Lipocalin 2 prevents intestinal inflammation by enhancing phagocytic bacterial clearance in macrophages

Lipocalin 2 (Lcn2), also called neutrophil gelatinase B-associated lipocalin (NGAL), is an anti-microbial peptide originally identified in neutrophil granules. Although Lcn2/NGAL expression is increased in the inflamed intestinal tissues of patients with inflammatory bowel disease, the role of Lcn2/...

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Published inScientific reports Vol. 6; no. 1; p. 35014
Main Authors Toyonaga, Takahiko, Matsuura, Minoru, Mori, Kiyoshi, Honzawa, Yusuke, Minami, Naoki, Yamada, Satoshi, Kobayashi, Taku, Hibi, Toshifumi, Nakase, Hiroshi
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 13.10.2016
Nature Publishing Group
Subjects
13/106
38/77
631/250/2504/342
64/60
692/4020/1503/257
82/80
Animals
Colitis - genetics
Colitis - microbiology
Colon
Disease Models, Animal
E coli
Escherichia coli - physiology
Gene Knockout Techniques
Humanities and Social Sciences
Humans
Immunology
Inflammation
Inflammatory bowel disease
Interleukin-10 - genetics
Lipocalin-2 - genetics
Lipocalin-2 - metabolism
Macrophages
Macrophages - immunology
Macrophages - microbiology
Mice
Mice, Knockout
multidisciplinary
Neutrophils
Phagocytosis
Rodents
Science
Online AccessGet full text
ISSN2045-2322
2045-2322
DOI10.1038/srep35014

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Abstract Lipocalin 2 (Lcn2), also called neutrophil gelatinase B-associated lipocalin (NGAL), is an anti-microbial peptide originally identified in neutrophil granules. Although Lcn2/NGAL expression is increased in the inflamed intestinal tissues of patients with inflammatory bowel disease, the role of Lcn2/NGAL in the development of intestinal inflammation remains unclear. Here we investigated the role of Lcn2/NGAL in intestinal inflammation using a spontaneous mouse colitis model, interleukin-10 knock out (IL-10 KO) mice. Lcn2 expression in the colonic tissues of IL-10 KO mice increased with the development of colitis. Lcn2/IL-10 double-KO mice showed a more rapid onset and development of colitis compared to IL-10 KO mice. Lcn2 enhanced phagocytic bacterial clearance in macrophages in vitro after infection with Escherichia coli . Transfer of Lcn2-repleted macrophages prevented the development of colitis in Lcn2/IL-10 double-KO mice in vivo . Our findings revealed that Lcn2 prevents the development of intestinal inflammation. One crucial factor seems to be the enhancement of phagocytic bacterial clearance in macrophages by Lcn2.
AbstractList Lipocalin 2 (Lcn2), also called neutrophil gelatinase B-associated lipocalin (NGAL), is an anti-microbial peptide originally identified in neutrophil granules. Although Lcn2/NGAL expression is increased in the inflamed intestinal tissues of patients with inflammatory bowel disease, the role of Lcn2/NGAL in the development of intestinal inflammation remains unclear. Here we investigated the role of Lcn2/NGAL in intestinal inflammation using a spontaneous mouse colitis model, interleukin-10 knock out (IL-10 KO) mice. Lcn2 expression in the colonic tissues of IL-10 KO mice increased with the development of colitis. Lcn2/IL-10 double-KO mice showed a more rapid onset and development of colitis compared to IL-10 KO mice. Lcn2 enhanced phagocytic bacterial clearance in macrophages in vitro after infection with Escherichia coli. Transfer of Lcn2-repleted macrophages prevented the development of colitis in Lcn2/IL-10 double-KO mice in vivo. Our findings revealed that Lcn2 prevents the development of intestinal inflammation. One crucial factor seems to be the enhancement of phagocytic bacterial clearance in macrophages by Lcn2.
Lipocalin 2 (Lcn2), also called neutrophil gelatinase B-associated lipocalin (NGAL), is an anti-microbial peptide originally identified in neutrophil granules. Although Lcn2/NGAL expression is increased in the inflamed intestinal tissues of patients with inflammatory bowel disease, the role of Lcn2/NGAL in the development of intestinal inflammation remains unclear. Here we investigated the role of Lcn2/NGAL in intestinal inflammation using a spontaneous mouse colitis model, interleukin-10 knock out (IL-10 KO) mice. Lcn2 expression in the colonic tissues of IL-10 KO mice increased with the development of colitis. Lcn2/IL-10 double-KO mice showed a more rapid onset and development of colitis compared to IL-10 KO mice. Lcn2 enhanced phagocytic bacterial clearance in macrophages in vitro after infection with Escherichia coli . Transfer of Lcn2-repleted macrophages prevented the development of colitis in Lcn2/IL-10 double-KO mice in vivo . Our findings revealed that Lcn2 prevents the development of intestinal inflammation. One crucial factor seems to be the enhancement of phagocytic bacterial clearance in macrophages by Lcn2.
