Contribution of mesothelial cells in the expression of inflammatory-related factors in omental adipose tissue of obese subjects
Objective: The objective of this study was to determine the contribution of mesothelial cells, present in human omental adipose tissue (OAT) but not in the subcutaneous depot (SAT), on the expression of inflammation-related factors. Design: Comparison of the expression profiles of inflammation-relat...
Saved in:
| Published in | International Journal of Obesity Vol. 32; no. 1; pp. 112 - 120 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.01.2008
Nature Publishing Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0307-0565 1476-5497 1476-5497 |
| DOI | 10.1038/sj.ijo.0803688 |
Cover
| Abstract | Objective:
The objective of this study was to determine the contribution of mesothelial cells, present in human omental adipose tissue (OAT) but not in the subcutaneous depot (SAT), on the expression of inflammation-related factors.
Design:
Comparison of the expression profiles of inflammation-related genes in mesothelial cells with those in the adipocyte-enriched (AEF) and stromal vascular fractions (SVF) and localization of interleukin-18 (IL-18) expression in adipose depots.
Subjects:
Eleven obese Caucasian female subjects undergoing gastric bypass surgery (body mass index: 43.6±1.3 kg/m
2
; age: 41.6±2.3 years).
Measurements:
The expression profiles of cytokine and chemokine-related genes in mesothelial cells and in cell fractions prepared from OAT were assessed by the microarray technique. The differential expression of IL-18 was confirmed by real-time PCR and the protein was localized in adipose depots by immunohistochemistry.
Results:
Microarray data analysis demonstrated that, of the 16 cytokine and chemokine-related genes that were upregulated in mesothelial cells compared with the AEF, IL-18 was the cytokine with the highest differential expression. IL-18 expression was similar in mesothelial cells and the SVF. In both SAT and OAT, IL-18 was immunolocalized in neutrophils and mast cells, but not in macrophages nor adipocytes. This cytokine was also detected in mesothelial cells in OAT. This additional source of expression may explain the higher IL-18 expression levels in OAT than SAT (+5.9-fold).
Conclusion:
By their capacity to express inflammatory-related factors, and in particular the proinflammatory cytokine IL-18 in OAT, mesothelial cells appear as a new player in the process of low-grade inflammation associated with obesity. |
|---|---|
| AbstractList | The objective of this study was to determine the contribution of mesothelial cells, present in human omental adipose tissue (OAT) but not in the subcutaneous depot (SAT), on the expression of inflammation-related factors.
Comparison of the expression profiles of inflammation-related genes in mesothelial cells with those in the adipocyte-enriched (AEF) and stromal vascular fractions (SVF) and localization of interleukin-18 (IL-18) expression in adipose depots.
Eleven obese Caucasian female subjects undergoing gastric bypass surgery (body mass index: 43.6+/-1.3 kg/m(2); age: 41.6+/-2.3 years).
The expression profiles of cytokine and chemokine-related genes in mesothelial cells and in cell fractions prepared from OAT were assessed by the microarray technique. The differential expression of IL-18 was confirmed by real-time PCR and the protein was localized in adipose depots by immunohistochemistry.
Microarray data analysis demonstrated that, of the 16 cytokine and chemokine-related genes that were upregulated in mesothelial cells compared with the AEF, IL-18 was the cytokine with the highest differential expression. IL-18 expression was similar in mesothelial cells and the SVF. In both SAT and OAT, IL-18 was immunolocalized in neutrophils and mast cells, but not in macrophages nor adipocytes. This cytokine was also detected in mesothelial cells in OAT. This additional source of expression may explain the higher IL-18 expression levels in OAT than SAT (+5.9-fold).
By their capacity to express inflammatory-related factors, and in particular the proinflammatory cytokine IL-18 in OAT, mesothelial cells appear as a new player in the process of low-grade inflammation associated with obesity. The objective of this study was to determine the contribution of mesothelial cells, present in human omental adipose tissue (OAT) but not in the subcutaneous depot (SAT), on the expression of inflammation-related factors. Comparison of the expression profiles of inflammation-related genes in mesothelial cells with those in the adipocyte-enriched (AEF) and stromal vascular fractions (SVF) and localization of interleukin-18 (IL-18) expression in adipose depots. Eleven obese Caucasian female subjects undergoing gastric bypass surgery (body mass index: 43.6+/-1.3 kg/m(2); age: 41.6+/-2.3 years). The expression profiles of cytokine and chemokine-related genes in mesothelial cells and in cell fractions prepared from OAT were assessed by the microarray technique. The differential expression of IL-18 was confirmed by real-time PCR and the protein was localized in adipose depots by immunohistochemistry. Microarray data analysis