Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk - Setchell, Kenneth DR; Brown, Nadine M; Zhao, Xueheng; Lindley, Stephanie L; Heubi, James E; King, Eileen C; Messina, Mark J (The American journal of clinical nutrition, 2011)
Keywords: administration & dosage; Adult; adults; Aged; Animals; Biological and medical sciences; blood; Breast; Breast - drug effects; Breast - metabolism; Breast cancer; breast neoplasms; Breast Neoplasms - chemically induced; Breast Neoplasms - prevention & control; breasts; Cancer; chemically induced; Child, Preschool; Cross-Over Studies; Diet; Disease Models, Animal; drug effects; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; genistein; Genistein - blood; Humans; Infant; infant formulas; infants; Isoflavones; Isoflavones - administration & dosage; Isoflavones - blood; Male; Mammary Glands, Animal; Mammary Glands, Animal - drug effects; Mammary Glands, Animal - metabolism; Mammary Neoplasms, Experimental; Mammary Neoplasms, Experimental - chemically induced; Mammary Neoplasms, Experimental - prevention & control; mass spectrometry; Metabolism; Mice; Mice, Inbred C57BL; Mice, Nude; Mice, Transgenic; Middle Aged; oral administration; Premenopause; Premenopause - blood; prevention & control; Rats; Rats, Sprague-Dawley; risk; Rodents; Soy Foods; Soy products; soymilk; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vitamin B; Young Adult; Human; Isoflavone; Breast disease; Rodentia; Breast cancer; Malignant tumor; Soybean; Metabolism; Mammary gland diseases; Vertebrata; Mammalia; Risk factor; Cancer