Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease - Kinchen, James; Chen, Hannah H.; Parikh, Kaushal; Antanaviciute, Agne; Jagielowicz, Marta; Fawkner-Corbett, David; Ashley, Neil; Cubitt, Laura; Mellado-Gomez, Esther; Attar, Moustafa; Sharma, Eshita; Wills, Quin; et al. (Cell, 2018)
Keywords: Animals; Cell Proliferation; colitis; Colitis - genetics; Colitis - physiopathology; Colon - physiology; crypt niche; CyTOF; disease severity; epithelial cells; Epithelial Cells - metabolism; epithelium; fibroblasts; Fibroblasts - physiology; genes; Genetic Heterogeneity; Homeostasis; Humans; immunity; Inflammation; inflammatory bowel disease; Inflammatory Bowel Diseases - physiopathology; Intestinal Mucosa - immunology; Intestinal Mucosa - physiology; intestines; Intestines - immunology; Intestines - physiology; Mesenchymal Stem Cells - physiology; mesenchyme; Mesoderm - metabolism; Mesoderm - physiology; Mice; Mice, Inbred C57BL; Myofibroblasts; oxidative stress; Pericytes; protein-lysine 6-oxidase; RAW 264.7 Cells; Single-Cell Analysis - methods; single-cell RNA-seq; SOX6; SOXD Transcription Factors - physiology; stem cells; stratification; stromal cell; target discovery; Thromboplastin - physiology; TNFSF14; transcription factors; Tumor Necrosis Factor Ligand Superfamily Member 14 - genetics; tumor necrosis factors; Wnt Signaling Pathway - physiology; Wnts; stromal cell; mesenchyme; target discovery; TNFSF14; stratification; single-cell RNA-seq; SOX6; crypt niche; CyTOF; inflammatory bowel disease; Wnts