Lipocalin 2 (Lcn2), also called neutrophil gelatinase B-associated lipocalin (NGAL), is an anti-microbial peptide originally identified in neutrophil granules. Although Lcn2/NGAL expression is increased in the inflamed intestinal tissues of patients with inflammatory bowel disease, the role of Lcn2/NGAL in the development of intestinal inflammation remains unclear. Here we investigated the role of Lcn2/NGAL in intestinal inflammation using a spontaneous mouse colitis model, interleukin-10 knock out (IL-10 KO) mice. Lcn2 expression in the colonic tissues of IL-10 KO mice increased with the development of colitis. Lcn2/IL-10 double-KO mice showed a more rapid onset and development of colitis compared to IL-10 KO mice. Lcn2 enhanced phagocytic bacterial clearance in macrophages in vitro after infection with Escherichia coli. Transfer of Lcn2-repleted macrophages prevented the development of colitis in Lcn2/IL-10 double-KO mice in vivo. Our findings revealed that Lcn2 prevents the development of intestinal inflammation. One crucial factor seems to be the enhancement of phagocytic bacterial clearance in macrophages by Lcn2.Lipocalin 2 (Lcn2), also called neutrophil gelatinase B-associated lipocalin (NGAL), is an anti-microbial peptide originally identified in neutrophil granules. Although Lcn2/NGAL expression is increased in the inflamed intestinal tissues of patients with inflammatory bowel disease, the role of Lcn2/NGAL in the development of intestinal inflammation remains unclear. Here we investigated the role of Lcn2/NGAL in intestinal inflammation using a spontaneous mouse colitis model, interleukin-10 knock out (IL-10 KO) mice. Lcn2 expression in the colonic tissues of IL-10 KO mice increased with the development of colitis. Lcn2/IL-10 double-KO mice showed a more rapid onset and development of colitis compared to IL-10 KO mice. Lcn2 enhanced phagocytic bacterial clearance in macrophages in vitro after infection with Escherichia coli. Transfer of Lcn2-repleted macrophages prevented the development of colitis in Lcn2/IL-10 double-KO mice in vivo. Our findings revealed that Lcn2 prevents the development of intestinal inflammation. One crucial factor seems to be the enhancement of phagocytic bacterial clearance in macrophages by Lcn2.
ArticleNumber 35014
Author Yamada, Satoshi
Toyonaga, Takahiko
Matsuura, Minoru
Honzawa, Yusuke
Minami, Naoki
Kobayashi, Taku
Nakase, Hiroshi
Hibi, Toshifumi
Mori, Kiyoshi
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  organization: Department of Gastroenterology & Hepatology, Graduate School of Medicine, Kyoto University, 54 shogoin, Kawahara-cho, Sakyo-ku, Kyoto
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  surname: Mori
  fullname: Mori, Kiyoshi
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  givenname: Yusuke
  surname: Honzawa
  fullname: Honzawa, Yusuke
  organization: Department of Gastroenterology & Hepatology, Graduate School of Medicine, Kyoto University, 54 shogoin, Kawahara-cho, Sakyo-ku, Kyoto
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  surname: Kobayashi
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  surname: Hibi
  fullname: Hibi, Toshifumi
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  organization: Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27734904$$D View this record in MEDLINE/PubMed
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Cites_doi 10.4049/jimmunol.171.12.6630
10.1038/ng1954
10.1172/JCI59150
10.1038/nri3228
10.1038/ni.2419
10.1016/j.jcmgh.2016.03.007
10.1210/me.2007-0420
10.1006/cyto.1998.0355
10.1111/jgh.12073
10.1016/S1097-2765(02)00708-6
10.1136/gutjnl-2011-300694
10.1128/IAI.66.11.5224-5231.1998
10.1038/nrmicro1046
10.1016/S0167-4838(00)00148-5
10.1016/S0021-9258(18)82217-7
10.1038/ng2032
10.4049/jimmunol.0803282
10.1136/gut.38.3.414
10.1093/aje/kwn218
10.1007/s00535-011-0516-5
10.1172/JCI67911
10.1038/ctg.2012.2
10.1136/gut.2010.221879
10.1124/jpet.108.141085
10.2310/JIM.0b013e3181ccc20c
10.1111/cei.12136
10.1038/ng.215
10.1038/nri3532
10.1038/nri2707
10.1111/apt.12501
10.1016/S1097-2765(02)00710-4
10.1038/ncpgasthep0528
10.1038/nature03104
10.1073/pnas.1407001111
10.1152/ajpgi.00004.2013
10.1016/j.clim.2003.09.013
10.1053/j.gastro.2006.05.051
10.4049/jimmunol.1101128
10.1136/gut.2010.216929
10.1128/AEM.69.2.1251-1262.2003
10.1111/j.1572-0241.1999.01439.x
10.12938/bifidus.25.99
10.1016/j.cell.2005.10.027
10.1371/journal.pone.0044328
10.1016/j.immuni.2013.08.026
10.1016/j.immuni.2014.03.012
10.1084/jem.192.2.227
