Prevalence of long QTc interval in methadone maintenance patients
There is a concern about cardiac rhythm disorders related to QTc interval prolongation induced by methadone. A cross-sectional study was designed to evaluate the prevalence of long QTc (LQTc) interval in patients in methadone maintenance treatment (MMT) and risk factors for LQTc. The study populatio...
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| Published in | Drug and alcohol dependence Vol. 99; no. 1-3; pp. 327 - 332 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Shannon
Elsevier Ireland Ltd
01.01.2009
Elsevier |
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| Online Access | Get full text |
| ISSN | 0376-8716 1879-0046 1879-0046 |
| DOI | 10.1016/j.drugalcdep.2008.06.018 |
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| Abstract | There is a concern about cardiac rhythm disorders related to QTc interval prolongation induced by methadone. A cross-sectional study was designed to evaluate the prevalence of long QTc (LQTc) interval in patients in methadone maintenance treatment (MMT) and risk factors for LQTc.
The study population included 109 subjects (74 males, median age 43 years). Socio-demographic and toxicological variables were recorded, as well as concomitant use of drugs related with QT prolongation, history of heart diseases, and corrected QT interval by heart rate (QTc) in the ECG. Plasma concentrations of (R)-methadone and (S)-methadone enantiomers were determined in 69 subjects.
Ten patients (9.2%) presented a QTc above 440ms but a QTc above 500ms was observed in only 2 (1.8%). Patients with QTc above 440ms compared with the remaining subjects were older (median [25th–75th percentile range]: 49 [39–56] years vs. 37 [33–43]; Wilcoxon's W=217.5, p=0.002) and took a higher daily dose of methadone (median [25th–75th percentile range]: 120 [66–228]mg/day vs. 60 [40–110]mg/day; W=298.5, p=0.037). Methadone dose correlated with QTc interval (Pearson's r2=0.291, p=0.002). Patients with and without long QTc showed no differences in plasma concentrations of (R)-methadone and (S)-methadone enantiomers.
The prevalence of LQTc was 9.2%. An association between LQTc and methadone doses was observed but the relationship with plasma concentrations of methadone enantiomers is unclear. |
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| AbstractList | There is a concern about cardiac rhythm disorders related to QTc interval prolongation induced by methadone. A cross-sectional study was designed to evaluate the prevalence of long QTc (LQTc) interval in patients in methadone maintenance treatment (MMT) and risk factors for LQTc.BACKGROUNDThere is a concern about cardiac rhythm disorders related to QTc interval prolongation induced by methadone. A cross-sectional study was designed to evaluate the prevalence of long QTc (LQTc) interval in patients in methadone maintenance treatment (MMT) and risk factors for LQTc.The study population included 109 subjects (74 males, median age 43 years). Socio-demographic and toxicological variables were recorded, as well as concomitant use of drugs related with QT prolongation, history of heart diseases, and corrected QT interval by heart rate (QTc) in the ECG. Plasma concentrations of (R)-methadone and (S)-methadone enantiomers were determined in 69 subjects.METHODSThe study population included 109 subjects (74 males, median age 43 years). Socio-demographic and toxicological variables were recorded, as well as concomitant use of drugs related with QT prolongation, history of heart diseases, and corrected QT interval by heart rate (QTc) in the ECG. Plasma concentrations of (R)-methadone and (S)-methadone enantiomers were determined in 69 subjects.Ten patients (9.2%) presented a QTc above 440 ms but a QTc above 500 ms was observed in only 2 (1.8%). Patients with QTc above 440 ms compared with the remaining subjects were older (median [25th-75th percentile range]: 49 [39-56] years vs. 37 [33-43]; Wilcoxon's W=217.5, p=0.002) and took a higher daily dose of methadone (median [25th-75th percentile range]: 120 [66-228] mg/day vs. 60 [40-110] mg/day; W=298.5, p=0.037). Methadone dose correlated with QTc interval (Pearson's