Inhibition of histone deacetylase activity increases chromosomal instability by the aberrant regulation of mitotic checkpoint activation - Shin, Hyun-Jin; Baek, Kwan-Hyuck; Jeon, Ae-Hwa; Kim, So-Jung; Jang, Kyung-Lib; Sung, Young-Chul; Kim, Chang-Min; Lee, Chang-Woo (Oncogene, 2003)
Keywords: Acetylation; Acetylation - drug effects; Acetyltransferases - antagonists & inhibitors; Acetyltransferases - physiology; Apoptosis; Apoptosis - drug effects; Biological and medical sciences; Biomarkers; Cancer; Cell Biology; Cell cycle; Cell Cycle Proteins; Cell survival; Chromatin; Chromosome Aberrations; Chromosomes; Chromosomes, Human - ultrastructure; Cyclin A - metabolism; Cyclin B - metabolism; Deacetylation; DNA biosynthesis; Enzyme Inhibitors - pharmacology; Extracellular signal-regulated kinase; Fundamental and applied biological sciences. Psychology; Genes. Genome; Genomic instability; HeLa Cells - cytology; HeLa Cells - enzymology; Histone Acetyltransferases; Histone deacetylase; Histones - metabolism; Human Genetics; Humans; Hydroxamic Acids - pharmacology; Inhibitor of Apoptosis Proteins; Internal Medicine; Interphase - drug effects; Kinases; Localization; MAP Kinase Signaling System - drug effects; Medicine; Medicine & Public Health; Metaphase - drug effects; Microtubules - drug effects; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases - metabolism; Mitogen-Activated Protein Kinases - physiology; Mitosis; Mitosis - drug effects; Mitosis - physiology; Molecular and cellular biology; Molecular genetics; Nocodazole - pharmacology; Oncology; original-paper; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Polyploidy; Protein Kinases - genetics; Protein Kinases - metabolism; Protein Processing, Post-Translational - drug effects; Protein-Serine-Threonine Kinases; Proteins - metabolism; Saccharomyces cerevisiae Proteins - antagonists & inhibitors; Saccharomyces cerevisiae Proteins - physiology; Transcription; Yeast; Instability; Regulation(control); Activation; Inhibition; Histone