Down-regulation of oxidative stress and COX-2 and iNOS expressions by dimethyl lithospermate in aged rat kidney
Oxidative stress has been proposed to be a major cause of aging and many age-related diseases. Peroxynitrite (ONOO − ), formed from the reaction of superoxide ( • O 2 − ) and nitric oxide (NO), is a cytotoxic species that can oxidize various cellular components, such as proteins, lipids, and DNA. Th...
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| Published in | Archives of pharmacal research Vol. 37; no. 8; pp. 1032 - 1038 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Heidelberg
Pharmaceutical Society of Korea
01.08.2014
대한약학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-6269 1976-3786 1976-3786 |
| DOI | 10.1007/s12272-014-0332-6 |
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| Abstract | Oxidative stress has been proposed to be a major cause of aging and many age-related diseases. Peroxynitrite (ONOO
−
), formed from the reaction of superoxide (
•
O
2
−
) and nitric oxide (NO), is a cytotoxic species that can oxidize various cellular components, such as proteins, lipids, and DNA. The present study investigated whether dimethyl lithospermate (DML), isolated from
Salvia miltiorrhiza
, modulates age-related increases of ONOO
−
, NO, and reactive species (RS) levels and expressions of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). For this study, 20-month-old rats were intraperitoneally injected with 5 or 10 mg/kg/day of DML, and 6-month-old rats were used as young control animals. Our results indicated that DML reduces ONOO
−
levels in a dose-dependent manner. The data also revealed that DML has significant inhibitory effects on NO metabolites and RS generation in a dose-dependent manner during aging. Furthermore, the results of Western blot analysis revealed that DML treatment reduces age-associated increases in COX-2 and iNOS expressions. Thus, this study found that DML caused the decrease of renal oxidative stress and COX-2 and iNOS expressions in aged rats. The significance of the present study is the finding of DML in its potential application against the aging process. |
|---|---|
| AbstractList | Oxidative stress has been proposed to be a major cause of aging and many age-related diseases. Peroxynitrite (ONOO(-)), formed from the reaction of superoxide ((•)O2 (-)) and nitric oxide (NO), is a cytotoxic species that can oxidize various cellular components, such as proteins, lipids, and DNA. The present study investigated whether dimethyl lithospermate (DML), isolated from Salvia miltiorrhiza, modulates age-related increases of ONOO(-), NO, and reactive species (RS) levels and expressions of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). For this study, 20-month-old rats were intraperitoneally injected with 5 or 10 mg/kg/day of DML, and 6-month-old rats were used as young control animals. Our results indicated that DML reduces ONOO(-) levels in a dose-dependent manner. The data also revealed that DML has significant inhibitory effects on NO metabolites and RS generation in a dose-dependent manner during aging. Furthermore, the results of Western blot analysis revealed that DML treatment reduces age-associated increases in COX-2 and iNOS expressions. Thus, this study found that DML caused the decrease of renal oxidative stress and COX-2 and iNOS expressions in aged rats. The significance of the present study is the finding of DML in its potential application against the aging process. Oxidative stress has been proposed to be a majorcause of aging and many age-related diseases. Peroxynitrite(ONOO-), formed from the reaction of superoxide (•O2-)and nitric oxide (NO), is a cytotoxic species that can oxidizevarious cellular components, such as proteins, lipids, andDNA. The present study investigated whether dimethyllithospermate (DML), isolated from Salvia miltiorrhiza,modulates age-related increases of ONOO-, NO, and reactivespecies (RS) levels and expressions of cyclooxygenase-2(COX-2) and inducible nitric oxide synthase (iNOS). For thisstudy, 20-month-old rats were intraperitoneally injected with5 or 10 mg/kg/day of DML, and 6-month-old rats were used as young control animals. Our results indicated that DMLreduces ONOO- levels in a dose-dependent manner. Thedata also revealed that DML has significant inhibitory effectson NO metabolites and RS generation in a dose-dependentmanner during aging. Furthermore, the results of Westernblot analysis revealed that DML treatment reduces ageassociatedincreases in COX-2 and iNOS expressions. Thus,this study found that DML caused the decrease of renaloxidative stress and COX-2 and iNOS expressions in agedrats. The significance of the present study is the finding ofDML in its potential application against the aging process. KCI Citation Count: 20 Oxidative stress has been proposed to be a major cause of aging and many age-related diseases. Peroxynitrite (ONOO − ), formed from the reaction of superoxide ( • O 2 − ) and nitric oxide (NO), is a cytotoxic species that can oxidize various cellular components, such as proteins, lipids, and DNA. The present study investigated whether dimethyl lithospermate (DML), isolated from Salvia miltiorrhiza , modulates age-related increases of ONOO − , NO, and reactive species (RS) levels and expressions of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). For this study, 20-month-old rats were intraperitoneally injected with 5 or 10 mg/kg/day of DML, and 6-month-old rats were used as young control animals. Our results indicated that DML reduces ONOO − levels in a dose-dependent manner. The data also revealed that DML has significant inhibitory effects on NO metabolites and RS generation in a dose-dependent manner during aging. Furthermore, the results of Western blot analysis revealed that DML treatment reduces age-associated increases in COX-2 and iNOS expressions. Thus, this study found that DML caused the decrease of renal oxidative stress and COX-2 and iNOS expressions in aged rats. The significance of the present study is the finding of DML in its potential application against the aging process. Oxidative stress has been proposed to be a major cause of aging and many age-related diseases. Peroxynitrite (ONOO⁻), formed from the reaction of superoxide (•O₂⁻) and nitric oxide (NO), is a cytotoxic species that can oxidize various cellular