Gingival crevicular fluid alkaline phosphatase activity as a non-invasive biomarker of skeletal maturation
To cite this article: Perinetti G, Baccetti T, Contardo L, Di Lenarda R: Gingival crevicular fluid alkaline phosphatase activity as a non‐invasive biomarker of skeletal maturation Orthod Craniofac Res 2011;14:44–50 Structured Authors – Perinetti G, Baccetti T, Contardo L, Di Lenarda R Objectives –...
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| Published in | Orthodontics & craniofacial research Vol. 14; no. 1; pp. 44 - 50 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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Oxford, UK
Blackwell Publishing Ltd
01.02.2011
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| Online Access | Get full text |
| ISSN | 1601-6335 1601-6343 1601-6343 |
| DOI | 10.1111/j.1601-6343.2010.01506.x |
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| Abstract | To cite this article:
Perinetti G, Baccetti T, Contardo L, Di Lenarda R:
Gingival crevicular fluid alkaline phosphatase activity as a non‐invasive biomarker of skeletal maturation
Orthod Craniofac Res 2011;14:44–50
Structured
Authors – Perinetti G, Baccetti T, Contardo L, Di Lenarda R
Objectives – To evaluate the gingival crevicular fluid (GCF) alkaline phosphatase (ALP) activity in growing subjects in relation to the stages of individual skeletal maturation.
Setting and Sample Population – The Department of Biomedicine, University of Trieste. Seventy‐two healthy growing subjects (45 women and 27 men; range, 7.8–17.7 years).
Materials and Methods – Double‐blind, prospective, cross‐sectional design. Samples of GCF were collected from each subject at the mesial and distal sites of both of the central incisors, in the maxilla and mandible. Skeletal maturation phase was assessed through the cervical vertebral maturation (CVM) method. Enzymatic activity was determined spectrophotometrically.
Results – The relationship between GCF ALP activity and CVM stages was significant. In particular, a twofold peak in enzyme activity was seen at the CS3 and CS4 pubertal stages, compared to the pre‐pubertal stages (CS1 and CS2) and post‐pubertal stages (CS5 and CS6), at both the maxillary and mandibular sites. No differences were seen between the maxillary and mandibular sites, or between the sexes.
Conclusions – As an adjunct to standard methods based upon radiographic parameters, the GCF ALP may be a candidate as a non‐invasive clinical biomarker for the identification of the pubertal growth spurt in periodontally healthy subjects scheduled for orthodontic treatment. |
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| AbstractList | To cite this article: Perinetti G, Baccetti T, Contardo L, Di Lenarda R:Gingival crevicular fluid alkaline phosphatase activity as a non-invasive biomarker of skeletal maturationOrthod Craniofac Res 2011; 14:44-50 Authors - Perinetti G, Baccetti T, Contardo L, Di Lenarda R Objectives - To evaluate the gingival crevicular fluid (GCF) alkaline phosphatase (ALP) activity in growing subjects in relation to the stages of individual skeletal maturation. Setting and Sample Population - The Department of Biomedicine, University of Trieste. Seventy-two healthy growing subjects (45 women and 27 men; range, 7.8-17.7years). Materials and Methods - Double-blind, prospective, cross-sectional design. Samples of GCF were collected from each subject at the mesial and distal sites of both of the central incisors, in the maxilla and mandible. Skeletal maturation phase was assessed through the cervical vertebral maturation (CVM) method. Enzymatic activity was determined spectrophotometrically. Results - The relationship between GCF ALP activity and CVM stages was significant. In particular, a twofold peak in enzyme activity was seen at the CS3 and CS4 pubertal stages, compared to the pre-pubertal stages (CS1 and CS2) and post-pubertal stages (CS5 and CS6), at both the maxillary and mandibular sites. No differences were seen between the maxillary and mandibular sites, or between the sexes. Conclusions - As an adjunct to standard methods based upon radiographic parameters, the GCF ALP may be a candidate as a non-invasive clinical biomarker for the identification of the pubertal growth spurt in periodontally healthy subjects scheduled for orthodontic treatment. To cite this article: Perinetti G, Baccetti T, Contardo L, Di Lenarda R: Gingival crevicular fluid alkaline phosphatase activity as a non‐invasive biomarker of skeletal maturation Orthod Craniofac Res 2011;14:44–50 Structured Authors – Perinetti G, Baccetti T, Contardo L, Di Lenarda R Objectives – To evaluate the gingival crevicular fluid (GCF) alkaline phosphatase (ALP) activity in growing subjects in relation to the stages of individual skeletal maturation. Setting and Sample Population – The Department of Biomedicine, University of Trieste. Seventy‐two healthy growing subjects (45 women and 27 men; range, 7.8–17.7 years). Materials and Methods – Double‐blind, prospective, cross‐sectional design. Samples of GCF were collected from each subject at the mesial and distal sites of both of the central incisors, in the maxilla and mandible. Skeletal maturation phase was assessed through the cervical vertebral maturation (CVM) method. Enzymatic activity was determined spectrophotometrically. Results – The relationship between GCF ALP activity and CVM stages was significant. In particular, a twofold peak in enzyme activity was seen at the CS3 and CS4 pubertal stages, compared to the pre‐pubertal stages (CS1 and CS2) and post‐pubertal stages (CS5 and CS6), at both the maxillary and mandibular sites. No differences were seen