r(2)=0.291, p=0.002). Patients with and without long QTc showed no differences in plasma concentrations of (R)-methadone and (S)-methadone enantiomers.RESULTSTen patients (9.2%) presented a QTc above 440 ms but a QTc above 500 ms was observed in only 2 (1.8%). Patients with QTc above 440 ms compared with the remaining subjects were older (median [25th-75th percentile range]: 49 [39-56] years vs. 37 [33-43]; Wilcoxon's W=217.5, p=0.002) and took a higher daily dose of methadone (median [25th-75th percentile range]: 120 [66-228] mg/day vs. 60 [40-110] mg/day; W=298.5, p=0.037). Methadone dose correlated with QTc interval (Pearson's r(2)=0.291, p=0.002). Patients with and without long QTc showed no differences in plasma concentrations of (R)-methadone and (S)-methadone enantiomers.The prevalence of LQTc was 9.2%. An association between LQTc and methadone doses was observed but the relationship with plasma concentrations of methadone enantiomers is unclear.CONCLUSIONSThe prevalence of LQTc was 9.2%. An association between LQTc and methadone doses was observed but the relationship with plasma concentrations of methadone enantiomers is unclear. There is a concern about cardiac rhythm disorders related to QTc interval prolongation induced by methadone. A cross-sectional study was designed to evaluate the prevalence of long QTc (LQTc) interval in patients in methadone maintenance treatment (MMT) and risk factors for LQTc. The study population included 109 subjects (74 males, median age 43 years). Socio-demographic and toxicological variables were recorded, as well as concomitant use of drugs related with QT prolongation, history of heart diseases, and corrected QT interval by heart rate (QTc) in the ECG. Plasma concentrations of (R)-methadone and (S)-methadone enantiomers were determined in 69 subjects. Ten patients (9.2%) presented a QTc above 440 ms but a QTc above 500 ms was observed in only 2 (1.8%). Patients with QTc above 440 ms compared with the remaining subjects were older (median [25th-75th percentile range]: 49 [39-56] years vs. 37 [33-43]; Wilcoxon's W=217.5, p=0.002) and took a higher daily dose of methadone (median [25th-75th percentile range]: 120 [66-228] mg/day vs. 60 [40-110] mg/day; W=298.5, p=0.037). Methadone dose correlated with QTc interval (Pearson's r(2)=0.291, p=0.002). Patients with and without long QTc showed no differences in plasma concentrations of (R)-methadone and (S)-methadone enantiomers. The prevalence of LQTc was 9.2%. An association between LQTc and methadone doses was observed but the relationship with plasma concentrations of methadone enantiomers is unclear. Background There is a concern about cardiac rhythm disorders related to QTc interval prolongation induced by methadone. A cross-sectional study was designed to evaluate the prevalence of long QTc (LQTc) interval in patients in methadone maintenance treatment (MMT) and risk factors for LQTc. Methods The study population included 109 subjects (74 males, median age 43 years). Socio-demographic and toxicological variables were recorded, as well as concomitant use of drugs related with QT prolongation, history of heart diseases, and corrected QT interval by heart rate (QTc) in the ECG. Plasma concentrations of (R)-methadone and (S)-methadone enantiomers were determined in 69 subjects. Results Ten patients (9.2%) presented a QTc above 440 ms but a QTc above 500 ms was observed in only 2 (1.8%). Patients with QTc above 440 ms compared with the remaining subjects were older (median [25th-75th percentile range]: 49 [39-56] years vs. 37 [33-43]; Wilcoxon's W = 217.5, p = 0.002) and took a higher daily dose of methadone (median [25th-75th percentile range]: 120 [66-228] mg/day vs. 60 [40-110] mg/day; W = 298.5, p = 0.037). Methadone dose correlated with QTc interval (Pearson's r2 = 0.291, p = 0.002). Patients with and without long QTc showed no differences in plasma concentrations of (R)-methadone and (S)-methadone enantiomers. Conclusions The prevalence of LQTc was 9.2%. An association between LQTc and methadone doses was observed but the relationship with plasma concentrations of methadone enantiomers is unclear. [Copyright 2008 Elsevier Ireland Ltd.] There is a concern about