Activation of sphingosine kinase mediates suppressive effect of interleukin‐6 on human multiple myeloma cell apoptosis - Li, Qing‐Fang; Wu, Chu‐Tse; Duan, Hai‐Feng; Sun, Hui‐Yan; Wang, Hua; Lu, Zhuo‐Zhuang; Zhang, Qun‐Wei; Liu, Hong‐Jun; Wang, Li‐Sheng (British journal of haematology, 2007)
Keywords: apoptosis; Apoptosis - drug effects; Biological and medical sciences; Cell Proliferation; Dexamethasone - pharmacology; Enzyme Activation; Glucocorticoids - pharmacology; Hematologic and hematopoietic diseases; Humans; Immunodeficiencies. Immunoglobulinopathies; Immunoglobulinopathies; Immunopathology; Interleukin-6 - pharmacology; interleukin‐6; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Medical sciences; Mitogen-Activated Protein Kinase Kinases - physiology; multiple myeloma; Multiple Myeloma - enzymology; Multiple Myeloma - pathology; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins - metabolism; Phosphatidylinositol 3-Kinases - physiology; Phosphotransferases (Alcohol Group Acceptor) - metabolism; Phosphotransferases (Alcohol Group Acceptor) - physiology; Proto-Oncogene Proteins c-bcl-2 - metabolism; Recombinant Proteins - pharmacology; RNA interference; Signal Transduction - physiology; sphingosine kinase; Tumor Cells, Cultured; Up-Regulation - drug effects; Human; Immunopathology; multiple myeloma; RNA interference; Hematology; Enzyme; Transferases; sphingosine kinase; Cytokine; Malignant hemopathy; Sphinganine kinase; Myeloma; interleukin-6; Interleukin 6; Immunoglobulinopathy; Cell death; Lymphoproliferative syndrome; Apoptosis