二氟吡咯烷的光化学合成、分析及表征综合实验设计
光化学合成技术具有反应条件温和、设备简单、利用光能等优点，近年来已成为合成化学中的一个研究热点。但在目前本科生有机化学实验教学中，鲜见光化学合成反应相关实验。含氟氮杂环广泛存在于天然产物和药物活性分子中，也是有机合成的重要中间体。结合团队近年的科研成果，设计了一个光化学合成二氟吡咯环的综合性实验，由底物和产物制备、结构表征、光化学合成分析等部分组成。此实验可训练提高学生有机合成、结构解析等技能，通过将科研成果转化为有机化学实验教学，激发学生对有机化学实验的学习兴趣，并对培养学生的创新意识和树立“绿色合成”理念具有积极作用。...
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| Published in | 大学化学 Vol. 39; no. 11; pp. 196 - 203 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
北京大学
28.11.2024
中国化学会 烟台大学药学院,山东 烟台 264005 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1000-8438 |
| DOI | 10.3866/PKU.DXHX202401022 |
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| Abstract | 光化学合成技术具有反应条件温和、设备简单、利用光能等优点，近年来已成为合成化学中的一个研究热点。但在目前本科生有机化学实验教学中，鲜见光化学合成反应相关实验。含氟氮杂环广泛存在于天然产物和药物活性分子中，也是有机合成的重要中间体。结合团队近年的科研成果，设计了一个光化学合成二氟吡咯环的综合性实验，由底物和产物制备、结构表征、光化学合成分析等部分组成。此实验可训练提高学生有机合成、结构解析等技能，通过将科研成果转化为有机化学实验教学，激发学生对有机化学实验的学习兴趣，并对培养学生的创新意识和树立“绿色合成”理念具有积极作用。 |
|---|---|
| AbstractList | G64%O6; 光化学合成技术具有反应条件温和、设备简单、利用光能等优点,近年来已成为合成化学中的一个研究热点.但在目前本科生有机化学实验教学中,鲜见光化学合成反应相关实验.含氟氮杂环广泛存在于天然产物和药物活性分子中,也是有机合成的重要中间体.结合团队近年的科研成果,设计了一个光化学合成二氟吡咯环的综合性实验,由底物和产物制备、结构表征、光化学合成分析等部分组成.此实验可训练提高学生有机合成、结构解析等技能,通过将科研成果转化为有机化学实验教学,激发学生对有机化学实验的学习兴趣,并对培养学生的创新意识和树立"绿色合成"理念具有积极作用. 光化学合成技术具有反应条件温和、设备简单、利用光能等优点，近年来已成为合成化学中的一个研究热点。但在目前本科生有机化学实验教学中，鲜见光化学合成反应相关实验。含氟氮杂环广泛存在于天然产物和药物活性分子中，也是有机合成的重要中间体。结合团队近年的科研成果，设计了一个光化学合成二氟吡咯环的综合性实验，由底物和产物制备、结构表征、光化学合成分析等部分组成。此实验可训练提高学生有机合成、结构解析等技能，通过将科研成果转化为有机化学实验教学，激发学生对有机化学实验的学习兴趣，并对培养学生的创新意识和树立“绿色合成”理念具有积极作用。 |
| Abstract_FL | Photochemical synthesis technology has gained attention in the field of synthetic chemistry due to its mild reaction conditions,simple equipment,and utilization of light energy.However,photochemical synthesis experiments are rarely incorporated into undergraduate organic chemistry laboratory courses.Fluorine-containing nitrogen heterocycles are widely present in natural products and bioactive molecules,serving as important intermediates in organic synthesis.Based on our team's recent research achievements,a comprehensive experiment for the photochemical synthesis of difluoropyrroles has been designed.This experiment encompasses the preparation of substrates and products,structural characterization,and analysis of photochemical synthesis.It aims to enhance students'skills in organic synthesis and structural analysis,while also sparking their interest in organic chemistry experiments.Furthermore,it plays a significant role in cultivating students'innovative consciousness and promoting the concept of"green synthesis"by incorporating scientific research outcomes into organic chemistry laboratory teaching. |
| Author | 王薪 孙良龙 于婷婷 陈鸶 孙凯 史同同 |
| AuthorAffiliation | 烟台大学药学院,山东 烟台 264005 |
| AuthorAffiliation_xml | – name: 烟台大学药学院,山东 烟台 264005 |
| Author_FL | Xin Wang Lianglong Sun Tongtong Shi Si Chen Tingting Yu Kai Sun |
| Author_FL_xml | – sequence: 1 fullname: Tingting Yu – sequence: 2 fullname: Si Chen – sequence: 3 fullname: Lianglong Sun – sequence: 4 fullname: Tongtong Shi – sequence: 5 fullname: Kai Sun – sequence: 6 fullname: Xin Wang |
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| Keywords | 氮杂环 光化学合成 二氟吡咯烷 绿色化学 Difluoropyrroles Nitrogen heterocycle Photochemical synthesis Green chemistry |
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