Prediction of missense mutation functionality depends on both the algorithm and sequence alignment employed - Hicks, Stephanie; Wheeler, David A.; Plon, Sharon E.; Kimmel, Marek (Human mutation, 2011)
Keywords: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Algorithms; Align-GVGD; BRCA1; BRCA1 protein; BRCA1 Protein - genetics; BRCA1 Protein - metabolism; Computational Biology; Evolution; Genes, Tumor Suppressor; Humans; Missense mutation; MLH1; MLH1 protein; MSH2; MSH2 protein; multiple sequence alignment; Mutation, Missense - genetics; MutL Protein Homolog 1; MutS Homolog 2 Protein - genetics; MutS Homolog 2 Protein - metabolism; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Nucleotide sequence; p53 protein; PolyPhen-2; Protein structure; Sequence Alignment - methods; Sequence Analysis, Protein; SIFT; TP53; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Xvar