10.4049/jimmunol.151.3.1535
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References Yang (CR9) 2002; 10
Schaible, Kaufmann (CR10) 2004; 2
Flo (CR11) 2004; 432
Arai, Takanashi, Kitagawa, Okayasu (CR42) 1998; 10
Flower, North, Sansom (CR5) 2000; 1482
Hampe (CR35) 2007; 39
Sellon (CR41) 1998; 66
Obata (CR27) 2012; 188
Nielsen (CR16) 1996; 38
Mikami (CR39) 2008; 327
Rioux (CR34) 2007; 39
Nagashima, Hisada, Sato, Mochizuki (CR44) 2003; 69
Zigmond (CR22) 2014; 40
Playford (CR7) 2006; 131
Stallhofer (CR26) 2015; 21
Zhang (CR31) 2008; 22
Werner (CR4) 2011; 60
Devireddy, Gazin, Zhu, Green (CR8) 2005; 123
Lassen (CR37) 2014; 111
Cayatte (CR25) 2012; 16
Abreu (CR23) 2010; 10
Medina-Contreras (CR48) 2011; 121
Gautier (CR30) 2012; 13
Vazquez-Torres, Jones-Carson, Mastroeni, Ischiropoulos, Fang (CR47) 2000; 192
Uza (CR40) 2011; 60
Chassaing (CR15) 2012; 7
Bolignano (CR19) 2010; 58
Gallo, Hooper (CR28) 2012; 12
Ogawa, Andoh, Araki, Bamba, Fujiyama (CR43) 2004; 110
Bakhautdin (CR49) 2013; 62
Chan (CR14) 2009; 182
Østvik (CR17) 2013; 173
Cowland, Sørensen, Sehested, Borregaard (CR24) 2003; 171
Warszawska (CR32) 2013; 123
Valatas, Vakas, Kolios (CR21) 2013; 305
Goetz (CR6) 2002; 10
Fujimoto (CR46) 2013; 28
Aamodt (CR3) 2008; 168
Oikonomou (CR18) 2012; 47
Sartor (CR1) 2006; 3
Singh (CR29) 2016; 2
Deretic, Saitoh, Akira (CR33) 2013; 13
Bonilla (CR38) 2013; 39
Meheus (CR13) 1993; 151
Nagashima, Mochizuki, Hisada, Suzuki, Shimomura (CR45) 2006; 25
Kjeldsen, Johnsen, Sengeløv, Borregaard (CR12) 1993; 268
Spooren (CR2) 2013; 38
McCarroll (CR36) 2008; 40
Nielsen (CR20) 1999; 94
J Zhang (BFsrep35014_CR31) 2008; 22
Y Arai (BFsrep35014_CR42) 1998; 10
N Uza (BFsrep35014_CR40) 2011; 60
UE Schaible (BFsrep35014_CR10) 2004; 2
B Bakhautdin (BFsrep35014_CR49) 2013; 62
JM Warszawska (BFsrep35014_CR32) 2013; 123
K Nagashima (BFsrep35014_CR45) 2006; 25
V Deretic (BFsrep35014_CR33) 2013; 13
L Kjeldsen (BFsrep35014_CR12) 1993; 268
SA McCarroll (BFsrep35014_CR36) 2008; 40
T Werner (BFsrep35014_CR4) 2011; 60
S Mikami (BFsrep35014_CR39) 2008; 327
K Nagashima (BFsrep35014_CR44) 2003; 69
V Valatas (BFsrep35014_CR21) 2013; 305
J Yang (BFsrep35014_CR9) 2002; 10
CE Spooren (BFsrep35014_CR2) 2013; 38
Y Obata (BFsrep35014_CR27) 2012; 188
RK Sellon (BFsrep35014_CR41) 1998; 66
DH Goetz (BFsrep35014_CR6) 2002; 10
V Singh (BFsrep35014_CR29) 2016; 2
TH Flo (BFsrep35014_CR11) 2004; 432
C Cayatte (BFsrep35014_CR25) 2012; 16
JD Rioux (BFsrep35014_CR34) 2007; 39
O Medina-Contreras (BFsrep35014_CR48) 2011; 121
EL Gautier (BFsrep35014_CR30) 2012; 13
A Vazquez-Torres (BFsrep35014_CR47) 2000; 192
DL Bonilla (BFsrep35014_CR38) 2013; 39
AE Østvik (BFsrep35014_CR17) 2013; 173
DR Flower (BFsrep35014_CR5) 2000; 1482
RB Sartor (BFsrep35014_CR1) 2006; 3
LA Meheus (BFsrep35014_CR13) 1993; 151
MT Abreu (BFsrep35014_CR23) 2010; 10
T Fujimoto (BFsrep35014_CR46) 2013; 28
LR Devireddy (BFsrep35014_CR8) 2005; 123
RJ Playford (BFsrep35014_CR7) 2006; 131
A Ogawa (BFsrep35014_CR43) 2004; 110
B Chassaing (BFsrep35014_CR15) 2012; 7
E Zigmond (BFsrep35014_CR22) 2014; 40
G Aamodt (BFsrep35014_CR3) 2008; 168
KG Lassen (BFsrep35014_CR37) 2014; 111
D Bolignano (BFsrep35014_CR19) 2010; 58
BS Nielsen (BFsrep35014_CR16) 1996; 38
J Stallhofer (BFsrep35014_CR26) 2015; 21
KA Oikonomou (BFsrep35014_CR18) 2012; 47
JB Cowland (BFsrep35014_CR24) 2003; 171
RL Gallo (BFsrep35014_CR28) 2012; 12
YR Chan (BFsrep35014_CR14) 2009; 182
OH Nielsen (BFsrep35014_CR20) 1999; 94
J Hampe (BFsrep35014_CR35) 2007; 39
17200669 - Nat Genet. 2007 Feb;39(2):207-11
12453412 - Mol Cell. 2002 Nov;10 (5):1033-43
19342674 - J Immunol. 2009 Apr 15;182(8):4947-56
7683678 - J Biol Chem. 1993 May 15;268(14 ):10425-32
18716065 - J Pharmacol Exp Ther. 2008 Nov;327(2):383-92
12453413 - Mol Cell. 2002 Nov;10(5):1045-56
24118051 - Aliment Pharmacol Ther. 2013 Nov;38(10 ):1172-87
22279105 - J Immunol. 2012 Mar 1;188(5):2427-36
26263469 - Inflamm Bowel Dis. 2015 Oct;21(10 ):2327-40
15550940 - Nat Rev Microbiol. 2004 Dec;2(12):946-53
21076126 - Gut. 2011 Mar;60(3):325-33
23668802 - Clin Exp Immunol. 2013 Sep;173(3):502-11
20098461 - Nat Rev Immunol. 2010 Feb;10 (2):131-44
10520846 - Am J Gastroenterol. 1999 Oct;94(10 ):2923-8
19165925 - Nat Genet. 2008 Sep;40(9):1107-12
23216550 - J Gastroenterol Hepatol. 2013 Apr;28(4):613-9
12571054 - Appl Environ Microbiol. 2003 Feb;69(2):1251-62
15531878 - Nature. 2004 Dec 16;432(7019):917-21
24064518 - Nat Rev Immunol. 2013 Oct;13(10):722-37
20061984 - J Investig Med. 2010 Mar;58(3):569-71
23023392 - Nat Immunol. 2012 Nov;13(11):1118-28