demonstrated that, of the 16 cytokine and chemokine-related genes that were upregulated in mesothelial cells compared with the AEF, IL-18 was the cytokine with the highest differential expression. IL-18 expression was similar in mesothelial cells and the SVF. In both SAT and OAT, IL-18 was immunolocalized in neutrophils and mast cells, but not in macrophages nor adipocytes. This cytokine was also detected in mesothelial cells in OAT. This additional source of expression may explain the higher IL-18 expression levels in OAT than SAT (+5.9-fold). By their capacity to express inflammatory-related factors, and in particular the proinflammatory cytokine IL-18 in OAT, mesothelial cells appear as a new player in the process of low-grade inflammation associated with obesity. Objective: The objective of this study was to determine the contribution of mesothelial cells, present in human omental adipose tissue (OAT) but not in the subcutaneous depot (SAT), on the expression of inflammation-related factors. Design: Comparison of the expression profiles of inflammation-related genes in mesothelial cells with those in the adipocyte-enriched (AEF) and stromal vascular fractions (SVF) and localization of interleukin-18 (IL-18) expression in adipose depots. Subjects: Eleven obese Caucasian female subjects undergoing gastric bypass surgery (body mass index: 43.6±1.3 kg/m 2 ; age: 41.6±2.3 years). Measurements: The expression profiles of cytokine and chemokine-related genes in mesothelial cells and in cell fractions prepared from OAT were assessed by the microarray technique. The differential expression of IL-18 was confirmed by real-time PCR and the protein was localized in adipose depots by immunohistochemistry. Results: Microarray data analysis demonstrated that, of the 16 cytokine and chemokine-related genes that were upregulated in mesothelial cells compared with the AEF, IL-18 was the cytokine with the highest differential expression. IL-18 expression was similar in mesothelial cells and the SVF. In both SAT and OAT, IL-18 was immunolocalized in neutrophils and mast cells, but not in macrophages nor adipocytes. This cytokine was also detected in mesothelial cells in OAT. This additional source of expression may explain the higher IL-18 expression levels in OAT than SAT (+5.9-fold). Conclusion: By their capacity to express inflammatory-related factors, and in particular the proinflammatory cytokine IL-18 in OAT, mesothelial cells appear as a new player in the process of low-grade inflammation associated with obesity. The objective of this study was to determine the contribution of mesothelial cells, present in human omental adipose tissue (OAT) but not in the subcutaneous depot (SAT), on the expression of inflammation-related factors.OBJECTIVEThe objective of this study was to determine the contribution of mesothelial cells, present in human omental adipose tissue (OAT) but not in the subcutaneous depot (SAT), on the expression of inflammation-related factors.Comparison of the expression profiles of inflammation-related genes in mesothelial cells with those in the adipocyte-enriched (AEF) and stromal vascular fractions (SVF) and localization of interleukin-18 (IL-18) expression in adipose depots.DESIGNComparison of the expression profiles of inflammation-related genes in mesothelial cells with those in the adipocyte-enriched (AEF) and stromal vascular fractions (SVF) and localization of interleukin-18 (IL-18) expression in adipose depots.Eleven obese Caucasian female subjects undergoing gastric bypass surgery (body mass index: 43.6+/-1.3 kg/m(2); age: 41.6+/-2.3 years).SUBJECTSEleven obese Caucasian female subjects undergoing gastric bypass surgery (body mass index: 43.6+/-1.3 kg/m(2); age: 41.6+/-2.3 years).The expression profiles of cytokine and chemokine-related genes in mesothelial cells and in cell fractions prepared from OAT were assessed by the microarray technique. The differential expression of IL-18 was confirmed by real-time PCR and the protein was localized in adipose depots by immunohistochemistry.MEASUREMENTSThe expression profiles of cytokine and chemokine-related genes in mesothelial cells and in cell fractions prepared from OAT were assessed by the microarray technique. The differential expression of IL-18 was confirmed by real-time PCR and the protein was localized in adipose depots by immunohistochemistry.Microarray data analysis demonstrated that, of the 16 cytokine and chemokine-related genes that were upregulated in mesothelial cells compared with the AEF, IL-18 was the cytokine with the highest differential expression. IL-18 expression was similar in mesothelial cells and the SVF. In both SAT and OAT, IL-18 was immunolocalized in neutrophils and mast cells, but not in macrophages nor adipocytes. This cytokine was also detected in mesothelial cells in OAT. This additional source of expression may explain the higher IL-18 expression levels in OAT than SAT (+5.9-fold).RESULTSMicroarray data analysis demonstrated that, of the 16 cytokine and chemokine-related genes that were upregulated in mesothelial cells compared with the AEF, IL-18 was the cytokine with the highest differential