基质金属蛋白酶与乳腺癌
R737.9; 基质金属蛋白酶家族是锌依赖蛋白酶,是参与正常细胞外基质代谢的重要酶类.大量研究表明,它们在乳腺癌的浸润和转移中起着极为重要的作用.近来也有报道,它们对乳腺原发肿瘤的发生和生长也有重要的影响,基质金属蛋白酶以多种机制参与这些过程.临床上,基质金属蛋白酶对乳腺癌的治疗及预后的判断也有重要的价值.目前已经开发多种基质金属蛋白酶抑制剂治疗肿瘤并在进行Ⅰ、Ⅱ期临床试验,几种药物已经进入Ⅲ期临床试验.现在,人们采用多种方法研究基质金属蛋白酶对乳腺癌作用机制,以期为乳腺癌的治疗开辟一条新的途径....
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Published in | 癌症 Vol. 21; no. 9; pp. 1029 - 1034 |
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Main Authors | , |
Format | Journal Article |
Language | Chinese |
Published |
中山大学肿瘤防治中心胸科,广东广州,510060
2002
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Subjects | |
Online Access | Get full text |
ISSN | 1000-467X |
DOI | 10.3321/j.issn:1000-467X.2002.09.027 |
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Abstract | R737.9; 基质金属蛋白酶家族是锌依赖蛋白酶,是参与正常细胞外基质代谢的重要酶类.大量研究表明,它们在乳腺癌的浸润和转移中起着极为重要的作用.近来也有报道,它们对乳腺原发肿瘤的发生和生长也有重要的影响,基质金属蛋白酶以多种机制参与这些过程.临床上,基质金属蛋白酶对乳腺癌的治疗及预后的判断也有重要的价值.目前已经开发多种基质金属蛋白酶抑制剂治疗肿瘤并在进行Ⅰ、Ⅱ期临床试验,几种药物已经进入Ⅲ期临床试验.现在,人们采用多种方法研究基质金属蛋白酶对乳腺癌作用机制,以期为乳腺癌的治疗开辟一条新的途径. |
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AbstractList | R737.9; 基质金属蛋白酶家族是锌依赖蛋白酶,是参与正常细胞外基质代谢的重要酶类.大量研究表明,它们在乳腺癌的浸润和转移中起着极为重要的作用.近来也有报道,它们对乳腺原发肿瘤的发生和生长也有重要的影响,基质金属蛋白酶以多种机制参与这些过程.临床上,基质金属蛋白酶对乳腺癌的治疗及预后的判断也有重要的价值.目前已经开发多种基质金属蛋白酶抑制剂治疗肿瘤并在进行Ⅰ、Ⅱ期临床试验,几种药物已经进入Ⅲ期临床试验.现在,人们采用多种方法研究基质金属蛋白酶对乳腺癌作用机制,以期为乳腺癌的治疗开辟一条新的途径. |
Author | 杨名添 姚广裕 |
AuthorAffiliation | 中山大学肿瘤防治中心胸科,广东广州,510060 |
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Keywords | 基质金属蛋白酶 预后 乳腺肿瘤 基质金属蛋白酶抑制剂 转移 |
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Snippet | R737.9; 基质金属蛋白酶家族是锌依赖蛋白酶,是参与正常细胞外基质代谢的重要酶类.大量研究表明,它们在乳腺癌的浸润和转移中起着极为重要的作用.近来也有报道,它们对乳腺原... |
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Title | 基质金属蛋白酶与乳腺癌 |
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