cardiac rhythm disorders related to QTc interval prolongation induced by methadone. A cross-sectional study was designed to evaluate the prevalence of long QTc (LQTc) interval in patients in methadone maintenance treatment (MMT) and risk factors for LQTc. The study population included 109 subjects (74 males, median age 43 years). Socio-demographic and toxicological variables were recorded, as well as concomitant use of drugs related with QT prolongation, history of heart diseases, and corrected QT interval by heart rate (QTc) in the ECG. Plasma concentrations of (R)-methadone and (S)-methadone enantiomers were determined in 69 subjects. Ten patients (9.2%) presented a QTc above 440ms but a QTc above 500ms was observed in only 2 (1.8%). Patients with QTc above 440ms compared with the remaining subjects were older (median [25th–75th percentile range]: 49 [39–56] years vs. 37 [33–43]; Wilcoxon's W=217.5, p=0.002) and took a higher daily dose of methadone (median [25th–75th percentile range]: 120 [66–228]mg/day vs. 60 [40–110]mg/day; W=298.5, p=0.037). Methadone dose correlated with QTc interval (Pearson's r2=0.291, p=0.002). Patients with and without long QTc showed no differences in plasma concentrations of (R)-methadone and (S)-methadone enantiomers. The prevalence of LQTc was 9.2%. An association between LQTc and methadone doses was observed but the relationship with plasma concentrations of methadone enantiomers is unclear. Abstract Background There is a concern about cardiac rhythm disorders related to QTc interval prolongation induced by methadone. A cross-sectional study was designed to evaluate the prevalence of long QTc (LQTc) interval in patients in methadone maintenance treatment (MMT) and risk factors for LQTc. Methods The study population included 109 subjects (74 males, median age 43 years). Socio-demographic and toxicological variables were recorded, as well as concomitant use of drugs related with QT prolongation, history of heart diseases, and corrected QT interval by heart rate (QTc) in the ECG. Plasma concentrations of ( R )-methadone and ( S )-methadone enantiomers were determined in 69 subjects. Results Ten patients (9.2%) presented a QTc above 440 ms but a QTc above 500 ms was observed in only 2 (1.8%). Patients with QTc above 440 ms compared with the remaining subjects were older (median [25th–75th percentile range]: 49 [39–56] years vs. 37 [33–43]; Wilcoxon's W = 217.5, p = 0.002) and took a higher daily dose of methadone (median [25th–75th percentile range]: 120 [66–228] mg/day vs. 60 [40–110] mg/day; W = 298.5, p = 0.037). Methadone dose correlated with QTc interval (Pearson's r2 = 0.291, p = 0.002). Patients with and without long QTc showed no differences in plasma concentrations of ( R )-methadone and ( S )-methadone enantiomers. Conclusions The prevalence of LQTc was 9.2%. An association between LQTc and methadone doses was observed but the relationship with plasma concentrations of methadone enantiomers is unclear. |
| Author | Torrens, Marta Pastor, Antoni Cladellas, Mercè Farré, Magí Fonseca, Francina Marti-Almor, Julio de la Torre, Rafael |
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| Cites_doi | 10.1016/j.jinf.2006.11.001 10.1002/elps.200305418 10.1002/pds.1112 10.1016/j.jelectrocard.2005.09.001 10.1111/j.1365-2125.2004.02221.x 10.1111/j.1365-2125.2004.02079.x 10.1016/j.jpainsymman.2006.02.010 10.1161/01.CIR.88.2.782 10.1097/01.jcp.0000132347.81455.57 10.7326/0003-4819-137-6-200209170-00010 10.1007/s002280050128 10.1111/j.1360-0443.2006.01668.x 10.1159/000081416 10.2165/00003088-200241140-00003 10.1016/j.ahj.2007.01.040 10.1080/15563650701275322 10.1592/phco.2005.25.11.1523 10.7326/0003-4819-139-2-200307150-00021 10.1056/NEJMcp0706513 10.1016/j.jpainsymman.2004.06.012 10.1016/S0376-8716(98)00096-9 10.1016/S0002-9149(00)01170-X 10.1097/01.jcp.0000246218.28186.5d 10.1111/j.1360-0443.2005.01089.x 10.1038/sj.clpt.6100120 10.1111/j.1360-0443.2006.01512.x 10.1016/j.amjcard.2004.11.055 10.1016/S0304-3959(03)00205-7 10.1016/j.amjmed.2007.10.009 |
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| Keywords | Arrhythmia Methadone maintenance treatment (MMT) Corrected-QT interval Human QT interval Drug addiction Replacement therapy Prevalence Opiates Cardiovascular disease Patient Methadone Narcotic analgesic Addiction Heart disease Maintenance treatment Public health |
