The BioPlex Network: A Systematic Exploration of the Human Interactome
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) c...
Saved in:
| Published in | Cell Vol. 162; no. 2; pp. 425 - 440 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
16.07.2015
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0092-8674 1097-4172 |
| DOI | 10.1016/j.cell.2015.06.043 |
Cover
| Abstract | Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%–100% coverage for most CORUM complexes. The network readily subdivides into communities that correspond to complexes or clusters of functionally related proteins. More generally, network architecture reflects cellular localization, biological process, and molecular function, enabling functional characterization of thousands of proteins. Network structure also reveals associations among thousands of protein domains, suggesting a basis for examining structurally related proteins. Finally, BioPlex, in combination with other approaches, can be used to reveal interactions of biological or clinical significance. For example, mutations in the membrane protein VAPB implicated in familial amyotrophic lateral sclerosis perturb a defined community of interactors.
[Display omitted]
•2,594 AP-MS experiments provide 23,744 interactions involving 7,668 proteins•The network subdivides into complexes and clusters of functionally related proteins•Network architecture reveals subcellular localization and PFAM domain associations•The network offers a roadmap for characterization of poorly studied proteins
An interaction network for human proteins developed from affinity purification-mass spectrometry analyses provides a basis for understanding the architecture of protein complexes and for functional characterization of over 2,500 proteins. |
|---|---|
| AbstractList | Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network readily subdivides into communities that correspond to complexes or clusters of functionally related proteins. More generally, network architecture reflects cellular localization, biological process, and molecular function, enabling functional characterization of thousands of proteins. Network structure also reveals associations among thousands of protein domains, suggesting a basis for examining structurally related proteins. Finally, BioPlex, in combination with other approaches, can be used to reveal interactions of biological or clinical significance. For example, mutations in the membrane protein VAPB implicated in familial amyotrophic lateral sclerosis perturb a defined community of interactors. Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%–100% coverage for most CORUM complexes. The network readily subdivides into communities that correspond to complexes or clusters of functionally related proteins. More generally, network architecture reflects cellular localization, biological process, and molecular function, enabling functional characterization of thousands of proteins. Network structure also reveals associations among thousands of protein domains, suggesting a basis for examining structurally related proteins. Finally, BioPlex, in combination with other approaches, can be used to reveal interactions of biological or clinical significance. For example, mutations in the membrane protein VAPB implicated in familial amyotrophic lateral sclerosis perturb a defined community of interactors. [Display omitted] •2,594 AP-MS experiments provide 23,744 interactions involving 7,668 proteins•The network subdivides into complexes and clusters of functionally related proteins•Network architecture reveals subcellular localization and PFAM domain associations•The network offers a roadmap for characterization of poorly studied proteins An interaction network for human proteins developed from affinity purification-mass spectrometry analyses provides a basis for understanding the architecture of protein complexes and for functional characterization of over 2,500 proteins. |
| Author | Zhai, Bo Vaites, Laura Pontano Colby, Greg Baltier, Kurt Harper, J. Wade Kolippakkam, Deepak Szpyt, John Rad, Ramin De Camilli, Pietro Obar, Robert A. Huttlin, Edward L. Ordureau, Alban Chick, Joel Gebreab, Fana Wühr, Martin Ting, Lily Erickson, Brian K. Harris, Tim Guarani, Virginia Zarraga, Gabriela Mintseris, Julian Sowa, Mathew E. Gygi, Steven P. Bruckner, Raphael J. Dong, Rui Artavanis-Tsakonas, Spyros Gygi, Melanie P. Paulo, Joao A. Tam, Stanley |
| AuthorAffiliation | 3 Biogen, Cambridge, MA, 02142 2 Department of Cell Biology and Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT, 06519 1 Department of Cell Biology, Harvard Medical School, Boston, MA, 02115 |
| AuthorAffiliation_xml | – name: 1 Department of Cell Biology, Harvard Medical School, Boston, MA, 02115 – name: 2 Department of Cell Biology and Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT, 06519 – name: 3 Biogen, Cambridge, MA, 02142 |
| Author_xml | – sequence: 1 givenname: Edward L. surname: Huttlin fullname: Huttlin, Edward L. organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 2 givenname: Lily surname: Ting fullname: Ting, Lily organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 3 givenname: Raphael J. surname: Bruckner fullname: Bruckner, Raphael J. organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 4 givenname: Fana surname: Gebreab fullname: Gebreab, Fana organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 5 givenname: Melanie P. surname: Gygi fullname: Gygi, Melanie P. organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 6 givenname: John surname: Szpyt fullname: Szpyt, John organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 7 givenname: Stanley surname: Tam fullname: Tam, Stanley organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 8 givenname: Gabriela surname: Zarraga fullname: Zarraga, Gabriela organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 9 givenname: Greg surname: Colby fullname: Colby, Greg organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 10 givenname: Kurt surname: Baltier fullname: Baltier, Kurt organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 11 givenname: Rui surname: Dong fullname: Dong, Rui organization: Department of Cell Biology and Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT 06519, USA – sequence: 12 givenname: Virginia surname: Guarani fullname: Guarani, Virginia organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 13 givenname: Laura Pontano surname: Vaites fullname: Vaites, Laura Pontano organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 14 givenname: Alban surname: Ordureau fullname: Ordureau, Alban organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 15 givenname: Ramin surname: Rad fullname: Rad, Ramin organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 16 givenname: Brian K. surname: Erickson fullname: Erickson, Brian K. organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 17 givenname: Martin surname: Wühr fullname: Wühr, Martin organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 18 givenname: Joel surname: Chick fullname: Chick, Joel organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 19 givenname: Bo surname: Zhai fullname: Zhai, Bo organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 20 givenname: Deepak surname: Kolippakkam fullname: Kolippakkam, Deepak organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 21 givenname: Julian surname: Mintseris fullname: Mintseris, Julian organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 22 givenname: Robert A. surname: Obar fullname: Obar, Robert A. organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 23 givenname: Tim surname: Harris fullname: Harris, Tim organization: Biogen, Cambridge, MA 02142, USA – sequence: 24 givenname: Spyros surname: Artavanis-Tsakonas fullname: Artavanis-Tsakonas, Spyros organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 25 givenname: Mathew E. surname: Sowa fullname: Sowa, Mathew E. organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 26 givenname: Pietro surname: De Camilli fullname: De Camilli, Pietro organization: Department of Cell Biology and Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT 06519, USA – sequence: 27 givenname: Joao A. surname: Paulo fullname: Paulo, Joao A. organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 28 givenname: J. Wade surname: Harper fullname: Harper, J. Wade email: wade_harper@hms.harvard.edu organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 29 givenname: Steven P. surname: Gygi fullname: Gygi, Steven P. email: steven_gygi@hms.harvard.edu organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26186194$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkc1u1DAUhS1URKeFF2CBsmSTcO2Jf4IQUqlaWqkCJMracpwb6iGxB9tT2rfHw7QIWJSNbcnnO_fqnAOy54NHQp5TaChQ8WrVWJymhgHlDYgG2uUjsqDQybqlku2RBUDHaiVku08OUloBgOKcPyH7TFAlaNcuyOnlFVbvXPg04U31AfOPEL-9ro6qz7cp42yys9XJzXoKsTyDr8JY5QKcbWbjq3OfMRqbw4xPyePRTAmf3d2H5MvpyeXxWX3x8f358dFFbTlvcz121PCOUZTKGgHl5KLFYTR9L9UIQy9Yq4xcSqpwMJ0dOVjZcxADcGXpuDwkb3e-600_42DR52gmvY5uNvFWB-P03z_eXemv4Vq3okRCaTF4eWcQw_cNpqxnl7YxGo9hkzQrITGmZCf_K6Wik4xRRVmRvvhzrd_73OdcBGonsDGkFHHU1uVfkZYt3aQp6G2leqW3A_S2Ug1Cl0oLyv5B790fhN7sICxlXDuMOlmH3uLgItqsh-Aewn8CVgO6Pw |
