Indoxyl Sulfate, a Uremic Toxin, Stimulates Reactive Oxygen Species Production and Erythrocyte Cell Death Supposedly by an Organic Anion Transporter 2 (OAT2) and NADPH Oxidase Activity-Dependent Pathways - Dias, Gabriela Ferreira; Bonan, Natalia Borges; Steiner, Thiago Maass; Tozoni, Sara Soares; Rodrigues, Silvia; Nakao, Lia Sumie; Kuntsevich, Viktoriya; Pecoits Filho, Roberto; Kotanko, Peter; Moreno-Amaral, Andréa N. (Toxins, 2018)
Keywords: Adult; Anemia; Anions; Blood; Buffers; Cell death; chronic kidney disease; Dosage; eryptosis; Eryptosis - drug effects; Erythrocytes; Erythrocytes - drug effects; Erythrocytes - metabolism; Female; Glutathione; Hemodialysis; Hemoglobin; Humans; Indican - toxicity; indoxyl sulfate; Inhibitors; Ketoprofen; Kidney diseases; Male; NAD(P)H oxidase; NADPH Oxidases - metabolism; Organic Anion Transporters, Sodium-Independent - metabolism; Oxidase; Oxidative stress; Pathogenesis; Pretreatment; Reactive oxygen species; Reactive Oxygen Species - metabolism; Renal Dialysis; Signal Transduction; Sulfates; Toxins; Toxins, Biological - toxicity; Uremia; Young Adult; United States--US; chronic kidney disease; eryptosis; indoxyl sulfate; oxidative stress