Serum lathosterol levels in human subjects reflect changes in whole body cholesterol synthesis induced by lovastatin but not dietary cholesterol

We measured serum lathosterol levels and whole body cholesterol synthesis by sterol balance in 12 human subjects on a metabolic ward in four randomly allocated, 6-7 week periods: 1) lovastatin (40 mg b.i.d.) + low cholesterol diet (mean 246 mg/day); 2) lovastatin + high cholesterol diet (mean 1071 m...

Full description

Saved in:

Bibliographic Details
Published in	Journal of lipid research Vol. 36; no. 2; pp. 343 - 348
Main Author	Duane, W C
Format	Journal Article
Language	English
Published	United States Elsevier Inc 01.02.1995 Elsevier
Subjects	Biomarkers BIOSINTESIS BIOSYNTHESE biosynthesis blood blood serum CHOLESTEROL Cholesterol - biosynthesis Cholesterol - blood cholesterol metabolism Cholesterol, Dietary Cholesterol, Dietary - pharmacology COLESTEROL diet study techniques DIETA drug therapy ESTEROLES Humans hydroxymethylglutaryl-CoA reductases Lovastatin Lovastatin - pharmacology Male measurement MEDICION MESURE METABOLISME METABOLISMO METABOLITE metabolites METABOLITOS OXIDORREDUCTASAS OXYDOREDUCTASE pharmacology REGIME ALIMENTAIRE SERUM SANGUIN STEROL SUERO SANGUINEO TERAPEUTICA MEDICAMENTOSA THERAPEUTIQUE MEDICAMENTEUSE
Online Access	Get full text
ISSN	0022-2275 1539-7262
DOI	10.1016/S0022-2275(20)39911-9

Cover

Abstract	We measured serum lathosterol levels and whole body cholesterol synthesis by sterol balance in 12 human subjects on a metabolic ward in four randomly allocated, 6-7 week periods: 1) lovastatin (40 mg b.i.d.) + low cholesterol diet (mean 246 mg/day); 2) lovastatin + high cholesterol diet (mean 1071 mg/day); 3) low cholesterol diet alone; and 4) high cholesterol diet alone. Whole body cholesterol synthesis was significantly reduced both by lovastatin (P = 0.0004) and by high dietary cholesterol (P = 0.0005). Serum total lathosterol (micrograms/dl) was reduced by lovastatin (P < 0.0001), but was not significantly altered (and actually tended to increase) during consumption of the high cholesterol diet, presumably because eggs contained appreciable lathosterol as demonstrated by direct analysis. Results were similar for total versus free lathosterol and for lathosterol expressed as micrograms/dl serum versus micrograms/100 mg cholesterol. We conclude that serum lathosterol does not reflect changes in cholesterol synthesis induced by dietary cholesterol. Studies using serum lathosterol as an indicator of cholesterol synthesis must be carefully controlled for dietary cholesterol.
AbstractList	We measured serum lathosterol levels and whole body cholesterol synthesis by sterol balance in 12 human subjects on a metabolic ward in four randomly allocated, 6-7 week periods: 1) lovastatin (40 mg b.i.d.) + low cholesterol diet (mean 246 mg/day); 2) lovastatin + high cholesterol diet (mean 1071 mg/day); 3) low cholesterol diet alone; and 4) high cholesterol diet alone. Whole body cholesterol synthesis was significantly reduced both by lovastatin (P = 0.0004) and by high dietary cholesterol (P = 0.0005). Serum total lathosterol (micrograms/dl) was reduced by lovastatin (P < 0.0001), but was not significantly altered (and actually tended to increase) during consumption of the high cholesterol diet, presumably because eggs contained appreciable lathosterol as demonstrated by direct analysis. Results were similar for total versus free lathosterol and for lathosterol expressed as micrograms/dl serum versus micrograms/100 mg cholesterol. We conclude that serum lathosterol does not reflect changes in cholesterol synthesis induced by dietary cholesterol. Studies using serum lathosterol as an indicator of cholesterol synthesis must be carefully controlled for dietary cholesterol. We measured serum lathosterol levels and whole body cholesterol synthesis by sterol balance in 12 human subjects on a metabolic ward in four randomly allocated, 6-7 week periods: 1) lovastatin (40 mg b.i.d) + low cholesterol diet (mean 246 mg/day); 2) lovastatin + high cholesterol diet (mean 1071 mg/day); 3) low cholesterol diet alone; and 4) high cholesterol diet alone. Whole body cholesterol synthesis was significantly reduced both by lovastatin (P= 0.0004) and by high dietary