| CitedBy_id | crossref_primary_10_1016_j_cell_2021_06_003 crossref_primary_10_3390_ijms22116047 crossref_primary_10_1016_j_tibs_2015_11_007 crossref_primary_10_1091_mbc_E18_07_0469 crossref_primary_10_1093_bioinformatics_btac815 crossref_primary_10_1016_j_jbc_2024_105681 crossref_primary_10_1016_j_bbapap_2021_140672 crossref_primary_10_1021_acs_jproteome_9b00825 crossref_primary_10_1371_journal_pcbi_1005625 crossref_primary_10_1016_j_jmb_2021_167347 crossref_primary_10_1038_s41598_018_21740_z crossref_primary_10_1093_bib_bbab007 crossref_primary_10_1093_bioinformatics_btaa1099 crossref_primary_10_1021_acssynbio_8b00499 crossref_primary_10_1080_00949655_2025_2472803 crossref_primary_10_3389_fgene_2019_00294 crossref_primary_10_1186_s13046_021_02159_3 crossref_primary_10_1093_bioinformatics_btx743 crossref_primary_10_7554_eLife_27574 crossref_primary_10_1080_13510002_2024_2312320 crossref_primary_10_1371_journal_pone_0167307 crossref_primary_10_1083_jcb_201804111 crossref_primary_10_3389_fphys_2017_00539 crossref_primary_10_1016_j_jbc_2021_101496 crossref_primary_10_1093_database_baac049 crossref_primary_10_3390_cells11030380 crossref_primary_10_3389_fimmu_2022_909816 crossref_primary_10_1016_j_coisb_2017_04_015 crossref_primary_10_1002_cm_21560 crossref_primary_10_7554_eLife_88328_4 crossref_primary_10_1016_j_xgen_2024_100691 crossref_primary_10_1007_s11010_016_2836_5 crossref_primary_10_1016_j_ymeth_2018_12_008 crossref_primary_10_1093_nar_gkaa743 crossref_primary_10_3389_fgene_2019_00023 crossref_primary_10_1016_j_celrep_2017_10_017 crossref_primary_10_1021_acscatal_2c01060 crossref_primary_10_1093_nargab_lqab010 crossref_primary_10_1111_boc_202200014 crossref_primary_10_7554_eLife_58041 crossref_primary_10_1093_bib_bbz085 crossref_primary_10_15252_embj_2018100158 crossref_primary_10_1073_pnas_2023360118 crossref_primary_10_1007_s10528_023_10373_1 crossref_primary_10_1038_ncomms13573 crossref_primary_10_1074_jbc_AC118_002052 crossref_primary_10_1038_s41598_024_83680_1 crossref_primary_10_1021_acs_jproteome_8b00383 crossref_primary_10_1128_mSystems_00303_18 crossref_primary_10_1631_jzus_B1900181 crossref_primary_10_1242_jcs_220061 crossref_primary_10_1002_ijc_30762 crossref_primary_10_1091_mbc_e17_01_0017 crossref_primary_10_1073_pnas_1705367114 crossref_primary_10_1177_25152564231183897 crossref_primary_10_1134_S0026893321030092 crossref_primary_10_1002_1873_3468_13794 crossref_primary_10_1016_j_yexcr_2020_112057 crossref_primary_10_1021_acs_biochem_9b00539 crossref_primary_10_1002_advs_202416243 crossref_primary_10_1039_D1SC00814E crossref_primary_10_1002_jcp_27053 crossref_primary_10_1016_j_isci_2024_109585 crossref_primary_10_1016_j_schres_2018_05_015 crossref_primary_10_1038_mi_2017_18 crossref_primary_10_1128_MCB_00303_16 crossref_primary_10_1016_j_nbd_2021_105395 crossref_primary_10_3390_ijms19051444 crossref_primary_10_1016_j_jhep_2021_09_021 crossref_primary_10_1186_s13062_023_00384_8 crossref_primary_10_1093_nar_gky167 crossref_primary_10_1016_j_compbiomed_2018_04_015 crossref_primary_10_1038_nbt_3955 crossref_primary_10_1091_mbc_E19_08_0439_T crossref_primary_10_1016_j_scib_2021_01_003 crossref_primary_10_1007_s13361_016_1382_4 crossref_primary_10_1016_j_cels_2021_07_009 crossref_primary_10_1016_j_molmet_2017_07_013 crossref_primary_10_1016_j_jacc_2016_10_031 crossref_primary_10_1371_journal_pbio_3001207 crossref_primary_10_1016_j_molcel_2016_07_008 crossref_primary_10_1016_j_csbj_2022_10_011 crossref_primary_10_4049_jimmunol_1900750 crossref_primary_10_1016_j_jbc_2022_101956 crossref_primary_10_1089_cmb_2019_0179 crossref_primary_10_18632_oncotarget_14104 crossref_primary_10_1007_s11515_018_1501_7 crossref_primary_10_1016_j_devcel_2021_01_016 crossref_primary_10_1016_j_tcb_2016_08_010 crossref_primary_10_1038_srep37767 crossref_primary_10_1016_j_ymeth_2018_11_004 crossref_primary_10_1021_jacs_4c03069 crossref_primary_10_1016_j_cell_2016_02_035 crossref_primary_10_1038_s41586_020_2023_4 crossref_primary_10_1016_j_jbc_2022_101986 crossref_primary_10_3390_cells10092198 crossref_primary_10_3389_fchem_2021_718405 crossref_primary_10_1039_C6MB00735J crossref_primary_10_1016_j_jbc_2024_107407 crossref_primary_10_1111_febs_16031 crossref_primary_10_1111_bph_13505 crossref_primary_10_1016_j_jmb_2019_08_014 crossref_primary_10_1038_s41419_017_0022_7 crossref_primary_10_1007_s11033_018_4170_3 crossref_primary_10_1016_j_braindev_2021_04_006 crossref_primary_10_1371_journal_pone_0310946 crossref_primary_10_1038_s41568_021_00431_4 crossref_primary_10_1021_acs_jmedchem_7b00137 crossref_primary_10_12677_ACM_2023_1371696 crossref_primary_10_1007_s12551_022_01038_1 crossref_primary_10_3724_abbs_2024105 crossref_primary_10_1016_j_molcel_2024_08_030 crossref_primary_10_1038_nrg_2017_8 crossref_primary_10_1073_pnas_2219925120 crossref_primary_10_1242_jcs_251819 crossref_primary_10_1074_mcp_RA117_000470 crossref_primary_10_1074_mcp_RA117_000471 crossref_primary_10_3390_biom13050853 crossref_primary_10_1038_s41419_023_05891_0 crossref_primary_10_1631_jzus_B2000356 crossref_primary_10_1093_hmg_ddx316 crossref_primary_10_1016_j_cotox_2016_10_007 crossref_primary_10_3390_e23101271 crossref_primary_10_1016_j_devcel_2021_03_005 crossref_primary_10_1038_srep39049 crossref_primary_10_1002_rcm_9153 crossref_primary_10_1371_journal_pone_0233311 crossref_primary_10_1080_03008207_2024_2349818 crossref_primary_10_1016_j_cels_2018_08_004 crossref_primary_10_1002_jgm_3667 crossref_primary_10_1021_acs_jproteome_4c00248 crossref_primary_10_1038_s41531_025_00870_y crossref_primary_10_1155_2019_3542537 crossref_primary_10_3389_fnins_2015_00448 crossref_primary_10_1038_ncb3627 crossref_primary_10_1016_j_gene_2016_11_046 crossref_primary_10_1016_j_bbadis_2018_07_001 crossref_primary_10_7554_eLife_88328 crossref_primary_10_1038_s41467_022_28171_5 crossref_primary_10_1038_s41598_018_21453_3 crossref_primary_10_3389_fphys_2019_01093 crossref_primary_10_1097_YPG_0000000000000220 crossref_primary_10_1515_jib_2018_0069 crossref_primary_10_18632_oncotarget_24183 crossref_primary_10_1016_j_autrev_2020_102643 crossref_primary_10_1093_nar_gkaa143 crossref_primary_10_1007_s00018_018_2968_8 crossref_primary_10_1016_j_ajhg_2016_06_014 crossref_primary_10_3892_ol_2019_10993 crossref_primary_10_1021_acs_biochem_7b00265 crossref_primary_10_1084_jem_20191689 crossref_primary_10_1038_s41598_020_67875_w crossref_primary_10_1073_pnas_1805757115 crossref_primary_10_1002_cpps_84 crossref_primary_10_1073_pnas_1702849114 crossref_primary_10_1038_s41598_024_51193_6 crossref_primary_10_1126_science_aav1391 crossref_primary_10_1016_j_jmgm_2019_04_003 crossref_primary_10_1021_acs_jproteome_6b00728 crossref_primary_10_3389_fnins_2017_00743 crossref_primary_10_1101_gr_230938_117 crossref_primary_10_1021_acs_analchem_9b02372 crossref_primary_10_1016_j_cub_2016_01_049 crossref_primary_10_1016_j_isci_2023_107474 crossref_primary_10_1038_s41592_022_01684_z crossref_primary_10_1016_j_molcel_2019_03_027 crossref_primary_10_1091_mbc_e16_04_0209 crossref_primary_10_1371_journal_pone_0153534 crossref_primary_10_3390_ijms21217980 crossref_primary_10_1016_j_bbamcr_2018_10_020 crossref_primary_10_1038_s41598_019_45349_y crossref_primary_10_3389_fgene_2018_00670 crossref_primary_10_1038_s41467_025_56489_3 crossref_primary_10_1093_ibd_izaa352 crossref_primary_10_1016_j_csbj_2021_09_013 crossref_primary_10_1038_s41598_017_12858_7 crossref_primary_10_1038_s41467_021_24217_2 crossref_primary_10_1016_j_tibtech_2016_05_015 crossref_primary_10_5487_TR_2017_33_3_205 crossref_primary_10_1038_s44319_024_00125_6 crossref_primary_10_1016_j_cels_2021_05_012 crossref_primary_10_1038_s41467_023_44139_5 crossref_primary_10_1038_srep43584 crossref_primary_10_1038_s41467_018_03751_6 crossref_primary_10_1002_anie_202417804 crossref_primary_10_1126_scisignal_aaq1087 crossref_primary_10_1590_0074_02760180506 crossref_primary_10_1016_j_cellsig_2017_06_020 crossref_primary_10_1126_scisignal_adl4738 crossref_primary_10_1016_j_cell_2024_10_038 crossref_primary_10_1021_acs_jproteome_3c00125 crossref_primary_10_1007_s00429_020_02144_0 crossref_primary_10_1158_0008_5472_CAN_20_2946 crossref_primary_10_1016_j_cbi_2017_02_013 crossref_primary_10_3390_ijms22116093 crossref_primary_10_1038_nrm_2017_130 crossref_primary_10_1074_mcp_RA118_000924 crossref_primary_10_1093_hmg_ddw208 crossref_primary_10_1136_jitc_2021_002443 crossref_primary_10_1242_jcs_244442 crossref_primary_10_1074_jbc_M116_757112 crossref_primary_10_1016_j_molcel_2016_06_033 crossref_primary_10_1038_s41467_023_39881_9 crossref_primary_10_1126_science_adn7277 crossref_primary_10_1111_age_13128 crossref_primary_10_2139_ssrn_3219264 crossref_primary_10_1093_g3journal_jkad013 crossref_primary_10_1186_s40478_025_01949_6 crossref_primary_10_1039_D4OB01058B crossref_primary_10_1002_prot_25757 crossref_primary_10_1016_j_cellsig_2020_109782 crossref_primary_10_1016_j_nbd_2024_106517 crossref_primary_10_3390_biom14040409 crossref_primary_10_1016_j_cell_2024_03_027 crossref_primary_10_1089_jir_2022_0063 crossref_primary_10_15252_embj_2019104369 crossref_primary_10_2217_fon_2016_0014 crossref_primary_10_1016_j_jmb_2021_167318 crossref_primary_10_1681_ASN_2021040543 crossref_primary_10_1074_jbc_M117_787291 crossref_primary_10_1016_j_copbio_2020_02_005 crossref_primary_10_15252_embr_202255208 crossref_primary_10_1016_j_cell_2020_01_025 crossref_primary_10_1073_pnas_2420961122 crossref_primary_10_1186_s12920_022_01173_4 crossref_primary_10_1021_acs_biochem_1c00067 crossref_primary_10_1371_journal_pgen_1006074 crossref_primary_10_1038_ncomms10961 crossref_primary_10_1038_nprot_2017_040 crossref_primary_10_1038_nmeth_4256 crossref_primary_10_1111_and_13812 crossref_primary_10_1002_ctm2_208 crossref_primary_10_1007_s11427_017_9175_2 crossref_primary_10_1038_s43587_022_00290_0 crossref_primary_10_1016_j_tcb_2015_10_013 crossref_primary_10_1074_mcp_TIR118_001270 crossref_primary_10_1016_j_bbadis_2016_05_012 crossref_primary_10_3389_fgene_2019_00715 crossref_primary_10_1074_jbc_RA118_007283 crossref_primary_10_1002_dneu_22584 crossref_primary_10_1016_j_celrep_2017_06_016 crossref_primary_10_1016_j_xpro_2022_101608 crossref_primary_10_1074_jbc_M117_807487 crossref_primary_10_3390_cells8091049 crossref_primary_10_1038_s41592_022_01616_x crossref_primary_10_1093_jb_mvy100 crossref_primary_10_1080_15592294_2016_1216284 crossref_primary_10_1016_j_celrep_2018_10_097 crossref_primary_10_1038_549293a crossref_primary_10_1371_journal_pcbi_1007396 crossref_primary_10_1016_j_molcel_2018_06_039 crossref_primary_10_1042_BST20150187 crossref_primary_10_1038_s42003_021_02258_z crossref_primary_10_7554_eLife_57519 crossref_primary_10_1186_s13023_024_03437_x crossref_primary_10_1021_acs_jproteome_9b00378 crossref_primary_10_1186_s12860_021_00352_y crossref_primary_10_1016_j_jbc_2022_102062 crossref_primary_10_1038_nchembio_2386 crossref_primary_10_1038_s43018_024_00789_y crossref_primary_10_1002_wrna_1514 crossref_primary_10_3389_fgene_2015_00344 crossref_primary_10_1242_jcs_194068 crossref_primary_10_3389_fonc_2023_1126550 crossref_primary_10_1016_j_sbi_2017_05_003 crossref_primary_10_1534_genetics_120_303147 crossref_primary_10_1038_s41556_019_0328_z crossref_primary_10_1021_acs_jproteome_8b00711 crossref_primary_10_1080_14789450_2019_1638769 crossref_primary_10_3390_genes11070738 crossref_primary_10_1111_febs_13995 crossref_primary_10_1016_j_celrep_2022_110834 crossref_primary_10_1016_j_jmb_2020_02_032 crossref_primary_10_1016_j_biochi_2020_02_015 crossref_primary_10_1016_j_cell_2016_07_027 crossref_primary_10_1038_s41467_021_24919_7 crossref_primary_10_1038_s41587_022_01474_0 crossref_primary_10_1126_scisignal_aar1976 crossref_primary_10_1016_j_crmeth_2024_100880 crossref_primary_10_3390_cells11071175 crossref_primary_10_1007_s10522_017_9741_5 