lines viable and undergoing cell death after radiotherapy and chemotherapy treatment. An increase of 3.8–7.5 dB (
p < 0.001) in UIB was measured from three cell lines. No increase in UIB was measured from one cell line. An increase in CSV was found for all cell samples after cell death. The results suggest that an increase in CSV could have a significant contribution to the increases measured in UIB after cell death in cell samples exposed to anticancer therapies. (E-mail:
rvlad@lakeridgehealth.on.ca) |
|---|---|
| AbstractList | This study aims to explain the contribution of changes in cellular size variance (CSV) to increases in ultrasound-integrated backscatter (UIB) measured from cell samples undergoing cell death. A Monte Carlo algorithm was used to compare simulations of 2D distributions of cells, uniform (CSV = 0)
versus heterogeneous (CSV > 0) and the same mean cellular size (
M
¯
). UIB increased in arrangements with heterogeneous cellular sizes from 3.6dB (
M
¯
= 20 μm, CSV = 0 μm/CSV = 18 μm) to 5.6 dB (
M
¯
=10 μm, CSV = 0 μm/CSV = 8 μm). Experimentally, UIB (10 to 30 MHz) was measured from cell samples of four tumor cell lines viable and undergoing cell death after radiotherapy and chemotherapy treatment. An increase of 3.8–7.5 dB (
p < 0.001) in UIB was measured from three cell lines. No increase in UIB was measured from one cell line. An increase in CSV was found for all cell samples after cell death. The results suggest that an increase in CSV could have a significant contribution to the increases measured in UIB after cell death in cell samples exposed to anticancer therapies. (E-mail:
rvlad@lakeridgehealth.on.ca) Abstract This study aims to explain the contribution of changes in cellular size variance (CSV) to increases in ultrasound-integrated backscatter (UIB) measured from cell samples undergoing cell death. A Monte Carlo algorithm was used to compare simulations of 2D distributions of cells, uniform (CSV = 0) versus heterogeneous (CSV > 0) and the same mean cellular size ( M ¯ ). UIB increased in arrangements with heterogeneous cellular sizes from 3.6dB ( M ¯ = 20 μm, CSV = 0 μm/CSV = 18 μm) to 5.6 dB ( M ¯ =10 μm, CSV = 0 μm/CSV = 8 μm). Experimentally, UIB (10 to 30 MHz) was measured from cell samples of four tumor cell lines viable and undergoing cell death after radiotherapy and chemotherapy treatment. An increase of 3.8–7.5 dB ( p < 0.001) in UIB was measured from three cell lines. No increase in UIB was measured from one cell line. An increase in CSV was found for all cell samples after cell death. The results suggest that an increase in CSV could have a significant contribution to the increases measured in UIB after cell death in cell samples exposed to anticancer therapies. (E-mail: rvlad@lakeridgehealth.on.ca ) This study aims to explain the contribution of changes in cellular size variance (CSV) to increases in ultrasound-integrated backscatter (UIB) measured from cell samples undergoing cell death. A Monte Carlo algorithm was used to compare simulations of 2D distributions of cells, uniform (CSV = 0) versus heterogeneous (CSV > 0) and the same mean cellular size (M ). UIB increased in arrangements with heterogeneous cellular sizes from 3.6dB (M = 20 mum, CSV = 0 microm/CSV = 18 microm) to 5.6 dB (M =10 microm, CSV = 0 microm/CSV = 8 microm). Experimentally, UIB (10 to 30 MHz) was measured from cell samples of four tumor cell lines viable and undergoing cell death after radiotherapy and chemotherapy treatment. An increase of 3.8-7.5 dB (p < 0.001) in UIB was measured from three cell lines. No increase in UIB was measured from one cell line. An increase in CSV was found for all cell samples after cell death. The results suggest that an increase in CSV could have a significant contribution to the increases measured in UIB after cell death in cell samples exposed to anticancer therapies. This study aims to explain the contribution of changes in cellular size variance (CSV) to increases in ultrasound-integrated backscatter (UIB) measured from cell samples undergoing cell death. A Monte Carlo algorithm was used to compare simulations of 2D distributions of cells, uniform (CSV = 0) versus heterogeneous (CSV 0) and the same mean cellular size ([inline image][inline image]). UIB increased in arrangements with heterogeneous cellular sizes from 3.6dB ([inline image][inline image] = 20 mu m, CSV = 0 mu m/CSV = 18 mu m) to 5.6 dB ([inline image][inline image]=10 mu m, CSV = 0 mu m/CSV = 8 mu m). Experimentally, UIB (10 to 30 MHz) was measured from cell samples of four tumor cell lines viable and undergoing cell death after radiotherapy and chemotherapy treatment. An increase of 3.8-7.5 dB (p 0.001) in UIB was measured from three cell lines. No increase in UIB was measured from one cell line. An increase in CSV was found for all cell samples after cell death. The results suggest that an increase in CSV could have a significant contribution to the increases measured in UIB after cell death in cell samples exposed to anticancer therapies. (E-mail: rvladakeridgehealth.on.ca) This