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| References | Nordin, Kohli, Beca, Zaharia, Gran, Leiden, Marantz (bib25) 2006; 39 Pearson, Woosley (bib26) 2005; 14 Cruciani, Sekine, Homel, Lussier, Yap, Suzuki, Schweitzer, Yancovitz, Lapin, Shaiova, Sheu, Portenoy (bib5) 2005; 29 Piguet, Desmeules, Ehret, Stoller, Dayer (bib28) 2004; 24 European Agency for the Evaluation of Medical Products. Committee for Propietary Medical Products, 2005. The Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs. CHMP/ICH/2/04. Leavitt, S.B., 2005. Methadone-Drug* Interactions (*Medications, illicit drugs, & other substances). Addiction Treatment Forum. Third ed. Available at Roden (bib29) 2008; 358 Foster, Somogyi, White, Bochner (bib11) 2004; 57 Brugal, Domingo-Salvany, Puig, Barrio, Garcia de Olalla, de la Fuente (bib2) 2005; 100 Kornick, Kilborn, Santiago-Palma, Schulman, Thaler, Keefe, Katchman, Pezzullo, Ebert, Woosley, Payne, Manfredi (bib17) 2003; 105 [Accessed 15 October 2007]. [Accessed on 15 October 2007]. Bazett (bib1) 1920; 7 Justo, Gal-Oz, Paran, Goldin, Zeltser (bib15) 2006; 101 Torrens, Castillo, San, del Moral, Gonzalez, de la Torre (bib33) 1998; 52 Mitchell, Dyer, Newcombe, Salter, Somogyi, Bochne, White (bib24) 2004; 58 Gupta, Lawrence, Krishnan, Kavinsky, Trohman (bib13) 2007; 153 Maremmani, Pacini, Cesaroni, Lovrecic, Perugi, Tagliamonte (bib21) 2005; 11 Martell, Arnsten, Ray, Gourevitch (bib23) 2003; 139 Service, Waring (bib31) 2008; 46 Chinello, Lisena, Angeletti, Boumis, Papetti, Petrosillo (bib3) 2007; 54 Chugh, Socoteanu, Reinier, Waltz, Jui, Gunson (bib4) 2008; 121 Hothorn, T., Hornik, K., 2006. ExactRankTests: Exact Distributions for Rank and Permutation Tests. R package version 0.8-16. Krantz, Lewkowiez, Hays, Woodroffe, Robertson, Mehler (bib18) 2002; 137 Kelly, Doble, Dawson (bib16) 2003; 24 Festa, D’Agostino, Rautaharju, Mykkamen, Haffner (bib10) 2000; 86 Skjervold, Bathen, Spigset (bib32) 2006; 6 Eap, Crettol, Rougier, Schläpfer, Sintra Grilo, Déglon, Besson, Croquette-Krokar, Carrupt, Abriel (bib7) 2007; 81 Krantz, Lowery, Martell, Gourevitch, Arnsten (bib19) 2005; 25 Fredheim, Borchgrevink, Hegrenaes, Kaasa, Dale, Klepstad (bib12) 2006; 32 Eap, Finkbeiner, Gastpar, Scherbaum, Powell, Baumann (bib8) 1996; 50 Eap, Buclin, Baumann (bib6) 2002; 41 Schwartz, Moss, Vincent, Crampton (bib30) 1993; 88 Peles, Bodner, Kreek, Rados, Adelson (bib27) 2007; 102 Martell, Arnsten, Krantz, Gourevitch (bib22) 2005; 95 Bazett (10.1016/j.drugalcdep.2008.06.018_bib1) 1920; 7 Fredheim (10.1016/j.drugalcdep.2008.06.018_bib12) 2006; 32 Skjervold (10.1016/j.drugalcdep.2008.06.018_bib32) 2006; 6 Krantz (10.1016/j.drugalcdep.2008.06.018_bib19) 2005; 25 Schwartz (10.1016/j.drugalcdep.2008.06.018_bib30) 1993; 88 Peles (10.1016/j.drugalcdep.2008.06.018_bib27) 2007; 102 Foster (10.1016/j.drugalcdep.2008.06.018_bib11) 2004; 57 10.1016/j.drugalcdep.2008.06.018_bib14 Piguet (10.1016/j.drugalcdep.2008.06.018_bib28) 2004; 24 Festa (10.1016/j.drugalcdep.2008.06.018_bib10) 2000; 86 Maremmani (10.1016/j.drugalcdep.2008.06.018_bib21) 2005; 11 Martell (10.1016/j.drugalcdep.2008.06.018_bib23) 2003; 139 Nordin (10.1016/j.drugalcdep.2008.06.018_bib25) 2006; 39 Justo (10.1016/j.drugalcdep.2008.06.018_bib15) 2006; 101 Brugal (10.1016/j.drugalcdep.2008.06.018_bib2) 2005; 100 Service (10.1016/j.drugalcdep.2008.06.018_bib31) 2008; 46 Chinello (10.1016/j.drugalcdep.2008.06.018_bib3) 2007; 54 Kelly (10.1016/j.drugalcdep.2008.06.018_bib16) 2003; 24 Pearson (10.1016/j.drugalcdep.2008.06.018_bib26) 2005; 14 Kornick (10.1016/j.drugalcdep.2008.06.018_bib17) 2003; 105 Chugh (10.1016/j.drugalcdep.2008.06.018_bib4) 2008; 121 Cruciani (10.1016/j.drugalcdep.2008.06.018_bib5) 2005; 29 10.1016/j.drugalcdep.2008.06.018_bib20 Martell (10.1016/j.drugalcdep.2008.06.018_bib22) 2005; 95 Eap (10.1016/j.drugalcdep.2008.06.018_bib6) 2002; 41 Eap (10.1016/j.drugalcdep.2008.06.018_bib8) 1996; 50 Torrens (10.1016/j.drugalcdep.2008.06.018_bib33) 1998; 52 Gupta (10.1016/j.drugalcdep.2008.06.018_bib13) 2007; 153 10.1016/j.drugalcdep.2008.06.018_bib9 Eap (10.1016/j.drugalcdep.2008.06.018_bib7) 2007; 81 Krantz (10.1016/j.drugalcdep.2008.06.018_bib18) 2002; 137 Mitchell (10.1016/j.drugalcdep.2008.06.018_bib24) 2004; 58 Roden (10.1016/j.drugalcdep.2008.06.018_bib29) 2008; 358 |