expression. IL-18 expression was similar in mesothelial cells and the SVF. In both SAT and OAT, IL-18 was immunolocalized in neutrophils and mast cells, but not in macrophages nor adipocytes. This cytokine was also detected in mesothelial cells in OAT. This additional source of expression may explain the higher IL-18 expression levels in OAT than SAT (+5.9-fold).By their capacity to express inflammatory-related factors, and in particular the proinflammatory cytokine IL-18 in OAT, mesothelial cells appear as a new player in the process of low-grade inflammation associated with obesity.CONCLUSIONBy their capacity to express inflammatory-related factors, and in particular the proinflammatory cytokine IL-18 in OAT, mesothelial cells appear as a new player in the process of low-grade inflammation associated with obesity. |
| Audience | Academic |
| Author | Giusti, V Mansourian, R Zbinden, I Leone-Vautravers, P Mace, K Fuerholz, A Avanti, O Blancher, F Wagniere, S Darimont, C |
| Author_xml | – sequence: 1 fullname: Darimont, C – sequence: 2 fullname: Avanti, O – sequence: 3 fullname: Blancher, F – sequence: 4 fullname: Wagniere, S – sequence: 5 fullname: Mansourian, R – sequence: 6 fullname: Zbinden, I – sequence: 7 fullname: Leone-Vautravers, P – sequence: 8 fullname: Fuerholz, A – sequence: 9 fullname: Giusti, V – sequence: 10 fullname: Mace, K |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20113633$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/17637700$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkktv1DAUhSNURKeFLUuIQHSX6XUcx8myGvGSKrGAri3HuZ5x5MSD7Uh0xV_H0xkYWlEhLyxb3zk693GWnUxuwix7SWBJgDaXYViawS2hAVo3zZNsQSpeF6xq-Um2AAq8AFaz0-wshAEAGIPyWXZKeE05B1hkP1duit50czRuyp3ORwwubtAaaXOF1obcTHn6yPHH1mMIB8xM2spxlNH528KjlRH7XEuV3ncKN-IUk4XszdYFzKMJYcad0nWY3mHuBlQxPM-eamkDvjjc59nNh_ffVp-K6y8fP6-urgvFKhoLWjEuZYek1w2oFnteA6dNXbY1V6h1rYCRutJd21WKq1ZTbBBqXdUS2opzep5d7H233n2fMUQxmrCrT07o5iA4kLalVflfMLW3oS0jCXzzABzc7KdUhChJW1apwSxBb_fQWloUqWkueql2juKKtEAYYbRJ1PIfVDo9jkalgWuT_u8JLv4SbFDauAnO3g0x3AdfHULO3Yi92HozSn8rfi9AAt4dABmUtNrLSZnwhyuBEFpTeoyovAvBoz5agdhtogiDSJsoDpuYBNUDgTJR7gKm2ox9XHa5l4XkP63RH7v6qOL1XqGlE3LtU_qbryk3BWjSCKCivwD7LPrm |
| CODEN | IJOBDP |
| CitedBy_id | crossref_primary_10_1097_MOL_0b013e32832402a2 crossref_primary_10_1016_j_cmet_2024_11_006 crossref_primary_10_1371_journal_pone_0167337 crossref_primary_10_1007_s00125_011_2103_y crossref_primary_10_1515_hsz_2019_0451 crossref_primary_10_1016_j_cmet_2023_02_002 crossref_primary_10_3945_ajcn_2008_25970 crossref_primary_10_1155_2011_587495 crossref_primary_10_1016_j_ando_2024_05_008 crossref_primary_10_1021_pr800942k crossref_primary_10_18499_2225_7357_2020_9_2_90_99 crossref_primary_10_2139_ssrn_3188404 crossref_primary_10_1210_jc_2012_3438 crossref_primary_10_1007_s11605_009_0855_1 crossref_primary_10_1210_endocr_bqab224 crossref_primary_10_3389_fendo_2022_971745 crossref_primary_10_1016_j_celrep_2022_111046 crossref_primary_10_3390_ijms22010261 crossref_primary_10_1172_JCI129187 crossref_primary_10_2337_db07_0767 crossref_primary_10_1038_oby_2009_502 crossref_primary_10_1016_j_celrep_2021_109388 crossref_primary_10_1111_j_1365_2265_2011_04141_x crossref_primary_10_1016_j_tem_2015_07_003 crossref_primary_10_1007_s41669_025_00561_7 crossref_primary_10_1155_2013_861496 crossref_primary_10_1159_000430088 crossref_primary_10_1016_j_biomaterials_2022_121728 crossref_primary_10_7554_eLife_39636 crossref_primary_10_1210_en_2015_1205 crossref_primary_10_1515_pp_2016_0009 |
| Cites_doi | 10.1016/S1357-2725(03)00242-5 10.1210/jc.2003-031365 10.1038/oby.2004.153 10.1007/BF02631284 10.2337/diabetes.54.10.2932 10.1006/mvre.1997.2038 10.1016/j.biochi.2005.08.010 10.2337/diabetes.49.5.688 10.1210/jcem.87.8.8781 10.1210/en.2004-0924 10.1007/s00429-004-0446-6 10.1074/jbc.M301977200 10.1006/mvre.1997.2039 10.1530/eje.1.01897 10.1172/JCI200319246 10.1038/oby.2002.83 10.1038/oby.2005.72 10.1093/bioinformatics/bth319 10.1016/0300-9629(93)90323-V 10.1079/BJN20041213 10.1210/jc.2004-1696 10.1046/j.1365-2249.1998.00592.x 10.1016/j.bbrc.2005.09.068 10.1038/nm1415 10.2337/db06-0133 10.1158/1078-0432.CCR-03-0801 10.1016/j.metabol.2006.04.008 10.1016/S0741-5214(94)70019-2 10.1016/S0065-2776(08)60389-2 10.1111/j.1445-1433.2004.03220.x 10.4049/jimmunol.162.12.7322 10.1182/blood.V75.7.1490.1490 |
| ContentType | Journal Article |
| Copyright | Springer Nature Limited 2008 2008 INIST-CNRS COPYRIGHT 2008 Nature Publishing Group Copyright Nature Publishing Group Jan 2008 |
| Copyright_xml | – notice: Springer Nature Limited 2008 – notice: 2008 INIST-CNRS – notice: COPYRIGHT 2008 Nature Publishing Group – notice: Copyright Nature Publishing Group Jan 2008 |
| DBID | FBQ AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 3V. 7T2 7TK 7TS 7X2 7X7 7XB 88E 88G 8AO 8C1 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA ATCPS AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0K M0S M1P M2M M7P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ Q9U 7S9 L.6 7X8 |
| DOI | 10.1038/sj.ijo.0803688 |