cholesterol (P= 0.0005). Serum total lathosterol (micrograms/dl) was reduced by lovastatin (P 0.0001), but was not significantly altered (and actually tended to increase) during consumption of the high cholesterol diet, presumably because eggs contained appreciable lathosterol as demonstrated by direct analysis. Results were similar for total versus free lathosterol and for lathosterol expressed as microgram/dl serum versus micrograms/100 mg cholesterol. We conclude that serum lathosterol does not reflect changes in cholesterol synthesis induced by dietary cholesterol. Studies using serum lathosterol as an indicator of cholesterol synthesis must be carefully controlled for dietary cholesterol We measured serum lathosterol levels and whole body cholesterol synthesis by sterol balance in 12 human subjects on a metabolic ward in four randomly allocated, 6-7 week periods: 1) lovastatin (40 mg b.i.d) + low cholesterol diet (mean 246 mg/day); 2) lovastatin + high cholesterol diet (mean 1071 mg/day); 3) low cholesterol diet alone; and 4) high cholesterol diet alone. Whole body cholesterol synthesis was significantly reduced both by lovastatin (P= 0.0004) and by high dietary cholesterol (P= 0.0005). Serum total lathosterol (micrograms/dl) was reduced by lovastatin (P < 0.0001), but was not significantly altered (and actually tended to increase) during consumption of the high cholesterol diet, presumably because eggs contained appreciable lathosterol as demonstrated by direct analysis. Results were similar for total versus free lathosterol and for lathosterol expressed as microgram/dl serum versus micrograms/100 mg cholesterol. We conclude that serum lathosterol does not reflect changes in cholesterol synthesis induced by dietary cholesterol. Studies using serum lathosterol as an indicator of cholesterol synthesis must be carefully controlled for dietary cholesterol. We measured serum lathosterol levels and whole body cholesterol synthesis by sterol balance in 12 human subjects on a metabolic ward in four randomly allocated, 6-7 week periods: 1) lovastatin (40 mg b.i.d.) + low cholesterol diet (mean 246 mg/day); 2) lovastatin + high cholesterol diet (mean 1071 mg/day); 3) low cholesterol diet alone; and 4) high cholesterol diet alone. Whole body cholesterol synthesis was significantly reduced both by lovastatin (P = 0.0004) and by high dietary cholesterol (P = 0.0005). Serum total lathosterol (micrograms/dl) was reduced by lovastatin (P < 0.0001), but was not significantly altered (and actually tended to increase) during consumption of the high cholesterol diet, presumably because eggs contained appreciable lathosterol as demonstrated by direct analysis. Results were similar for total versus free lathosterol and for lathosterol expressed as micrograms/dl serum versus micrograms/100 mg cholesterol. We conclude that serum lathosterol does not reflect changes in cholesterol synthesis induced by dietary cholesterol. Studies using serum lathosterol as an indicator of cholesterol synthesis must be carefully controlled for dietary cholesterol.We measured serum lathosterol levels and whole body cholesterol synthesis by sterol balance in 12 human subjects on a metabolic ward in four randomly allocated, 6-7 week periods: 1) lovastatin (40 mg b.i.d.) + low cholesterol diet (mean 246 mg/day); 2) lovastatin + high cholesterol diet (mean 1071 mg/day); 3) low cholesterol diet alone; and 4) high cholesterol diet alone. Whole body cholesterol synthesis was significantly reduced both by lovastatin (P = 0.0004) and by high dietary cholesterol (P = 0.0005). Serum total lathosterol (micrograms/dl) was reduced by lovastatin (P < 0.0001), but was not significantly altered (and actually tended to increase) during consumption of the high cholesterol diet, presumably because eggs contained appreciable lathosterol as demonstrated by direct analysis. Results were similar for total versus free lathosterol and for lathosterol expressed as micrograms/dl serum versus micrograms/100 mg cholesterol. We conclude that serum lathosterol does not reflect changes in cholesterol synthesis induced by dietary cholesterol. Studies using serum lathosterol as an indicator of cholesterol synthesis must be carefully controlled for dietary cholesterol.