components, such as proteins, lipids, and DNA. The present study investigated whether dimethyl lithospermate (DML), isolated from Salvia miltiorrhiza, modulates age-related increases of ONOO⁻, NO, and reactive species (RS) levels and expressions of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). For this study, 20-month-old rats were intraperitoneally injected with 5 or 10 mg/kg/day of DML, and 6-month-old rats were used as young control animals. Our results indicated that DML reduces ONOO⁻levels in a dose-dependent manner. The data also revealed that DML has significant inhibitory effects on NO metabolites and RS generation in a dose-dependent manner during aging. Furthermore, the results of Western blot analysis revealed that DML treatment reduces age-associated increases in COX-2 and iNOS expressions. Thus, this study found that DML caused the decrease of renal oxidative stress and COX-2 and iNOS expressions in aged rats. The significance of the present study is the finding of DML in its potential application against the aging process. Oxidative stress has been proposed to be a major cause of aging and many age-related diseases. Peroxynitrite (ONOO(-)), formed from the reaction of superoxide ((•)O2 (-)) and nitric oxide (NO), is a cytotoxic species that can oxidize various cellular components, such as proteins, lipids, and DNA. The present study investigated whether dimethyl lithospermate (DML), isolated from Salvia miltiorrhiza, modulates age-related increases of ONOO(-), NO, and reactive species (RS) levels and expressions of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). For this study, 20-month-old rats were intraperitoneally injected with 5 or 10 mg/kg/day of DML, and 6-month-old rats were used as young control animals. Our results indicated that DML reduces ONOO(-) levels in a dose-dependent manner. The data also revealed that DML has significant inhibitory effects on NO metabolites and RS generation in a dose-dependent manner during aging. Furthermore, the results of Western blot analysis revealed that DML treatment reduces age-associated increases in COX-2 and iNOS expressions. Thus, this study found that DML caused the decrease of renal oxidative stress and COX-2 and iNOS expressions in aged rats. The significance of the present study is the finding of DML in its potential application against the aging process.Oxidative stress has been proposed to be a major cause of aging and many age-related diseases. Peroxynitrite (ONOO(-)), formed from the reaction of superoxide ((•)O2 (-)) and nitric oxide (NO), is a cytotoxic species that can oxidize various cellular components, such as proteins, lipids, and DNA. The present study investigated whether dimethyl lithospermate (DML), isolated from Salvia miltiorrhiza, modulates age-related increases of ONOO(-), NO, and reactive species (RS) levels and expressions of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). For this study, 20-month-old rats were intraperitoneally injected with 5 or 10 mg/kg/day of DML, and 6-month-old rats were used as young control animals. Our results indicated that DML reduces ONOO(-) levels in a dose-dependent manner. The data also revealed that DML has significant inhibitory effects on NO metabolites and RS generation in a dose-dependent manner during aging. Furthermore, the results of Western blot analysis revealed that DML treatment reduces age-associated increases in COX-2 and iNOS expressions. Thus, this study found that DML caused the decrease of renal oxidative stress and COX-2 and iNOS expressions in aged rats. The significance of the present study is the finding of DML in its potential application against the aging process. |
| Author | Kim, Hyung Keun Yoon, Taek Rim Choi, Yeon Ja Lee, Juyoun Lee, Jun Sik Choi, Jae Sue Chung, Jin Chung, Hae Young Kim, Hyung Suk |
| Author_xml | – sequence: 1 givenname: Yeon Ja surname: Choi fullname: Choi, Yeon Ja organization: Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University – sequence: 2 givenname: Hyung Suk surname: Kim fullname: Kim, Hyung Suk organization: Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University – sequence: 3 givenname: Juyoun surname: Lee fullname: Lee, Juyoun organization: Department of Periodontology, School of Dentistry, Pusan National University – sequence: 4 givenname: Jin surname: Chung fullname: Chung, Jin organization: Department of Periodontology, School of Dentistry, Pusan National University – sequence: 5 givenname: Jun Sik surname: Lee fullname: Lee, Jun Sik organization: Department of Biology, College of Natural Science, Chosun University – sequence: 6 givenname: Jae Sue surname: Choi fullname: Choi, Jae Sue organization: Faculty of Food Science and Biotechnology, Pukyong National University – sequence: 7 givenname: Taek Rim surname: Yoon fullname: Yoon, Taek Rim organization: Heart Research Center of Chonnam National University Hospital – sequence: 8 givenname: Hyung Keun surname: Kim fullname: Kim, Hyung Keun email: chemokines@paran.com organization: Heart Research Center of Chonnam National University Hospital – sequence: 9 givenname: Hae Young surname: Chung fullname: Chung, Hae Young email: hyjung@pusan.ac.kr organization: Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24469601$$D View this record in MEDLINE/PubMed https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001900213$$DAccess content in National Research Foundation of Korea (NRF) |
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| Keywords | Aging iNOS ONOO COX-2 Reactive species Dimethyl lithospermate |
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), formed from the reaction of superoxide... Oxidative stress has been proposed to be a major cause of aging and many age-related diseases. Peroxynitrite (ONOO(-)), formed from the reaction of superoxide... Oxidative stress has been proposed to be a major cause of aging and many age-related diseases. Peroxynitrite (ONOO⁻), formed from the reaction of superoxide... Oxidative stress has been proposed to be a majorcause of aging and many age-related diseases. Peroxynitrite(ONOO-), formed from the reaction of superoxide... |
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| Title | Down-regulation of oxidative stress and COX-2 and iNOS expressions by dimethyl lithospermate in aged rat kidney |
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