| DatabaseName | AGRIS CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health and Safety Science Abstracts (Full archive) Neurosciences Abstracts Physical Education Index Agricultural Science Collection Health & Medical Collection (Proquest) ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Psychology Database (Alumni) ProQuest Pharma Collection Public Health Database ProQuest SciTech Collection ProQuest Natural Science Journals Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Central Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection (Proquest) ProQuest Health & Medical Complete (Alumni) Biological Sciences Agricultural Science Database ProQuest Health & Medical Collection Medical Database Psychology Collection (Proquest) Biological Science Database (Proquest) Proquest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic AGRICOLA AGRICOLA - Academic MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database ProQuest One Psychology ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China Physical Education Index Environmental Sciences and Pollution Management ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Agricultural & Environmental Science Collection Biological Science Collection Health & Safety Science Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Public Health ProQuest Biological Science Collection ProQuest Central Basic ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) AGRICOLA AGRICOLA - Academic MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Agricultural Science Database MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database – sequence: 4 dbid: FBQ name: AGRIS url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN sourceTypes: Publisher |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Diet & Clinical Nutrition Recreation & Sports Public Health |
| EISSN | 1476-5497 |
| EndPage | 120 |
| ExternalDocumentID | 1412898051 A190151538 17637700 20113633 10_1038_sj_ijo_0803688 US201300877504 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | Switzerland |
| GeographicLocations_xml | – name: Switzerland |
| GroupedDBID | .55 .GJ 1GH 29J 36B 39C 5RE 7X2 7X7 8R4 8R5 A8Z ABDBF ABOCM ABPTK ABUWG ADBBV AFFNX AI. ALMA_UNASSIGNED_HOLDINGS ATCPS AZQEC B0M BAWUL BENPR BHPHI BPHCQ DIK DWQXO EAD EAP EBC EBD EBS EMB EMK EMOBN EPL ESTFP ESX F5P FBQ FYUFA GNUQQ HCIFZ IAO IHR ITC J5H M0K M1P M2M MVM NAO OK1 Q2X RNT RNTTT SV3 TUS VH1 WH7 X7M ZA5 ZGI ZXP ~8M ACUHS AAYXX CITATION IQODW --- -Q- ..I .L3 .XZ 0R~ 1CY 2FS 2WC 4.4 406 53G 5GY 70F 88E 8AO 8C1 8FE 8FH 8FI 8FJ AACDK AAHBH AANZL AASML AATNV AAWTL AAYZH ABAKF ABAWZ ABBRH ABCQX ABDBE ABFSG ABIVO ABJNI ABLJU ABRTQ ABZZP ACAOD ACGFS ACKTT ACPRK ACRQY ACSTC ACZOJ ADHUB ADXHL AEFQL AEJRE AEMSY AENEX AEUYN AEVLU AEXYK AEZWR AFBBN AFDZB AFHIU AFKRA AFRAH AFSHS AGAYW AGHAI AGQEE AHMBA AHSBF AHWEU AIGIU AILAN AIXLP AJRNO ALFFA ALIPV AMYLF APEBS ATHPR AXYYD AYFIA BBNVY BKKNO BVXVI CCPQU CGR CS3 CUY CVF DNIVK DPUIP DU5 E3Z EBLON ECM EE. EIF EIOEI EJD FDQFY FERAY FIGPU FIZPM FSGXE HMCUK HZ~ IHW INH INR IPY IWAJR JSO JZLTJ KQ8 L7B M7P NPM NQJWS O9- OVD P2P P6G PHGZM PHGZT PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PSYQQ RNS ROL SNX SNYQT SOHCF SOJ SRMVM SWTZT TAOOD TBHMF TDRGL TEORI TR2 TSG UKHRP ~KM 3V. 7T2 7TK 7TS 7XB 8FK C1K K9. LK8 PKEHL PQEST PQUKI PRINS Q9U 7S9 L.6 7X8 PUEGO |
| ID | FETCH-LOGICAL-c543t-3457aabe1df80c9ed76073862967ceff6c05164fb9b4c7c9f3e8e06f46a094773 |
| IEDL.DBID | BENPR |
| ISSN | 0307-0565 1476-5497 |
| IngestDate | Sun Sep 28 12:25:38 EDT 2025 Fri Sep 05 07:38:53 EDT 2025 Tue Oct 28 11:49:40 EDT 2025 Mon Oct 20 23:06:08 EDT 2025 Mon Oct 20 17:13:46 EDT 2025 Thu May 22 21:13:59 EDT 2025 Mon Jul 21 05:31:19 EDT 2025 Mon Jul 21 09:13:34 EDT 2025 Thu Apr 24 23:06:19 EDT 2025 Wed Oct 01 03:42:56 EDT 2025 Fri Feb 21 02:39:41 EST 2025 Wed Dec 27 19:27:20 EST 2023 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | transcriptomics adipose tissue cytokines mast cells neutrophils Human Obesity Adipose tissue Nutrition Nutrition disorder Cytokine Granulocyte Omentum Inflammation Mesothelial cell Mast cell Neutrophil Nutritional status |
| Language | English |
| License | http://www.springer.com/tdm CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c543t-3457aabe1df80c9ed76073862967ceff6c05164fb9b4c7c9f3e8e06f46a094773 |
| Notes | http://www.nature.com/ijo/ ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| PMID | 17637700 |
| PQID | 219243775 |
| PQPubID | 38864 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_70199342 proquest_miscellaneous_47683951 proquest_journals_219243775 gale_infotracmisc_A190151538 gale_infotracacademiconefile_A190151538 gale_healthsolutions_A190151538 pubmed_primary_17637700 pascalfrancis_primary_20113633 crossref_primary_10_1038_sj_ijo_0803688 crossref_citationtrail_10_1038_sj_ijo_0803688 springer_journals_10_1038_sj_ijo_0803688 fao_agris_US201300877504 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2008-01-01 |
| PublicationDateYYYYMMDD | 2008-01-01 |
| PublicationDate_xml | – month: 01 year: 2008 text: 2008-01-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: Basingstoke – name: England |
| PublicationTitle | International Journal of Obesity |
| PublicationTitleAbbrev | Int J Obes |
| PublicationTitleAlternate | Int J Obes (Lond) |
| PublicationYear | 2008 |