16377569 - Cell. 2005 Dec 29;123(7):1293-305
18801890 - Am J Epidemiol. 2008 Nov 1;168(9):1065-72
11058743 - Biochim Biophys Acta. 2000 Oct 18;1482(1-2):9-24
18292240 - Mol Endocrinol. 2008 Jun;22(6):1416-26
9878126 - Cytokine. 1998 Nov;10(11):890-6
22345661 - Gut. 2013 Feb;62(2):209-19
27458605 - Cell Mol Gastroenterol Hepatol. 2016 Jul;2(4):482-498.e6
16952550 - Gastroenterology. 2006 Sep;131(3):809-17
21471570 - Gut. 2011 Nov;60(11):1494-505
22957064 - PLoS One. 2012;7(9):e44328
22045567 - J Clin Invest. 2011 Dec;121(12):4787-95
10899909 - J Exp Med. 2000 Jul 17;192(2):227-36
23238132 - Clin Transl Gastroenterol. 2012 Feb 16;3:e10
24821797 - Proc Natl Acad Sci U S A. 2014 May 27;111(21):7741-6
9784526 - Infect Immun. 1998 Nov;66(11):5224-31
24792913 - Immunity. 2014 May 15;40(5):720-33
14962796 - Clin Immunol. 2004 Jan;110(1):55-62
8675096 - Gut. 1996 Mar;38(3):414-20
16819502 - Nat Clin Pract Gastroenterol Hepatol. 2006 Jul;3(7):390-407
22728527 - Nat Rev Immunol. 2012 Jun 25;12(7):503-16
14662866 - J Immunol. 2003 Dec 15;171(12 ):6630-9
17435756 - Nat Genet. 2007 May;39(5):596-604
8335946 - J Immunol. 1993 Aug 1;151(3):1535-47
23863624 - J Clin Invest. 2013 Aug;123(8):3363-72
22200942 - J Gastroenterol. 2012 May;47(5):519-30
23989010 - Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(11):G763-85
24035364 - Immunity. 2013 Sep 19;39(3):537-47
References_xml – volume: 171
  start-page: 6630
  year: 2003
  end-page: 6639
  ident: CR24
  article-title: Neutrophil gelatinase-associated lipocalin is up-regulated in human epithelial cells by IL-1 beta, but not by TNF-alpha
  publication-title: J Immunol.
  doi: 10.4049/jimmunol.171.12.6630
– volume: 39
  start-page: 207
  year: 2007
  end-page: 211
  ident: CR35
  article-title: A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
  publication-title: Nat Genet
  doi: 10.1038/ng1954
– volume: 121
  start-page: 4787
  year: 2011
  end-page: 4795
  ident: CR48
  article-title: CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice
  publication-title: J Clin Invest.
  doi: 10.1172/JCI59150
– volume: 12
  start-page: 503
  year: 2012
  end-page: 516
  ident: CR28
  article-title: Epithelial antimicrobial defence of the skin and intestine
  publication-title: Nat Rev Immunol.
  doi: 10.1038/nri3228
– volume: 13
  start-page: 1118
  year: 2012
  end-page: 1128
  ident: CR30
  article-title: Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
  publication-title: Nat Immunol.
  doi: 10.1038/ni.2419
– volume: 2
  start-page: 482
  year: 2016
  end-page: 498
  ident: CR29
  article-title: Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis
  publication-title: Cell Mol Gastroenterol Hepatol.
  doi: 10.1016/j.jcmgh.2016.03.007
– volume: 22
  start-page: 1416
  year: 2008
  end-page: 1426
  ident: CR31
  article-title: The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages
  publication-title: Mol Endocrinol.
  doi: 10.1210/me.2007-0420
– volume: 10
  start-page: 890
  year: 1998
  end-page: 896
  ident: CR42
  article-title: Involvement of interleukin-1 in the development of ulcerative colitis induced by dextran sulfate sodium in mice
  publication-title: Cytokine.
  doi: 10.1006/cyto.1998.0355
– volume: 28
  start-page: 613
  year: 2013
  end-page: 619
  ident: CR46
  article-title: Decreased abundance of Faecalibacterium prausnitzii in the gut microbiota of Crohn’s disease
  publication-title: J Gastroenterol Hepatol.
  doi: 10.1111/jgh.12073
– volume: 10
  start-page: 1033
  year: 2002
  end-page: 1043
  ident: CR6
  article-title: The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition
  publication-title: Mol Cell.
  doi: 10.1016/S1097-2765(02)00708-6
– volume: 62
  start-page: 209
  year: 2013
  end-page: 219
  ident: CR49
  article-title: Protective role of macrophage-derived ceruloplasmin in inflammatory bowel disease
  publication-title: Gut.
  doi: 10.1136/gutjnl-2011-300694
– volume: 66
  start-page: 5224
  year: 1998
  end-page: 5231
  ident: CR41
  article-title: Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice
  publication-title: Infect Immun.
  doi: 10.1128/IAI.66.11.5224-5231.1998
– volume: 2
  start-page: 946
  year: 2004
  end-page: 953
  ident: CR10
  article-title: Iron and microbial infection
  publication-title: Nat Rev Microbiol.
  doi: 10.1038/nrmicro1046
– volume: 1482
  start-page: 9
  year: 2000
  end-page: 24
  ident: CR5
  article-title: The lipocalin protein family: structural and sequence overview
  publication-title: Biochim Biophys Acta.
