Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1 - Nosol, Kamil; Romane, Ksenija; Irobalieva, Rossitza N.; Alam, Amer; Kowal, Julia; Fujita, Naoya; Locher, Kaspar P. (Proceedings of the National Academy of Sciences - PNAS, 2020)
Keywords: Acridines - metabolism; Antibodies, Monoclonal - metabolism; Antineoplastic Agents, Phytogenic - metabolism; ATP Binding Cassette Transporter, Subfamily B - antagonists & inhibitors; ATP Binding Cassette Transporter, Subfamily B - chemistry; ATP Binding Cassette Transporter, Subfamily B - metabolism; Biological Sciences; Biophysics and Computational Biology; Cell Proliferation; Cryoelectron Microscopy - methods; Drug Resistance, Multiple; Extrusion; HEK293 Cells; Humans; Inhibitors; Models, Molecular; Monoclonal antibodies; Multidrug resistance; Phenylalanine; Protein Binding; Protein Conformation; Substrate inhibition; Tetrahydroisoquinolines - metabolism; Therapeutic applications; Vincristine; Vincristine - metabolism; P-glycoprotein; ABCB1; ABC transporter; single-particle cryoelectron microscopy; structure