| Publisher | Nature Publishing Group UK Nature Publishing Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing – name: Nature Publishing Group |
| References | Escobar-Morreale, Botella-Carretero, Villuendas, Sancho, San Millan (CR4) 2004; 89 Thorand, Kolb, Baumert, Koenig, Chambless, Meisinger (CR2) 2005; 54 Mineau-Hanschke, Patton, Hechtman, Shepro (CR22) 1993; 104 Yao, Platell, Hall (CR29) 2004; 74 Wilkosz, Ireland, Khwaja, Walker, Butt, de Giorgio-Miller (CR14) 2005; 209 Chung-Welch, Patton, Shepro, Cambria (CR19) 1997; 54 Mutsaers (CR17) 2004; 36 Fain, Tichansky, Madan (CR9) 2006; 55 Netea, Joosten, Lewis, Jensen, Voshol, Kullberg (CR5) 2006; 12 Gabrielsson, Olofsson, Sjogren, Jernas, Elander, Lonn (CR26) 2005; 13 Vohl, Sladek, Robitaille, Gurd, Marceau, Richard (CR13) 2004; 12 Cancello, Tordjman, Poitou, Guilhem, Bouillot, Hugol (CR12) 2006; 55 Visser, Tekstra, Brouwer-Steenbergen, Tuk, Boorsma, Sampat-Sardjoepersad (CR18) 1998; 112 Bruun, Lihn, Pedersen, Richelsen (CR11) 2005; 90 Trayhurn, Wood (CR1) 2004; 92 Darimont, Avanti, Zbinden, Leone-Vautravers, Mansourian, Giusti (CR25) 2006; 88 Rotter, Nagaev, Smith (CR34) 2003; 278 Skurk, Kolb, Muller-Scholze, Rohrig, Hauner, Herder (CR7) 2005; 152 Wood, Wang, Jenkins, Trayhurn (CR8) 2005; 337 Gabrielsson, Johansson, Jennische, Jernas, Itoh, Peltonen (CR27) 2002; 10 Esposito, Pontillo, Ciotola, Di Palo, Grella, Nicoletti (CR3) 2002; 87 Chung-Welch, Patton, Shepro, Cambria (CR21) 1997; 54 Takahashi, Hata, Mukai, Sawasaki (CR20) 1991; 27A Williams, Wang, Castrillo, Jarrell (CR15) 1994; 19 van Hinsbergh, Kooistra, Scheffer, Hajo van Bockel, van Muijen (CR16) 1990; 75 Mansourian, Mutch, Antille, Aubert, Fogel, Le Goff (CR24) 2004; 20 Pirhonen, Sareneva, Kurimoto, Julkunen, Matikainen (CR30) 1999; 162 Okamura, Tsutsui, Kashiwamura, Yoshimoto, Nakanishi (CR32) 1998; 70 Skurk, Herder, Kraft, Muller-Scholze, Hauner, Kolb (CR6) 2005; 146 Hassan, Bera, Pastan (CR23) 2004; 10 Weisberg, McCann, Desai, Rosenbaum, Leibel, Ferrante (CR10) 2003; 112 Lofgren, van Harmelen, Reynisdottir, Naslund, Ryden, Rossner (CR33) 2000; 49 Hutson, Stocco (CR31) 1989; 2 Bjorntorp (CR28) 1996; 20 IS Wood (BF0803688_CR8) 2005; 337 CE Visser (BF0803688_CR18) 1998; 112 H Okamura (BF0803688_CR32) 1998; 70 SE Mutsaers (BF0803688_CR17) 2004; 36 SP Weisberg (BF0803688_CR10) 2003; 112 P Lofgren (BF0803688_CR33) 2000; 49 B Thorand (BF0803688_CR2) 2005; 54 V Yao (BF0803688_CR29) 2004; 74 R Cancello (BF0803688_CR12) 2006; 55 C Darimont (BF0803688_CR25) 2006; 88 JM Bruun (BF0803688_CR11) 2005; 90 N Chung-Welch (BF0803688_CR19) 1997; 54 K Esposito (BF0803688_CR3) 2002; 87 T Skurk (BF0803688_CR6) 2005; 146 J Pirhonen (BF0803688_CR30) 1999; 162 HF Escobar-Morreale (BF0803688_CR4) 2004; 89 S Wilkosz (BF0803688_CR14) 2005; 209 P Trayhurn (BF0803688_CR1) 2004; 92 K Takahashi (BF0803688_CR20) 1991; 27A T Skurk (BF0803688_CR7) 2005; 152 P Bjorntorp (BF0803688_CR28) 1996; 20 R Hassan (BF0803688_CR23) 2004; 10 VW van Hinsbergh (BF0803688_CR16) 1990; 75 JC Hutson (BF0803688_CR31) 1989; 2 BG Gabrielsson (BF0803688_CR26) 2005; 13 BG Gabrielsson (BF0803688_CR27) 2002; 10 R Mineau-Hanschke (BF0803688_CR22) 1993; 104 R Mansourian (BF0803688_CR24) 2004; 20 JN Fain (BF0803688_CR9) 2006; 55 V Rotter (BF0803688_CR34) 2003; 278 MC Vohl (BF0803688_CR13) 2004; 12 MG Netea (BF0803688_CR5) 2006; 12 SK Williams (BF0803688_CR15) 1994; 19 N Chung-Welch (BF0803688_CR21) 1997; 54 |
| References_xml | – volume: 36 start-page: 9 year: 2004 end-page: 16 ident: CR17 article-title: The mesothelial cell publication-title: Int J Biochem Cell Biol doi: 10.1016/S1357-2725(03)00242-5 – volume: 89 start-page: 806 year: 2004 end-page: 811 ident: CR4 article-title: Serum interleukin-18 concentrations are increased in the polycystic ovary syndrome: relationship to insulin resistance and to obesity publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2003-031365 – volume: 12 start-page: 1217 year: 2004 end-page: 1222 ident: CR13 article-title: A survey of genes differentially expressed in subcutaneous and visceral adipose tissue in men publication-title: Obes Res doi: 10.1038/oby.2004.153 – volume: 27A start-page: 542 year: 1991 end-page: 548 ident: CR20 article-title: Close similarity between cultured human omental mesothelial cells and endothelial cells in cytochemical markers and plasminogen activator production publication-title: In vitro Cell Dev Biol doi: 10.1007/BF02631284 – volume: 54 start-page: 2932 year: 2005 end-page: 2938 ident: CR2 article-title: Elevated levels of interleukin-18 predict the development of type 2 diabetes: results from the MONICA/KORA Augsburg Study, 1984–2002 publication-title: Diabetes doi: 10.2337/diabetes.54.10.2932 – volume: 54 start-page: 108 year: 1997 end-page: 120 ident: CR21 article-title: Human omental microvascular endothelial and mesothelial cells: characterization of two distinct mesodermally derived epithelial cells publication-title: Microvasc Res doi: 10.1006/mvre.1997.2038 – volume: 88 start-page: 309 year: 2006 end-page: 318 ident: CR25 article-title: Liver X receptor preferentially activates lipogenesis in human preadipocytes publication-title: Biochimie doi: 