  doi: 10.1016/S0167-4838(00)00148-5
– volume: 268
  start-page: 10425
  year: 1993
  end-page: 10432
  ident: CR12
  article-title: Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase
  publication-title: J Biol Chem.
  doi: 10.1016/S0021-9258(18)82217-7
– volume: 39
  start-page: 596
  year: 2007
  end-page: 604
  ident: CR34
  article-title: Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
  publication-title: Nat Genet
  doi: 10.1038/ng2032
– volume: 182
  start-page: 4947
  year: 2009
  end-page: 4956
  ident: CR14
  article-title: Lipocalin 2 is required for pulmonary host defense against Klebsiella infection
  publication-title: J Immunol.
  doi: 10.4049/jimmunol.0803282
– volume: 38
  start-page: 414
  year: 1996
  end-page: 420
  ident: CR16
  article-title: Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases
  publication-title: Gut.
  doi: 10.1136/gut.38.3.414
– volume: 168
  start-page: 1065
  year: 2008
  end-page: 1072
  ident: CR3
  article-title: The association between water supply and inflammatory bowel disease based on a 1990-1993 cohort study in southeastern Norway
  publication-title: Am J Epidemiol.
  doi: 10.1093/aje/kwn218
– volume: 47
  start-page: 519
  year: 2012
  end-page: 530
  ident: CR18
  article-title: Neutrophil gelatinase-associated lipocalin (NGAL) in inflammatory bowel disease: association with pathophysiology of inflammation, established markers, and disease activity
  publication-title: J Gastroenterol.
  doi: 10.1007/s00535-011-0516-5
– volume: 123
  start-page: 3363
  year: 2013
  end-page: 3372
  ident: CR32
  article-title: Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes
  publication-title: J Clin Invest.
  doi: 10.1172/JCI67911
– volume: 16
  start-page: e10
  year: 2012
  ident: CR25
  article-title: Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease
  publication-title: Clin Transl Gastroenterol.
  doi: 10.1038/ctg.2012.2
– volume: 60
  start-page: 1494
  year: 2011
  end-page: 1505
  ident: CR40
  article-title: SR-PSOX/CXCL16 plays a critical role in the progression of colonic inflammation
  publication-title: Gut.
  doi: 10.1136/gut.2010.221879
– volume: 327
  start-page: 383
  year: 2008
  end-page: 392
  ident: CR39
  article-title: Blockade of CXCL12/CXCR4 axis ameliorates murine experimental colitis
  publication-title: J Pharmacol Exp Ther.
  doi: 10.1124/jpet.108.141085
– volume: 58
  start-page: 569
  year: 2010
  end-page: 571
  ident: CR19
  article-title: Neutrophil gelatinase-associated lipocalin levels in patients with crohn disease undergoing treatment with infliximab
  publication-title: J Investig Med.
  doi: 10.2310/JIM.0b013e3181ccc20c
– volume: 173
  start-page: 502
  year: 2013
  end-page: 511
  ident: CR17
  article-title: Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2
  publication-title: Clin Exp Immunol.
  doi: 10.1111/cei.12136
– volume: 40
  start-page: 1107
  year: 2008
  end-page: 1112
  ident: CR36
  article-title: Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn’s disease
  publication-title: Nat Genet
  doi: 10.1038/ng.215
– volume: 13
  start-page: 722
  year: 2013
  end-page: 737
  ident: CR33
  article-title: Autophagy in infection, inflammation and immunity
  publication-title: Nat Rev Immunol.
  doi: 10.1038/nri3532
– volume: 10
  start-page: 131
  year: 2010
  end-page: 144
  ident: CR23
  article-title: Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function
  publication-title: Nat Rev Immunol.
  doi: 10.1038/nri2707
– volume: 38
  start-page: 1172
  year: 2013
  end-page: 1187
  ident: CR2
  article-title: Review article: the association of diet with onset and relapse in patients with inflammatory bowel disease
  publication-title: Aliment Pharmacol Ther.
  doi: 10.1111/apt.12501
– volume: 10
  start-page: 1045
  year: 2002
  end-page: 1056
  ident: CR9
  article-title: An iron delivery pathway mediated by a lipocalin
  publication-title: Mol Cell.
  doi: 10.1016/S1097-2765(02)00710-4
– volume: 3
  start-page: 390
  year: 2006
  end-page: 407
  ident: CR1
  article-title: Mechanisms of disease: pathogenesis of Crohn’s disease and ulcerative colitis
  publication-title: Nat Clin Pract Gastroenterol Hepatol.
  doi: 10.1038/ncpgasthep0528
– volume: 432
  start-page: 917
  year: 2004
  end-page: 921
  ident: CR11
  article-title: Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
  publication-title: Nature.
  doi: 10.1038/nature03104
– volume: 111
  start-page: 7741
  year: 2014
  end-page: 7746
  ident: CR37
  article-title: Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1407001111
– volume: 305
  start-page: G763
  year: 2013
  end-page: G785
  ident: CR21
  article-title: The value of experimental models of colitis in predicting efficacy of biological therapies for inflammatory bowel diseases
  publication-title: Am J Physiol Gastrointest Liver Physiol.
  doi: 10.1152/ajpgi.00004.2013
– volume: 110
  start-page: 55
  year: 2004
  end-page: 62
  ident: CR43
  article-title: Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice
  publication-title: Clin Immunol.
  doi: 10.1016/j.clim.2003.09.013
– volume: 131
  start-page: 809
  year: 2006
  end-page: 817
  ident: CR7
  article-title: Effects of mouse and human lipocalin homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin on gastrointestinal mucosal integrity and repair
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2006.05.051
– volume: 188
  start-page: 2427
  year: 2012
  end-page: 2436
  ident: CR27
  article-title: Epithelial cell-intrinsic Notch signaling plays an essential role in the maintenance of gut immune homeostasis
  publication-title: J Immunol.