crossref_primary_10_1021_acs_jproteome_0c00929 crossref_primary_10_1038_s41591_021_01572_7 crossref_primary_10_1038_s41586_023_06739_5 crossref_primary_10_1186_s13024_016_0132_1 crossref_primary_10_1038_s41467_023_44572_6 crossref_primary_10_1098_rsif_2018_0248 crossref_primary_10_3390_cells10123447 crossref_primary_10_1016_j_mcn_2023_103905 crossref_primary_10_1038_s42255_022_00553_5 crossref_primary_10_1016_j_semcdb_2022_02_019 crossref_primary_10_7554_eLife_43561 crossref_primary_10_1089_scd_2019_0210 crossref_primary_10_1134_S2079086424600644 crossref_primary_10_1016_j_mcpro_2023_100608 crossref_primary_10_3390_cells10071750 crossref_primary_10_1152_ajpheart_00658_2022 crossref_primary_10_1002_pro_70016 crossref_primary_10_1111_tra_12929 crossref_primary_10_1016_j_ceb_2019_12_002 crossref_primary_10_1021_acs_biochem_8b00726 crossref_primary_10_1016_j_tibs_2017_09_003 crossref_primary_10_1126_sciadv_adr9364 crossref_primary_10_1242_jcs_211748 crossref_primary_10_1016_j_csbj_2020_10_010 crossref_primary_10_1126_scisignal_aaf6670 crossref_primary_10_1371_journal_pcbi_1009736 crossref_primary_10_1038_s41598_019_57187_z crossref_primary_10_1042_BSR20231093 crossref_primary_10_1093_nar_gky973 crossref_primary_10_1186_s12575_016_0046_x crossref_primary_10_1371_journal_pcbi_1006474 crossref_primary_10_1016_j_celrep_2018_11_076 crossref_primary_10_1093_bioadv_vbae182 crossref_primary_10_1177_25152564231156994 crossref_primary_10_1242_jcs_219469 crossref_primary_10_1021_acs_jproteome_6b00517 crossref_primary_10_1016_j_chembiol_2024_08_008 crossref_primary_10_1186_s13046_019_1137_8 crossref_primary_10_18097_pbmc20247005315 crossref_primary_10_1002_mas_21574 crossref_primary_10_1038_s41540_020_00168_0 crossref_primary_10_1038_s41467_024_47959_1 crossref_primary_10_1002_pmic_201500400 crossref_primary_10_1186_s12964_019_0460_1 crossref_primary_10_1111_nyas_13334 crossref_primary_10_1007_s00018_021_03856_0 crossref_primary_10_1074_jbc_M115_704973 crossref_primary_10_1016_j_molcel_2019_10_018 crossref_primary_10_1074_mcp_R119_001803 crossref_primary_10_1016_j_celrep_2018_10_055 crossref_primary_10_1083_jcb_202205062 crossref_primary_10_1038_s41421_017_0001_2 crossref_primary_10_3390_biom13101450 crossref_primary_10_7554_eLife_62067 crossref_primary_10_15252_msb_20188438 crossref_primary_10_3389_fchem_2017_00102 crossref_primary_10_1016_j_pharmthera_2023_108478 crossref_primary_10_1016_j_jbc_2025_108225 crossref_primary_10_1128_MCB_00150_20 crossref_primary_10_1146_annurev_genet_120116_024704 crossref_primary_10_1016_j_jchromb_2020_122509 crossref_primary_10_1126_scisignal_abq1007 crossref_primary_10_1038_s41392_021_00709_x crossref_primary_10_1016_j_gpb_2020_11_003 crossref_primary_10_3390_ijms22062905 crossref_primary_10_3390_ijms251910597 crossref_primary_10_26508_lsa_202201852 crossref_primary_10_1016_j_cell_2016_06_037 crossref_primary_10_1002_pmic_202100247 crossref_primary_10_1038_s41588_021_00840_z crossref_primary_10_1016_j_bbapap_2016_02_017 crossref_primary_10_1016_j_ymgme_2017_11_005 crossref_primary_10_1074_mcp_M116_065326 crossref_primary_10_1016_j_cell_2018_09_014 crossref_primary_10_1111_jdv_17350 crossref_primary_10_1126_science_aac7557 crossref_primary_10_3390_cells11162546 crossref_primary_10_1128_JVI_00356_18 crossref_primary_10_1371_journal_pone_0214110 crossref_primary_10_3892_ol_2021_13111 crossref_primary_10_1016_j_cels_2023_04_007 crossref_primary_10_1371_journal_pone_0198461 crossref_primary_10_1038_s41592_021_01194_4 crossref_primary_10_1038_srep38882 crossref_primary_10_1016_j_jpsychires_2019_05_024 crossref_primary_10_1186_s12931_022_01963_5 crossref_primary_10_7554_eLife_40499 crossref_primary_10_1038_s41596_020_0332_6 crossref_primary_10_1038_s41467_018_06768_z crossref_primary_10_1016_j_jbc_2023_103025 crossref_primary_10_1038_s41588_024_02070_5 crossref_primary_10_1002_mgg3_1152 crossref_primary_10_1074_mcp_O115_056986 crossref_primary_10_1093_bioadv_vbae130 crossref_primary_10_1097_CM9_0000000000003181 crossref_primary_10_1083_jcb_202008037 crossref_primary_10_1073_pnas_1522750113 crossref_primary_10_1007_s12035_016_0140_8 crossref_primary_10_1073_pnas_2309211121 crossref_primary_10_1089_cmb_2019_0138 crossref_primary_10_1073_pnas_1722299115 crossref_primary_10_3389_fmed_2021_690594 crossref_primary_10_1186_s12859_023_05425_7 crossref_primary_10_1126_science_abf2911 crossref_primary_10_1074_jbc_RA119_008231 crossref_primary_10_1016_j_bcp_2019_05_006 crossref_primary_10_1002_ajmg_a_62020 crossref_primary_10_1016_j_molmet_2017_10_014 crossref_primary_10_1021_acs_biochem_6b00756 crossref_primary_10_1371_journal_pone_0169338 crossref_primary_10_1016_j_cell_2020_03_046 crossref_primary_10_1016_j_celrep_2022_110411 crossref_primary_10_3390_cells10071780 crossref_primary_10_1016_j_tibtech_2024_10_008 crossref_primary_10_1016_j_ymeth_2019_11_003 crossref_primary_10_1016_j_cub_2018_08_022 crossref_primary_10_3390_biomedicines10082044 crossref_primary_10_1016_j_cell_2020_02_012 crossref_primary_10_1038_srep39985 crossref_primary_10_1016_j_bbrc_2024_149658 crossref_primary_10_1021_acs_jproteome_7b00571 crossref_primary_10_1021_acs_jproteome_7b00572 crossref_primary_10_1074_mcp_M116_061333 crossref_primary_10_1016_j_cbpa_2021_102107 crossref_primary_10_1016_j_ajhg_2018_05_011 crossref_primary_10_1016_j_tcb_2018_06_005 crossref_primary_10_1038_s41467_024_46737_3 crossref_primary_10_1016_j_febslet_2015_11_022 crossref_primary_10_3389_fimmu_2022_997851 crossref_primary_10_7554_eLife_81398 crossref_primary_10_1155_2016_6186281 crossref_primary_10_3390_ijms20163916 crossref_primary_10_1111_exd_14575 crossref_primary_10_1021_acsmeasuresciau_3c00068 crossref_primary_10_5483_BMBRep_2021_54_1_241 crossref_primary_10_1016_j_celrep_2019_09_060 crossref_primary_10_1038_nmeth_4083 crossref_primary_10_3390_cells11193058 crossref_primary_10_1172_JCI138267 crossref_primary_10_1016_j_celrep_2019_07_019 crossref_primary_10_12688_wellcomeopenres_15232_2 crossref_primary_10_12688_wellcomeopenres_15232_1 crossref_primary_10_1007_s00216_021_03367_8 crossref_primary_10_1177_2515256419883136 crossref_primary_10_1186_s12881_017_0503_7 crossref_primary_10_1016_j_immuni_2024_09_013 crossref_primary_10_1186_s13578_022_00828_0 crossref_primary_10_1016_j_molcel_2022_01_004 crossref_primary_10_1038_ejhg_2017_96 crossref_primary_10_1194_jlr_R085324 crossref_primary_10_1038_s41467_020_14586_5 crossref_primary_10_7554_eLife_45916 crossref_primary_10_3389_fcvm_2024_1478600 crossref_primary_10_15252_embj_2018101220 crossref_primary_10_3390_ijms21062054 crossref_primary_10_1038_s41564_018_0273_9 crossref_primary_10_1016_j_jbc_2021_100874 crossref_primary_10_1126_science_aan0218 crossref_primary_10_1002_dneu_22542 crossref_primary_10_3390_ijms24010666 crossref_primary_10_1016_j_ceb_2016_04_002 crossref_primary_10_1016_j_cell_2018_06_016 crossref_primary_10_15252_msb_202010016 crossref_primary_10_1016_j_bbamcr_2017_08_006 crossref_primary_10_1371_journal_pone_0272428 crossref_primary_10_3389_fnmol_2019_00029 crossref_primary_10_1080_19336950_2019_1568824 crossref_primary_10_7554_eLife_37059 crossref_primary_10_1016_j_cell_2020_02_049 crossref_primary_10_1038_s41416_020_01250_4 crossref_primary_10_1242_jcs_260227 crossref_primary_10_1038_s41598_018_24224_2 crossref_primary_10_1186_s12014_019_9236_2 crossref_primary_10_1038_s41467_019_11809_2 crossref_primary_10_1016_j_ajhg_2019_11_002 crossref_primary_10_1038_s41467_021_23799_1 crossref_primary_10_1080_21690707_2016_1248273 crossref_primary_10_1002_ange_202417804 crossref_primary_10_1371_journal_pcbi_1006657 crossref_primary_10_1021_acs_jproteome_5b01008 crossref_primary_10_1016_j_cell_2022_04_011 crossref_primary_10_1093_nar_gkw363 crossref_primary_10_1002_psp4_12670 crossref_primary_10_1038_s41587_020_0652_7 crossref_primary_10_1016_j_celrep_2022_111717 crossref_primary_10_1021_acs_analchem_0c00839 crossref_primary_10_1016_j_mcpro_2024_100744 crossref_primary_10_1016_j_sbi_2017_02_005 crossref_primary_10_1042_BST20231116 crossref_primary_10_1038_s41746_024_01175_9 crossref_primary_10_29220_CSAM_2022_29_6_655 crossref_primary_10_1007_s42977_021_00107_y crossref_primary_10_3389_fimmu_2019_02067 crossref_primary_10_1016_j_bbalip_2020_158837 crossref_primary_10_1158_2326_6066_CIR_19_0159 crossref_primary_10_1021_acs_jproteome_7b00363 crossref_primary_10_3390_cimb43030146 crossref_primary_10_1016_j_celrep_2022_110875 crossref_primary_10_1016_j_molcel_2022_02_029 crossref_primary_10_1016_j_tig_2023_08_003 crossref_primary_10_1038_s41585_019_0195_1 crossref_primary_10_1371_journal_pone_0197092 crossref_primary_10_1371_journal_pone_0243075 crossref_primary_10_1038_ncomms11491 crossref_primary_10_3389_fcell_2021_697831 crossref_primary_10_18632_oncotarget_9368 crossref_primary_10_1093_bib_bbab372 crossref_primary_10_1080_14789450_2019_1551135 crossref_primary_10_1007_s12079_021_00650_2 crossref_primary_10_1093_database_baab087 crossref_primary_10_1016_j_molcel_2018_11_035 crossref_primary_10_1016_j_jtbi_2016_08_028 crossref_primary_10_1042_BSR20203094 crossref_primary_10_1016_j_chembiol_2023_09_012 crossref_primary_10_1038_s41467_021_21146_y crossref_primary_10_1016_j_ceb_2016_02_011 crossref_primary_10_1080_23723556_2018_1561118 crossref_primary_10_1083_jcb_201608128 crossref_primary_10_1016_j_molcel_2021_10_001 crossref_primary_10_1039_C8MO00042E crossref_primary_10_1038_s42003_020_0851_2 crossref_primary_10_1126_scisignal_adp9377 crossref_primary_10_1016_j_jtbi_2019_110124 crossref_primary_10_7554_eLife_18715 crossref_primary_10_1016_j_jprot_2017_07_008 crossref_primary_10_14336_AD_2024_0209 crossref_primary_10_15252_msb_20167490 crossref_primary_10_1016_j_jmb_2018_07_006 crossref_primary_10_1016_j_cels_2017_04_006 crossref_primary_10_1038_s41586_020_2286_9 crossref_primary_10_1186_s13195_021_00850_3 crossref_primary_10_1039_C7MB00430C crossref_primary_10_1002_jcp_29369 crossref_primary_10_1016_j_devcel_2018_09_024 crossref_primary_10_1002_jssc_202000930 crossref_primary_10_1038_s41467_019_10920_8 crossref_primary_10_1093_g3journal_jkac243 crossref_primary_10_1038_s41598_017_05960_3 crossref_primary_10_3390_data9080101 crossref_primary_10_3390_cimb46020073 crossref_primary_10_7717_peerj_1525 crossref_primary_10_2139_ssrn_3206267 crossref_primary_10_1038_s41589_022_01062_y crossref_primary_10_1111_tra_12549 crossref_primary_10_1093_nar_gky239 crossref_primary_10_1002_ijc_31736 crossref_primary_10_1242_dmm_033803 crossref_primary_10_1038_ng_3831 crossref_primary_10_1007_s40995_020_01025_9 crossref_primary_10_3389_fncel_2019_00092 