10.1016/j.biochi.2005.08.010 – volume: 2 start-page: 249 year: 1989 end-page: 253 ident: CR31 article-title: Comparison of cellular and secreted proteins of macrophages from the testis and peritoneum on two-dimensional polyacrylamide gels: evidence of tissue specific function publication-title: Reg Immunol – volume: 49 start-page: 688 year: 2000 end-page: 692 ident: CR33 article-title: Secretion of tumor necrosis factor-alpha shows a strong relationship to insulin-stimulated glucose transport in human adipose tissue publication-title: Diabetes doi: 10.2337/diabetes.49.5.688 – volume: 87 start-page: 3864 year: 2002 end-page: 3866 ident: CR3 article-title: Weight loss reduces interleukin-18 levels in obese women publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.87.8.8781 – volume: 146 start-page: 1006 year: 2005 end-page: 1011 ident: CR6 article-title: Production and release of macrophage migration inhibitory factor from human adipocytes publication-title: Endocrinology doi: 10.1210/en.2004-0924 – volume: 209 start-page: 251 year: 2005 end-page: 261 ident: CR14 article-title: A comparative study of the structure of human and murine greater omentum publication-title: Anat Embryol (Berl) doi: 10.1007/s00429-004-0446-6 – volume: 278 start-page: 45777 year: 2003 end-page: 45784 ident: CR34 article-title: Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects publication-title: J Biol Chem doi: 10.1074/jbc.M301977200 – volume: 54 start-page: 121 year: 1997 end-page: 134 ident: CR19 article-title: Two-stage isolation procedure for obtaining homogenous populations of microvascular endothelial and mesothelial cells from human omentum publication-title: Microvasc Res doi: 10.1006/mvre.1997.2039 – volume: 152 start-page: 863 year: 2005 end-page: 868 ident: CR7 article-title: The proatherogenic cytokine interleukin-18 is secreted by human adipocytes publication-title: Eur J Endocrinol doi: 10.1530/eje.1.01897 – volume: 112 start-page: 1796 year: 2003 end-page: 1808 ident: CR10 article-title: Obesity is associated with macrophage accumulation in adipose tissue publication-title: J Clin Invest doi: 10.1172/JCI200319246 – volume: 10 start-page: 608 year: 2002 end-page: 616 ident: CR27 article-title: Depot-specific expression of fibroblast growth factors in human adipose tissue publication-title: Obes Res doi: 10.1038/oby.2002.83 – volume: 13 start-page: 649 year: 2005 end-page: 652 ident: CR26 article-title: Evaluation of reference genes for studies of gene expression in human adipose tissue publication-title: Obes Res doi: 10.1038/oby.2005.72 – volume: 75 start-page: 1490 year: 1990 end-page: 1497 ident: CR16 article-title: Characterization and fibrinolytic properties of human omental tissue mesothelial cells. Comparison with endothelial cells publication-title: Blood – volume: 20 start-page: 2726 year: 2004 end-page: 2737 ident: CR24 article-title: The global error assessment (GEA) model for the selection of differentially expressed genes in microarray data publication-title: Bioinformatics doi: 10.1093/bioinformatics/bth319 – volume: 104 start-page: 313 year: 1993 end-page: 319 ident: CR22 article-title: Immunolocalization of cytokeratin 19 in bovine and human pulmonary microvascular endothelial cells publication-title: Comp Biochem Physiol Comp Physiol doi: 10.1016/0300-9629(93)90323-V – volume: 162 start-page: 7322 year: 1999 end-page: 7329 ident: CR30 article-title: Virus infection activates IL-1 beta and IL-18 production in human macrophages by a caspase-1-dependent pathway publication-title: J Immunol – volume: 92 start-page: 347 year: 2004 end-page: 355 ident: CR1 article-title: Adipokines: inflammation and the pleiotropic role of white adipose tissue publication-title: Br J Nutr doi: 10.1079/BJN20041213 – volume: 90 start-page: 2282 year: 2005 end-page: 2289 ident: CR11 article-title: Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2004-1696 – volume: 112 start-page: 270 year: 1998 end-page: 275 ident: CR18 article-title: Chemokines produced by mesothelial cells: huGRO-alpha, IP-10, MCP-1 and RANTES publication-title: Clin Exp Immunol doi: 10.1046/j.1365-2249.1998.00592.x – volume: 337 start-page: 422 year: 2005 end-page: 429 ident: CR8 article-title: The pro-inflammatory cytokine IL-18 is expressed in human adipose tissue and strongly upregulated by TNFalpha in human adipocytes publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2005.09.068 – volume: 12 start-page: 650 year: 2006 end-page: 656 ident: CR5 article-title: Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance publication-title: Nat Med doi: 10.1038/nm1415 – volume: 55 start-page: 1554 year: 2006 end-page: 1561 ident: CR12 article-title: Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity publication-title: Diabetes doi: 10.2337/db06-0133 – volume: 10 start-page: 3937 year: 2004 end-page: 3942 ident: CR23 article-title: Mesothelin: a new target for immunotherapy publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-03-0801 – volume: 55 start-page: 1113 year: 2006 end-page: 1121 ident: CR9 article-title: Most of the interleukin 1 receptor antagonist, cathepsin S, macrophage migration inhibitory factor, nerve growth