In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs - Sun, Lei; Li, Pan; Ju, Xiaohui; Rao, Jian; Huang, Wenze; Ren, Lili; Zhang, Shaojun; Xiong, Tuanlin; Xu, Kui; Zhou, Xiaolin; Gong, Mingli; Miska, Eric; et al. (Cell, 2021)
Keywords: Animals; Cell Line; Chlorocebus aethiops; computer simulation; COVID-19 Drug Treatment; COVID-19 infection; Deep Learning; Drug Repositioning; drug reproposing; genome; host factor; Humans; landscapes; liver; lungs; Nucleic Acid Conformation; oligonucleotides; pandemic; RBP binding prediction; RNA; RNA secondary structure; RNA, Viral - chemistry; RNA-Binding Proteins - antagonists & inhibitors; RNA-Binding Proteins - metabolism; SARS-CoV-2; SARS-CoV-2 - drug effects; SARS-CoV-2 - genetics; Severe acute respiratory syndrome coronavirus 2; therapeutics; SARS-CoV-2; host factor; RBP binding prediction; drug reproposing; RNA secondary structure