Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

Two decades of studies in multiple model organisms have established the Hippo pathway as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ transcription co-activators, the Hippo pathway regulates cell proliferation, apoptosis, and stemness in response to a wide range of...

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Published in	Cell Vol. 163; no. 4; pp. 811 - 828
Main Authors	Yu, Fa-Xing, Zhao, Bin, Guan, Kun-Liang
Format	Journal Article
Language	English
Published	United States Elsevier Inc 05.11.2015
Subjects	Animals apoptosis carcinogenesis Cell Physiological Phenomena cell polarity cell proliferation energy G-protein coupled receptors Homeostasis Humans ligands neoplasms Neoplasms - metabolism Organ Size Protein-Serine-Threonine Kinases - metabolism Signal Transduction
Online Access	Get full text
ISSN	0092-8674 1097-4172 1097-4172
DOI	10.1016/j.cell.2015.10.044

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Abstract	Two decades of studies in multiple model organisms have established the Hippo pathway as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ transcription co-activators, the Hippo pathway regulates cell proliferation, apoptosis, and stemness in response to a wide range of extracellular and intracellular signals, including cell-cell contact, cell polarity, mechanical cues, ligands of G-protein-coupled receptors, and cellular energy status. Dysregulation of the Hippo pathway exerts a significant impact on cancer development. Further investigation of the functions and regulatory mechanisms of this pathway will help uncovering the mystery of organ size control and identify new targets for cancer treatment. In response to a variety of cellular signals, the Hippo pathway plays key roles in regulating tissue homeostasis, stemness, and cancer development.
AbstractList	Two decades of studies in multiple model organisms have established the Hippo pathway as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ transcription co-activators, the Hippo pathway regulates cell proliferation, apoptosis, and stemness in response to a wide range of extracellular and intracellular signals, including cell-cell contact, cell polarity, mechanical cues, ligands of G-protein coupled receptors, and cellular energy status. Dysregulation of the Hippo pathway exerts a significant impact on cancer development. Further investigation of the functions and regulatory mechanisms of this pathway will help uncovering the mystery of organ size control and identify new targets for cancer treatment. Two decades of studies in multiple model organisms have established the Hippo pathway as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ transcription co-activators, the Hippo pathway regulates cell proliferation, apoptosis, and stemness in response to a wide range of extracellular and intracellular signals, including cell-cell contact, cell polarity, mechanical cues, ligands of G-protein-coupled receptors, and cellular energy status. Dysregulation of the Hippo pathway exerts a significant impact on cancer development. Further investigation of the functions and regulatory mechanisms of this pathway will help uncovering the mystery of organ size control and identify new targets for cancer treatment.Two decades of studies in multiple model organisms have established the Hippo pathway as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ transcription co-activators, the Hippo pathway regulates cell proliferation, apoptosis, and stemness in response to a wide range of extracellular and intracellular signals, including cell-cell contact, cell polarity, mechanical cues, ligands of G-protein-coupled receptors, and cellular energy status. Dysregulation of the Hippo pathway exerts a significant impact on cancer development. Further investigation of the functions and regulatory mechanisms of this pathway will help uncovering the mystery of organ size control and identify new targets for cancer treatment. Two decades of studies in multiple model organisms have established the Hippo pathway as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ transcription co-activators, the Hippo pathway regulates cell proliferation, apoptosis, and stemness in response to a wide range of extracellular and intracellular signals, including cell-cell contact, cell polarity, mechanical cues, ligands of G-protein-coupled receptors, and cellular energy status. Dysregulation of the Hippo pathway exerts a significant impact on cancer development. Further investigation of the functions and regulatory mechanisms of this pathway will help uncovering the mystery of organ size control and identify new targets for cancer treatment. In response to a variety of cellular signals, the Hippo pathway plays key roles in regulating tissue homeostasis, stemness, and cancer development.
Author	Zhao, Bin Yu, Fa-Xing Guan, Kun-Liang
AuthorAffiliation	3 Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA 1 Children's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China 2 Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, Zhejiang 310058, China
AuthorAffiliation_xml	– name: 3 Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA – name: 1 Children's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China – name: 2 Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, Zhejiang 310058, China
Author_xml	– sequence: 1 givenname: Fa-Xing surname: Yu fullname: Yu, Fa-Xing email: fxyu@fudan.edu.cn organization: Children’s Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China – sequence: 2 givenname: Bin surname: Zhao fullname: Zhao, Bin organization: Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, Zhejiang 310058, China – sequence: 3 givenname: Kun-Liang surname: Guan fullname: Guan, Kun-Liang email: kuguan@ucsd.edu organization: Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26544935$$D View this record in MEDLINE/PubMed
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Snippet	Two decades of studies in multiple model organisms have established the Hippo pathway as a key regulator of organ size and tissue homeostasis. By inhibiting...
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SubjectTerms	Animals apoptosis carcinogenesis Cell Physiological Phenomena cell polarity cell proliferation energy G-protein coupled receptors Homeostasis Humans ligands neoplasms Neoplasms - metabolism Organ Size Protein-Serine-Threonine Kinases - metabolism Signal Transduction
Title	Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
URI	https://dx.doi.org/10.1016/j.cell.2015.10.044 https://www.ncbi.nlm.nih.gov/pubmed/26544935 https://www.proquest.com/docview/1731784392 https://www.proquest.com/docview/2000264678 https://pubmed.ncbi.nlm.nih.gov/PMC4638384
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