  doi: 10.4049/jimmunol.1101128
– volume: 60
  start-page: 325
  year: 2011
  end-page: 333
  ident: CR4
  article-title: Depletion of luminal iron alters the gut microbiota and prevents Crohn’s disease-like ileitis
  publication-title: Gut.
  doi: 10.1136/gut.2010.216929
– volume: 69
  start-page: 1251
  year: 2003
  end-page: 1262
  ident: CR44
  article-title: Application of new primer-enzyme combinations to terminal restriction fragment length polymorphism profiling of bacterial populations in human feces
  publication-title: Appl Environ Microbiol.
  doi: 10.1128/AEM.69.2.1251-1262.2003
– volume: 94
  start-page: 2923
  year: 1999
  end-page: 2928
  ident: CR20
  article-title: Rectal dialysate and fecal concentrations of neutrophil gelatinase-associated lipocalin, interleukin-8, and tumor necrosis factor-alpha in ulcerative colitis
  publication-title: Am J Gastroenterol.
  doi: 10.1111/j.1572-0241.1999.01439.x
– volume: 21
  start-page: 2327
  year: 2015
  end-page: 2340
  ident: CR26
  article-title: Lipocalin-2 Is a Disease Activity Marker in Inflammatory Bowel Disease Regulated by IL-17A, IL-22, and TNF-α and Modulated by IL23R Genotype Status
  publication-title: Inflamm Bowel Dis.
– volume: 25
  start-page: 99
  year: 2006
  end-page: 107
  ident: CR45
  article-title: Phylogenetic analysis of 16S ribosomal RNA gene sequences from Human fecal microbiota and improved utility of terminal restriction fragment length polymorphism profiling
  publication-title: Bioscience Microflora.
  doi: 10.12938/bifidus.25.99
– volume: 123
  start-page: 1293
  year: 2005
  end-page: 1305
  ident: CR8
  article-title: A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake
  publication-title: Cell.
  doi: 10.1016/j.cell.2005.10.027
– volume: 7
  start-page: e44328
  year: 2012
  ident: CR15
  article-title: Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation
  publication-title: Plos One.
  doi: 10.1371/journal.pone.0044328
– volume: 39
  start-page: 537
  year: 2013
  end-page: 547
  ident: CR38
  article-title: Autophagy regulates phagocytosis by modulating the expression of scavenger receptors
  publication-title: Immunity.
  doi: 10.1016/j.immuni.2013.08.026
– volume: 40
  start-page: 720
  year: 2014
  end-page: 733
  ident: CR22
  article-title: Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis
  publication-title: Immunity.
  doi: 10.1016/j.immuni.2014.03.012
– volume: 151
  start-page: 1535
  year: 1993
  end-page: 1547
  ident: CR13
  article-title: Identification by microsequencing of lipopolysaccharide-induced proteins secreted by mouse macrophages
  publication-title: J Immunol.
– volume: 192
  start-page: 227
  year: 2000
  end-page: 236
  ident: CR47
  article-title: Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages
  publication-title: J Exp Med.
  doi: 10.1084/jem.192.2.227
– volume: 40
  start-page: 720
  year: 2014
  ident: BFsrep35014_CR22
  publication-title: Immunity.
  doi: 10.1016/j.immuni.2014.03.012
– volume: 38
  start-page: 1172
  year: 2013
  ident: BFsrep35014_CR2
  publication-title: Aliment Pharmacol Ther.
  doi: 10.1111/apt.12501
– volume: 28
  start-page: 613
  year: 2013
  ident: BFsrep35014_CR46
  publication-title: J Gastroenterol Hepatol.
  doi: 10.1111/jgh.12073
– volume: 171
  start-page: 6630
  year: 2003
  ident: BFsrep35014_CR24
  publication-title: J Immunol.
  doi: 10.4049/jimmunol.171.12.6630
– volume: 10
  start-page: 890
  year: 1998
  ident: BFsrep35014_CR42
  publication-title: Cytokine.
  doi: 10.1006/cyto.1998.0355
– volume: 111
  start-page: 7741
  year: 2014
  ident: BFsrep35014_CR37
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1407001111
– volume: 10
  start-page: 1045
  year: 2002
  ident: BFsrep35014_CR9
  publication-title: Mol Cell.
  doi: 10.1016/S1097-2765(02)00710-4
– volume: 327
  start-page: 383
  year: 2008
  ident: BFsrep35014_CR39
  publication-title: J Pharmacol Exp Ther.
  doi: 10.1124/jpet.108.141085
– volume: 10
  start-page: 131
  year: 2010
  ident: BFsrep35014_CR23
  publication-title: Nat Rev Immunol.
  doi: 10.1038/nri2707
– volume: 1482
  start-page: 9
  year: 2000
  ident: BFsrep35014_CR5
  publication-title: Biochim Biophys Acta.
  doi: 10.1016/S0167-4838(00)00148-5
– volume: 3
  start-page: 390
  year: 2006
  ident: BFsrep35014_CR1
  publication-title: Nat Clin Pract Gastroenterol Hepatol.
  doi: 10.1038/ncpgasthep0528
– volume: 173
  start-page: 502
  year: 2013
  ident: BFsrep35014_CR17
  publication-title: Clin Exp Immunol.
  doi: 10.1111/cei.12136
– volume: 40
  start-page: 1107
  year: 2008
  ident: BFsrep35014_CR36
  publication-title: Nat Genet
  doi: 10.1038/ng.215
– volume: 7
  start-page: e44328
  year: 2012
  ident: BFsrep35014_CR15
  publication-title: Plos One.
  doi: 10.1371/journal.pone.0044328
– volume: 39
  start-page: 537
  year: 2013
  ident: BFsrep35014_CR38
  publication-title: Immunity.