crossref_primary_10_1038_s41417_021_00423_4 crossref_primary_10_1021_acs_jproteome_7b00843 crossref_primary_10_1074_mcp_RA117_000314 crossref_primary_10_1038_s41467_024_50121_6 crossref_primary_10_15252_embj_201694818 crossref_primary_10_3389_fnins_2021_680572 crossref_primary_10_1073_pnas_2219418120 crossref_primary_10_3390_ijms222413271 crossref_primary_10_1016_j_drudis_2016_07_005 crossref_primary_10_1016_j_isci_2023_106914 crossref_primary_10_1186_s13059_016_0913_4 crossref_primary_10_1039_C6MB00701E crossref_primary_10_3892_br_2024_1746 crossref_primary_10_1126_scisignal_aan2883 crossref_primary_10_3390_molecules25061396 crossref_primary_10_1016_j_celrep_2021_109181 crossref_primary_10_1080_15384101_2019_1586509 crossref_primary_10_1016_j_ydbio_2017_06_027 crossref_primary_10_1080_09537104_2019_1696457 crossref_primary_10_1016_j_molcel_2023_05_018 crossref_primary_10_1007_s10974_020_09590_7 crossref_primary_10_1016_j_canlet_2023_216058 crossref_primary_10_1038_s41598_018_28280_6 crossref_primary_10_1016_j_cell_2017_04_033 crossref_primary_10_1007_s00018_022_04516_7 crossref_primary_10_1016_j_ajpath_2018_02_015 crossref_primary_10_3389_fphys_2015_00364 crossref_primary_10_1038_s41374_022_00808_5 crossref_primary_10_1016_j_mad_2020_111284 crossref_primary_10_1371_journal_pcbi_1010287 crossref_primary_10_1016_j_imu_2021_100522 crossref_primary_10_7554_eLife_17828 crossref_primary_10_1074_mcp_TIR118_000661 crossref_primary_10_1016_j_bbrep_2024_101849 crossref_primary_10_1016_j_jmb_2023_168052 crossref_primary_10_1038_s42003_022_03377_x crossref_primary_10_7554_eLife_49894 crossref_primary_10_3390_cells10113063 crossref_primary_10_1038_s41596_023_00901_z crossref_primary_10_3390_ijms19123755 crossref_primary_10_1126_science_aat0576 crossref_primary_10_1515_pac_2018_0720 crossref_primary_10_1080_14789450_2018_1537788 crossref_primary_10_18632_oncotarget_25145 crossref_primary_10_1016_j_jmb_2016_10_021 crossref_primary_10_1051_medsci_2019035 crossref_primary_10_15252_emmm_201910812 crossref_primary_10_1038_s41592_022_01454_x crossref_primary_10_1038_s41592_019_0687_1 crossref_primary_10_7554_eLife_59699 crossref_primary_10_3389_fphys_2020_573372 crossref_primary_10_1016_j_molcel_2017_09_003 crossref_primary_10_1016_j_molcel_2023_06_019 crossref_primary_10_1098_rsob_170114 crossref_primary_10_1128_JVI_02034_17 crossref_primary_10_1016_j_ccell_2019_09_007 crossref_primary_10_1016_j_cels_2020_11_006 crossref_primary_10_1002_adtp_201800143 crossref_primary_10_1016_j_bbamcr_2016_10_017 crossref_primary_10_15252_msb_20167067 crossref_primary_10_1016_j_celrep_2023_112715 crossref_primary_10_1083_jcb_201607055 crossref_primary_10_1093_bioinformatics_btz623 crossref_primary_10_1038_s41467_018_03255_3 crossref_primary_10_1073_pnas_1820156116 crossref_primary_10_1093_bioinformatics_btae708 crossref_primary_10_1007_s00018_017_2644_4 crossref_primary_10_15252_embr_201947723 crossref_primary_10_1111_boc_201700031 crossref_primary_10_1016_j_devcel_2024_06_002 crossref_primary_10_1073_pnas_1615990113 crossref_primary_10_1002_jms_4653 crossref_primary_10_1038_s41467_024_51646_6 crossref_primary_10_1074_jbc_RA118_004677 crossref_primary_10_2147_OTT_S281157 crossref_primary_10_1038_nature19947 crossref_primary_10_1038_s41598_024_71002_4 crossref_primary_10_1038_nature19949 crossref_primary_10_1038_ncomms14356 crossref_primary_10_1186_s12862_016_0790_1 crossref_primary_10_3390_ijms24097884 crossref_primary_10_1242_jcs_261917 crossref_primary_10_1002_mas_21887 crossref_primary_10_1016_j_cell_2020_06_007 crossref_primary_10_1016_j_semcdb_2018_05_001 crossref_primary_10_1016_j_lfs_2017_12_016 crossref_primary_10_3389_fbioe_2020_00730 crossref_primary_10_3390_ijms22094450 crossref_primary_10_1038_nmeth_3566 crossref_primary_10_1016_j_celrep_2017_08_010 crossref_primary_10_1007_s00294_015_0519_5 crossref_primary_10_1371_journal_pone_0165420 crossref_primary_10_3389_fcvm_2023_1130388 crossref_primary_10_1534_g3_117_043513 crossref_primary_10_1083_jcb_201611138 crossref_primary_10_15252_embr_201745453 crossref_primary_10_1093_nar_gkw1102 crossref_primary_10_1038_s41380_018_0210_6 crossref_primary_10_1177_20458940211054325 crossref_primary_10_26508_lsa_202201474 crossref_primary_10_15252_embj_2020106536 crossref_primary_10_3389_fcell_2021_734950 crossref_primary_10_1038_s41467_023_36817_1 crossref_primary_10_1038_s41588_019_0475_y crossref_primary_10_1038_s41467_025_57858_8 crossref_primary_10_3389_fcvm_2021_791501 crossref_primary_10_1093_nar_gkab352 crossref_primary_10_1016_j_celrep_2025_115365 crossref_primary_10_1038_s41587_024_02428_4 crossref_primary_10_1128_JVI_02068_20 crossref_primary_10_3390_cells10113024 crossref_primary_10_3390_ijms20174128 crossref_primary_10_1021_acs_jproteome_9b00085 crossref_primary_10_1080_14789450_2017_1374179 crossref_primary_10_3389_fphys_2020_00661 crossref_primary_10_1016_j_molcel_2021_12_039 crossref_primary_10_1074_jbc_RA118_002073 crossref_primary_10_1080_17460441_2017_1304377 crossref_primary_10_1126_science_aag0839 crossref_primary_10_1016_j_cell_2016_09_026 crossref_primary_10_1186_s13073_024_01401_9 crossref_primary_10_1038_nature19754 crossref_primary_10_2174_1389203720666190325102255 crossref_primary_10_1128_JVI_01607_18 crossref_primary_10_1186_s12918_018_0567_9 crossref_primary_10_3390_genes11060677 crossref_primary_10_1080_10985549_2024_2384600 crossref_primary_10_14348_molcells_2020_0122 crossref_primary_10_1186_s13104_019_4219_y crossref_primary_10_1021_acs_analchem_0c04332 crossref_primary_10_1007_s00439_021_02384_y crossref_primary_10_1093_bioinformatics_btx244 crossref_primary_10_3390_ijms21228515 crossref_primary_10_1016_j_tplants_2019_01_006 crossref_primary_10_1016_j_cbpa_2018_09_016 crossref_primary_10_1016_j_cbpa_2018_09_020 crossref_primary_10_1038_srep30390 crossref_primary_10_1002_jcb_29822 crossref_primary_10_1007_s00018_020_03666_w crossref_primary_10_1038_s41556_019_0426_y crossref_primary_10_1038_s41598_019_50874_x crossref_primary_10_1093_bib_bbz107 crossref_primary_10_2139_ssrn_3314563 crossref_primary_10_1152_physrev_00038_2021 crossref_primary_10_1186_s12014_022_09370_0 crossref_primary_10_3389_fnmol_2021_672511 crossref_primary_10_1016_j_yjmcc_2016_09_007 crossref_primary_10_1021_acsptsci_0c00024 crossref_primary_10_1146_annurev_arplant_070522_052132 crossref_primary_10_1021_acs_jproteome_8b00927 crossref_primary_10_1007_s00018_016_2416_6 crossref_primary_10_1007_s00232_022_00225_1 crossref_primary_10_1007_s00005_015_0379_1 crossref_primary_10_1016_j_semcdb_2017_06_019 crossref_primary_10_1016_j_ajhg_2023_08_018 crossref_primary_10_1016_j_celrep_2016_11_005 crossref_primary_10_1038_s41592_022_01496_1 crossref_primary_10_1074_mcp_RA118_000822 crossref_primary_10_1016_j_xcrm_2023_101255 crossref_primary_10_1002_humu_23712 crossref_primary_10_1038_nprot_2016_020 crossref_primary_10_1021_acs_jproteome_4c00160 crossref_primary_10_1038_s41418_024_01354_x crossref_primary_10_1016_j_jprot_2020_103637 crossref_primary_10_1002_mas_21617 crossref_primary_10_1016_j_pbiomolbio_2018_10_001 crossref_primary_10_1038_s42003_020_0984_3 crossref_primary_10_1371_journal_pcbi_1010690 crossref_primary_10_3390_brainsci14010088 crossref_primary_10_1083_jcb_201902028 crossref_primary_10_3390_ijms20215400 crossref_primary_10_1111_febs_14828 crossref_primary_10_1134_S1068162024030178 crossref_primary_10_26508_lsa_202201670 crossref_primary_10_1038_s41467_019_11025_y crossref_primary_10_1074_jbc_M115_692749 crossref_primary_10_1074_jbc_M116_769216 crossref_primary_10_7554_eLife_35407 crossref_primary_10_15252_embr_201847472 crossref_primary_10_3390_medicina59050996 crossref_primary_10_26508_lsa_202402614 crossref_primary_10_1038_s41573_020_0063_y crossref_primary_10_3389_fimmu_2019_00578 crossref_primary_10_1126_science_aap8236 crossref_primary_10_1016_j_bbrc_2020_05_005 crossref_primary_10_1038_s41580_020_0231_2 crossref_primary_10_1093_nar_gkae1033 crossref_primary_10_1242_dmm_036681 crossref_primary_10_1021_acs_chemrev_1c00217 crossref_primary_10_1016_j_csbj_2023_02_005 crossref_primary_10_1038_nchembio_2515 crossref_primary_10_1016_j_xpro_2023_102293 crossref_primary_10_15252_embr_201641983 crossref_primary_10_1016_j_tins_2016_01_008 crossref_primary_10_3390_ijms21228719 crossref_primary_10_1016_j_physrep_2019_12_004 crossref_primary_10_1590_1678_4685_gmb_2019_0164 crossref_primary_10_1093_nar_gkx1169 crossref_primary_10_1016_j_abb_2018_12_018 crossref_primary_10_3389_fcell_2020_00792 crossref_primary_10_7554_eLife_35898 crossref_primary_10_5713_ab_24_0366 crossref_primary_10_1038_s41389_020_00260_4 crossref_primary_10_1038_s41598_017_05748_5 crossref_primary_10_1016_j_cell_2017_09_040 crossref_primary_10_1021_acs_jproteome_3c00685 crossref_primary_10_1038_s41467_019_10106_2 crossref_primary_10_1096_fj_202001062R crossref_primary_10_1016_j_mcpro_2024_100801 crossref_primary_10_1002_mas_21485 crossref_primary_10_1016_j_tibtech_2016_02_014 crossref_primary_10_1177_25152564211022515 crossref_primary_10_1038_s41592_020_0826_8 crossref_primary_10_1016_j_devcel_2018_05_002 crossref_primary_10_1002_cpbi_38 crossref_primary_10_1038_s41467_020_20670_7 crossref_primary_10_1038_s41467_020_14301_4 crossref_primary_10_1038_s42255_020_0250_5 crossref_primary_10_1021_acs_jproteome_8b00618 crossref_primary_10_1093_brain_awab018 crossref_primary_10_1021_acs_jproteome_7b00065 crossref_primary_10_1038_s42003_024_07360_6 crossref_primary_10_1002_jimd_70018 crossref_primary_10_1007_s00109_018_1714_x crossref_primary_10_1093_nar_gkab195 crossref_primary_10_1002_mc_22773 crossref_primary_10_1371_journal_pone_0208646 crossref_primary_10_1016_j_isci_2019_07_001 crossref_primary_10_1016_j_livsci_2017_05_004 crossref_primary_10_1021_acs_jproteome_4c01040 crossref_primary_10_1007_s12264_016_0021_1 crossref_primary_10_1016_j_crmeth_2022_100382 crossref_primary_10_1038_s41594_024_01246_1 crossref_primary_10_1186_s12864_017_4139_y crossref_primary_10_1038_nature18270 crossref_primary_10_1074_jbc_M117_814913 crossref_primary_10_3389_fimmu_2023_1103097 crossref_primary_10_1016_j_cels_2018_03_001 crossref_primary_10_1016_j_molcel_2016_09_003 crossref_primary_10_12688_f1000research_8818_1 crossref_primary_10_3389_fgene_2018_00162 crossref_primary_10_3390_cancers12020336 crossref_primary_10_15252_embr_201846570 crossref_primary_10_1038_s41594_023_01109_1 crossref_primary_10_1038_nrneph_2017_83 crossref_primary_10_1038_s41573_020_0086_4 crossref_primary_10_1038_s41467_020_15090_6 crossref_primary_10_1016_j_ajhg_2019_02_018 