Contribution of enhanced engagement of antigen presentation machinery to the clinical immunogenicity of a human interleukin (IL)‐21 receptor‐blocking therapeutic antibody - Xue, L.; Hickling, T.; Song, R.; Nowak, J.; Rup, B. (Clinical and experimental immunology, 2016)
Keywords: Antibodies, Monoclonal - pharmacology; Antibodies, Monoclonal - therapeutic use; Antigen presentation; Antigen Presentation - drug effects; antigen processing and presentation; Antigens, CD - metabolism; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cytokines; Dendritic Cells - drug effects; Dendritic Cells - immunology; Endosomes - metabolism; Epitopes, T-Lymphocyte - metabolism; HLA-DR Antigens - metabolism; Humans; IL‐21 receptor; immunogenicity; Interleukins - immunology; Lymphocyte Activation - drug effects; Machinery; Original; Risk assessment; T cell epitope; T cell proliferation; T-Lymphocytes - immunology; Translational; Tumor Necrosis Factor-alpha - secretion; Tumor necrosis factor-TNF; T cell epitope; antigen processing and presentation; T cell proliferation; IL-21 receptor; immunogenicity