  doi: 10.1016/j.immuni.2013.08.026
– volume: 94
  start-page: 2923
  year: 1999
  ident: BFsrep35014_CR20
  publication-title: Am J Gastroenterol.
  doi: 10.1111/j.1572-0241.1999.01439.x
– volume: 16
  start-page: e10
  year: 2012
  ident: BFsrep35014_CR25
  publication-title: Clin Transl Gastroenterol.
  doi: 10.1038/ctg.2012.2
– volume: 2
  start-page: 946
  year: 2004
  ident: BFsrep35014_CR10
  publication-title: Nat Rev Microbiol.
  doi: 10.1038/nrmicro1046
– volume: 123
  start-page: 3363
  year: 2013
  ident: BFsrep35014_CR32
  publication-title: J Clin Invest.
  doi: 10.1172/JCI67911
– volume: 305
  start-page: G763
  year: 2013
  ident: BFsrep35014_CR21
  publication-title: Am J Physiol Gastrointest Liver Physiol.
  doi: 10.1152/ajpgi.00004.2013
– volume: 432
  start-page: 917
  year: 2004
  ident: BFsrep35014_CR11
  publication-title: Nature.
  doi: 10.1038/nature03104
– volume: 192
  start-page: 227
  year: 2000
  ident: BFsrep35014_CR47
  publication-title: J Exp Med.
  doi: 10.1084/jem.192.2.227
– volume: 69
  start-page: 1251
  year: 2003
  ident: BFsrep35014_CR44
  publication-title: Appl Environ Microbiol.
  doi: 10.1128/AEM.69.2.1251-1262.2003
– volume: 39
  start-page: 207
  year: 2007
  ident: BFsrep35014_CR35
  publication-title: Nat Genet
  doi: 10.1038/ng1954
– volume: 58
  start-page: 569
  year: 2010
  ident: BFsrep35014_CR19
  publication-title: J Investig Med.
  doi: 10.2310/JIM.0b013e3181ccc20c
– volume: 62
  start-page: 209
  year: 2013
  ident: BFsrep35014_CR49
  publication-title: Gut.
  doi: 10.1136/gutjnl-2011-300694
– volume: 131
  start-page: 809
  year: 2006
  ident: BFsrep35014_CR7
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2006.05.051
– volume: 13
  start-page: 722
  year: 2013
  ident: BFsrep35014_CR33
  publication-title: Nat Rev Immunol.
  doi: 10.1038/nri3532
– volume: 39
  start-page: 596
  year: 2007
  ident: BFsrep35014_CR34
  publication-title: Nat Genet
  doi: 10.1038/ng2032
– volume: 188
  start-page: 2427
  year: 2012
  ident: BFsrep35014_CR27
  publication-title: J Immunol.
  doi: 10.4049/jimmunol.1101128
– volume: 182
  start-page: 4947
  year: 2009
  ident: BFsrep35014_CR14
  publication-title: J Immunol.
  doi: 10.4049/jimmunol.0803282
– volume: 22
  start-page: 1416
  year: 2008
  ident: BFsrep35014_CR31
  publication-title: Mol Endocrinol.
  doi: 10.1210/me.2007-0420
– volume: 2
  start-page: 482
  year: 2016
  ident: BFsrep35014_CR29
  publication-title: Cell Mol Gastroenterol Hepatol.
  doi: 10.1016/j.jcmgh.2016.03.007
– volume: 268
  start-page: 10425
  year: 1993
  ident: BFsrep35014_CR12
  publication-title: J Biol Chem.
  doi: 10.1016/S0021-9258(18)82217-7
– volume: 21
  start-page: 2327
  year: 2015
  ident: BFsrep35014_CR26
  publication-title: Inflamm Bowel Dis.
– volume: 110
  start-page: 55
  year: 2004
  ident: BFsrep35014_CR43
  publication-title: Clin Immunol.
  doi: 10.1016/j.clim.2003.09.013
– volume: 121
  start-page: 4787
  year: 2011
  ident: BFsrep35014_CR48
  publication-title: J Clin Invest.
  doi: 10.1172/JCI59150
– volume: 60
  start-page: 1494
  year: 2011
  ident: BFsrep35014_CR40
  publication-title: Gut.
  doi: 10.1136/gut.2010.221879
– volume: 10
  start-page: 1033
  year: 2002
  ident: BFsrep35014_CR6
  publication-title: Mol Cell.
  doi: 10.1016/S1097-2765(02)00708-6
– volume: 47
  start-page: 519
  year: 2012
  ident: BFsrep35014_CR18
  publication-title: J Gastroenterol.
  doi: 10.1007/s00535-011-0516-5
– volume: 66
  start-page: 5224
  year: 1998
  ident: BFsrep35014_CR41
  publication-title: Infect Immun.
  doi: 10.1128/IAI.66.11.5224-5231.1998
– volume: 168
  start-page: 1065
  year: 2008
  ident: BFsrep35014_CR3
  publication-title: Am J Epidemiol.
  doi: 10.1093/aje/kwn218
– volume: 12
  start-page: 503
  year: 2012
  ident: BFsrep35014_CR28
  publication-title: Nat Rev Immunol.
  doi: 10.1038/nri3228
– volume: 25
  start-page: 99
  year: 2006
  ident: BFsrep35014_CR45
  publication-title: Bioscience Microflora.
  doi: 10.12938/bifidus.25.99
– volume: 151
  start-page: 1535
  year: 1993
  ident: BFsrep35014_CR13
  publication-title: J Immunol.
  doi: 10.4049/jimmunol.151.3.1535
– volume: 13
  start-page: 1118
  year: 2012
  ident: BFsrep35014_CR30
  publication-title: Nat Immunol.
