雷公藤多甙诱导HL-60细胞凋亡

R733.71; 目的:探讨雷公藤多甙对HL-60细胞凋亡的作用.方法:应用细胞形态学检查,DNA凝胶电泳及流式细胞仪分析检测.结果:HL-60细胞加上雷公藤多甙10mg/L孵育72h,流式细胞仪检测细胞凋亡率为29.4%(与空白对照组比较,P<0.01).电镜检查和光镜检查均可见细胞核固缩、碎裂等.DNA电泳显示明显的梯状条带.结论:雷公藤多甙能诱导HL 60细胞凋亡,提示雷公藤多甙可能具有抗白血病作用....

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Published in癌症 Vol. 19; no. 12; pp. 1095 - 1097
Main Authors 唐加明, 陈安薇, 李濠德, 秦自科
Format Journal Article
LanguageChinese
Published 广州市第二人民医院血液科,广东广州510150%中山医科大学肿瘤医院综合三科,广东广州510060 2000
Subjects
细胞凋亡
雷公藤多甙
HL-60细胞
白血病
Online AccessGet full text
ISSN1000-467X
DOI10.3321/j.issn:1000-467X.2000.12.007

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Abstract R733.71; 目的:探讨雷公藤多甙对HL-60细胞凋亡的作用.方法:应用细胞形态学检查,DNA凝胶电泳及流式细胞仪分析检测.结果:HL-60细胞加上雷公藤多甙10mg/L孵育72h,流式细胞仪检测细胞凋亡率为29.4%(与空白对照组比较,P<0.01).电镜检查和光镜检查均可见细胞核固缩、碎裂等.DNA电泳显示明显的梯状条带.结论:雷公藤多甙能诱导HL 60细胞凋亡,提示雷公藤多甙可能具有抗白血病作用.
AbstractList R733.71; 目的:探讨雷公藤多甙对HL-60细胞凋亡的作用.方法:应用细胞形态学检查,DNA凝胶电泳及流式细胞仪分析检测.结果:HL-60细胞加上雷公藤多甙10mg/L孵育72h,流式细胞仪检测细胞凋亡率为29.4%(与空白对照组比较,P<0.01).电镜检查和光镜检查均可见细胞核固缩、碎裂等.DNA电泳显示明显的梯状条带.结论:雷公藤多甙能诱导HL 60细胞凋亡,提示雷公藤多甙可能具有抗白血病作用.
Author 陈安薇
李濠德
秦自科
唐加明
AuthorAffiliation 广州市第二人民医院血液科,广东广州510150%中山医科大学肿瘤医院综合三科,广东广州510060
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Author_FL CHEN An-wei
QIN Zi-ke
TANG Jia-ming
LI Hao-de
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DocumentTitle_FL Apoptosis induced by tripterygium glycosides in HL-60 cells
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Keywords 细胞凋亡
雷公藤多甙
HL-60细胞
白血病
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Snippet R733.71; 目的:探讨雷公藤多甙对HL-60细胞凋亡的作用.方法:应用细胞形态学检查,DNA凝胶电泳及流式细胞仪分析检测.结果:HL-60细胞加上雷公藤多甙10mg/L孵育72h,流式细胞仪...
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Title 雷公藤多甙诱导HL-60细胞凋亡
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