Exosomal hsa-miR-933 in Gastric Juice as a Potential Biomarker for Functional Dyspepsia

Background MicroRNAs (miRNAs) in exosomes represent disease-specific profiles and are applied as biomarkers in oncology. However, in functional dyspepsia (FD), the role of exosomal miRNAs has not been fully elucidated. Aims To investigate exosomal miRNAs as potential biomarkers of FD using liquid bi...

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Published inDigestive diseases and sciences Vol. 65; no. 12; pp. 3493 - 3501
Main Authors Tanaka, Fumio, Takashima, Shingo, Nadatani, Yuji, Otani, Koji, Hosomi, Shuhei, Kamata, Noriko, Taira, Koichi, Nagami, Yasuaki, Tanigawa, Tetsuya, Fukumoto, Shinya, Watanabe, Toshio, Murakami, Yoshiki, Kawada, Norifumi, Fujiwara, Yasuhiro
Format Journal Article
LanguageEnglish
Published New York Springer US 01.12.2020
Springer
Springer Nature B.V
Subjects
Abdominal Pain - diagnosis
Abdominal Pain - etiology
Adult
Age
Antibodies
Biochemistry
Biomarkers
Biomarkers - analysis
Biopsy
Circulating MicroRNA - analysis
Comparative analysis
Disease
DNA microarrays
Down-Regulation
Dyspepsia
Dyspepsia - diagnosis
Dyspepsia - epidemiology
Dyspepsia - genetics
Dyspepsia - physiopathology
Exosomes - genetics
Female
Gastric Juice - metabolism
Gastroenterology
Gastroesophageal reflux
Gene Expression Profiling - methods
Health care
Health savings accounts
Hepatology
Humans
Infections
Japan
Liquid Biopsy - methods
Male
Medicine
Medicine & Public Health
MicroRNA
MicroRNAs
MicroRNAs - analysis
MicroRNAs - classification
Nonsteroidal anti-inflammatory drugs
Oncology
Original Article
Pathophysiology
Preventive medicine
Questionnaires
Retrospective Studies
Somatotropin
Transplant Surgery
Japan
Biomarkers
Circulating microRNA
Dyspepsia
MicroRNAs
Gastric juice
Online AccessGet full text
ISSN0163-2116
1573-2568
1573-2568
DOI10.1007/s10620-020-06096-7

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Abstract Background MicroRNAs (miRNAs) in exosomes represent disease-specific profiles and are applied as biomarkers in oncology. However, in functional dyspepsia (FD), the role of exosomal miRNAs has not been fully elucidated. Aims To investigate exosomal miRNAs as potential biomarkers of FD using liquid biopsy. Methods This retrospective cohort study included 11 subjects with FD and 11 age- and sex-matched healthy controls (HCs). We collected gastric juice and isolated exosomal miRNAs. In a discovery cohort, expression levels of 2565 miRNAs were evaluated by 3D-Gene ® microarray. miRNA expression profiles from exosomes of subjects with FD and HCs were compared by two normalization methods: (1) global normalization and (2) normalization by internal control. Subsequently, in a validation cohort, the expression levels of miRNAs were validated by quantitative reverse transcription PCR (RT-qPCR). Results Through microarray analysis using the two methods, we identified 39 miRNAs that were consistently and significantly downregulated in FD cases compared with those in HCs. Of these, 12 miRNAs (hsa-miR-933, hsa-miR-345-5p, hsa-miR-708-5p, hsa-miR-203a-3p, hsa-miR-619-5p, hsa-miR-4294, hsa-miR-4481, hsa-miR-196a-5p, hsa-miR-3918, hsa-miR-372-3p, hsa-miR-658, and hsa-miR-3654) were further validated by RT-qPCR. Our results indicated that hsa-miR-933 was significantly downregulated in FD compared with HCs (0.317 ± 0.205-fold, P  = 0.0317). Furthermore, the expression level of hsa-miR-933 was negatively associated with dyspepsia score and the frequency of epigastric pain and/or burning ( P  < 0.01, r  = − 0.835; P  = 0.0280, r  = − 0.688, respectively). Conclusions Exosomal hsa-miR-933 in gastric juice could be a candidate biomarker for FD.