factor, and interleukin 18 release by explants of human adipose tissue is by the non-fat cells, not by the adipocytes publication-title: Metabolism doi: 10.1016/j.metabol.2006.04.008 – volume: 19 start-page: 916 year: 1994 end-page: 923 ident: CR15 article-title: Liposuction-derived human fat used for vascular graft sodding contains endothelial cells and not mesothelial cells as the major cell type publication-title: J Vasc Surg doi: 10.1016/S0741-5214(94)70019-2 – volume: 70 start-page: 281 year: 1998 end-page: 312 ident: CR32 article-title: Interleukin-18: a novel cytokine that augments both innate and acquired immunity publication-title: Adv Immunol doi: 10.1016/S0065-2776(08)60389-2 – volume: 20 start-page: 291 year: 1996 end-page: 302 ident: CR28 article-title: The regulation of adipose tissue distribution in humans publication-title: Int J Obes Relat Metab Disord – volume: 74 start-page: 997 year: 2004 end-page: 1002 ident: CR29 article-title: Peritoneal mesothelial cells produce inflammatory related cytokines publication-title: ANZ J Surg doi: 10.1111/j.1445-1433.2004.03220.x – volume: 87 start-page: 3864 year: 2002 ident: BF0803688_CR3 publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.87.8.8781 – volume: 162 start-page: 7322 year: 1999 ident: BF0803688_CR30 publication-title: J Immunol doi: 10.4049/jimmunol.162.12.7322 – volume: 88 start-page: 309 year: 2006 ident: BF0803688_CR25 publication-title: Biochimie doi: 10.1016/j.biochi.2005.08.010 – volume: 146 start-page: 1006 year: 2005 ident: BF0803688_CR6 publication-title: Endocrinology doi: 10.1210/en.2004-0924 – volume: 36 start-page: 9 year: 2004 ident: BF0803688_CR17 publication-title: Int J Biochem Cell Biol doi: 10.1016/S1357-2725(03)00242-5 – volume: 90 start-page: 2282 year: 2005 ident: BF0803688_CR11 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2004-1696 – volume: 112 start-page: 270 year: 1998 ident: BF0803688_CR18 publication-title: Clin Exp Immunol doi: 10.1046/j.1365-2249.1998.00592.x – volume: 54 start-page: 2932 year: 2005 ident: BF0803688_CR2 publication-title: Diabetes doi: 10.2337/diabetes.54.10.2932 – volume: 19 start-page: 916 year: 1994 ident: BF0803688_CR15 publication-title: J Vasc Surg doi: 10.1016/S0741-5214(94)70019-2 – volume: 209 start-page: 251 year: 2005 ident: BF0803688_CR14 publication-title: Anat Embryol (Berl) doi: 10.1007/s00429-004-0446-6 – volume: 55 start-page: 1554 year: 2006 ident: BF0803688_CR12 publication-title: Diabetes doi: 10.2337/db06-0133 – volume: 10 start-page: 608 year: 2002 ident: BF0803688_CR27 publication-title: Obes Res doi: 10.1038/oby.2002.83 – volume: 54 start-page: 121 year: 1997 ident: BF0803688_CR19 publication-title: Microvasc Res doi: 10.1006/mvre.1997.2039 – volume: 13 start-page: 649 year: 2005 ident: BF0803688_CR26 publication-title: Obes Res doi: 10.1038/oby.2005.72 – volume: 10 start-page: 3937 year: 2004 ident: BF0803688_CR23 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-03-0801 – volume: 337 start-page: 422 year: 2005 ident: BF0803688_CR8 publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2005.09.068 – volume: 54 start-page: 108 year: 1997 ident: BF0803688_CR21 publication-title: Microvasc Res doi: 10.1006/mvre.1997.2038 – volume: 89 start-page: 806 year: 2004 ident: BF0803688_CR4 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2003-031365 – volume: 12 start-page: 650 year: 2006 ident: BF0803688_CR5 publication-title: Nat Med doi: 10.1038/nm1415 – volume: 74 start-page: 997 year: 2004 ident: BF0803688_CR29 publication-title: ANZ J Surg doi: 10.1111/j.1445-1433.2004.03220.x – volume: 278 start-page: 45777 year: 2003 ident: BF0803688_CR34 publication-title: J Biol Chem doi: 10.1074/jbc.M301977200 – volume: 2 start-page: 249 year: 1989 ident: BF0803688_CR31 publication-title: Reg Immunol – volume: 70 start-page: 281 year: 1998 ident: BF0803688_CR32 publication-title: Adv Immunol doi: 10.1016/S0065-2776(08)60389-2 – volume: 20 start-page: 291 year: 1996 ident: BF0803688_CR28 publication-title: Int J Obes Relat Metab Disord – volume: 49 start-page: 688 year: 2000 ident: BF0803688_CR33 publication-title: Diabetes doi: 10.2337/diabetes.49.5.688 – volume: 92 start-page: 347 year: 2004 ident: BF0803688_CR1 publication-title: Br J Nutr doi: 10.1079/BJN20041213 – volume: 55 start-page: 1113 year: 2006 ident: BF0803688_CR9 publication-title: Metabolism doi: 10.1016/j.metabol.2006.04.008 – volume: 112 start-page: 1796 year: 2003 ident: BF0803688_CR10 publication-title: J Clin Invest doi: 10.1172/JCI200319246 – volume: 104 start-page: 313 year: 1993 ident: BF0803688_CR22 publication-title: Comp Biochem Physiol Comp Physiol doi: 10.1016/0300-9629(93)90323-V – volume: 152 start-page: 863 year: 2005 ident: BF0803688_CR7 publication-title: Eur J Endocrinol doi: 10.1530/eje.1.01897 – volume: 27A start-page: 542 year: 1991 ident: BF0803688_CR20 publication-title: In vitro Cell Dev Biol doi: 10.1007/BF02631284 – volume: 12 start-page: 1217 year: 2004 ident: BF0803688_CR13 publication-title: Obes Res doi: 10.1038/oby.2004.153 – volume: 75 start-page: 1490 year: 1990 ident: BF0803688_CR16 publication-title: Blood doi: 10.1182/blood.V75.7.1490.1490 – volume: 20 start-page: 2726 year: 2004 ident: BF0803688_CR24 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bth319 |
