Synthesis and Biological Evaluation of Andrographolide C-Glycoside Derivatives as a-Glycosidase Inhibitors

A series of new andrographolide C-glycoside derivatives were synthesized by a facile route. The new com- pounds showed higher potency than the parent andrographolide evaluated as a-glycosidase inhibitors in the pre- liminary study.

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Bibliographic Details
Published inChinese journal of chemistry Vol. 30; no. 4; pp. 914 - 918
Main Author 严琳 徐海伟 刘丰五 赵瑾 刘宏民
Format Journal Article
LanguageEnglish
Published Shanghai Wiley Subscription Services, Inc 01.04.2012
Subjects
合成
生物评价
穿心莲内酯
糖苷酶抑制剂
衍生物
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ISSN1001-604X
1614-7065
DOI10.1002/cjoc.201100179

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Summary:A series of new andrographolide C-glycoside derivatives were synthesized by a facile route. The new com- pounds showed higher potency than the parent andrographolide evaluated as a-glycosidase inhibitors in the pre- liminary study.
Bibliography:31-1547/O6
A series of new andrographolide C-glycoside derivatives were synthesized by a facile route. The new com- pounds showed higher potency than the parent andrographolide evaluated as a-glycosidase inhibitors in the pre- liminary study.
andrographolide, β-C-glycosidic ketone, a-glycosidase inhibitor
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ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201100179