crossref_primary_10_1016_j_csbj_2022_05_049 crossref_primary_10_1016_j_jmb_2021_166944 crossref_primary_10_1039_D1CB00069A crossref_primary_10_1007_s00335_024_10096_7 crossref_primary_10_1186_s12864_018_5139_2 crossref_primary_10_3390_cells9051152 crossref_primary_10_18632_oncotarget_22413 crossref_primary_10_1038_s41598_023_40037_4 crossref_primary_10_1038_s41598_017_12772_y crossref_primary_10_1007_s00401_017_1704_z crossref_primary_10_1002_pmic_201700478 crossref_primary_10_1038_s41598_022_24246_x crossref_primary_10_1021_acsnano_7b02650 crossref_primary_10_1016_j_heliyon_2019_e01667 crossref_primary_10_1016_j_hsr_2024_100194 crossref_primary_10_1101_mcs_a003285 crossref_primary_10_3390_membranes6010008 crossref_primary_10_3390_genes7070037 crossref_primary_10_1016_j_ceca_2017_06_007 crossref_primary_10_1016_j_heliyon_2024_e32743 crossref_primary_10_1074_jbc_M117_788430 crossref_primary_10_1016_j_celrep_2024_114417 crossref_primary_10_1186_s12864_018_4876_6 crossref_primary_10_1038_s41467_023_40223_y crossref_primary_10_1002_advs_202301714 crossref_primary_10_1016_j_celrep_2020_108493 crossref_primary_10_1016_j_cels_2017_09_011 crossref_primary_10_1038_s41467_023_44233_8 crossref_primary_10_1371_journal_pgen_1007071 crossref_primary_10_1021_acs_jproteome_3c00892 crossref_primary_10_1093_nar_gkab1034 crossref_primary_10_1039_C7MT00269F crossref_primary_10_1016_j_gpb_2022_09_008 crossref_primary_10_1038_s41467_023_42069_w crossref_primary_10_12688_f1000research_16987_1 crossref_primary_10_1080_14789450_2016_1233064 crossref_primary_10_1016_j_cell_2020_07_025 crossref_primary_10_1016_j_celrep_2019_11_014 crossref_primary_10_1007_s00018_021_03813_x crossref_primary_10_1038_s41467_018_06992_7 crossref_primary_10_1161_CIRCRESAHA_119_314806 crossref_primary_10_1021_acs_jproteome_1c00437 crossref_primary_10_1038_s41467_019_09533_y crossref_primary_10_3390_cells10081865 crossref_primary_10_1177_25152564241273598 crossref_primary_10_3390_cells10010025 crossref_primary_10_15252_msb_20188792 crossref_primary_10_1007_s42399_019_00084_3 crossref_primary_10_1016_j_celrep_2021_109631 crossref_primary_10_1016_j_pnpbp_2020_110015 crossref_primary_10_1016_j_cell_2020_08_034 crossref_primary_10_1016_j_cell_2021_04_011 crossref_primary_10_1093_jb_mvab004 crossref_primary_10_1038_s41392_018_0022_9 crossref_primary_10_1111_bjh_15041 crossref_primary_10_1039_D1SC06898A crossref_primary_10_7554_eLife_20799 crossref_primary_10_18632_oncotarget_12879 crossref_primary_10_15252_embr_202050835 crossref_primary_10_1126_science_abe9403 crossref_primary_10_1128_mBio_00852_20 crossref_primary_10_2174_1568026620666200226105312 crossref_primary_10_1007_s00018_023_04706_x crossref_primary_10_1107_S2059798320005355 crossref_primary_10_1158_0008_5472_CAN_15_2325_T crossref_primary_10_1161_CIRCGEN_120_003196 crossref_primary_10_1074_jbc_M117_796045 crossref_primary_10_1186_s12863_020_00890_y crossref_primary_10_1038_s41594_019_0249_3 crossref_primary_10_1093_nar_gkx981 crossref_primary_10_1007_s00216_024_05171_6 crossref_primary_10_1016_j_chembiol_2019_04_001 crossref_primary_10_7554_eLife_28257 crossref_primary_10_1083_jcb_201707050 crossref_primary_10_1093_hmg_ddac120 crossref_primary_10_1007_s13361_019_02191_w crossref_primary_10_1021_acscatal_1c03330 crossref_primary_10_15252_embj_201798701 crossref_primary_10_1002_bies_202100126 crossref_primary_10_1371_journal_pcbi_1007403 crossref_primary_10_1021_acs_jproteome_9b00427 crossref_primary_10_1021_acs_jproteome_3c00832 crossref_primary_10_1016_j_cell_2023_04_003 crossref_primary_10_1016_j_coisb_2017_09_004 crossref_primary_10_1021_acs_jproteome_3c00839 crossref_primary_10_1038_s41592_021_01107_5 crossref_primary_10_3390_genes10090650 crossref_primary_10_1002_1873_3468_12037 crossref_primary_10_1016_j_bbalip_2016_02_009 crossref_primary_10_1007_s00018_022_04497_7 crossref_primary_10_1002_pro_3430 crossref_primary_10_1016_j_laa_2018_01_009 crossref_primary_10_3390_ijms21145124 crossref_primary_10_1080_13816810_2020_1868013 crossref_primary_10_1016_j_cub_2016_12_038 crossref_primary_10_1038_s41467_022_28341_5 crossref_primary_10_1073_pnas_1902931116 crossref_primary_10_1021_acs_jproteome_9b00435 crossref_primary_10_3390_cancers13174296 crossref_primary_10_1038_s41598_019_42990_5 crossref_primary_10_3390_jcm9072277 crossref_primary_10_15252_embj_2019102608 crossref_primary_10_1016_j_jbc_2021_100562 crossref_primary_10_1021_acs_jproteome_8b00217 crossref_primary_10_1038_nature22376 crossref_primary_10_1371_journal_pgen_1008519 crossref_primary_10_1002_2211_5463_13572 crossref_primary_10_1038_s41592_019_0461_4 crossref_primary_10_1016_j_csbj_2022_07_050 crossref_primary_10_1016_j_ceb_2018_12_010 crossref_primary_10_1038_srep27401 crossref_primary_10_1016_j_genrep_2018_07_010 crossref_primary_10_3389_fmicb_2017_02183 crossref_primary_10_1007_s12551_021_00836_3 crossref_primary_10_1038_s41598_017_11374_y crossref_primary_10_1016_j_chembiol_2020_09_005 crossref_primary_10_1038_nature22366 crossref_primary_10_1016_j_chembiol_2017_02_002 crossref_primary_10_1007_s00441_021_03537_1 crossref_primary_10_1002_mc_23000 crossref_primary_10_1038_s41586_021_04109_7 crossref_primary_10_1016_j_celrep_2018_06_022 crossref_primary_10_1038_s41467_019_11105_z crossref_primary_10_1126_science_aat8127 crossref_primary_10_1021_acs_jproteome_2c00637 crossref_primary_10_1093_nar_gky638 crossref_primary_10_1371_journal_pbio_3000975 crossref_primary_10_1186_s40246_020_00297_x crossref_primary_10_1021_acs_analchem_3c04497 crossref_primary_10_1371_journal_pbio_3000970 crossref_primary_10_1038_s41467_021_22648_5 crossref_primary_10_1083_jcb_202311189 crossref_primary_10_1038_ng_3558 crossref_primary_10_1038_s41467_020_17078_8 crossref_primary_10_3389_fcell_2020_615600 crossref_primary_10_1126_sciadv_aar5701 crossref_primary_10_1038_nature20170 crossref_primary_10_1021_acs_jproteome_1c00859 crossref_primary_10_1093_bib_bbae561 crossref_primary_10_1038_s41467_024_52558_1 crossref_primary_10_15252_msb_202010125 crossref_primary_10_1371_journal_pone_0199472 crossref_primary_10_1016_j_csbj_2022_06_040 crossref_primary_10_1093_bib_bbad229 crossref_primary_10_3390_ijms25031470 crossref_primary_10_1016_j_tibtech_2021_08_006 crossref_primary_10_1016_j_tibs_2017_02_006 crossref_primary_10_1038_s41408_018_0149_5 crossref_primary_10_3389_fimmu_2025_1479814 crossref_primary_10_1155_2018_1435934 crossref_primary_10_1073_pnas_1805633115 crossref_primary_10_15252_embj_2021110393 crossref_primary_10_1074_jbc_RA118_004928 crossref_primary_10_7554_eLife_31879 crossref_primary_10_1016_j_ajhg_2017_01_002 crossref_primary_10_1038_s41431_018_0237_9 crossref_primary_10_1016_j_cels_2018_04_011 crossref_primary_10_3389_fimmu_2019_02160 crossref_primary_10_1371_journal_pone_0156599 crossref_primary_10_3389_fpls_2015_00947 crossref_primary_10_1093_hmg_ddx183 crossref_primary_10_1016_j_bbrc_2019_02_096 crossref_primary_10_1038_s41419_021_03908_0 crossref_primary_10_1093_nar_gky458 crossref_primary_10_1016_j_copbio_2019_12_009 crossref_primary_10_1016_j_metabol_2020_154227 crossref_primary_10_1016_j_celrep_2015_09_009 crossref_primary_10_1007_s13402_024_00938_6 crossref_primary_10_1016_j_sbi_2018_04_005 crossref_primary_10_1038_s41598_024_84493_y crossref_primary_10_1038_s41418_019_0395_5 crossref_primary_10_1016_j_drudis_2019_06_020 crossref_primary_10_1016_j_euroneuro_2018_03_006 crossref_primary_10_26508_lsa_202302525 crossref_primary_10_1016_j_ebiom_2018_12_039 crossref_primary_10_1039_C9SC04336E crossref_primary_10_1038_nmeth_3901 crossref_primary_10_2144_btn_2023_0051 crossref_primary_10_1016_j_cell_2022_10_003 crossref_primary_10_1093_bib_bbad496 crossref_primary_10_1242_dev_201283 crossref_primary_10_1093_bib_bbad010 crossref_primary_10_1126_science_aan0346 crossref_primary_10_1242_jcs_239566 crossref_primary_10_34133_research_0219 crossref_primary_10_1016_j_compbiolchem_2020_107291 crossref_primary_10_1186_s12860_020_00278_x crossref_primary_10_1038_s41467_019_12013_y crossref_primary_10_1016_j_yexcr_2021_112722 crossref_primary_10_3390_biom7010001 crossref_primary_10_1042_BST20160219 crossref_primary_10_3390_jdb9040055 crossref_primary_10_1002_smtd_201900075 crossref_primary_10_1016_j_cels_2018_05_019 crossref_primary_10_1089_ars_2021_0091 crossref_primary_10_1126_science_abf3066 crossref_primary_10_1111_acel_13194 crossref_primary_10_1126_science_abf3067 crossref_primary_10_1038_s41467_019_09233_7 crossref_primary_10_1038_srep43939 crossref_primary_10_12688_f1000research_7629_1 crossref_primary_10_1038_s41592_021_01184_6 crossref_primary_10_1093_nar_gky679 crossref_primary_10_1371_journal_pcbi_1007617 crossref_primary_10_1016_j_ygeno_2018_12_006 crossref_primary_10_1007_s13361_016_1545_3 crossref_primary_10_1016_j_molcel_2020_07_001 crossref_primary_10_1038_s41467_024_51979_2 |
| Cites_doi | 10.1128/MCB.22.3.835-848.2002 10.1038/ncomms4996 10.1111/j.2517-6161.1995.tb02031.x 10.1016/j.cell.2011.08.047 10.1016/S0171-9335(98)80083-6 10.1038/nature03607 10.1093/nar/gkt1223 10.1093/nar/gkp914 10.1016/j.str.2005.04.010 10.1016/j.tcb.2008.03.006 10.1093/nar/gks1094 10.1038/415141a 10.1016/j.cell.2014.10.050 10.1093/nar/gks1118 10.1093/nar/gkq1116 10.1186/1741-7007-12-39 10.1016/j.cell.2009.04.042 10.1103/PhysRevE.69.066133 10.1093/nar/gkt569 10.1016/j.cell.2008.07.009 10.1016/j.cell.2013.09.056 10.1038/nmeth1019 10.1126/science.286.5439.509 10.1016/j.cell.2011.02.016 10.1038/msb.2013.26 10.1007/s00018-012-1247-3 10.1038/nature11354 10.1101/gad.947001 10.1101/gad.193169.112 10.1016/j.cell.2012.08.011 10.1093/database/bar009 10.1038/nmeth.1638 10.1016/j.cell.2014.05.039 10.1016/1044-0305(94)80016-2 10.1091/mbc.E12-09-0651 10.1016/j.tcb.2004.09.015 10.1038/nature04670 10.1093/nar/gkr930 10.1093/nar/gkq537 10.1016/j.cell.2011.05.006 10.1038/415180a |
| ContentType | Journal Article |
| Copyright | 2015 Elsevier Inc. Copyright © 2015 Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: 2015 Elsevier Inc. – notice: Copyright © 2015 Elsevier Inc. All rights reserved. |
| DBID | 6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7S9 L.6 5PM |
| DOI | 10.1016/j.cell.2015.06.043 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE AGRICOLA |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1097-4172 |
| EndPage | 440 |
| ExternalDocumentID | PMC4617211 26186194 10_1016_j_cell_2015_06_043 S0092867415007680 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NINDS NIH HHS grantid: R37NS036251 – fundername: NIDDK NIH HHS grantid: K01 DK098285 – fundername: Howard Hughes Medical Institute – fundername: NHGRI NIH HHS grantid: U41 HG006673 – fundername: NIDDK NIH HHS grantid: K01DK098285 – fundername: NINDS NIH HHS grantid: R37 NS036251 |