Author	Duane, W C
Author_xml	– sequence: 1 givenname: W C surname: Duane fullname: Duane, W C organization: Department of Medicine, Veterans Affairs Medical Center, Minneapolis, MN, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/7751822$$D View this record in MEDLINE/PubMed
BookMark	eNqFUstuEzEUHaGikhZ-AKmSVwgWA7ZnPPaIRYWqApUqsQhdW37cSRw542J7gvIXfHKdB5Vgk5WvfB6-vvdcVGdjGKGqrgj-SDDpPs0xprSmlLP3FH9o-p6Qun9RzQhr-prTjp5Vs2fKq-oipRXGpG07cl6dc86IoHRW_ZlDnNbIq7wMKUMMHnnYgE_IjWg5rdWI0qRXYHJCEQZfCmSWalzAnvF7GTwgHey23JbyaJG2Y15CcjuOnQxYpLfIh41KWeUi01NGY8jIOsgq_qN9Xb0clE_w5nheVg9fb3_efK_vf3y7u_lyXxvWilz3hIGieBBN2yjVCc65pb3WVNhuYKohhjFGGWusAKEMwWCswg00gPnQWtFcVncHXxvUSj5Gty6NyKCc3F-EuJAqZmc8yJaxVg-Ecg5dy4fyHMaWaaMxWE25Ll7vDl6PMfyaykfk2iUD3qsRwpQk55SLFtOTxFbwvu_ErrurI3HSa7DP_R33VvDPB9zEkFJZjDRuN9ow5qiclwTLXUjkPiRylwBJsdyHRPZFzf5T__U_pXt70A0qSLWILsmHec9xS0RTwOsDWMIDGwdRJuNgLMt3saSmjNWdsH8CpJHfLQ
CitedBy_id	crossref_primary_10_1007_s11745_000_0616_9 crossref_primary_10_1016_j_nut_2013_03_020 crossref_primary_10_1136_jim_2017_000495 crossref_primary_10_1007_s11745_998_0192_z crossref_primary_10_1097_MOL_0000000000000069 crossref_primary_10_1016_S0022_2275_20_37301_6 crossref_primary_10_1016_j_jsbmb_2015_02_012 crossref_primary_10_1016_S0022_2275_20_30045_6 crossref_primary_10_1016_j_trsl_2018_07_002 crossref_primary_10_1016_S0021_9150_97_00173_1 crossref_primary_10_3945_jn_114_195503 crossref_primary_10_1186_1476_511X_13_72 crossref_primary_10_3390_metabo14050245 crossref_primary_10_1016_j_jacl_2008_01_008 crossref_primary_10_1016_S0022_2275_20_33481_7 crossref_primary_10_1152_ajpendo_00324_2001 crossref_primary_10_1016_0021_9150_95_05611_4 crossref_primary_10_1017_S0007114507811998 crossref_primary_10_1373_49_8_1347 crossref_primary_10_1111_j_1365_2265_2005_02396_x crossref_primary_10_1016_S0022_2275_20_31643_6 crossref_primary_10_1016_S0022_2275_20_37589_1 crossref_primary_10_1152_ajpendo_1997_273_3_E462 crossref_primary_10_2220_biomedres_31_213 crossref_primary_10_1093_clinchem_43_10_1896 crossref_primary_10_1016_S0021_9150_97_00131_7 crossref_primary_10_1016_S0021_9150_97_00153_6 crossref_primary_10_1111_joim_12682 crossref_primary_10_1016_S0021_9150_02_00054_0 crossref_primary_10_1016_j_atherosclerosis_2016_03_018 crossref_primary_10_1002_hep_510300119 crossref_primary_10_1038_sj_bjp_0701831
Cites_doi	10.3109/00365518809085764 10.1172/JCI116666 10.1016/S0022-2275(20)34764-7 10.1016/S0022-2275(20)38603-X 10.1016/S0022-2275(20)41977-7 10.1016/S0022-2275(20)38456-X 10.1093/ajcn/59.6.1325 10.1056/NEJM198505163122007 10.1016/S0022-2275(20)39534-1 10.1016/S0022-2275(20)41990-X 10.1016/0026-0495(92)90050-K 10.3109/00365518909105417 10.1172/JCI113013 10.1016/S0022-2275(20)38144-X 10.1016/0024-3205(69)90007-1 10.1080/00365519009091065 10.1056/NEJM198807073190105 10.1016/S0022-2275(20)41548-2
ContentType	Journal Article
Copyright	1995 © 1995 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.
Copyright_xml	– notice: 1995 © 1995 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.