between the maxillary and mandibular sites, or between the sexes. Conclusions – As an adjunct to standard methods based upon radiographic parameters, the GCF ALP may be a candidate as a non‐invasive clinical biomarker for the identification of the pubertal growth spurt in periodontally healthy subjects scheduled for orthodontic treatment. To evaluate the gingival crevicular fluid (GCF) alkaline phosphatase (ALP) activity in growing subjects in relation to the stages of individual skeletal maturation.OBJECTIVESTo evaluate the gingival crevicular fluid (GCF) alkaline phosphatase (ALP) activity in growing subjects in relation to the stages of individual skeletal maturation.The Department of Biomedicine, University of Trieste. Seventy-two healthy growing subjects (45 women and 27 men; range, 7.8-17.7 years).SETTING AND SAMPLE POPULATIONThe Department of Biomedicine, University of Trieste. Seventy-two healthy growing subjects (45 women and 27 men; range, 7.8-17.7 years).Double-blind, prospective, cross-sectional design. Samples of GCF were collected from each subject at the mesial and distal sites of both of the central incisors, in the maxilla and mandible. Skeletal maturation phase was assessed through the cervical vertebral maturation (CVM) method. Enzymatic activity was determined spectrophotometrically.MATERIALS AND METHODSDouble-blind, prospective, cross-sectional design. Samples of GCF were collected from each subject at the mesial and distal sites of both of the central incisors, in the maxilla and mandible. Skeletal maturation phase was assessed through the cervical vertebral maturation (CVM) method. Enzymatic activity was determined spectrophotometrically.The relationship between GCF ALP activity and CVM stages was significant. In particular, a twofold peak in enzyme activity was seen at the CS3 and CS4 pubertal stages, compared to the pre-pubertal stages (CS1 and CS2) and post-pubertal stages (CS5 and CS6), at both the maxillary and mandibular sites. No differences were seen between the maxillary and mandibular sites, or between the sexes.RESULTSThe relationship between GCF ALP activity and CVM stages was significant. In particular, a twofold peak in enzyme activity was seen at the CS3 and CS4 pubertal stages, compared to the pre-pubertal stages (CS1 and CS2) and post-pubertal stages (CS5 and CS6), at both the maxillary and mandibular sites. No differences were seen between the maxillary and mandibular sites, or between the sexes.As an adjunct to standard methods based upon radiographic parameters, the GCF ALP may be a candidate as a non-invasive clinical biomarker for the identification of the pubertal growth spurt in periodontally healthy subjects scheduled for orthodontic treatment.CONCLUSIONSAs an adjunct to standard methods based upon radiographic parameters, the GCF ALP may be a candidate as a non-invasive clinical biomarker for the identification of the pubertal growth spurt in periodontally healthy subjects scheduled for orthodontic treatment. To evaluate the gingival crevicular fluid (GCF) alkaline phosphatase (ALP) activity in growing subjects in relation to the stages of individual skeletal maturation. The Department of Biomedicine, University of Trieste. Seventy-two healthy growing subjects (45 women and 27 men; range, 7.8-17.7 years). Double-blind, prospective, cross-sectional design. Samples of GCF were collected from each subject at the mesial and distal sites of both of the central incisors, in the maxilla and mandible. Skeletal maturation phase was assessed through the cervical vertebral maturation (CVM) method. Enzymatic activity was determined spectrophotometrically. The relationship between GCF ALP activity and CVM stages was significant. In particular, a twofold peak in enzyme activity was seen at the CS3 and CS4 pubertal stages, compared to the pre-pubertal stages (CS1 and CS2) and post-pubertal stages (CS5 and CS6), at both the maxillary and mandibular sites. No differences were seen between the maxillary and mandibular sites, or between the sexes. As an adjunct to standard methods based upon radiographic parameters, the GCF ALP may be a candidate as a non-invasive clinical biomarker for the identification of the pubertal growth spurt in periodontally healthy subjects scheduled for orthodontic treatment. |
| Author | Perinetti, G Baccetti, T Di Lenarda, R Contardo, L |
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Perinetti G, Baccetti T, Contardo L, Di Lenarda R:
Gingival crevicular fluid alkaline phosphatase activity as a non‐invasive biomarker... To evaluate the gingival crevicular fluid (GCF) alkaline phosphatase (ALP) activity in growing subjects in relation to the stages of individual skeletal... To cite this article: Perinetti G, Baccetti T, Contardo L, Di Lenarda R:Gingival crevicular fluid alkaline phosphatase activity as a non-invasive biomarker of... |
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| SubjectTerms | Adolescent Age Determination by Skeleton Alkaline phosphatase Alkaline Phosphatase - analysis Alkaline Phosphatase - metabolism Biomarkers Cervical Vertebrae - growth & development Child Clinical trials Cross-Sectional Studies diagnosis Double-Blind Method Enzymatic activity Female Gingiva gingival crevicular fluid Gingival Crevicular Fluid - enzymology Humans Incisors Male Mandible Maxilla Maxillofacial Development Observer Variation Orthodontics Prospective Studies Puberty - physiology Sex skeletal age measurement Statistics, Nonparametric Vertebrae |
| Title | Gingival crevicular fluid alkaline phosphatase activity as a non-invasive biomarker of skeletal maturation |
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