| References_xml | – volume: 24 start-page: 446 year: 2004 end-page: 448 ident: bib28 article-title: QT interval prolongation in patients on methadone with concomitant drugs publication-title: J. Clin. Psychopharmacol. – volume: 121 start-page: 66 year: 2008 end-page: 71 ident: bib4 article-title: A community-based evaluation of sudden death associated with therapeutic levels of methadone publication-title: Am. J. Med. – volume: 54 start-page: 597 year: 2007 end-page: 602 ident: bib3 article-title: Role of antiretroviral treatment in prolonging QTc interval in HIV-positive patients publication-title: J. Infect. – volume: 6 start-page: 687 year: 2006 end-page: 689 ident: bib32 article-title: Methadone and the QT interval. Relations to the serum concentrations of methadone and its enantiomers ( publication-title: J. Clin. Psychopharmacol. – reference: [Accessed on 15 October 2007]. – volume: 358 start-page: 169 year: 2008 end-page: 176 ident: bib29 article-title: Long-QT syndrome publication-title: N. Engl. J. Med. – volume: 41 start-page: 1153 year: 2002 end-page: 1193 ident: bib6 article-title: Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence publication-title: Clin. Pharmacokinet. – volume: 139 start-page: 154 year: 2003 end-page: 155 ident: bib23 article-title: The impact of methadone induction on cardiac conduction in opiate users publication-title: Ann. Intern. Med. – volume: 57 start-page: 742 year: 2004 end-page: 756 ident: bib11 article-title: Population pharmacokinetics of ( publication-title: Br. J. Clin. Pharmacol. – volume: 39 start-page: 199 year: 2006 end-page: 205 ident: bib25 article-title: Importance of hepatitis C coinfection in the development of QT prolongation in HIV-infected patients publication-title: J. Electrocardiol. – reference: Leavitt, S.B., 2005. Methadone-Drug* Interactions (*Medications, illicit drugs, & other substances). Addiction Treatment Forum. Third ed. Available at: – volume: 11 start-page: 44 year: 2005 end-page: 49 ident: bib21 article-title: QTc interval prolongation in patients on long-term methadone maintenance therapy publication-title: Eur. Addict. Res. – volume: 24 start-page: 2106 year: 2003 end-page: 2110 ident: bib16 article-title: Chiral separation of methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP) by capillary electrophoresis using cyclodextrin derivatives publication-title: Electrophoresis – volume: 137 start-page: 501 year: 2002 end-page: 504 ident: bib18 article-title: Torsade de pointes associated with very-high-dose methadone publication-title: Ann. Intern. Med. – volume: 101 start-page: 1333 year: 2006 end-page: 1338 ident: bib15 article-title: Methadone-associated Torsades de Pointes (polymorphic ventricular tachycardia) in opioid-dependent patients publication-title: Addiction – volume: 81 start-page: 719 year: 2007 end-page: 728 ident: bib7 article-title: Stereoselective block of hERG channel by ( publication-title: Clin. Pharmacol. Ther. – volume: 105 start-page: 499 year: 2003 end-page: 506 ident: bib17 article-title: QTc interval prolongation associated with intravenous methadone publication-title: Pain – volume: 14 start-page: 747 year: 2005 end-page: 753 ident: bib26 article-title: QT prolongation and torsades de pointes among methadone users: reports to the FDA spontaneous reporting system publication-title: Pharmacoepidemiol. Drug Saf. – volume: 52 start-page: 193 year: 1998 end-page: 200 ident: bib33 article-title: Plasma methadone concentrations as an indicator of opioid withdrawal symptoms and heroin use in a methadone maintenance program publication-title: Drug Alcohol Depend. – volume: 102 start-page: 289 year: 2007 end-page: 300 ident: bib27 article-title: Corrected-QT intervals as related to methadone dose and serum level in methadone maintenance treatment (MMT) patients—a cross-sectional study publication-title: Addiction – volume: 29 start-page: 385 year: 2005 end-page: 391 ident: bib5 article-title: Measurement of QTc in