DBID	6I. AAFTH FBQ AAYXX CITATION CGR CUY CVF ECM EIF NPM 7S9 L.6 7X8 DOA
DOI	10.1016/S0022-2275(20)39911-9
DatabaseName	ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access AGRIS CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed AGRICOLA AGRICOLA - Academic MEDLINE - Academic DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AGRICOLA AGRICOLA - Academic MEDLINE - Academic
DatabaseTitleList	AGRICOLA MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: FBQ name: AGRIS url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN sourceTypes: Publisher
DeliveryMethod	fulltext_linktorsrc
Discipline	Anatomy & Physiology Chemistry
EISSN	1539-7262
EndPage	348
ExternalDocumentID	oai_doaj_org_article_4554bf1277e647faa600d5bcb0edb27b 7751822 10_1016_S0022_2275_20_39911_9 US9704183 S0022227520399119
Genre	Research Support, U.S. Gov't, Non-P.H.S Research Support, U.S. Gov't, P.H.S Clinical Trial Randomized Controlled Trial Journal Article
GrantInformation_xml	– fundername: NIDDK NIH HHS grantid: R01-DK42433
GroupedDBID	--- -~X .55 .GJ 0SF 0VX 18M 29K 2WC 34G 39C 4.4 53G 5GY 5RE 5VS 6I. AAEDW AAFTH AAFWJ AAXUO AAYOK ABCQX ABOCM ACCCW ACGFO ACKIV ACNCT ACPRK ADBBV AENEX AEXQZ AFFNX AFOSN AFPKN AHPSJ AI. ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS BAWUL BTFSW C1A CS3 D-I DIK DU5 E3Z EBS EJD F5P FDB FRP GROUPED_DOAJ GX1 H13 HH5 HYE H~9 J5H KQ8 L7B MVM OK1 P2P RHF RHI ROL RPM TBC TR2 TWZ VH1 W8F WH7 WOQ X7M XFK YHG YKV ZA5 ZGI ZXP ~KM 0R~ ADVLN AITUG AKRWK FBQ AALRI AAYWO AAYXX ACVFH ADCNI AEUPX AFPUW AIGII AKBMS AKYEP CITATION CGR CUY CVF ECM EIF NPM 7S9 L.6 7X8
ID	FETCH-LOGICAL-c548t-915ea20f8343aa68777d29bb28d6f5a31c5552553d8e8ac10ecda03e3e07f4d83
IEDL.DBID	DOA
ISSN	0022-2275
IngestDate	Wed Aug 27 01:29:12 EDT 2025 Mon Aug 18 10:50:31 EDT 2025 Wed Oct 01 14:52:45 EDT 2025 Thu Jan 02 22:56:54 EST 2025 Wed Oct 01 05:18:29 EDT 2025 Thu Apr 24 23:06:08 EDT 2025 Thu Apr 03 09:43:56 EDT 2025 Fri Feb 23 02:46:34 EST 2024
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	2
Language	English
License	This is an open access article under the CC BY license.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c548t-915ea20f8343aa68777d29bb28d6f5a31c5552553d8e8ac10ecda03e3e07f4d83
Notes	9704183 S30 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 ObjectType-Undefined-3
OpenAccessLink	https://doaj.org/article/4554bf1277e647faa600d5bcb0edb27b
PMID	7751822
PQID	48799688
PQPubID	24069
PageCount	6
ParticipantIDs	doaj_primary_oai_doaj_org_article_4554bf1277e647faa600d5bcb0edb27b proquest_miscellaneous_77278402 proquest_miscellaneous_48799688 pubmed_primary_7751822 crossref_citationtrail_10_1016_S0022_2275_20_39911_9 crossref_primary_10_1016_S0022_2275_20_39911_9 fao_agris_US9704183 elsevier_sciencedirect_doi_10_1016_S0022_2275_20_39911_9
ProviderPackageCode	CITATION AAYXX
PublicationCentury	1900
PublicationDate	1995-02-01
PublicationDateYYYYMMDD	1995-02-01
PublicationDate_xml	– month: 02 year: 1995 text: 1995-02-01 day: 01
PublicationDecade	1990
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	Journal of lipid research
PublicationTitleAlternate	J Lipid Res
PublicationYear	1995
Publisher	Elsevier Inc Elsevier
Publisher_xml	– name: Elsevier Inc – name: Elsevier