AbstractList Background MicroRNAs (miRNAs) in exosomes represent disease-specific profiles and are applied as biomarkers in oncology. However, in functional dyspepsia (FD), the role of exosomal miRNAs has not been fully elucidated. Aims To investigate exosomal miRNAs as potential biomarkers of FD using liquid biopsy. Methods This retrospective cohort study included 11 subjects with FD and 11 age- and sex-matched healthy controls (HCs). We collected gastric juice and isolated exosomal miRNAs. In a discovery cohort, expression levels of 2565 miRNAs were evaluated by 3D-Gene.sup.® microarray. miRNA expression profiles from exosomes of subjects with FD and HCs were compared by two normalization methods: (1) global normalization and (2) normalization by internal control. Subsequently, in a validation cohort, the expression levels of miRNAs were validated by quantitative reverse transcription PCR (RT-qPCR). Results Through microarray analysis using the two methods, we identified 39 miRNAs that were consistently and significantly downregulated in FD cases compared with those in HCs. Of these, 12 miRNAs (hsa-miR-933, hsa-miR-345-5p, hsa-miR-708-5p, hsa-miR-203a-3p, hsa-miR-619-5p, hsa-miR-4294, hsa-miR-4481, hsa-miR-196a-5p, hsa-miR-3918, hsa-miR-372-3p, hsa-miR-658, and hsa-miR-3654) were further validated by RT-qPCR. Our results indicated that hsa-miR-933 was significantly downregulated in FD compared with HCs (0.317 ± 0.205-fold, P = 0.0317). Furthermore, the expression level of hsa-miR-933 was negatively associated with dyspepsia score and the frequency of epigastric pain and/or burning (P < 0.01, r = - 0.835; P = 0.0280, r = - 0.688, respectively). Conclusions Exosomal hsa-miR-933 in gastric juice could be a candidate biomarker for FD.
BackgroundMicroRNAs (miRNAs) in exosomes represent disease-specific profiles and are applied as biomarkers in oncology. However, in functional dyspepsia (FD), the role of exosomal miRNAs has not been fully elucidated.AimsTo investigate exosomal miRNAs as potential biomarkers of FD using liquid biopsy.MethodsThis retrospective cohort study included 11 subjects with FD and 11 age- and sex-matched healthy controls (HCs). We collected gastric juice and isolated exosomal miRNAs. In a discovery cohort, expression levels of 2565 miRNAs were evaluated by 3D-Gene® microarray. miRNA expression profiles from exosomes of subjects with FD and HCs were compared by two normalization methods: (1) global normalization and (2) normalization by internal control. Subsequently, in a validation cohort, the expression levels of miRNAs were validated by quantitative reverse transcription PCR (RT-qPCR).ResultsThrough microarray analysis using the two methods, we identified 39 miRNAs that were consistently and significantly downregulated in FD cases compared with those in HCs. Of these, 12 miRNAs (hsa-miR-933, hsa-miR-345-5p, hsa-miR-708-5p, hsa-miR-203a-3p, hsa-miR-619-5p, hsa-miR-4294, hsa-miR-4481, hsa-miR-196a-5p, hsa-miR-3918, hsa-miR-372-3p, hsa-miR-658, and hsa-miR-3654) were further validated by RT-qPCR. Our results indicated that hsa-miR-933 was significantly downregulated in FD compared with HCs (0.317 ± 0.205-fold, P = 0.0317). Furthermore, the expression level of hsa-miR-933 was negatively associated with dyspepsia score and the frequency of epigastric pain and/or burning (P < 0.01, r = − 0.835; P = 0.0280, r = − 0.688, respectively).ConclusionsExosomal hsa-miR-933 in gastric juice could be a candidate biomarker for FD.