patients receiving chronic methadone therapy publication-title: J. Pain Symptom Manage. – volume: 46 start-page: 71 year: 2008 end-page: 73 ident: bib31 article-title: QT prolongation and delayed atrioventricular conduction caused by acute ingestion of trazodone publication-title: Clin. Toxicol. – volume: 25 start-page: 1523 year: 2005 end-page: 1529 ident: bib19 article-title: Effects of methadone on QT-interval dispersion publication-title: Pharmacotherapy – volume: 7 start-page: 353 year: 1920 end-page: 370 ident: bib1 article-title: An analysis of the time-relations of electrocardiograms publication-title: Heart – volume: 86 start-page: 1117 year: 2000 ident: bib10 article-title: Relation of systemic blood pressure, left ventricular mass, insulin sensitivity, and coronary artery disease to QT interval duration in nondiabetic and type 2 diabetic subjects publication-title: Am. J. Cardiol. – volume: 100 start-page: 981 year: 2005 end-page: 989 ident: bib2 article-title: Evaluating the impact of methadone maintenance programmes on mortality due to overdose and aids in a cohort of heroin users in Spain publication-title: Addiction – volume: 153 start-page: 891 year: 2007 end-page: 899 ident: bib13 article-title: Current concepts in the mechanisms and management of drug-induced QT prolongation and torsade de pointes publication-title: Am. Heart J. – reference: European Agency for the Evaluation of Medical Products. Committee for Propietary Medical Products, 2005. The Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs. CHMP/ICH/2/04. – reference: [Accessed 15 October 2007]. – volume: 58 start-page: 609 year: 2004 end-page: 617 ident: bib24 article-title: Subjective and physiological responses among racemic-methadone maintenance patients in relation to relative ( publication-title: Br. J. Clin. Pharmacol. – volume: 88 start-page: 782 year: 1993 end-page: 784 ident: bib30 article-title: Diagnostic criteria for the long QT syndrome: an update publication-title: Circulation – reference: Hothorn, T., Hornik, K., 2006. ExactRankTests: Exact Distributions for Rank and Permutation Tests. R package version 0.8-16. – volume: 50 start-page: 385 year: 1996 end-page: 389 ident: bib8 article-title: Replacement of ( publication-title: Eur. J. Clin. Pharmacol. – volume: 95 start-page: 915 year: 2005 end-page: 918 ident: bib22 article-title: Impact of methadone treatment on cardiac repolarization and conduction in opioid users publication-title: Am. J. Cardiol. – volume: 32 start-page: 180 year: 2006 end-page: 185 ident: bib12 article-title: Opioid switching from morphine to methadone causes a minor but not clinically significant increase in QTc time: a prospective 9-month follow-up study publication-title: J. Pain Symptom Manage. – volume: 54 start-page: 597 year: 2007 ident: 10.1016/j.drugalcdep.2008.06.018_bib3 article-title: Role of antiretroviral treatment in prolonging QTc interval in HIV-positive patients publication-title: J. Infect. doi: 10.1016/j.jinf.2006.11.001 – volume: 24 start-page: 2106 year: 2003 ident: 10.1016/j.drugalcdep.2008.06.018_bib16 article-title: Chiral separation of methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP) by capillary electrophoresis using cyclodextrin derivatives publication-title: Electrophoresis doi: 10.1002/elps.200305418 – volume: 14 start-page: 747 year: 2005 ident: 10.1016/j.drugalcdep.2008.06.018_bib26 article-title: QT prolongation and torsades de pointes among methadone users: reports to the FDA spontaneous reporting system publication-title: Pharmacoepidemiol. Drug Saf. doi: 10.1002/pds.1112 – volume: 39 start-page: 199 year: 2006 ident: 10.1016/j.drugalcdep.2008.06.018_bib25 article-title: Importance of hepatitis C coinfection in the development of QT prolongation in HIV-infected patients publication-title: J. Electrocardiol. doi: 10.1016/j.jelectrocard.2005.09.001 – volume: 58 start-page: 609 year: 2004 ident: 10.1016/j.drugalcdep.2008.06.018_bib24 article-title: Subjective and physiological responses among racemic-methadone maintenance patients in relation to relative (S)- vs. (R)-methadone exposure publication-title: Br. J. Clin. Pharmacol. doi: 10.1111/j.1365-2125.2004.02221.x – volume: 57 start-page: 