References	Grundy (bib18) 1988; 319 Duane (bib10) 1993; 92 Lin, Connor (bib8) 1980; 21 Lund, Olund, Bjorkhem (bib14) 1990; 50 Uusitupa, Miettinen, Happonen, Ebeling, Turtola, Voutilainen, Pyorala (bib6) 1992; 12 Mitchell, Stone, Logan, Duane (bib11) 1991; 32 Miettinen (bib17) 1982; 23 Miettinen (bib1) 1969; 8 Bjorkhem, Miettinen, ReihnCr, Ewerth, Angelin, Einarsson (bib2) 1987; 28 Meijer, Van der Palen, De Vries, Kempen, Van der Voort, Van Zutphen, Beyen (bib15) 1992; 33 Koivisto, Miettinen (bib16) 1988; 48 Quint50, Grundy, Ahrens (bib7) 1971; 12 Lund, Sisfontes, ReihnCr, Bjorkhem (bib13) 1989; 49 Vanhanen, Kesaniemi, Miettinen (bib5) 1992; 41 Schaefer, Levy (bib12) 1985; 312 McNamara, Kolb, Parker, Batwin, Samuel, Brown, Ahrens (bib9) 1987; 79 Kempen, Glatz, Gevers Leuven, van der Voort, Katan (bib3) 1988; 29 Elmberger, KalCn, Lund, ReihnCr, Eriksson, Berglund, Angelin, Dallner (bib4) 1991; 32 Vuoristo, Miettinen (bib19) 1994; 59 Miettinen (10.1016/S0022-2275(20)39911-9_bib17) 1982; 23 Bjorkhem (10.1016/S0022-2275(20)39911-9_bib2) 1987; 28 Meijer (10.1016/S0022-2275(20)39911-9_bib15) 1992; 33 Grundy (10.1016/S0022-2275(20)39911-9_bib18) 1988; 319 Kempen (10.1016/S0022-2275(20)39911-9_bib3) 1988; 29 Vanhanen (10.1016/S0022-2275(20)39911-9_bib5) 1992; 41 Lund (10.1016/S0022-2275(20)39911-9_bib14) 1990; 50 Uusitupa (10.1016/S0022-2275(20)39911-9_bib6) 1992; 12 Lund (10.1016/S0022-2275(20)39911-9_bib13) 1989; 49 Quint50 (10.1016/S0022-2275(20)39911-9_bib7) 1971; 12 Schaefer (10.1016/S0022-2275(20)39911-9_bib12) 1985; 312 Elmberger (10.1016/S0022-2275(20)39911-9_bib4) 1991; 32 Mitchell (10.1016/S0022-2275(20)39911-9_bib11) 1991; 32 McNamara (10.1016/S0022-2275(20)39911-9_bib9) 1987; 79 Vuoristo (10.1016/S0022-2275(20)39911-9_bib19) 1994; 59 Lin (10.1016/S0022-2275(20)39911-9_bib8) 1980; 21 Duane (10.1016/S0022-2275(20)39911-9_bib10) 1993; 92 Miettinen (10.1016/S0022-2275(20)39911-9_bib1) 1969; 8 Koivisto (10.1016/S0022-2275(20)39911-9_bib16) 1988; 48
References_xml	– volume: 32 start-page: 935 year: 1991 end-page: 940 ident: bib4 article-title: Effects of pravastatin and cholestryramine on products of the mevalonate pathway in familial hypercholesterolemia publication-title: J Lipid Res. – volume: 312 start-page: 1300 year: 1985 end-page: 1310 ident: bib12 article-title: Pathogenesis and management of lipoprotein disorders publication-title: N. Engl. J Med. – volume: 29 start-page: 1149 year: 1988 end-page: 1155 ident: bib3 article-title: Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans publication-title: J. Lipid Res. – volume: 12 start-page: 803 year: 1992 end-page: 807 ident: bib6 article-title: Lathosterol and other noncholesterol sterols during treatment of hypercholesterolemia with lovastatin alone and with cholestyramine or guar gum publication-title: Arteriosclet: Thromb. – volume: 23 start-page: 466 year: 1982 end-page: 473 ident: bib17 article-title: Diurnal variation of cholesterol precursors squalene and methyl sterols in human plasma lipoproteins publication-title: J. Lipid Res. – volume: 59 start-page: 1325 year: 1994 end-page: 1331 ident: bib19 article-title: Absorption, metabolism, and serum concentrations of cholesterol in vegetarians: effects of cholesterol feeding publication-title: Am. J Clin. Nutr. – volume: 79 start-page: 1729 year: 1987 end-page: 1739 ident: bib9 article-title: Heterogeneity of cholesterol homeostasis in man publication-title: J. Clin. Invest. – volume: 32 start-page: 1143 year: 1991 end-page: 1149 ident: bib11 article-title: Role of cholesterol synthesis in regulation of bile acid synthesis and biliary cholesterol secretion in humans publication-title: J. Lipid Res. – volume: 48 start-page: 501 year: 1988 end-page: 507 ident: bib16 article-title: Evaluation of bile acid malabsorption by plasma cholesterol precursor sterols in familial hypercholesterolemia patients with and without ileal exclusion. Scand publication-title: J. Clin. Lab. Invest. – volume: 41 start-page: 588 year: 1992 end-page: 595 ident: bib5 article-title: Pravastatin lowers serum cholesterol, cholesterolprecursor