Transcriptional regulation of the sodium channel gene (SCN5A) by GATA4 in human heart - Tarradas, Anna; Pinsach-Abuin, Mel·lina; Mackintosh, Carlos; Llorà-Batlle, Oriol; Pérez-Serra, Alexandra; Batlle, Montserrat; Pérez-Villa, Félix; Zimmer, Thomas; Garcia-Bassets, Ivan; Brugada, Ramon; Beltran-Alvarez, Pedro; Pagans, Sara (Journal of molecular and cellular cardiology, 2017)
Keywords: Animals; Arrhythmia; Arítmia; Binding Sites; Cardiac arrhythmias; Cardiovascular; Cell Line; Cor; Diseases; GATA4; GATA4 Transcription Factor - metabolism; GATA5; GATA5 Transcription Factor - metabolism; GATA6; Gene Expression Profiling; Gene Expression Regulation; Heart; Humans; Malalties; Mutation; Myocardium - metabolism; NAV1.5 Voltage-Gated Sodium Channel - genetics; NAV1.5 Voltage-Gated Sodium Channel - metabolism; Promoter Regions, Genetic; Protein Binding; Rats; RNA, Messenger - genetics; RNA, Small Interfering - genetics; SCN5A; Transcription, Genetic; Transcriptional regulation; GATA6; GATA5; Cardiac arrhythmias; GATA4; ChIP; cRNA; Transcriptional regulation; NaV1.5; HEK; ddPCR; TF; GATA-BS; Re-ChIP; TSS; SCN5A; WT; transcription factor; sequential ChIP; transcription start site; chromatin immunoprecipitation; sodium channel, voltage-gated, type V alpha subunit; human embryonic kidney; Na V1.5; GATA binding sites; complementary RNA; droplet digital PCR; wild-type