| GroupedDBID | --- --K -DZ -ET -~X 0R~ 0WA 1RT 1~5 29B 2FS 2WC 3EH 4.4 457 4G. 53G 5GY 5RE 62- 6I. 6J9 7-5 85S AACTN AAEDT AAEDW AAFTH AAFWJ AAIAV AAKRW AAKUH AAUCE AAVLU AAXJY AAXUO AAYJJ ABCQX ABJNI ABMAC ABMWF ABOCM ABVKL ACGFO ACGFS ACNCT ADBBV ADEZE ADJPV AEFWE AENEX AEXQZ AFTJW AGHFR AGHSJ AGKMS AHHHB AIDAL AITUG ALKID ALMA_UNASSIGNED_HOLDINGS AMRAJ ASPBG AVWKF AZFZN BAWUL CS3 DIK DU5 E3Z EBS EJD F5P FCP FDB FIRID HH5 IH2 IHE IXB J1W JIG K-O KOO KQ8 L7B LX5 M3Z M41 N9A NCXOZ O-L O9- OK1 P2P RCE RIG RNS ROL RPZ SCP SDG SDP SES SSZ TAE TN5 TR2 TWZ UKR UPT VQA WH7 WQ6 YZZ ZA5 ZCA .-4 .55 .GJ .HR 1CY 1VV 2KS 3O- 5VS 6TJ 9M8 AAHBH AAIKJ AALRI AAMRU AAQFI AAQXK AAYWO AAYXX ABDGV ABDPE ABEFU ABWVN ACRPL ACVFH ADCNI ADMUD ADNMO ADVLN ADXHL AETEA AEUPX AFPUW AGCQF AGQPQ AI. AIGII AKAPO AKBMS AKRWK AKYEP APXCP CITATION FEDTE FGOYB G-2 HVGLF HZ~ H~9 MVM OHT OMK OZT PUQ R2- UBW UHB VH1 X7M YYP YYQ ZGI ZHY ZKB ZY4 CGR CUY CVF ECM EFKBS EIF NPM 7X8 7S9 L.6 5PM |
| ID | FETCH-LOGICAL-c554t-f91a5921e78ca6078c564edfabb78f0db6248a73718eda9cf50c7b506d058c1f3 |
| IEDL.DBID | IXB |
| ISSN | 0092-8674 |
| IngestDate | Thu Aug 21 18:26:36 EDT 2025 Thu Sep 04 17:30:57 EDT 2025 Thu Sep 04 15:58:51 EDT 2025 Tue Jul 15 03:06:31 EDT 2025 Tue Jul 01 02:16:52 EDT 2025 Thu Apr 24 23:07:24 EDT 2025 Fri Feb 23 02:30:34 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| License | http://www.elsevier.com/open-access/userlicense/1.0 Copyright © 2015 Elsevier Inc. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c554t-f91a5921e78ca6078c564edfabb78f0db6248a73718eda9cf50c7b506d058c1f3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0092867415007680 |
| PMID | 26186194 |
| PQID | 1697221812 |
| PQPubID | 23479 |
| PageCount | 16 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4617211 proquest_miscellaneous_2000228797 proquest_miscellaneous_1697221812 pubmed_primary_26186194 crossref_citationtrail_10_1016_j_cell_2015_06_043 crossref_primary_10_1016_j_cell_2015_06_043 elsevier_sciencedirect_doi_10_1016_j_cell_2015_06_043 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2015-07-16 |
| PublicationDateYYYYMMDD | 2015-07-16 |
| PublicationDate_xml | – month: 07 year: 2015 text: 2015-07-16 day: 16 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Cell |
| PublicationTitleAlternate | Cell |
| PublicationYear | 2015 |
| Publisher | Elsevier Inc |
| Publisher_xml | – name: Elsevier Inc |
| References | Yang, Boehm, Yang, Salehi-Ashtiani, Hao, Shen, Lubonja, Thomas, Alkan, Bhimdi (bib41) 2011; 8 Ho, Gruhler, Heilbut, Bader, Moore, Adams, Millar, Taylor, Bennett, Boutilier (bib15) 2002; 415 Mesmin, Antonny, Drin (bib25) 2013; 70 Lev, Ben Halevy, Peretti, Dahan (bib20) 2008; 18 Taipale, Tucker, Peng, Krykbaeva, Lin, Larsen, Choi, Berger, Gingras, Lindquist (bib37) 2014; 158 Boxem, Maliga, Klitgord, Li, Lemmens, Mana, de Lichtervelde, Mul, van de Peut, Devos (bib5) 2008; 134 Palla, Derényi, Farkas, Vicsek (bib30) 2005; 435 Mroczek, Krwawicz, Kutner, Lazniewski, Kuciński, Ginalski, Dziembowski (bib28) 2012; 26 Krogan, Cagney, Yu, Zhong, Guo, Ignatchenko, Li, Pu, Datta, Tikuisis (bib18) 2006; 440 Rolland, Taşan, Charloteaux, Pevzner, Zhong, Sahni, Yi, Lemmens, Fontanillo, Mosca (bib31) 2014; 159 Ruepp, Waegele, Lechner, Brauner, Dunger-Kaltenbach, Fobo, Frishman, Montrone, Mewes (bib32) 2010; 38 Wójcik, Tanaka, Paweletz, Naab, Wilk (bib40) 1998; 77 Babu, Vlasblom, Pu, Guo, Graham, Bean, Burston, Vizeacoumar, Snider, Phanse (bib1) 2012; 489 Eng, McCormack, Yates (bib7) 1994; 5 Joshi, Greco, Guise, Luo, Yu, Nesvizhskii, Cristea (bib16) 2013; 9 Licata, Briganti, Peluso, Perfetto, Iannuccelli, Galeota, Sacco, Palma, Nardozza, Santonico (bib21) 2012; 40 Vidal, Cusick, Barabási (bib38) 2011; 144 Sowa, Bennett, Gygi, Harper (bib33) 2009; 138 Warde-Farley, Donaldson, Comes, Zuberi, Badrawi, Chao, Franz, Grouios, Kazi, Lopes (bib39) 2010; 38 Kaiser, Brickner, Reilein, Fenn, Walter, Brunger (bib17) 2005; 13 Franceschini, Szklarczyk, Frankild, Kuhn, Simonovic, Roth, Lin, Minguez, Bork, von Mering, Jensen (bib9) 2013; 41 Gosselin, Martineau, Morales, Czjzek, Glippa, Gauffeny, Morin, Le Corguillé, Pyronnet, Cormier, Cosson (bib12) 2013; 41 Stark, Breitkreutz, Chatr-Aryamontri, Boucher, Oughtred, Livstone, Nixon, Van Auken, Wang, Shi (bib35) 2011; 39 Barabasi, Albert (bib2) 1999; 286 Finn, Bateman, Clements, Coggill, Eberhardt, Eddy, Heger, Hetherington, Holm, Mistry (bib8) 2014; 42 Kuzmichev, Zhang, Erdjument-Bromage, Tempst, Reinberg (bib19) 2002; 22 Mesmin, Bigay, Moser von Filseck, Lacas-Gervais, Drin, Antonny (bib26) 2013; 155 Elias, Gygi (bib6) 2007; 4 Masson, Tarsounas, Stasiak, Stasiak, Shah, McIlwraith, Benson, West (bib24) 2001; 15 Magrane, Consortium (bib22) 2011; 2011 Stoica, De Vos, Paillusson, Mueller, Sancho, Lau, Vizcay-Barrena, Lin, Xu, Lewis (bib36) 2014; 5 Spiess, Meyer, Reissmann, Frydman (bib34) 2004; 14 Baron, Pedrioli, Tyagi, Johnson, Wood, Fountaine, Wightman, Alexandru (bib3) 2014; 12 Havugimana, Hart, Nepusz, Yang, Turinsky, Li, Wang, Boutz, Fong, Phanse (bib14) 2012; 150 Gavin, Bösche, Krause, Grandi, Marzioch, Bauer, Schultz, Rick, Michon, Cruciat (bib11) 2002; 415 Malovannaya, Lanz, Jung, Bulynko, Le, Chan, Ding, Shi, Yucer, Krenciute (bib23) 2011; 145 Fung, Nishimura, Sasarman, Shoubridge (bib10) 2013; 24 Guruharsha, Rual, Zhai, Mintseris, Vaidya, Vaidya, Beekman, Wong, Rhee, Cenaj (bib13) 2011; 147 Newman (bib29) 2004; 69 Benjamini, Hochberg (bib4) 1995; 57 Mi, Muruganujan, Thomas (bib27) 2013; 41 Newman (10.1016/j.cell.2015.06.043_bib29) 2004; 69 Rolland (10.1016/j.cell.2015.06.043_bib31) 2014; 159 Spiess (10.1016/j.cell.2015.06.043_bib34) 2004; 14 Malovannaya (10.1016/j.cell.2015.06.043_bib23) 2011; 145 Taipale (10.1016/j.cell.2015.06.043_bib37) 2014; 158 Warde-Farley (10.1016/j.cell.2015.06.043_bib39) 2010; 38 Mi (10.1016/j.cell.2015.06.043_bib27) 2013; 41 Mroczek (10.1016/j.cell.2015.06.043_bib28) 2012; 26 Stark (10.1016/j.cell.2015.06.043_bib35) 2011; 39 Ho (10.1016/j.cell.2015.06.043_bib15) 2002; 415 Finn (10.1016/j.cell.2015.06.043_bib8) 2014; 42 Guruharsha (10.1016/j.cell.2015.06.043_bib13) 2011; 147 Boxem (10.1016/j.cell.2015.06.043_bib5) 2008; 134 Stoica (10.1016/j.cell.2015.06.043_bib36) 2014; 5 Barabasi (10.1016/j.cell.2015.06.043_bib2) 1999; 286 Baron (10.1016/j.cell.2015.06.043_bib3) 2014; 12 Licata (10.1016/j.cell.2015.06.043_bib21) 2012; 40 Mesmin (10.1016/j.cell.2015.06.043_bib25) 2013; 70 Joshi (10.1016/j.cell.2015.06.043_bib16) 2013; 9 Magrane (10.1016/j.cell.2015.06.043_bib22) 2011; 2011 Kaiser (10.1016/j.cell.2015.06.043_bib17) 2005; 13 Ruepp (10.1016/j.cell.2015.06.043_bib32) 2010; 38 Krogan (10.1016/j.cell.2015.06.043_bib18) 2006; 440 Franceschini (10.1016/j.cell.2015.06.043_bib9) 2013; 41 Palla (10.1016/j.cell.2015.06.043_bib30) 2005; 435 Sowa (10.1016/j.cell.2015.06.043_bib33) 2009; 138 Babu (10.1016/j.cell.2015.06.043_bib1) 2012; 489 Fung (10.1016/j.cell.2015.06.043_bib10) 2013; 24 Wójcik (10.1016/j.cell.2015.06.043_bib40) 1998; 77 Masson (10.1016/j.cell.2015.06.043_bib24) 2001; 15 Eng (10.1016/j.cell.2015.06.043_bib7) 1994; 5 Kuzmichev (10.1016/j.cell.2015.06.043_bib19) 2002; 22 Gosselin (10.1016/j.cell.2015.06.043_bib12) 2013; 41 Mesmin (10.1016/j.cell.2015.06.043_bib26) 2013; 155 Yang (10.1016/j.cell.2015.06.043_bib41) 2011; 8 Elias (10.1016/j.cell.2015.06.043_bib6) 2007; 4 Benjamini (10.1016/j.cell.2015.06.043_bib4) 1995; 57 Gavin (10.1016/j.cell.2015.06.043_bib11) 2002; 415 Havugimana (10.1016/j.cell.2015.06.043_bib14) 2012; 150 Lev (10.1016/j.cell.2015.06.043_bib20) 2008; 18 Vidal (10.1016/j.cell.2015.06.043_bib38) 2011; 144 24209621 - Cell. 2013 Nov 7;155(4):830-43 24893131 - Nat Commun. 2014;5:3996 18468439 - Trends Cell Biol. 2008 Jun;18(6):282-90 22036573 - Cell. 2011 Oct 28;147(3):690-703 11751635 - Genes Dev. 2001 Dec 15;15(24):3296-307 15244693 - Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Jun;69(6 Pt 2):066133 22096227 - Nucleic Acids Res. 2012 Jan;40(Database issue):D857-61 16004875 - Structure. 2005 Jul;13(7):1035-45 21447597 - Database (Oxford). 2011;2011:bar009 15944704 - Nature. 2005 Jun 9;435(7043):814-8 22939629 - Cell. 2012 Aug 31;150(5):1068-81 21071413 - Nucleic Acids Res. 2011 Jan;39(Database issue):D698-704 24226387 - J Am Soc Mass Spectrom. 1994 Nov;5(11):976-89 18692475 - Cell. 2008 Aug 8;134(3):534-45 22899009 - Genes Dev. 2012 Sep 1;26(17):1911-25 19615732 - Cell. 2009 Jul 23;138(2):389-403 20576703 - Nucleic Acids Res. 2010 Jul;38(Web Server issue):W214-20 24288371 - Nucleic Acids Res. 2014 Jan;42(Database issue):D222-30 24885147 - BMC Biol. 2014;12:39 23171548 - Mol Biol Cell. 2013 Feb;24(3):184-93 23203871 - Nucleic Acids Res. 2013 Jan;41(Database issue):D808-15 11805826 - Nature. 2002 Jan 10;415(6868):141-7 23193289 - Nucleic Acids Res. 2013 Jan;41(Database issue):D377-86 22940862 - Nature. 2012 Sep 27;489(7417):585-9 9840465 - Eur J Cell Biol. 1998 Oct;77(2):151-60 25416956 - Cell. 2014 Nov 20;159(5):1212-26 11784859 - Mol Cell Biol. 2002 Feb;22(3):835-48 16554755 - Nature. 2006 Mar 30;440(7084):637-43 17327847 - Nat Methods. 2007 Mar;4(3):207-14 23283302 - Cell Mol Life Sci. 2013 Sep;70(18):3405-21 23814182 - Nucleic Acids Res. 2013 Sep;41(16):7783-92 25036637 - Cell. 2014 Jul 17;158(2):434-48 21414488 - Cell. 2011 Mar 18;144(6):986-98 15519848 - Trends Cell Biol. 2004 Nov;14(11):598-604 19884131 - Nucleic Acids Res. 2010 Jan;38(Database issue):D497-501 23752268 - Mol Syst Biol. 2013;9:672 21706014 - Nat Methods. 2011 Aug;8(8):659-61 11805837 - Nature. 2002 Jan 10;415(6868):180-3 21620140 - Cell. 2011 May 27;145(5):787-99 10521342 - Science. 1999 Oct 15;286(5439):509-12 |