sterols, fecal steroids, and cholesterol absorption in man publication-title: Metab. Clin. Exp. – volume: 21 start-page: 1042 year: 1980 end-page: 1052 ident: bib8 article-title: The long term effects of dietary cholesterol upon the plasma lipids, lipoproteins, cholesterol absorption, and the sterol balance in man: the demonstration of feedback inhibition of cholesterol biosynthesis and increased bile acid excretion publication-title: J. Lipid Res. – volume: 8 start-page: 713 year: 1969 end-page: 721 ident: bib1 article-title: Serum squalene and methylsterols as indicators of cholesterol synthesis in vivo publication-title: Lifc Sci. – volume: 50 start-page: 723 year: 1990 end-page: 728 ident: bib14 article-title: Determination of serum levels of unesterified lanosterol by isotope dilution- mass spectrometry. Scand publication-title: J. Clin. Lab. Invest. – volume: 28 start-page: 1137 year: 1987 end-page: 1143 ident: bib2 article-title: Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver publication-title: J Lipid Res. – volume: 92 start-page: 911 year: 1993 end-page: 918 ident: bib10 article-title: Effects of lovastatin and dietary cholesterol on sterol homeostasis in healthy human subjects publication-title: J Clin. Invest. – volume: 49 start-page: 165 year: 1989 end-page: 171 ident: bib13 article-title: Determination of serum levels of unesterified lathosterol by isotope dilution-mass spectrometry publication-title: Scad J Clin. Lab. Invest. – volume: 319 start-page: 24 year: 1988 end-page: 33 ident: bib18 article-title: HMG-CoA reductase inhibitors for treatment of hypercholesterolemia publication-title: N. Engl. J. Med. – volume: 12 start-page: 233 year: 1971 end-page: 247 ident: bib7 article-title: Effects of dietary cholesterol on the regulation of total body cholesterol in man publication-title: J Lipid Res. – volume: 33 start-page: 281 year: 1992 end-page: 286 ident: bib15 article-title: Evaluation of the use of serum lathosterol concentration to assess whole-body cholesterol synthesis in rabbits publication-title: J Lipid Res. – volume: 48 start-page: 501 year: 1988 ident: 10.1016/S0022-2275(20)39911-9_bib16 article-title: Evaluation of bile acid malabsorption by plasma cholesterol precursor sterols in familial hypercholesterolemia patients with and without ileal exclusion. Scand publication-title: J. Clin. Lab. Invest. doi: 10.3109/00365518809085764 – volume: 92 start-page: 911 year: 1993 ident: 10.1016/S0022-2275(20)39911-9_bib10 article-title: Effects of lovastatin and dietary cholesterol on sterol homeostasis in healthy human subjects publication-title: J Clin. Invest. doi: 10.1172/JCI116666 – volume: 21 start-page: 1042 year: 1980 ident: 10.1016/S0022-2275(20)39911-9_bib8 article-title: The long term effects of dietary cholesterol upon the plasma lipids, lipoproteins, cholesterol absorption, and the sterol balance in man: the demonstration of feedback inhibition of cholesterol biosynthesis and increased bile acid excretion publication-title: J. Lipid Res. doi: 10.1016/S0022-2275(20)34764-7 – volume: 28 start-page: 1137 year: 1987 ident: 10.1016/S0022-2275(20)39911-9_bib2 article-title: Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver publication-title: J Lipid Res. doi: 10.1016/S0022-2275(20)38603-X – volume: 32 start-page: 1143 year: 1991 ident: 10.1016/S0022-2275(20)39911-9_bib11 article-title: Role of cholesterol synthesis in regulation of bile acid synthesis and biliary cholesterol secretion in humans publication-title: J. Lipid Res. doi: 10.1016/S0022-2275(20)41977-7 – volume: 29 start-page: 1149 year: 1988 ident: 10.1016/S0022-2275(20)39911-9_bib3 