Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial - Mackenzie, Isla S; Rogers, Amy; Poulter, Neil R; Williams, Bryan; Brown, Morris J; Webb, David J; Ford, Ian; Rorie, David A; Guthrie, Greg; Grieve, J W Kerr; Pigazzani, Filippo; Rothwell, Peter M; et al. (The Lancet (British edition), 2022)
Keywords: Adolescent; Adult; Adults; Aged; Antihypertensive Agents - therapeutic use; Antihypertensives; Blood pressure; Cardiovascular diseases; Cerebral infarction; Clinical trials; Diuretics; Dosage; Female; Health services; Heart attacks; Humans; Hypertension; Hypertension - chemically induced; Ischemia; Male; Morning; Myocardial infarction; Myocardial Infarction - drug therapy; Patient compliance; Patients; Prospective Studies; Questionnaires; Safety; State Medicine; Stroke; Time and Motion Studies; Treatment Outcome; United Kingdom - epidemiology; United Kingdom; United Kingdom--UK; Scotland