| References_xml | – volume: 57 start-page: 289 year: 1995 end-page: 300 ident: bib4 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J. R. Stat. Soc., B – volume: 489 start-page: 585 year: 2012 end-page: 589 ident: bib1 article-title: Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiae publication-title: Nature – volume: 138 start-page: 389 year: 2009 end-page: 403 ident: bib33 article-title: Defining the human deubiquitinating enzyme interaction landscape publication-title: Cell – volume: 4 start-page: 207 year: 2007 end-page: 214 ident: bib6 article-title: Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry publication-title: Nat. Methods – volume: 5 start-page: 976 year: 1994 end-page: 989 ident: bib7 article-title: An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database publication-title: J. Am. Soc. Mass Spectrom. – volume: 77 start-page: 151 year: 1998 end-page: 160 ident: bib40 article-title: Proteasome activator (PA28) subunits, alpha, beta and gamma (Ki antigen) in NT2 neuronal precursor cells and HeLa S3 cells publication-title: Eur. J. Cell Biol. – volume: 41 start-page: D808 year: 2013 end-page: D815 ident: bib9 article-title: STRING v9.1: protein-protein interaction networks, with increased coverage and integration publication-title: Nucleic Acids Res. – volume: 440 start-page: 637 year: 2006 end-page: 643 ident: bib18 article-title: Global landscape of protein complexes in the yeast Saccharomyces cerevisiae publication-title: Nature – volume: 415 start-page: 180 year: 2002 end-page: 183 ident: bib15 article-title: Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry publication-title: Nature – volume: 12 start-page: 39 year: 2014 ident: bib3 article-title: VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase publication-title: BMC Biol. – volume: 9 start-page: 672 year: 2013 ident: bib16 article-title: The functional interactome landscape of the human histone deacetylase family publication-title: Mol. Syst. Biol. – volume: 15 start-page: 3296 year: 2001 end-page: 3307 ident: bib24 article-title: Identification and purification of two distinct complexes containing the five RAD51 paralogs publication-title: Genes Dev. – volume: 2011 start-page: bar009 year: 2011 ident: bib22 article-title: UniProt Knowledgebase: a hub of integrated protein data publication-title: Database (Oxford) – volume: 8 start-page: 659 year: 2011 end-page: 661 ident: bib41 article-title: A public genome-scale lentiviral expression library of human ORFs publication-title: Nat. Methods – volume: 145 start-page: 787 year: 2011 end-page: 799 ident: bib23 article-title: Analysis of the human endogenous coregulator complexome publication-title: Cell – volume: 435 start-page: 814 year: 2005 end-page: 818 ident: bib30 article-title: Uncovering the overlapping community structure of complex networks in nature and society publication-title: Nature – volume: 70 start-page: 3405 year: 2013 end-page: 3421 ident: bib25 article-title: Insights into the mechanisms of sterol transport between organelles publication-title: Cell. Mol. Life Sci. – volume: 41 start-page: 7783 year: 2013 end-page: 7792 ident: bib12 article-title: Tracking a refined eIF4E-binding motif reveals Angel1 as a new partner of eIF4E publication-title: Nucleic Acids Res. – volume: 24 start-page: 184 year: 2013 end-page: 193 ident: bib10 article-title: The conserved interaction of C7orf30 with MRPL14 promotes biogenesis of the mitochondrial large ribosomal subunit and mitochondrial translation publication-title: Mol. Biol. Cell – volume: 147 start-page: 690 year: 2011 end-page: 703 ident: bib13 article-title: A protein complex network of Drosophila melanogaster publication-title: Cell – volume: 159 start-page: 1212 year: 2014 end-page: 1226 ident: bib31 article-title: A proteome-scale map of the human interactome network publication-title: Cell – volume: 42 start-page: D222 year: 2014 end-page: D230 ident: bib8 article-title: Pfam: the protein families database publication-title: Nucleic Acids Res. – volume: 13 start-page: 1035 year: 2005 end-page: 1045 ident: bib17 article-title: Structural basis of FFAT motif-mediated ER targeting publication-title: Structure – volume: 26 start-page: 1911 year: 2012 end-page: 1925 ident: bib28 article-title: C16orf57, a gene mutated in poikiloderma with neutropenia, encodes a putative phosphodiesterase responsible for the U6 snRNA 3′ end modification publication-title: Genes Dev. – volume: 18 start-page: 282 year: 2008 end-page: 290 ident: bib20 article-title: The VAP protein family: from cellular functions to motor neuron disease publication-title: Trends Cell Biol. – volume: 144 start-page: 986 year: 2011 end-page: 998 ident: bib38 article-title: Interactome networks and human disease publication-title: Cell – volume: 38 start-page: W214 year: 2010 end-page: W220 ident: bib39 article-title: The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function publication-title: Nucleic Acids Res. – volume: 40 start-page: D857 year: 2012 end-page: D861 ident: bib21 article-title: MINT, the molecular interaction database: 2012 update publication-title: Nucleic Acids Res. – volume: 150 start-page: 1068 year: 2012 end-page: 1081 ident: bib14 article-title: A census of human soluble protein complexes publication-title: Cell – volume: 38 start-page: D497 year: 2010 end-page: D501 ident: bib32 article-title: CORUM: the comprehensive resource of mammalian protein complexes--2009 publication-title: Nucleic Acids Res. – volume: 39 start-page: D698 year: 2011 end-page: D704 ident: bib35 article-title: The BioGRID Interaction Database: 2011 update publication-title: Nucleic Acids Res. – volume: 134 start-page: 534 year: 2008 end-page: 545 ident: bib5 article-title: A protein domain-based interactome network for C. elegans early embryogenesis publication-title: Cell – volume: 22 start-page: 835 year: 2002 end-page: 848 ident: bib19 article-title: Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1) publication-title: Mol. Cell. Biol. – volume: 155 start-page: 830 year: 2013 end-page: 843 ident: bib26 article-title: A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP publication-title: Cell – volume: 41 start-page: D377 year: 2013 end-page: D386 ident: bib27 article-title: PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees publication-title: Nucleic Acids Res. – volume: 286 start-page: 509 year: 1999 end-page: 512 ident: bib2 article-title: Emergence of scaling in random networks publication-title: Science – volume: 5 start-page: 3996 year: 2014 ident: bib36 article-title: ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43 publication-title: Nat. Commun. – volume: 415 start-page: 141 year: 2002 end-page: 147 ident: bib11 article-title: Functional organization of the yeast proteome by systematic analysis of protein complexes publication-title: Nature – volume: 69 start-page: 066133 year: 2004 ident: bib29 article-title: Fast algorithm for detecting community structure in networks publication-title: Phys. Rev. E Stat. Nonlin. Soft Matter Phys. – volume: 14 start-page: 598 year: 2004 end-page: 604 ident: bib34 article-title: Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets publication-title: Trends Cell Biol. – volume: 158 start-page: 434 year: 2014 end-page: 448 ident: bib37 article-title: A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways publication-title: Cell – volume: 22 start-page: 835 year: 2002 ident: 10.1016/j.cell.2015.06.043_bib19 article-title: Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1) publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.22.3.835-848.2002 – volume: 5 start-page: 3996 year: 2014 ident: 10.1016/j.cell.2015.06.043_bib36 article-title: ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43 publication-title: Nat. Commun. doi: 10.1038/ncomms4996 – volume: 57 start-page: 289 year: 1995 ident: 10.1016/j.cell.2015.06.043_bib4 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J. R. Stat. Soc., B doi: 10.1111/j.2517-6161.1995.tb02031.x – volume: 147 start-page: 690 year: 2011 ident: 10.1016/j.cell.2015.06.043_bib13 article-title: A protein complex network of Drosophila melanogaster publication-title: Cell doi: 10.1016/j.cell.2011.08.047 – volume: 77 start-page: 151 year: 1998 ident: 10.1016/j.cell.2015.06.043_bib40 article-title: Proteasome activator (PA28) subunits, alpha, beta and gamma (Ki antigen) in NT2 neuronal precursor cells and HeLa S3 cells publication-title: Eur. J. Cell Biol. doi: 10.1016/S0171-9335(98)80083-6 – volume: 435 start-page: 814 year: 2005 ident: 10.1016/j.cell.2015.06.043_bib30 article-title: Uncovering the overlapping community structure of complex networks in nature and society publication-title: Nature doi: 10.1038/nature03607 – volume: 42 start-page: D222 year: 2014 ident: 10.1016/j.cell.2015.06.043_bib8 article-title: Pfam: the protein families database publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkt1223 – volume: 38 start-page: D497 year: 2010 ident: 10.1016/j.cell.2015.06.043_bib32 article-title: CORUM: the comprehensive resource of mammalian protein complexes--2009 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkp914 – volume: 13 start-page: 1035 year: 2005 ident: 10.1016/j.cell.2015.06.043_bib17 article-title: Structural basis of FFAT motif-mediated ER targeting publication-title: Structure doi: 10.1016/j.str.2005.04.010 – volume: 18 start-page: 282 year: 2008 ident: 10.1016/j.cell.2015.06.043_bib20 article-title: The VAP protein family: from cellular functions to motor neuron disease publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2008.03.006 – volume: 41 start-page: D808 year: 2013 ident: 10.1016/j.cell.2015.06.043_bib9 article-title: STRING v9.1: protein-protein interaction networks, with increased coverage and integration publication-title: Nucleic Acids Res. doi: 10.1093/nar/gks1094 – volume: 415 start-page: 141 year: 2002 ident: 10.1016/j.cell.2015.06.043_bib11 article-title: Functional organization of the yeast proteome by systematic analysis of protein complexes publication-title: Nature doi: 10.1038/415141a – volume: 159 start-page: 1212 year: 2014 ident: 10.1016/j.cell.2015.06.043_bib31 article-title: A proteome-scale map of the human interactome network publication-title: Cell doi: 10.1016/j.cell.2014.10.050 – volume: 41 start-page: D377 year: 2013 ident: 10.1016/j.cell.2015.06.043_bib27 article-title: PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees publication-title: Nucleic Acids Res. doi: 10.1093/nar/gks1118 – volume: 39 start-page: D698 year: 2011 ident: 10.1016/j.cell.2015.06.043_bib35 article-title: The BioGRID Interaction Database: 2011 update publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq1116 – volume: 12 start-page: 39 year: 2014 ident: 10.1016/j.cell.2015.06.043_bib3 article-title: VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase publication-title: BMC Biol. doi: 10.1186/1741-7007-12-39 – volume: 138 start-page: 389 year: 2009 ident: 10.1016/j.cell.2015.06.043_bib33 article-title: Defining the human deubiquitinating enzyme interaction landscape publication-title: Cell doi: 10.1016/j.cell.2009.04.042 – volume: 69 start-page: 066133 year: 2004 ident: 10.1016/j.cell.2015.06.043_bib29 article-title: Fast algorithm for