MicroRNAs (miRNAs) in exosomes represent disease-specific profiles and are applied as biomarkers in oncology. However, in functional dyspepsia (FD), the role of exosomal miRNAs has not been fully elucidated. To investigate exosomal miRNAs as potential biomarkers of FD using liquid biopsy. This retrospective cohort study included 11 subjects with FD and 11 age- and sex-matched healthy controls (HCs). We collected gastric juice and isolated exosomal miRNAs. In a discovery cohort, expression levels of 2565 miRNAs were evaluated by 3D-Gene.sup.® microarray. miRNA expression profiles from exosomes of subjects with FD and HCs were compared by two normalization methods: (1) global normalization and (2) normalization by internal control. Subsequently, in a validation cohort, the expression levels of miRNAs were validated by quantitative reverse transcription PCR (RT-qPCR). Through microarray analysis using the two methods, we identified 39 miRNAs that were consistently and significantly downregulated in FD cases compared with those in HCs. Of these, 12 miRNAs (hsa-miR-933, hsa-miR-345-5p, hsa-miR-708-5p, hsa-miR-203a-3p, hsa-miR-619-5p, hsa-miR-4294, hsa-miR-4481, hsa-miR-196a-5p, hsa-miR-3918, hsa-miR-372-3p, hsa-miR-658, and hsa-miR-3654) were further validated by RT-qPCR. Our results indicated that hsa-miR-933 was significantly downregulated in FD compared with HCs (0.317 ± 0.205-fold, P = 0.0317). Furthermore, the expression level of hsa-miR-933 was negatively associated with dyspepsia score and the frequency of epigastric pain and/or burning (P < 0.01, r = - 0.835; P = 0.0280, r = - 0.688, respectively). Exosomal hsa-miR-933 in gastric juice could be a candidate biomarker for FD.
Background MicroRNAs (miRNAs) in exosomes represent disease-specific profiles and are applied as biomarkers in oncology. However, in functional dyspepsia (FD), the role of exosomal miRNAs has not been fully elucidated. Aims To investigate exosomal miRNAs as potential biomarkers of FD using liquid biopsy. Methods This retrospective cohort study included 11 subjects with FD and 11 age- and sex-matched healthy controls (HCs). We collected gastric juice and isolated exosomal miRNAs. In a discovery cohort, expression levels of 2565 miRNAs were evaluated by 3D-Gene ® microarray. miRNA expression profiles from exosomes of subjects with FD and HCs were compared by two normalization methods: (1) global normalization and (2) normalization by internal control. Subsequently, in a validation cohort, the expression levels of miRNAs were validated by quantitative reverse transcription PCR (RT-qPCR). Results Through microarray analysis using the two methods, we identified 39 miRNAs that were consistently and significantly downregulated in FD cases compared with those in HCs. Of these, 12 miRNAs (hsa-miR-933, hsa-miR-345-5p, hsa-miR-708-5p, hsa-miR-203a-3p, hsa-miR-619-5p, hsa-miR-4294, hsa-miR-4481, hsa-miR-196a-5p, hsa-miR-3918, hsa-miR-372-3p, hsa-miR-658, and hsa-miR-3654) were further validated by RT-qPCR. Our results indicated that hsa-miR-933 was significantly downregulated in FD compared with HCs (0.317 ± 0.205-fold, P  = 0.0317). Furthermore, the expression level of hsa-miR-933 was negatively associated with dyspepsia score and the frequency of epigastric pain and/or burning ( P  < 0.01, r  = − 0.835; P  = 0.0280, r  = − 0.688, respectively). Conclusions Exosomal hsa-miR-933 in gastric juice could be a candidate biomarker for FD.
