食管间质瘤与平滑肌肿瘤的临床鉴别及治疗

R735.1; 背景与目的:食管间质瘤与平滑肌肿瘤虽然具有不同的病理学特征,但是临床上不易鉴别.本研究比较食管间质瘤和平滑肌肿瘤的临床特征,并探讨其治疗原则.方法:用免疫组织化学法检测原诊断为食管平滑肌(肉)瘤20例和间质瘤1例肿瘤组织中CD117和CD34等一组抗体表达,结合病理学形态表现和临床表现进行分析,并总结各自的治疗原则及疗效.结果:16例原诊断为食管平滑肌瘤有5例CD117(+),按照间质瘤评定标准,均为非高度侵袭危险性食管间质瘤,余11例CD117(-);1例原间质瘤CD117(+)和CD34(+),为高度侵袭危险性食管间质瘤;4例食管平滑肌肉瘤CD117(-)和CD34(-)....

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Published in癌症 Vol. 25; no. 7; pp. 901 - 905
Main Authors 张旭, 戎铁华, 吴秋良, 傅剑华, 龙浩, 张兰军, 马国伟, 苏晓东, 李小东, 汪道峰, 胡祎, 杨弘
Format Journal Article
LanguageChinese
Published 中山大学肿瘤防治中心病理科,广东,广州,510060 2006
华南肿瘤学国家重点实验室,广东,广州,510060
中山大学肿瘤防治中心,胸科,广东,广州,510060%华南肿瘤学国家重点实验室,广东,广州,510060
Subjects
治疗
诊断
食管肿瘤
平滑肌肿瘤
间质瘤
免疫组化
Online AccessGet full text
ISSN1000-467X
DOI10.3321/j.issn:1000-467X.2006.07.023

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Abstract R735.1; 背景与目的:食管间质瘤与平滑肌肿瘤虽然具有不同的病理学特征,但是临床上不易鉴别.本研究比较食管间质瘤和平滑肌肿瘤的临床特征,并探讨其治疗原则.方法:用免疫组织化学法检测原诊断为食管平滑肌(肉)瘤20例和间质瘤1例肿瘤组织中CD117和CD34等一组抗体表达,结合病理学形态表现和临床表现进行分析,并总结各自的治疗原则及疗效.结果:16例原诊断为食管平滑肌瘤有5例CD117(+),按照间质瘤评定标准,均为非高度侵袭危险性食管间质瘤,余11例CD117(-);1例原间质瘤CD117(+)和CD34(+),为高度侵袭危险性食管间质瘤;4例食管平滑肌肉瘤CD117(-)和CD34(-).食管非高度侵袭危险性间质瘤和平滑肌瘤的病理学形态表现、临床表现、治疗方法和预后没有明显差异;食管高度侵袭危险性间质瘤和平滑肌肉瘤的病理学形态表现、临床表现、治疗方法和预后也没有明显差异.结论:病理学形态表现和临床表现无法区分食管间质瘤和平滑肌肿瘤,CD117等抗体的免疫组织化学法检测是区分食管间质瘤和平滑肌肿瘤必不可少的手段.食管非高度侵袭危险性间质瘤和平滑肌瘤局部切除术或部分食管切除术可以达到根治,预后良好;高度侵袭危险性食管间质瘤和平滑肌肉瘤需行食管部分切除术.
AbstractList R735.1; 背景与目的:食管间质瘤与平滑肌肿瘤虽然具有不同的病理学特征,但是临床上不易鉴别.本研究比较食管间质瘤和平滑肌肿瘤的临床特征,并探讨其治疗原则.方法:用免疫组织化学法检测原诊断为食管平滑肌(肉)瘤20例和间质瘤1例肿瘤组织中CD117和CD34等一组抗体表达,结合病理学形态表现和临床表现进行分析,并总结各自的治疗原则及疗效.结果:16例原诊断为食管平滑肌瘤有5例CD117(+),按照间质瘤评定标准,均为非高度侵袭危险性食管间质瘤,余11例CD117(-);1例原间质瘤CD117(+)和CD34(+),为高度侵袭危险性食管间质瘤;4例食管平滑肌肉瘤CD117(-)和CD34(-).食管非高度侵袭危险性间质瘤和平滑肌瘤的病理学形态表现、临床表现、治疗方法和预后没有明显差异;食管高度侵袭危险性间质瘤和平滑肌肉瘤的病理学形态表现、临床表现、治疗方法和预后也没有明显差异.结论:病理学形态表现和临床表现无法区分食管间质瘤和平滑肌肿瘤,CD117等抗体的免疫组织化学法检测是区分食管间质瘤和平滑肌肿瘤必不可少的手段.食管非高度侵袭危险性间质瘤和平滑肌瘤局部切除术或部分食管切除术可以达到根治,预后良好;高度侵袭危险性食管间质瘤和平滑肌肉瘤需行食管部分切除术.
Author 马国伟
吴秋良
龙浩
张兰军
李小东
张旭
戎铁华
傅剑华
杨弘
胡祎
苏晓东
汪道峰
AuthorAffiliation 华南肿瘤学国家重点实验室,广东,广州,510060;中山大学肿瘤防治中心,胸科,广东,广州,510060%华南肿瘤学国家重点实验室,广东,广州,510060;中山大学肿瘤防治中心病理科,广东,广州,510060
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MA Guo-Wei
RONG Tie-Hua
LONG Hao
YANG Hong
ZHANG Lan-Jun
WU Qiu-Liang
LI Xiao-Dong
FU Jian-Hua
SU Xiao-Dong
WANG Dao-Feng
HU Yi
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Keywords 治疗
诊断
食管肿瘤
平滑肌肿瘤
间质瘤
免疫组化
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华南肿瘤学国家重点实验室,广东,广州,510060
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Snippet R735.1; 背景与目的:食管间质瘤与平滑肌肿瘤虽然具有不同的病理学特征,但是临床上不易鉴别.本研究比较食管间质瘤和平滑肌肿瘤的临床特征,并探讨其治疗原则.方法:用免疫组...
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Title 食管间质瘤与平滑肌肿瘤的临床鉴别及治疗
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