Association between HLA‐B1502 Allele and Antiepileptic Drug‐Induced Cutaneous Reactions in Han Chinese
A previous study conducted in Taiwan found a 100% association between HLA‐B*1502 allele and carbamazepine‐induced Stevens‐Johnson syndrome (SJS) in Han Chinese subjects, with an extremely high odds ratio compared with carbamazepine‐tolerant subjects (odds ratio = 2,504). We examined this association...
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| Published in | Epilepsia (Copenhagen) Vol. 48; no. 5; pp. 1015 - 1018 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Malden, USA
Blackwell Publishing Inc
01.05.2007
Blackwell |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0013-9580 1528-1167 |
| DOI | 10.1111/j.1528-1167.2007.01022.x |
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| Abstract | A previous study conducted in Taiwan found a 100% association between HLA‐B*1502 allele and carbamazepine‐induced Stevens‐Johnson syndrome (SJS) in Han Chinese subjects, with an extremely high odds ratio compared with carbamazepine‐tolerant subjects (odds ratio = 2,504). We examined this association in 24 Hong Kong Han Chinese subjects who had cutaneous adverse reactions induced by different antiepileptic drugs (AEDs). They were matched with 48 AED‐tolerant controls. HLA‐B*1502 was associated with severe cutaneous reactions (SCR) induced by AEDs, which included carbamazepine, phenytoin, and lamotrigine (p = 0.001, odds ratio = 17.6), but was not associated with maculopapular exanthema (MPE) (p = 0.32). Further studies in larger samples of ethnically matched subjects should be conducted to confirm the findings. Identification of genetic polymorphisms predisposing to development of AED‐induced SCR offers the possibility of avoiding these high‐risk drugs in genetically susceptible individuals. |
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| AbstractList | A previous study conducted in Taiwan found a 100% association between HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome (SJS) in Han Chinese subjects, with an extremely high odds ratio compared with carbamazepine-tolerant subjects (odds ratio = 2,504). We examined this association in 24 Hong Kong Han Chinese subjects who had cutaneous adverse reactions induced by different antiepileptic drugs (AEDs). They were matched with 48 AED-tolerant controls. HLA-B*1502 was associated with severe cutaneous reactions (SCR) induced by AEDs, which included carbamazepine, phenytoin, and lamotrigine (p = 0.001, odds ratio = 17.6), but was not associated with maculopapular exanthema (MPE) (p = 0.32). Further studies in larger samples of ethnically matched subjects should be conducted to confirm the findings. Identification of genetic polymorphisms predisposing to development of AED-induced SCR offers the possibility of avoiding these high-risk drugs in genetically susceptible individuals.A previous study conducted in Taiwan found a 100% association between HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome (SJS) in Han Chinese subjects, with an extremely high odds ratio compared with carbamazepine-tolerant subjects (odds ratio = 2,504). We examined this association in 24 Hong Kong Han Chinese subjects who had cutaneous adverse reactions induced by different antiepileptic drugs (AEDs). They were matched with 48 AED-tolerant controls. HLA-B*1502 was associated with severe cutaneous reactions (SCR) induced by AEDs, which included carbamazepine, phenytoin, and lamotrigine (p = 0.001, odds ratio = 17.6), but was not associated with maculopapular exanthema (MPE) (p = 0.32). Further studies in larger samples of ethnically matched subjects should be conducted to confirm the findings. Identification of genetic polymorphisms predisposing to development of AED-induced SCR offers the possibility of avoiding these high-risk drugs in genetically susceptible individuals. A previous study conducted in Taiwan found a 100% association between HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome (SJS) in Han Chinese subjects, with an extremely high odds ratio compared with carbamazepine-tolerant subjects (odds ratio = 2,504). We examined this association in 24 Hong Kong Han Chinese subjects who had cutaneous adverse reactions induced by different antiepileptic drugs (AEDs). They were matched with 48 AED-tolerant controls. HLA-B*1502 