Targeted Allele Suppression Prevents Progressive Hearing Loss in the Mature Murine Model of Human TMC1 Deafness - Yoshimura, Hidekane; Shibata, Seiji B.; Ranum, Paul T.; Moteki, Hideaki; Smith, Richard J.H. (Molecular therapy, 2019)
Keywords: adeno-associated virus; Age; Animal models; Animals; Cell survival; Cochlea; Cochlea - metabolism; Cochlea - physiopathology; Cochlea - ultrastructure; Cytomegalovirus; Deafness; Deafness - genetics; Deafness - physiopathology; Degeneration; Dependovirus - genetics; Disease Models, Animal; Ear; Ear, Inner - metabolism; Ear, Inner - physiopathology; Ear, Inner - ultrastructure; Ears & hearing; Gene silencing; Gene therapy; Genetic Therapy; Genetic Vectors - genetics; Gestational age; Hearing loss; Hearing Loss - genetics; Hearing Loss - physiopathology; Humans; Immunohistochemistry; inner ear; Maturation; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Inbred C3H; MicroRNAs; Microscopy, Electron, Scanning; miRNA; Neonates; Organ of Corti; Original; Quality of life; RNA Interference; RNA-mediated interference; Scanning electron microscopy; Studies; vestibule; Vestibule, Labyrinth - metabolism; Vestibule, Labyrinth - physiopathology; Vestibule, Labyrinth - ultrastructure; United States--US; cochlea; gene therapy; adeno-associated virus; vestibule; hearing loss; inner ear