NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy - Miloudi, Khalil; Oubaha, Malika; Ménard, Catherine; Dejda, Agnieszka; Guber, Vera; Cagnone, Gael; Wilson, Ariel M.; Tétreault, Nicolas; Mawambo, Gaëlle; Binet, Francois; Chidiac, Rony; Delisle, Chantal; et al. (Proceedings of the National Academy of Sciences - PNAS, 2019)
Keywords: Adaptor Proteins, Signal Transducing - biosynthesis; Adherens junctions; Animals; Antigens, CD - metabolism; Biological Sciences; Cadherins; Cadherins - metabolism; Calcium-Binding Proteins - biosynthesis; Capillary Permeability; Diabetes; Diabetes mellitus; diabetic macular edema; Diabetic retinopathy; Diabetic Retinopathy - pathology; DLL4; Edema; Endothelial cells; Enzyme Activation; Hyperglycemia; Hyperglycemia - metabolism; JAG1; Jagged-1 Protein - biosynthesis; Jagged1 protein; Ligands; Mice; Neuronal-glial interactions; Neutralization; Nitric Oxide - biosynthesis; NOTCH; Notch1 protein; Permeability; PNAS Plus; Receptor, Notch1 - metabolism; Retina; Retinal Vessels - metabolism; Retinopathy; Signal Transduction; Signaling; src-Family Kinases - metabolism; Vascular Endothelial Growth Factor Receptor-2 - metabolism; β-Catenin; DLL4; NOTCH; JAG1; diabetic retinopathy; diabetic macular edema