detecting community structure in networks publication-title: Phys. Rev. E Stat. Nonlin. Soft Matter Phys. doi: 10.1103/PhysRevE.69.066133 – volume: 41 start-page: 7783 year: 2013 ident: 10.1016/j.cell.2015.06.043_bib12 article-title: Tracking a refined eIF4E-binding motif reveals Angel1 as a new partner of eIF4E publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkt569 – volume: 134 start-page: 534 year: 2008 ident: 10.1016/j.cell.2015.06.043_bib5 article-title: A protein domain-based interactome network for C. elegans early embryogenesis publication-title: Cell doi: 10.1016/j.cell.2008.07.009 – volume: 155 start-page: 830 year: 2013 ident: 10.1016/j.cell.2015.06.043_bib26 article-title: A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP publication-title: Cell doi: 10.1016/j.cell.2013.09.056 – volume: 4 start-page: 207 year: 2007 ident: 10.1016/j.cell.2015.06.043_bib6 article-title: Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry publication-title: Nat. Methods doi: 10.1038/nmeth1019 – volume: 286 start-page: 509 year: 1999 ident: 10.1016/j.cell.2015.06.043_bib2 article-title: Emergence of scaling in random networks publication-title: Science doi: 10.1126/science.286.5439.509 – volume: 144 start-page: 986 year: 2011 ident: 10.1016/j.cell.2015.06.043_bib38 article-title: Interactome networks and human disease publication-title: Cell doi: 10.1016/j.cell.2011.02.016 – volume: 9 start-page: 672 year: 2013 ident: 10.1016/j.cell.2015.06.043_bib16 article-title: The functional interactome landscape of the human histone deacetylase family publication-title: Mol. Syst. Biol. doi: 10.1038/msb.2013.26 – volume: 70 start-page: 3405 year: 2013 ident: 10.1016/j.cell.2015.06.043_bib25 article-title: Insights into the mechanisms of sterol transport between organelles publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-012-1247-3 – volume: 489 start-page: 585 year: 2012 ident: 10.1016/j.cell.2015.06.043_bib1 article-title: Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiae publication-title: Nature doi: 10.1038/nature11354 – volume: 15 start-page: 3296 year: 2001 ident: 10.1016/j.cell.2015.06.043_bib24 article-title: Identification and purification of two distinct complexes containing the five RAD51 paralogs publication-title: Genes Dev. doi: 10.1101/gad.947001 – volume: 26 start-page: 1911 year: 2012 ident: 10.1016/j.cell.2015.06.043_bib28 article-title: C16orf57, a gene mutated in poikiloderma with neutropenia, encodes a putative phosphodiesterase responsible for the U6 snRNA 3′ end modification publication-title: Genes Dev. doi: 10.1101/gad.193169.112 – volume: 150 start-page: 1068 year: 2012 ident: 10.1016/j.cell.2015.06.043_bib14 article-title: A census of human soluble protein complexes publication-title: Cell doi: 10.1016/j.cell.2012.08.011 – volume: 2011 start-page: bar009 year: 2011 ident: 10.1016/j.cell.2015.06.043_bib22 article-title: UniProt Knowledgebase: a hub of integrated protein data publication-title: Database (Oxford) doi: 10.1093/database/bar009 – volume: 8 start-page: 659 year: 2011 ident: 10.1016/j.cell.2015.06.043_bib41 article-title: A public genome-scale lentiviral expression library of human ORFs publication-title: Nat. Methods doi: 10.1038/nmeth.1638 – volume: 158 start-page: 434 year: 2014 ident: 10.1016/j.cell.2015.06.043_bib37 article-title: A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways publication-title: Cell doi: 10.1016/j.cell.2014.05.039 – volume: 5 start-page: 976 year: 1994 ident: 10.1016/j.cell.2015.06.043_bib7 article-title: An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database publication-title: J. Am. Soc. Mass Spectrom. doi: 10.1016/1044-0305(94)80016-2 – volume: 24 start-page: 184 year: 2013 ident: 10.1016/j.cell.2015.06.043_bib10 article-title: The conserved interaction of C7orf30 with MRPL14 promotes biogenesis of the mitochondrial large ribosomal subunit and mitochondrial translation publication-title: Mol. Biol. Cell doi: 10.1091/mbc.E12-09-0651 – volume: 14 start-page: 598 year: 2004 ident: 10.1016/j.cell.2015.06.043_bib34 article-title: Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2004.09.015 – volume: 440 start-page: 637 year: 2006 ident: 10.1016/j.cell.2015.06.043_bib18 article-title: Global landscape of protein complexes in the yeast Saccharomyces cerevisiae publication-title: Nature doi: 10.1038/nature04670 – volume: 40 start-page: D857 year: 2012 ident: 10.1016/j.cell.2015.06.043_bib21 article-title: MINT, the molecular interaction database: 2012 update publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkr930 – volume: 38 start-page: W214 year: 2010 ident: 10.1016/j.cell.2015.06.043_bib39 article-title: The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq537 – volume: 145 start-page: 787 year: 2011 ident: 10.1016/j.cell.2015.06.043_bib23 article-title: Analysis of the human endogenous coregulator complexome publication-title: Cell doi: 10.1016/j.cell.2011.05.006 – volume: 415 start-page: 180 year: 2002 ident: 10.1016/j.cell.2015.06.043_bib15 article-title: Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry publication-title: Nature doi: 10.1038/415180a – reference: 16554755 - Nature. 2006 Mar 30;440(7084):637-43 – reference: 15244693 - Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Jun;69(6 Pt 2):066133 – reference: 25416956 - Cell. 2014 Nov 20;159(5):1212-26 – reference: 15519848 - Trends Cell Biol. 2004 Nov;14(11):598-604 – reference: 23203871 - Nucleic Acids Res. 2013 Jan;41(Database issue):D808-15 – reference: 18692475 - Cell. 2008 Aug 8;134(3):534-45 – reference: 11805837 - Nature. 2002 Jan 10;415(6868):180-3 – reference: 20576703 - Nucleic Acids Res. 2010 Jul;38(Web Server issue):W214-20 – reference: 25036637 - Cell. 2014 Jul 17;158(2):434-48 – reference: 24209621 - Cell. 2013 Nov 7;155(4):830-43 – reference: 24885147 - BMC Biol. 2014;12:39 – reference: 21706014 - Nat Methods. 2011 Aug;8(8):659-61 – reference: 23193289 - Nucleic Acids Res. 2013 Jan;41(Database issue):D377-86 – reference: 15944704 - Nature. 2005 Jun 9;435(7043):814-8 – reference: 24288371 - Nucleic Acids Res. 2014 Jan;42(Database issue):D222-30 – reference: 23814182 - Nucleic Acids Res. 2013 Sep;41(16):7783-92 – reference: 9840465 - Eur J Cell Biol. 1998 Oct;77(2):151-60 – reference: 21447597 - Database (Oxford). 2011;2011:bar009 – reference: 21414488 - Cell. 2011 Mar 18;144(6):986-98 – reference: 21071413 - Nucleic Acids Res. 2011 Jan;39(Database issue):D698-704 – reference: 16004875 - Structure. 2005 Jul;13(7):1035-45 – reference: 24893131 - Nat Commun. 2014;5:3996 – reference: 17327847 - Nat Methods. 2007 Mar;4(3):207-14 – reference: 11751635 - Genes Dev. 2001 Dec 15;15(24):3296-307 – reference: 19884131 - Nucleic Acids Res. 2010 Jan;38(Database issue):D497-501 – reference: 22940862 - Nature. 2012 Sep 27;489(7417):585-9 – reference: 19615732 - Cell. 2009 Jul 23;138(2):389-403 – reference: 18468439 - Trends Cell Biol. 2008 Jun;18(6):282-90 – reference: 22939629 - Cell. 2012 Aug 31;150(5):1068-81 – reference: 23752268 - Mol Syst Biol. 2013;9:672 – reference: 21620140 - Cell. 2011 May 27;145(5):787-99 – reference: 10521342 - Science. 1999 Oct 15;286(5439):509-12 – reference: 22899009 - Genes Dev. 2012 Sep 1;26(17):1911-25 – reference: 23283302 - Cell Mol Life Sci. 2013 Sep;70(18):3405-21 – reference: 11805826 - Nature. 2002 Jan 10;415(6868):141-7 – reference: 22096227 - Nucleic Acids Res. 2012 Jan;40(Database issue):D857-61 – reference: 11784859 - Mol Cell Biol. 2002 Feb;22(3):835-48 – reference: 23171548 - Mol Biol Cell. 2013 Feb;24(3):184-93 – reference: 22036573 - Cell. 2011 Oct 28;147(3):690-703 – reference: 24226387 - J Am Soc Mass Spectrom. 1994 Nov;5(11):976-89 |
| SSID | ssj0008555 |
| Score | 2.66898 |
| Snippet | Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput... |
| SourceID | pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 425 |
| SubjectTerms | amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Humans Mass Spectrometry membrane proteins mutation Protein Interaction Mapping Protein Interaction Maps Proteins - chemistry Proteins - isolation & purification Proteins - metabolism Proteomics - methods |
| Title | The BioPlex Network: A Systematic Exploration of the Human Interactome |
| URI | https://dx.doi.org/10.1016/j.cell.2015.06.043 https://www.ncbi.nlm.nih.gov/pubmed/26186194 https://www.proquest.com/docview/1697221812 https://www.proquest.com/docview/2000228797 https://pubmed.ncbi.nlm.nih.gov/PMC4617211 |
| Volume | 162 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ZS8QwEA4iCL6It-tFBN-k2CNH45uKiweKoMK-hTZNcEW7oivov3cmaYur6IOPbSaQJpmZb6ZzELKbccDQxlWRsqKKGCioSFWCAbtzxYvYpYpjNvLllTi9Y-cDPpgix20uDIZVNrI_yHQvrZs3-81u7j8Ph5jjq9JcoEb0v5PQbsesUkziGxx10jjnPHQxUMD5QN0kzoQYL3SOY3gX9zU8WfabcvoJPr_HUH5RSv15MtegSXoYFrxApmy9SGZCf8mPJdKHS0Dh6frRvtOrEPB9QA_pTVe-mYYYPH88dOQowEHq_frUuwqxGc-TXSZ3_ZPb49OoaZwQGUAH48ippOAqTazMTSEABBgumK1cUZYyd3FVipTlhcxAL9mqUMbx2MiSx6KKeW4Sl62Q6XpU2zVCwYAAg6MwnJWOWSZLYNlY2gRwGwCp1PZI0u6YNk1VcWxu8ajb8LEHjbuscZc1xtCxrEf2ujnPoabGn9S8PQg9cTM0CP0_5-20p6aBZXC4qO3o7VUnQsnUQ5vfadJQGUgq2SOr4aS7tabYYyBRrEfkxB3oCLBk9-RIPbz3pbuZ8Cb3-j-_aYPM4hP6lhOxSabHL292C0DRuNwGc-DsYtvf_U-XJwoG |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEB5CSmkvoekr26atCr0VEz_0sHpLQpbNayk0gb0JW5bIhsQb2g00_z4zkm26LcmhR1sjkDWamU_ypxmAL4VADG19k2gnm4RjgEp0Izmau9CiSn2uBd1GPp3KyTk_monZGuz3d2GIVtn5_ujTg7fu3ux0s7lzM5_THV-dl5IiYvidhPv2J4gGUlrah7O9wR2XQsQyBhpNH8W7mzOR5EWn48TvEiGJJy8eik7_os-_SZR_RKXxC9jo4CTbjSPehDXXvoSnscDk3SsY4ypg-PT9yv1m08j4_sZ22Y8hfzOLJLygH7bwDPEgCwf7LJwVUjWea_cazscHZ_uTpKuckFiEB8vE66wSOs-cKm0lEQVYIblrfFXXqvRpU8ucl5UqMDC5ptLWi9SqWqSySUVpM1-8gfV20botYLiDwB1HZQWvPXdc1WizqXIZAjdEUrkbQdbPmLFdWnGqbnFlev7YpaFZNjTLhkh0vBjB16HPTUyq8ai06BVhVpaGQa__aL_PvdYM2gw1V61b3P4ymdQqD9jmYZk8pgZSWo3gbdT0MNacigxkmo9ArayBQYBydq-2tPOLkLuby7Dnfvef3_QJnk3OTk_MyeH0-D08pxY6aM7kNqwvf966D4iQlvXHYAH3vCQMMA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+BioPlex+Network%3A+A+Systematic+Exploration+of+the+Human+Interactome&rft.jtitle=Cell&rft.au=Huttlin%2C+Edward+L.&rft.au=Ting%2C+Lily&rft.au=Bruckner%2C+Raphael+J.&rft.au=Gebreab%2C+Fana&rft.date=2015-07-16&rft.issn=0092-8674&rft.eissn=1097-4172&rft.volume=162&rft.issue=2&rft.spage=425&rft.epage=440&rft_id=info:doi/10.1016%2Fj.cell.2015.06.043&rft_id=info%3Apmid%2F26186194&rft.externalDocID=PMC4617211 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0092-8674&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0092-8674&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0092-8674&client=summon |