Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinson's disease - O’Keeffe, Fiona E.; Scott, Sarah A.; Tyers, Pam; O’Keeffe, Gerard W.; Dalley, Jeffrey W.; Zufferey, Romain; Caldwell, Maeve A. (Brain (London, England : 1878), 2008)
Keywords: Animals; Biological and medical sciences; Brain Tissue Transplantation - methods; Cell Differentiation; Cell Survival; Coculture Techniques; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Disease Models, Animal; Dopamine - biosynthesis; dopamine neurons; Female; Gene Transfer Techniques; Genetic Vectors; Homeodomain Proteins - metabolism; Lentivirus - genetics; Medical sciences; Mesencephalon - transplantation; Motor Activity; neural stem cells; Neurology; Neurons - pathology; Neurons - transplantation; Parkinson Disease - metabolism; Parkinson Disease - physiopathology; Parkinson Disease - therapy; Parkinson's disease; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction - methods; Stem Cell Transplantation - methods; Tissue Culture Techniques; transcription factors; Transcription Factors - metabolism; dopamine neurons; Parkinson's disease; neural stem cells; transcription factors; Animal model; Nervous system diseases; Dopamine; Stem cell; Parkinson disease; Catecholamine; Cerebral disorder; Central nervous system disease; Neurotransmitter; Dopaminergic neuron; Degenerative disease; Extrapyramidal syndrome