MicroRNAs (miRNAs) in exosomes represent disease-specific profiles and are applied as biomarkers in oncology. However, in functional dyspepsia (FD), the role of exosomal miRNAs has not been fully elucidated. To investigate exosomal miRNAs as potential biomarkers of FD using liquid biopsy. This retrospective cohort study included 11 subjects with FD and 11 age- and sex-matched healthy controls (HCs). We collected gastric juice and isolated exosomal miRNAs. In a discovery cohort, expression levels of 2565 miRNAs were evaluated by 3D-Gene microarray. miRNA expression profiles from exosomes of subjects with FD and HCs were compared by two normalization methods: (1) global normalization and (2) normalization by internal control. Subsequently, in a validation cohort, the expression levels of miRNAs were validated by quantitative reverse transcription PCR (RT-qPCR). Through microarray analysis using the two methods, we identified 39 miRNAs that were consistently and significantly downregulated in FD cases compared with those in HCs. Of these, 12 miRNAs (hsa-miR-933, hsa-miR-345-5p, hsa-miR-708-5p, hsa-miR-203a-3p, hsa-miR-619-5p, hsa-miR-4294, hsa-miR-4481, hsa-miR-196a-5p, hsa-miR-3918, hsa-miR-372-3p, hsa-miR-658, and hsa-miR-3654) were further validated by RT-qPCR. Our results indicated that hsa-miR-933 was significantly downregulated in FD compared with HCs (0.317 ± 0.205-fold, P = 0.0317). Furthermore, the expression level of hsa-miR-933 was negatively associated with dyspepsia score and the frequency of epigastric pain and/or burning (P < 0.01, r = - 0.835; P = 0.0280, r = - 0.688, respectively). Exosomal hsa-miR-933 in gastric juice could be a candidate biomarker for FD.
MicroRNAs (miRNAs) in exosomes represent disease-specific profiles and are applied as biomarkers in oncology. However, in functional dyspepsia (FD), the role of exosomal miRNAs has not been fully elucidated.BACKGROUNDMicroRNAs (miRNAs) in exosomes represent disease-specific profiles and are applied as biomarkers in oncology. However, in functional dyspepsia (FD), the role of exosomal miRNAs has not been fully elucidated.To investigate exosomal miRNAs as potential biomarkers of FD using liquid biopsy.AIMSTo investigate exosomal miRNAs as potential biomarkers of FD using liquid biopsy.This retrospective cohort study included 11 subjects with FD and 11 age- and sex-matched healthy controls (HCs). We collected gastric juice and isolated exosomal miRNAs. In a discovery cohort, expression levels of 2565 miRNAs were evaluated by 3D-Gene® microarray. miRNA expression profiles from exosomes of subjects with FD and HCs were compared by two normalization methods: (1) global normalization and (2) normalization by internal control. Subsequently, in a validation cohort, the expression levels of miRNAs were validated by quantitative reverse transcription PCR (RT-qPCR).METHODSThis retrospective cohort study included 11 subjects with FD and 11 age- and sex-matched healthy controls (HCs). We collected gastric juice and isolated exosomal miRNAs. In a discovery cohort, expression levels of 2565 miRNAs were evaluated by 3D-Gene® microarray. miRNA expression profiles from exosomes of subjects with FD and HCs were compared by two normalization methods: (1) global normalization and (2) normalization by internal control. Subsequently, in a validation cohort, the expression levels of miRNAs were validated by quantitative reverse transcription PCR (RT-qPCR).Through microarray analysis using the two methods, we identified 39 miRNAs that were consistently and significantly downregulated in FD cases compared with those in HCs. Of these, 12 miRNAs (hsa-miR-933, hsa-miR-345-5p, hsa-miR-708-5p, hsa-miR-203a-3p, hsa-miR-619-5p, hsa-miR-4294, hsa-miR-4481, hsa-miR-196a-5p, hsa-miR-3918, hsa-miR-372-3p, hsa-miR-658, and hsa-miR-3654) were further validated by RT-qPCR. Our results indicated that hsa-miR-933 was significantly downregulated in FD compared with HCs (0.317 ± 0.205-fold, P = 0.0317). Furthermore, the expression level of hsa-miR-933 was negatively associated with dyspepsia score and the frequency of epigastric pain and/or burning (P < 0.01, r = - 0.835; P = 0.0280, r = - 0.688, respectively).RESULTSThrough microarray analysis using the two methods, we identified 39 miRNAs that were consistently and significantly downregulated in FD cases compared with those in HCs. Of these, 12 miRNAs (hsa-miR-933, hsa-miR-345-5p, hsa-miR-708-5p, hsa-miR-203a-3p, hsa-miR-619-5p, hsa-miR-4294, hsa-miR-4481, hsa-miR-196a-5p, hsa-miR-3918, hsa-miR-372-3p, hsa-miR-658, and hsa-miR-3654) were further validated by RT-qPCR. Our results indicated that hsa-miR-933 was significantly downregulated in FD compared with HCs (0.317 ± 0.205-fold, P = 0.0317). Furthermore, the expression level of hsa-miR-933 was negatively associated with dyspepsia score and the frequency of epigastric pain and/or burning (P < 0.01, r = - 0.835; P = 0.0280, r = - 0.688, respectively).Exosomal hsa-miR-933 in gastric juice could be a candidate biomarker for FD.CONCLUSIONSExosomal hsa-miR-933 in gastric juice could be a candidate biomarker for FD.