article-title: Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans publication-title: J. Lipid Res. doi: 10.1016/S0022-2275(20)38456-X – volume: 59 start-page: 1325 year: 1994 ident: 10.1016/S0022-2275(20)39911-9_bib19 article-title: Absorption, metabolism, and serum concentrations of cholesterol in vegetarians: effects of cholesterol feeding publication-title: Am. J Clin. Nutr. doi: 10.1093/ajcn/59.6.1325 – volume: 312 start-page: 1300 year: 1985 ident: 10.1016/S0022-2275(20)39911-9_bib12 article-title: Pathogenesis and management of lipoprotein disorders publication-title: N. Engl. J Med. doi: 10.1056/NEJM198505163122007 – volume: 12 start-page: 803 year: 1992 ident: 10.1016/S0022-2275(20)39911-9_bib6 article-title: Lathosterol and other noncholesterol sterols during treatment of hypercholesterolemia with lovastatin alone and with cholestyramine or guar gum publication-title: Arteriosclet: Thromb. – volume: 12 start-page: 233 year: 1971 ident: 10.1016/S0022-2275(20)39911-9_bib7 article-title: Effects of dietary cholesterol on the regulation of total body cholesterol in man publication-title: J Lipid Res. doi: 10.1016/S0022-2275(20)39534-1 – volume: 32 start-page: 935 year: 1991 ident: 10.1016/S0022-2275(20)39911-9_bib4 article-title: Effects of pravastatin and cholestryramine on products of the mevalonate pathway in familial hypercholesterolemia publication-title: J Lipid Res. doi: 10.1016/S0022-2275(20)41990-X – volume: 41 start-page: 588 year: 1992 ident: 10.1016/S0022-2275(20)39911-9_bib5 article-title: Pravastatin lowers serum cholesterol, cholesterolprecursor sterols, fecal steroids, and cholesterol absorption in man publication-title: Metab. Clin. Exp. doi: 10.1016/0026-0495(92)90050-K – volume: 49 start-page: 165 year: 1989 ident: 10.1016/S0022-2275(20)39911-9_bib13 article-title: Determination of serum levels of unesterified lathosterol by isotope dilution-mass spectrometry publication-title: Scad J Clin. Lab. Invest. doi: 10.3109/00365518909105417 – volume: 79 start-page: 1729 year: 1987 ident: 10.1016/S0022-2275(20)39911-9_bib9 article-title: Heterogeneity of cholesterol homeostasis in man publication-title: J. Clin. Invest. doi: 10.1172/JCI113013 – volume: 23 start-page: 466 year: 1982 ident: 10.1016/S0022-2275(20)39911-9_bib17 article-title: Diurnal variation of cholesterol precursors squalene and methyl sterols in human plasma lipoproteins publication-title: J. Lipid Res. doi: 10.1016/S0022-2275(20)38144-X – volume: 8 start-page: 713 year: 1969 ident: 10.1016/S0022-2275(20)39911-9_bib1 article-title: Serum squalene and methylsterols as indicators of cholesterol synthesis in vivo publication-title: Lifc Sci. doi: 10.1016/0024-3205(69)90007-1 – volume: 50 start-page: 723 year: 1990 ident: 10.1016/S0022-2275(20)39911-9_bib14 article-title: Determination of serum levels of unesterified lanosterol by isotope dilution- mass spectrometry. Scand publication-title: J. Clin. Lab. Invest. doi: 10.1080/00365519009091065 – volume: 319 start-page: 24 year: 1988 ident: 10.1016/S0022-2275(20)39911-9_bib18 article-title: HMG-CoA reductase inhibitors for treatment of hypercholesterolemia publication-title: N. Engl. J. Med. doi: 10.1056/NEJM198807073190105 – volume: 33 start-page: 281 year: 1992 ident: 10.1016/S0022-2275(20)39911-9_bib15 article-title: Evaluation of the use of serum lathosterol concentration to assess whole-body cholesterol synthesis in rabbits publication-title: J Lipid Res. doi: 10.1016/S0022-2275(20)41548-2
SSID	ssj0014461
Score	1.6127013
Snippet	We measured serum lathosterol levels and whole body cholesterol synthesis by sterol balance in 12 human subjects on a metabolic ward in four randomly...