study aims to explain the contribution of changes in cellular size variance (CSV) to increases in ultrasound-integrated backscatter (UIB) measured from cell samples undergoing cell death. A Monte Carlo algorithm was used to compare simulations of 2D distributions of cells, uniform (CSV = 0) versus heterogeneous (CSV > 0) and the same mean cellular size (M ). UIB increased in arrangements with heterogeneous cellular sizes from 3.6dB (M = 20 mum, CSV = 0 microm/CSV = 18 microm) to 5.6 dB (M =10 microm, CSV = 0 microm/CSV = 8 microm). Experimentally, UIB (10 to 30 MHz) was measured from cell samples of four tumor cell lines viable and undergoing cell death after radiotherapy and chemotherapy treatment. An increase of 3.8-7.5 dB (p < 0.001) in UIB was measured from three cell lines. No increase in UIB was measured from one cell line. An increase in CSV was found for all cell samples after cell death. The results suggest that an increase in CSV could have a significant contribution to the increases measured in UIB after cell death in cell samples exposed to anticancer therapies.This study aims to explain the contribution of changes in cellular size variance (CSV) to increases in ultrasound-integrated backscatter (UIB) measured from cell samples undergoing cell death. A Monte Carlo algorithm was used to compare simulations of 2D distributions of cells, uniform (CSV = 0) versus heterogeneous (CSV > 0) and the same mean cellular size (M ). UIB increased in arrangements with heterogeneous cellular sizes from 3.6dB (M = 20 mum, CSV = 0 microm/CSV = 18 microm) to 5.6 dB (M =10 microm, CSV = 0 microm/CSV = 8 microm). Experimentally, UIB (10 to 30 MHz) was measured from cell samples of four tumor cell lines viable and undergoing cell death after radiotherapy and chemotherapy treatment. An increase of 3.8-7.5 dB (p < 0.001) in UIB was measured from three cell lines. No increase in UIB was measured from one cell line. An increase in CSV was found for all cell samples after cell death. The results suggest that an increase in CSV could have a significant contribution to the increases measured in UIB after cell death in cell samples exposed to anticancer therapies. |
| Author | Czarnota, Gregory J. Kolios, Michael C. Alajez, Nehad M. Saha, Ratan K. Vlad, Roxana M. Ranieri, Shawn |
| Author_xml | – sequence: 1 givenname: Roxana M. surname: Vlad fullname: Vlad, Roxana M. email: rvlad@lakeridgehealth.on.ca organization: Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada – sequence: 2 givenname: Ratan K. surname: Saha fullname: Saha, Ratan K. organization: Department of Physics, Ryerson University, Toronto, Ontario, Canada – sequence: 3 givenname: Nehad M. surname: Alajez fullname: Alajez, Nehad M. organization: Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada – sequence: 4 givenname: Shawn surname: Ranieri fullname: Ranieri, Shawn organization: Department of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada – sequence: 5 givenname: Gregory J. surname: Czarnota fullname: Czarnota, Gregory J. organization: Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada – sequence: 6 givenname: Michael C. surname: Kolios fullname: Kolios, Michael C. organization: Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada |
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| Keywords | Anticancer therapies Cellular sizes distribution Scatterer distribution Simulation Monte Carlo algorithm Cell death Apoptosis and mitotic arrest Cellular size variance Ultrasound integrated backscatter Sonography Antineoplastic agent Ultrasound imaging Backscattering Experimental study Algorithm Modeling Treatment Echography Numerical simulation Ultrasound Tumor cell Apoptosis Biomedical engineering |
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| Snippet | This study aims to explain the contribution of changes in cellular size variance (CSV) to increases in ultrasound-integrated backscatter (UIB) measured from... Abstract This study aims to explain the contribution of changes in cellular size variance (CSV) to increases in ultrasound-integrated backscatter (UIB)... |
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| SubjectTerms | Algorithms Anticancer therapies Antineoplastic Agents - therapeutic use Apoptosis and mitotic arrest Biological and medical sciences Cell Death Cell Line, Tumor Cell Size Cells, Cultured Cellular size variance Cellular sizes distribution Chemotherapy Humans Investigative techniques, diagnostic techniques (general aspects) Leukemia, Myeloid, Acute - diagnostic imaging Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - radiotherapy Medical sciences Miscellaneous. Technology Monte Carlo algorithm Monte Carlo Method Radiology Radiotherapy Scatterer distribution Simulation Tumor cell lines Ultrasonic investigative techniques Ultrasonics Ultrasonography Ultrasound Ultrasound integrated backscatter |
| Title | An Increase in Cellular Size Variance Contributes to the Increase in Ultrasound Backscatter During Cell Death |
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