chance at survival: gene expression noise and phenotypic diversification strategies
Phenotypic diversification plays a central role in evolution and provides species with a capacity to survive environmental adversity. The profound impact of random molecular events on the shaping of life is well accepted in the context of chance mutations and genetic drift; however, the evolution of...
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| Published in | Molecular microbiology Vol. 71; no. 6; pp. 1333 - 1340 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Oxford, UK : Blackwell Publishing Ltd
01.03.2009
Blackwell Publishing Ltd Blackwell |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0950-382X 1365-2958 1365-2958 |
| DOI | 10.1111/j.1365-2958.2009.06605.x |
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| Abstract | Phenotypic diversification plays a central role in evolution and provides species with a capacity to survive environmental adversity. The profound impact of random molecular events on the shaping of life is well accepted in the context of chance mutations and genetic drift; however, the evolution of the regulatory networks encoding microorganismal stress response and survival strategies might also have been significantly influenced by gene expression noise. This likelihood has inspired numerous investigations to characterize the sources of phenotypic diversity within isogenic populations, and to explore their direct and potential biological implications. Here, we discuss different scenarios where gene expression noise might bestow a selective advantage under stress, highlighting a potentially fundamental role of stochastic mechanisms in the evolution of microbial survival strategies. |
|---|---|
| AbstractList | Summary
Phenotypic diversification plays a central role in evolution and provides species with a capacity to survive environmental adversity. The profound impact of random molecular events on the shaping of life is well accepted in the context of chance mutations and genetic drift; however, the evolution of the regulatory networks encoding microorganismal stress response and survival strategies might also have been significantly influenced by gene expression noise. This likelihood has inspired numerous investigations to characterize the sources of phenotypic diversity within isogenic populations, and to explore their direct and potential biological implications. Here, we discuss different scenarios where gene expression noise might bestow a selective advantage under stress, highlighting a potentially fundamental role of stochastic mechanisms in the evolution of microbial survival strategies. Phenotypic diversification plays a central role in evolution and provides species with a capacity to survive environmental adversity. The profound impact of random molecular events on the shaping of life is well accepted in the context of chance mutations and genetic drift; however, the evolution of the regulatory networks encoding microorganismal stress response and survival strategies might also have been significantly influenced by gene expression noise. This likelihood has inspired numerous investigations to characterize the sources of phenotypic diversity within isogenic populations, and to explore their direct and potential biological implications. Here, we discuss different scenarios where gene expression noise might bestow a selective advantage under stress, highlighting a potentially fundamental role of stochastic mechanisms in the evolution of microbial survival strategies.Phenotypic diversification plays a central role in evolution and provides species with a capacity to survive environmental adversity. The profound impact of random molecular events on the shaping of life is well accepted in the context of chance mutations and genetic drift; however, the evolution of the regulatory networks encoding microorganismal stress response and survival strategies might also have been significantly influenced by gene expression noise. This likelihood has inspired numerous investigations to characterize the sources of phenotypic diversity within isogenic populations, and to explore their direct and potential biological implications. Here, we discuss different scenarios where gene expression noise might bestow a selective advantage under stress, highlighting a potentially fundamental role of stochastic mechanisms in the evolution of microbial survival strategies. SummaryPhenotypic diversification plays a central role in evolution and provides species with a capacity to survive environmental adversity. The profound impact of random molecular events on the shaping of life is well accepted in the context of chance mutations and genetic drift; however, the evolution of the regulatory networks encoding microorganismal stress response and survival strategies might also have been significantly influenced by gene expression noise. This likelihood has inspired numerous investigations to characterize the sources of phenotypic diversity within isogenic populations, and to explore their direct and potential biological implications. Here, we discuss different scenarios where gene expression noise might bestow a selective advantage under stress, highlighting a potentially fundamental role of stochastic mechanisms in the evolution of microbial survival strategies. Phenotypic diversification plays a central role in evolution and provides species with a capacity to survive environmental adversity. The profound impact of random molecular events on the shaping of life is well accepted in the context of chance mutations and genetic drift; however, the evolution of the regulatory networks encoding microorganismal stress response and survival strategies might also have been significantly influenced by gene expression noise. This likelihood has inspired numerous investigations to characterize the sources of phenotypic diversity within isogenic populations, and to explore their direct and potential biological implications. Here, we discuss different scenarios where gene expression noise might bestow a selective advantage under stress, highlighting a potentially fundamental role of stochastic mechanisms in the evolution of microbial survival strategies. |
| Author | Fraser, Dawn Kærn, Mads |
| Author_xml | – sequence: 1 fullname: Fraser, Dawn – sequence: 2 fullname: Kærn, Mads |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21217738$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19220745$$D View this record in MEDLINE/PubMed |
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| Snippet | Phenotypic diversification plays a central role in evolution and provides species with a capacity to survive environmental adversity. The profound impact of... Summary Phenotypic diversification plays a central role in evolution and provides species with a capacity to survive environmental adversity. The profound... SummaryPhenotypic diversification plays a central role in evolution and provides species with a capacity to survive environmental adversity. The profound... |
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| SubjectTerms | Adaptation, Physiological - genetics Biological and medical sciences Ecosystem Environment Evolution, Molecular Fundamental and applied biological sciences. Psychology Gene Expression Genetics, Population Microbiology Mutation Phenotype Stochastic Processes Stress, Physiological |
| Title | chance at survival: gene expression noise and phenotypic diversification strategies |
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