742 year: 2004 ident: 10.1016/j.drugalcdep.2008.06.018_bib11 article-title: Population pharmacokinetics of (R)-, (S)- and rac-methadone in methadone maintenance patients publication-title: Br. J. Clin. Pharmacol. doi: 10.1111/j.1365-2125.2004.02079.x – volume: 32 start-page: 180 year: 2006 ident: 10.1016/j.drugalcdep.2008.06.018_bib12 article-title: Opioid switching from morphine to methadone causes a minor but not clinically significant increase in QTc time: a prospective 9-month follow-up study publication-title: J. Pain Symptom Manage. doi: 10.1016/j.jpainsymman.2006.02.010 – volume: 88 start-page: 782 year: 1993 ident: 10.1016/j.drugalcdep.2008.06.018_bib30 article-title: Diagnostic criteria for the long QT syndrome: an update publication-title: Circulation doi: 10.1161/01.CIR.88.2.782 – volume: 24 start-page: 446 year: 2004 ident: 10.1016/j.drugalcdep.2008.06.018_bib28 article-title: QT interval prolongation in patients on methadone with concomitant drugs publication-title: J. Clin. Psychopharmacol. doi: 10.1097/01.jcp.0000132347.81455.57 – volume: 137 start-page: 501 year: 2002 ident: 10.1016/j.drugalcdep.2008.06.018_bib18 article-title: Torsade de pointes associated with very-high-dose methadone publication-title: Ann. Intern. Med. doi: 10.7326/0003-4819-137-6-200209170-00010 – volume: 50 start-page: 385 year: 1996 ident: 10.1016/j.drugalcdep.2008.06.018_bib8 article-title: Replacement of (R)-methadone by a double dose of (R,S)-methadone in addicts: interindividual variability of the (R)-/(S)-ratios and evidence of adaptative changes in methadone pharmacokinetics publication-title: Eur. J. Clin. Pharmacol. doi: 10.1007/s002280050128 – volume: 102 start-page: 289 year: 2007 ident: 10.1016/j.drugalcdep.2008.06.018_bib27 article-title: Corrected-QT intervals as related to methadone dose and serum level in methadone maintenance treatment (MMT) patients—a cross-sectional study publication-title: Addiction doi: 10.1111/j.1360-0443.2006.01668.x – volume: 11 start-page: 44 year: 2005 ident: 10.1016/j.drugalcdep.2008.06.018_bib21 article-title: QTc interval prolongation in patients on long-term methadone maintenance therapy publication-title: Eur. Addict. Res. doi: 10.1159/000081416 – volume: 41 start-page: 1153 year: 2002 ident: 10.1016/j.drugalcdep.2008.06.018_bib6 article-title: Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence publication-title: Clin. Pharmacokinet. doi: 10.2165/00003088-200241140-00003 – volume: 153 start-page: 891 year: 2007 ident: 10.1016/j.drugalcdep.2008.06.018_bib13 article-title: Current concepts in the mechanisms and management of drug-induced QT prolongation and torsade de pointes publication-title: Am. Heart J. doi: 10.1016/j.ahj.2007.01.040 – volume: 46 start-page: 71 year: 2008 ident: 10.1016/j.drugalcdep.2008.06.018_bib31 article-title: QT prolongation and delayed atrioventricular conduction caused by acute ingestion of trazodone publication-title: Clin. Toxicol. doi: 10.1080/15563650701275322 – volume: 25 start-page: 1523 year: 2005 ident: 10.1016/j.drugalcdep.2008.06.018_bib19 article-title: Effects of methadone on QT-interval dispersion publication-title: Pharmacotherapy doi: 10.1592/phco.2005.25.11.1523 – volume: 139 start-page: 154 year: 2003 ident: 10.1016/j.drugalcdep.2008.06.018_bib23 article-title: The impact of methadone induction on cardiac conduction in opiate users publication-title: Ann. Intern. Med. doi: 10.7326/0003-4819-139-2-200307150-00021 – volume: 358 start-page: 169 year: 2008 ident: 10.1016/j.drugalcdep.2008.06.018_bib29 article-title: Long-QT syndrome publication-title: N. Engl. J. Med. doi: 10.1056/NEJMcp0706513 – volume: 29 start-page: 385 year: 2005 ident: 10.1016/j.drugalcdep.2008.06.018_bib5 article-title: Measurement of QTc in patients receiving chronic methadone therapy publication-title: J. Pain Symptom Manage. doi: 10.1016/j.jpainsymman.2004.06.012 – volume: 52 start-page: 193 year: 1998 ident: 10.1016/j.drugalcdep.2008.06.018_bib33 article-title: Plasma methadone concentrations as an indicator of opioid withdrawal symptoms and heroin use in a methadone maintenance program publication-title: Drug Alcohol Depend. doi: 10.1016/S0376-8716(98)00096-9 – volume: 86 start-page: 1117 