SourceID	doaj proquest pubmed crossref fao elsevier
SourceType	Open Website Aggregation Database Index Database Enrichment Source Publisher
StartPage	343
SubjectTerms	Biomarkers BIOSINTESIS BIOSYNTHESE biosynthesis blood blood serum CHOLESTEROL Cholesterol - biosynthesis Cholesterol - blood cholesterol metabolism Cholesterol, Dietary Cholesterol, Dietary - pharmacology COLESTEROL diet study techniques DIETA drug therapy ESTEROLES Humans hydroxymethylglutaryl-CoA reductases Lovastatin Lovastatin - pharmacology Male measurement MEDICION MESURE METABOLISME METABOLISMO METABOLITE metabolites METABOLITOS OXIDORREDUCTASAS OXYDOREDUCTASE pharmacology REGIME ALIMENTAIRE SERUM SANGUIN STEROL SUERO SANGUINEO TERAPEUTICA MEDICAMENTOSA THERAPEUTIQUE MEDICAMENTEUSE
Title	Serum lathosterol levels in human subjects reflect changes in whole body cholesterol synthesis induced by lovastatin but not dietary cholesterol
URI	https://dx.doi.org/10.1016/S0022-2275(20)39911-9 https://www.ncbi.nlm.nih.gov/pubmed/7751822 https://www.proquest.com/docview/48799688 https://www.proquest.com/docview/77278402 https://doaj.org/article/4554bf1277e647faa600d5bcb0edb27b
Volume	36
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVFSB databaseName: Free Full-Text Journals in Chemistry customDbUrl: eissn: 1539-7262 dateEnd: 20241001 omitProxy: true ssIdentifier: ssj0014461 issn: 0022-2275 databaseCode: HH5 dateStart: 19590101 isFulltext: true titleUrlDefault: http://abc-chemistry.org/ providerName: ABC ChemistRy – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1539-7262 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0014461 issn: 0022-2275 databaseCode: KQ8 dateStart: 19591001 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1539-7262 dateEnd: 20241001 omitProxy: true ssIdentifier: ssj0014461 issn: 0022-2275 databaseCode: DIK dateStart: 19590101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1539-7262 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0014461 issn: 0022-2275 databaseCode: GX1 dateStart: 0 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 1539-7262 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0014461 issn: 0022-2275 databaseCode: AKRWK dateStart: 19591001 isFulltext: true providerName: Library Specific Holdings
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELagHOBSwZaK8Cg-IASHgGMnsfe4VFQVFRyAFb1ZduxUK6UO2iSq9l_wk5nJY8seqr1wjWznMV9m5rPnQcgbbgwHN8jEpRB5nHopYuWSPFbGKAEG3DGP-5Bfv-Xny_TLZXb5T6svjAkbygMPH-5jCvbOlgmX0uepLI0BC-0yW1jmneXSovYFMzaRqfH8AEhOMtUJ51xmt7k7mBs8XnzH2Xuwz0kSz3esUl-8f8c43S9NfbcL2puis8fkcPQh6WJ49ifkng8zcrQIwJ-vN_Qt7aM6--3yGXl4OnV0OyJ_QDF017QCpw9TO9Z1RSuMGWroKtC-WR9tOosbMw2FR8QNfTokBvcjbrCVLrW121DUmX5cotkEcCKbFY5xABRH7YZWGOKKp_yB2q6loW6pW_nWrHfmPiXLs88_T8_jsSNDXACzaUEzZt5wViqRCpAE1hJ0fG4tVy4vMyOSIssyICnCKa9MkTBfOMOEF57JMnVKHJODUAf_jFBnjSgLK73FimAlCJYzIZxPDObapj4i6SQRXYzlyrFrRqVv49JAkBoFqTnTvSD1PCIfttN-D_U69k34hOLeDsZy2_0FAKEeQaj3gTAiagKLHj2XwSOBpVb77j8DcGlzBTpdL3_MJUtBy0bk9QQ2DSDBQxwTfN01GggmUFSl7h4BfEkCbecROR5Qun03iWdsnD__H6_8gjyasvtZ8pIctOvOvwL_rLUn5MHi4vuvi5P-l_wLBMY2JA
linkProvider	Directory of Open Access Journals
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Serum+lathosterol+levels+in+human+subjects+reflect+changes+in+whole+body+cholesterol+synthesis+induced+by+lovastatin+but+not+dietary+cholesterol&rft.jtitle=Journal+of+lipid+research&rft.au=Duane%2C+W.C.+%28Veterans+Affairs+Medical+Center%2C+Minneapolis%2C+MN.%29&rft.date=1995-02-01&rft.issn=0022-2275&rft.volume=36&rft.issue=2&rft_id=info:doi/10.1016%2FS0022-2275%2820%2939911-9&rft.externalDocID=US9704183
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-2275&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-2275&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-2275&client=summon