  doi: 10.1038/ni.2419
– volume: 60
  start-page: 325
  year: 2011
  ident: BFsrep35014_CR4
  publication-title: Gut.
  doi: 10.1136/gut.2010.216929
– volume: 123
  start-page: 1293
  year: 2005
  ident: BFsrep35014_CR8
  publication-title: Cell.
  doi: 10.1016/j.cell.2005.10.027
– volume: 38
  start-page: 414
  year: 1996
  ident: BFsrep35014_CR16
  publication-title: Gut.
  doi: 10.1136/gut.38.3.414
– reference: 22200942 - J Gastroenterol. 2012 May;47(5):519-30
– reference: 24792913 - Immunity. 2014 May 15;40(5):720-33
– reference: 17435756 - Nat Genet. 2007 May;39(5):596-604
– reference: 15550940 - Nat Rev Microbiol. 2004 Dec;2(12):946-53
– reference: 24035364 - Immunity. 2013 Sep 19;39(3):537-47
– reference: 18292240 - Mol Endocrinol. 2008 Jun;22(6):1416-26
– reference: 20061984 - J Investig Med. 2010 Mar;58(3):569-71
– reference: 10520846 - Am J Gastroenterol. 1999 Oct;94(10 ):2923-8
– reference: 22345661 - Gut. 2013 Feb;62(2):209-19
– reference: 23989010 - Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(11):G763-85
– reference: 12453413 - Mol Cell. 2002 Nov;10(5):1045-56
– reference: 24064518 - Nat Rev Immunol. 2013 Oct;13(10):722-37
– reference: 9784526 - Infect Immun. 1998 Nov;66(11):5224-31
– reference: 24821797 - Proc Natl Acad Sci U S A. 2014 May 27;111(21):7741-6
– reference: 11058743 - Biochim Biophys Acta. 2000 Oct 18;1482(1-2):9-24
– reference: 18716065 - J Pharmacol Exp Ther. 2008 Nov;327(2):383-92
– reference: 22728527 - Nat Rev Immunol. 2012 Jun 25;12(7):503-16
– reference: 18801890 - Am J Epidemiol. 2008 Nov 1;168(9):1065-72
– reference: 26263469 - Inflamm Bowel Dis. 2015 Oct;21(10 ):2327-40
– reference: 14962796 - Clin Immunol. 2004 Jan;110(1):55-62
– reference: 12571054 - Appl Environ Microbiol. 2003 Feb;69(2):1251-62
– reference: 24118051 - Aliment Pharmacol Ther. 2013 Nov;38(10 ):1172-87
– reference: 16377569 - Cell. 2005 Dec 29;123(7):1293-305
– reference: 23023392 - Nat Immunol. 2012 Nov;13(11):1118-28
– reference: 22279105 - J Immunol. 2012 Mar 1;188(5):2427-36
– reference: 23216550 - J Gastroenterol Hepatol. 2013 Apr;28(4):613-9
– reference: 22045567 - J Clin Invest. 2011 Dec;121(12):4787-95
– reference: 21471570 - Gut. 2011 Nov;60(11):1494-505
– reference: 23668802 - Clin Exp Immunol. 2013 Sep;173(3):502-11
– reference: 8335946 - J Immunol. 1993 Aug 1;151(3):1535-47
– reference: 16819502 - Nat Clin Pract Gastroenterol Hepatol. 2006 Jul;3(7):390-407
– reference: 16952550 - Gastroenterology. 2006 Sep;131(3):809-17
– reference: 14662866 - J Immunol. 2003 Dec 15;171(12 ):6630-9
– reference: 10899909 - J Exp Med. 2000 Jul 17;192(2):227-36
– reference: 23863624 - J Clin Invest. 2013 Aug;123(8):3363-72
– reference: 20098461 - Nat Rev Immunol. 2010 Feb;10 (2):131-44
– reference: 19342674 - J Immunol. 2009 Apr 15;182(8):4947-56
– reference: 19165925 - Nat Genet. 2008 Sep;40(9):1107-12
– reference: 7683678 - J Biol Chem. 1993 May 15;268(14 ):10425-32
– reference: 9878126 - Cytokine. 1998 Nov;10(11):890-6
– reference: 17200669 - Nat Genet. 2007 Feb;39(2):207-11
– reference: 27458605 - Cell Mol Gastroenterol Hepatol. 2016 Jul;2(4):482-498.e6
– reference: 23238132 - Clin Transl Gastroenterol. 2012 Feb 16;3:e10
– reference: 12453412 - Mol Cell. 2002 Nov;10 (5):1033-43
– reference: 21076126 - Gut. 2011 Mar;60(3):325-33
– reference: 15531878 - Nature. 2004 Dec 16;432(7019):917-21
– reference: 8675096 - Gut. 1996 Mar;38(3):414-20
– reference: 22957064 - PLoS One. 2012;7(9):e44328
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Snippet Lipocalin 2 (Lcn2), also called neutrophil gelatinase B-associated lipocalin (NGAL), is an anti-microbial peptide originally identified in neutrophil granules....
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64/60
692/4020/1503/257
82/80
Animals
Colitis - genetics
Colitis - microbiology
Colon
Disease Models, Animal
E coli
Escherichia coli - physiology
Gene Knockout Techniques
Humanities and Social Sciences
Humans
Immunology
Inflammation
Inflammatory bowel disease
Interleukin-10 - genetics
Lipocalin-2 - genetics
Lipocalin-2 - metabolism
Macrophages
Macrophages - immunology
Macrophages - microbiology
Mice
Mice, Knockout
multidisciplinary
Neutrophils
Phagocytosis
Rodents
Science
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Title Lipocalin 2 prevents intestinal inflammation by enhancing phagocytic bacterial clearance in macrophages
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