year: 2000 ident: 10.1016/j.drugalcdep.2008.06.018_bib10 article-title: Relation of systemic blood pressure, left ventricular mass, insulin sensitivity, and coronary artery disease to QT interval duration in nondiabetic and type 2 diabetic subjects publication-title: Am. J. Cardiol. doi: 10.1016/S0002-9149(00)01170-X – volume: 6 start-page: 687 year: 2006 ident: 10.1016/j.drugalcdep.2008.06.018_bib32 article-title: Methadone and the QT interval. Relations to the serum concentrations of methadone and its enantiomers (R)-methadone and (S)-methadone publication-title: J. Clin. Psychopharmacol. doi: 10.1097/01.jcp.0000246218.28186.5d – volume: 100 start-page: 981 year: 2005 ident: 10.1016/j.drugalcdep.2008.06.018_bib2 article-title: Evaluating the impact of methadone maintenance programmes on mortality due to overdose and aids in a cohort of heroin users in Spain publication-title: Addiction doi: 10.1111/j.1360-0443.2005.01089.x – ident: 10.1016/j.drugalcdep.2008.06.018_bib14 – volume: 81 start-page: 719 year: 2007 ident: 10.1016/j.drugalcdep.2008.06.018_bib7 article-title: Stereoselective block of hERG channel by (S)-methadone and QT interval prolongation in CYP2B6 slow metabolizers publication-title: Clin. Pharmacol. Ther. doi: 10.1038/sj.clpt.6100120 – volume: 101 start-page: 1333 year: 2006 ident: 10.1016/j.drugalcdep.2008.06.018_bib15 article-title: Methadone-associated Torsades de Pointes (polymorphic ventricular tachycardia) in opioid-dependent patients publication-title: Addiction doi: 10.1111/j.1360-0443.2006.01512.x – volume: 95 start-page: 915 year: 2005 ident: 10.1016/j.drugalcdep.2008.06.018_bib22 article-title: Impact of methadone treatment on cardiac repolarization and conduction in opioid users publication-title: Am. J. Cardiol. doi: 10.1016/j.amjcard.2004.11.055 – volume: 105 start-page: 499 year: 2003 ident: 10.1016/j.drugalcdep.2008.06.018_bib17 article-title: QTc interval prolongation associated with intravenous methadone publication-title: Pain doi: 10.1016/S0304-3959(03)00205-7 – ident: 10.1016/j.drugalcdep.2008.06.018_bib9 – ident: 10.1016/j.drugalcdep.2008.06.018_bib20 – volume: 121 start-page: 66 year: 2008 ident: 10.1016/j.drugalcdep.2008.06.018_bib4 article-title: A community-based evaluation of sudden death associated with therapeutic levels of methadone publication-title: Am. J. Med. doi: 10.1016/j.amjmed.2007.10.009 – volume: 7 start-page: 353 year: 1920 ident: 10.1016/j.drugalcdep.2008.06.018_bib1 article-title: An analysis of the time-relations of electrocardiograms publication-title: Heart |
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| Snippet | There is a concern about cardiac rhythm disorders related to QTc interval prolongation induced by methadone. A cross-sectional study was designed to evaluate... Abstract Background There is a concern about cardiac rhythm disorders related to QTc interval prolongation induced by methadone. A cross-sectional study was... Background There is a concern about cardiac rhythm disorders related to QTc interval prolongation induced by methadone. A cross-sectional study was designed to... |
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| SubjectTerms | Addictive behaviors Adolescent Adult Adult and adolescent clinical studies Arrhythmia Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - epidemiology Biological and medical sciences Cardiac dysrhythmias Cardiology. Vascular system Corrected-QT interval Drug addiction Drug addicts Electrocardiography Female Heart Heart rate Heart Rate - drug effects Humans Logistic Models Long QT Syndrome - chemically induced Long QT Syndrome - epidemiology Male Medical sciences Methadone Methadone - administration & dosage Methadone - adverse effects Methadone - therapeutic use Methadone maintenance treatment (MMT) Middle Aged Miscellaneous Narcotics - administration & dosage Narcotics - adverse effects Narcotics - therapeutic use Opioid-Related Disorders - complications Opioid-Related Disorders - rehabilitation Prevalence Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Socioeconomic Factors Young Adult |
| Title | Prevalence of long QTc interval in methadone maintenance patients |
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