was associated with severe cutaneous reactions (SCR) induced by AEDs, which included carbamazepine, phenytoin, and lamotrigine (p = 0.001, odds ratio = 17.6), but was not associated with maculopapular exanthema (MPE) (p = 0.32). Further studies in larger samples of ethnically matched subjects should be conducted to confirm the findings. Identification of genetic polymorphisms predisposing to development of AED-induced SCR offers the possibility of avoiding these high-risk drugs in genetically susceptible individuals. A previous study conducted in Taiwan found a 100% association between HLA‐B*1502 allele and carbamazepine‐induced Steven s ‐Johnson syndrome (SJS) in Han Chinese subjects, with an extremely high odds ratio compared with carbamazepine‐tolerant subjects (odds ratio = 2,504). We examined this association in 24 Hong Kong Han Chinese subjects who had cutaneous adverse reactions induced by different antiepileptic drugs (AEDs). They were matched with 48 AED‐tolerant controls. HLA‐B*1502 was associated with severe cutaneous reactions (SCR) induced by AEDs, which included carbamazepine, phenytoin, and lamotrigine (p = 0.001, odds ratio = 17.6), but was not associated with maculopapular exanthema (MPE) (p = 0.32). Further studies in larger samples of ethnically matched subjects should be conducted to confirm the findings. Identification of genetic polymorphisms predisposing to development of AED‐induced SCR offers the possibility of avoiding these high‐risk drugs in genetically susceptible individuals. |
| Author | Kwan, Patrick Baum, Larry Cheng, Alice S.H. Yu, Evelyn Ng, Margaret H.L. Man, Celeste B.L. Lau, K.M. |
| Author_xml | – sequence: 1 givenname: Celeste B.L. surname: Man fullname: Man, Celeste B.L. – sequence: 2 givenname: Patrick surname: Kwan fullname: Kwan, Patrick – sequence: 3 givenname: Larry surname: Baum fullname: Baum, Larry – sequence: 4 givenname: Evelyn surname: Yu fullname: Yu, Evelyn – sequence: 5 givenname: K.M. surname: Lau fullname: Lau, K.M. – sequence: 6 givenname: Alice S.H. surname: Cheng fullname: Cheng, Alice S.H. – sequence: 7 givenname: Margaret H.L. surname: Ng fullname: Ng, Margaret H.L. |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18792668$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/17509004$$D View this record in MEDLINE/PubMed |
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| CODEN | EPILAK |
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| Keywords | Bullous dermatosis HLA-System HLA-Cutaneous reactions-Antiepileptic drugs-Rash-Stevens-Johnson syndrome Eye disease Skin disease Nervous system diseases Stomatology Epilepsy Central nervous system disease Anticonvulsant Stevens Johnson syndrome Cerebral disorder |
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| References | 2004; 114 1984; 47 1986; 42 1995; 46 2006; 16 2000; 53 2006; 6 1997; 49 1999; 40 2004; 428 2006; 118 2001; 47 2003; 63 e_1_2_5_14_1 e_1_2_5_9_1 e_1_2_5_8_1 e_1_2_5_11_1 e_1_2_5_7_1 e_1_2_5_10_1 e_1_2_5_6_1 e_1_2_5_13_1 e_1_2_5_5_1 e_1_2_5_4_1 e_1_2_5_3_1 e_1_2_5_2_1 Svensson CK (e_1_2_5_12_1) 2000; 53 Epilepsia. 2008 May;49(5):941 18852831 - Epilepsy Curr. 2008 Sep-Oct;8(5):120-1 22533645 - Epilepsia. 2012 May;53(5):929-30 |
| References_xml | – volume: 428 start-page: 486 year: 2004 article-title: Medical genetics: a marker for Stevens‐Johnson syndrome publication-title: Nature – volume: 114 start-page: 1209 year: 2004 end-page: 1215 article-title: Toxic epidermal necrolysis: effector cells are drug‐specific cytotoxic T cells publication-title: Journal of Allergy and Clinical Immunology – volume: 40 start-page: 985 year: 1999 end-page: 991 article-title: Lamotrigine‐associated rash: risk/benefit considerations in adults and children publication-title: Epilepsia – volume: 49 start-page: 542 year: 1997 end-page: 546 article-title: Risk of serious cutaneous disorders after initiation of use of phenytoin, carbamazepine, or sodium valproate: a record linkage study publication-title: Neurology – volume: 46 start-page: 355 year: 1995 end-page: 367 article-title: Phototyping: comprehensive DNA typing for HLA‐A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence‐specific primers (PCR‐SSP) publication-title: Tissue Antigens – volume: 16 start-page: 297 year: 2006 end-page: 306 article-title: Genetic susceptibility to