Global analyses revealed age‐related alterations in innate immune responses after stimulation of pathogen recognition receptors - Metcalf, Talibah U.; Cubas, Rafael A.; Ghneim, Khader; Cartwright, Michael J.; Grevenynghe, Julien Van; Richner, Justin M.; Olagnier, David P.; Wilkinson, Peter A.; Cameron, Mark J.; Park, Byung S.; Hiscott, John B.; Diamond, Michael S.; et al. (Aging cell, 2015)
Keywords: Adaptive Immunity - genetics; Adult; Aged; Aged, 80 and over; Aging; B cells; B-Lymphocytes - immunology; Biological response modifiers; Chemokines - metabolism; Comparative analysis; Cytokines - metabolism; Dendritic cells; Dendritic Cells - immunology; Disease susceptibility; Health aspects; Humans; Immune response; Immune system; Immunity, Innate - immunology; immunosenescence; Immunotherapy; innate immune agonists; innate immunity; Interferon; interferon signaling; Leukocytes, Mononuclear - metabolism; Lymphocyte Activation - genetics; Lymphocytes; Monocytes - immunology; Original; pattern recognition receptors; peripheral blood mononuclear cells; T cells; T-Lymphocytes - immunology; Vaccines; Young Adult; pattern recognition receptors; peripheral blood mononuclear cells; immunosenescence; interferon signaling; innate immunity; innate immune agonists