Audience Professional
Academic
Author Kamata, Noriko
Fukumoto, Shinya
Murakami, Yoshiki
Tanaka, Fumio
Takashima, Shingo
Nadatani, Yuji
Watanabe, Toshio
Kawada, Norifumi
Hosomi, Shuhei
Nagami, Yasuaki
Otani, Koji
Tanigawa, Tetsuya
Fujiwara, Yasuhiro
Taira, Koichi
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  surname: Tanaka
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  organization: Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Department of Premier Preventive Medicine, Graduate School of Medicine, Osaka City University
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  surname: Takashima
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IngestDate Thu Sep 04 18:19:59 EDT 2025
Sun Sep 07 03:37:22 EDT 2025
Tue Jun 17 21:30:24 EDT 2025
Tue Jun 10 20:50:42 EDT 2025
Wed Feb 19 02:29:49 EST 2025
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Thu Apr 24 22:58:25 EDT 2025
Fri Feb 21 02:34:04 EST 2025
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Issue 12
Keywords Biomarkers
Circulating microRNA
Dyspepsia
MicroRNAs
Gastric juice
Language English
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PublicationTitle Digestive diseases and sciences
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Snippet Background MicroRNAs (miRNAs) in exosomes represent disease-specific profiles and are applied as biomarkers in oncology. However, in functional dyspepsia (FD),...
MicroRNAs (miRNAs) in exosomes represent disease-specific profiles and are applied as biomarkers in oncology. However, in functional dyspepsia (FD), the role...
Background MicroRNAs (miRNAs) in exosomes represent disease-specific profiles and are applied as biomarkers in oncology. However, in functional dyspepsia (FD),...
BackgroundMicroRNAs (miRNAs) in exosomes represent disease-specific profiles and are applied as biomarkers in oncology. However, in functional dyspepsia (FD),...
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SubjectTerms Abdominal Pain - diagnosis
Abdominal Pain - etiology
Adult
Age
Antibodies
Biochemistry
Biomarkers
Biomarkers - analysis
Biopsy
Circulating MicroRNA - analysis
Comparative analysis
Disease
DNA microarrays
Down-Regulation
Dyspepsia
Dyspepsia - diagnosis
Dyspepsia - epidemiology
Dyspepsia - genetics
Dyspepsia - physiopathology
Exosomes - genetics
Female
Gastric Juice - metabolism
Gastroenterology
Gastroesophageal reflux
Gene Expression Profiling - methods
Health care
Health savings accounts
Hepatology
Humans
Infections
Japan
Liquid Biopsy - methods
Male
Medicine
Medicine & Public Health
MicroRNA
MicroRNAs
MicroRNAs - analysis
MicroRNAs - classification
Nonsteroidal anti-inflammatory drugs
Oncology
Original Article
Pathophysiology
Preventive medicine
Questionnaires
Retrospective Studies
Somatotropin
Transplant Surgery
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Title Exosomal hsa-miR-933 in Gastric Juice as a Potential Biomarker for Functional Dyspepsia
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