carbamazepine‐induced cutaneous adverse drug reactions publication-title: Pharmacogenetics and Genomics – volume: 47 start-page: 642 year: 1984 end-page: 644 article-title: Serum anticonvulsant concentrations and the risk of drug induced skin eruptions publication-title: Journal of Neurolology, Neurosurgery and Psychiatry – volume: 42 start-page: 351 year: 1986 end-page: 358 article-title: On the bias of commonly used measures of association for 2x2 tables publication-title: Biometrics – volume: 118 start-page: 233 year: 2006 end-page: 241 article-title: Activation of T cells by carbamazepine and carbamazepine metabolites publication-title: Journal of Allergy and Clinical Immunology – volume: 53 start-page: 357 year: 2000 end-page: 379 article-title: Cutaneous Drug Reactions publication-title: Pharmacological Reviews – volume: 6 start-page: 265 year: 2006 end-page: 268 article-title: A marker for Stevens‐Johnson syndrome …: ethnicity matters publication-title: Pharmacogenomics Journal – volume: 63 start-page: 732 year: 2003 end-page: 741 article-title: Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drug‐specific T cell clones publication-title: Molecular Pharmacology – volume: 47 start-page: 155 year: 2001 end-page: 174 article-title: Life‐threatening adverse events of antiepileptic drugs publication-title: Epilepsy Research – ident: e_1_2_5_5_1 doi: 10.1038/428486a – ident: e_1_2_5_7_1 doi: 10.1097/01.fpc.0000199500.46842.4a – ident: e_1_2_5_10_1 doi: 10.1124/mol.63.3.732 – ident: e_1_2_5_3_1 doi: 10.1111/j.1399-0039.1995.tb03127.x – ident: e_1_2_5_9_1 doi: 10.1038/sj.tpj.6500356 – ident: e_1_2_5_4_1 doi: 10.1136/jnnp.47.6.642 – ident: e_1_2_5_6_1 doi: 10.1111/j.1528-1157.1999.tb00807.x – volume: 53 start-page: 357 year: 2000 ident: e_1_2_5_12_1 article-title: Cutaneous Drug Reactions publication-title: Pharmacological Reviews doi: 10.1016/S0031-6997(24)01501-1 – ident: e_1_2_5_2_1 doi: 10.1016/S0920-1211(01)00306-0 – ident: e_1_2_5_14_1 doi: 10.1016/j.jaci.2006.03.005 – ident: e_1_2_5_13_1 doi: 10.1212/WNL.49.2.542 – ident: e_1_2_5_8_1 doi: 10.2307/2531055 – ident: e_1_2_5_11_1 doi: 10.1016/j.jaci.2004.07.047 – reference: 18852831 - Epilepsy Curr. 2008 Sep-Oct;8(5):120-1 – reference: 22533645 - Epilepsia. 2012 May;53(5):929-30 – reference: - Epilepsia. 2008 May;49(5):941 |
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| Snippet | A previous study conducted in Taiwan found a 100% association between HLA‐B*1502 allele and carbamazepine‐induced Stevens‐Johnson syndrome (SJS) in Han Chinese... A previous study conducted in Taiwan found a 100% association between HLA‐B*1502 allele and carbamazepine‐induced Steven s ‐Johnson syndrome (SJS) in Han... A previous study conducted in Taiwan found a 100% association between HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome (SJS) in Han Chinese... |
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| SubjectTerms | Adolescent Adult Alleles Anticonvulsants - adverse effects Anticonvulsants - therapeutic use Anticonvulsants. Antiepileptics. Antiparkinson agents Antiepileptic drugs Asian Continental Ancestry Group - genetics Biological and medical sciences Carbamazepine - adverse effects Carbamazepine - therapeutic use Case-Control Studies Child Cutaneous reactions Drug Eruptions - ethnology Drug Eruptions - etiology Drug Eruptions - genetics Drug Hypersensitivity - ethnology Drug Hypersensitivity - genetics Drug toxicity and drugs side effects treatment Epilepsy - drug therapy Epilepsy - ethnology Epilepsy - genetics Female Genetic Predisposition to Disease - ethnology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy HLA HLA-B Antigens - genetics HLA-B15 Antigen Hong Kong Humans Male Medical sciences Middle Aged Miscellaneous (drug allergy, mutagens, teratogens...) Nervous system (semeiology, syndromes) Neurology Neuropharmacology Pharmacogenetics Pharmacology. Drug treatments Phenytoin - adverse effects Phenytoin - therapeutic use Polymorphism, Genetic Rash Stevens-Johnson Syndrome - chemically induced Stevens-Johnson Syndrome - ethnology Stevens-Johnson Syndrome - genetics Stevens‐Johnson syndrome Triazines - adverse effects Triazines - therapeutic use |
| Title | Association between HLA‐B1502 Allele and Antiepileptic Drug‐Induced Cutaneous Reactions in Han Chinese |
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