| SSID | ssj0005502 ssj0033214 |
| Score | 2.0564291 |
| Snippet | Objective:
The objective of this study was to determine the contribution of mesothelial cells, present in human omental adipose tissue (OAT) but not in the... The objective of this study was to determine the contribution of mesothelial cells, present in human omental adipose tissue (OAT) but not in the subcutaneous... |
| SourceID | proquest gale pubmed pascalfrancis crossref springer fao |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 112 |
| SubjectTerms | Adipocytes Adipose tissue Adipose Tissue - cytology Adipose Tissue - metabolism Adipose tissues Adult Analysis bariatric surgery Biological and medical sciences Body fat Body mass index Chemokines Cytokines cytology Epidemiology Epithelial Cells Epithelial Cells - metabolism Epithelium Epithelium - metabolism Female gastric bypass surgery Gastrointestinal surgery Gene expression genetics Health Promotion and Disease Prevention Humans Immunohistochemistry Inflammation Inflammation - genetics Interleukin-18 Interleukin-18 - genetics Interleukin-18 - metabolism Internal Medicine Medical sciences Medicine Medicine & Public Health mesothelial cells Metabolic Diseases Metabolism Microarray Analysis Neutrophils Obesity Obesity - genetics Obesity - metabolism omentum Omentum - metabolism original-article Overweight persons Public Health Reverse Transcriptase Polymerase Chain Reaction subcutaneous fat Subcutaneous Fat, Abdominal Subcutaneous Fat, Abdominal - metabolism Tumor necrosis factor-TNF White people Whites women |
| Title | Contribution of mesothelial cells in the expression of inflammatory-related factors in omental adipose tissue of obese subjects |
| URI | https://link.springer.com/article/10.1038/sj.ijo.0803688 https://www.ncbi.nlm.nih.gov/pubmed/17637700 https://www.proquest.com/docview/219243775 https://www.proquest.com/docview/47683951 https://www.proquest.com/docview/70199342 |
| Volume | 32 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1476-5497 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0005502 issn: 0307-0565 databaseCode: KQ8 dateStart: 19970101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVEBS databaseName: EBSCO - Academic Search Ultimate customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 1476-5497 dateEnd: 20151130 omitProxy: true ssIdentifier: ssj0005502 issn: 0307-0565 databaseCode: ABDBF dateStart: 20050101 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost – providerCode: PRVEBS databaseName: EBSCOhost Food Science Source customDbUrl: eissn: 1476-5497 dateEnd: 20151130 omitProxy: false ssIdentifier: ssj0005502 issn: 0307-0565 databaseCode: A8Z dateStart: 20050101 isFulltext: true titleUrlDefault: https://search.ebscohost.com/login.aspx?authtype=ip,uid&profile=ehost&defaultdb=fsr providerName: EBSCOhost – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1476-5497 dateEnd: 20201105 omitProxy: true ssIdentifier: ssj0005502 issn: 0307-0565 databaseCode: DIK dateStart: 20050101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVLSH databaseName: SpringerLink Journals customDbUrl: mediaType: online eissn: 1476-5497 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0005502 issn: 0307-0565 databaseCode: AFBBN dateStart: 19970101 isFulltext: true providerName: Library Specific Holdings – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1476-5497 dateEnd: 20171231 omitProxy: true ssIdentifier: ssj0005502 issn: 0307-0565 databaseCode: 7X7 dateStart: 20050101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 1476-5497 dateEnd: 20171231 omitProxy: true ssIdentifier: ssj0005502 issn: 0307-0565 databaseCode: BENPR dateStart: 20050101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1476-5497 dateEnd: 20171231 omitProxy: true ssIdentifier: ssj0005502 issn: 0307-0565 databaseCode: 8C1 dateStart: 19970201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fb9MwELbWTkJICEGBLWwUPyDgJVsSO3bygNDYDw1QKwRU6pvlOA5q1TWFtBJv_OvcJU6qio2XRGkuiWufz2ff-fsIeZUmRSo1N74GZ9RHjis_C03mh7nQwsY8shmuQ47G4nrCP03j6R4ZtXthMK2ytYm1oc5Lg2vkpxHOFJiU8fvVTx9JozC42jJoaMeskL-rEcZ6ZD9CYKw-2f9wOf7ydZvzEQcduBRDip4WJhHcgLiFdGTJaTU_mc3LE_CmWMPJsh2yeoUuO_P9YKUrqMqi4cC4zUn9J8Baj1tXj8hD53DSs0ZDHpM9uxwQ72Jm1_Q1daigCzpuQfkH5N7IhdsHZLB1KkG4JkSvnpA_iGjV8mTRsqA3tsJ9XAtQZYqBgIrOlhR-oPa3S7OtxUCXQf1u6rC-X--hsTl1fD_4RNnwDFCdz1ZlZem61gl8sswsXFebDBeNqqdkcnX5_fzadzwOvok5W_uMx1LrzIZ5kQQmtbkUAXKNRqmQxhaFMGAZBC-yNONGmrRgNrGBKLjQMPmUkj0j_WW5tIeE5lpqEWZSB4HhuRVpqLmAk01BkHPrEb9tKmUcyDlybSxUHWxniarmCppWuab1yJtOftXAe9wpeQgtr_QPsL1q8i3CiC-CKcYB98hLVAfV7FztTIY6q50tHFLgM7UEGg0ojtFu7wP8KYTf2pE83pGEzm52bg93VK4rNPpxTDDmkaNWB5WzRpXq-g6UtLuLb8YEu6UtN5XiMO1k4G3fLYG4_SnjkUcOGtXeVhiMUVIGgUfetrq-_fbttfn8v8U8IvebtBxc6Tom_fWvjX0Bvt86G5KenEo4Jufh0PVuuLr4-PkvItlYSA |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF61RQIkhCA8alraPfC6uHW86137gFDVUqW0yYVG6m27Xq9RojQObCLgxC_iPzLjV4houfVkxR7bG8_szOzO4yPkVRLnidTc-BqcUR8xrvy0a1K_mwktbMRDm-I-ZH8gekP-6SK6WCO_m1oYTKtsdGKpqLPC4B75fogrBSZl9GH21UfQKAyuNggalVSc2p_fYcXm3p8cAXtfh-Hxx_PDnl-DCvgm4mzuMx5JrVPbzfI4MInNpAgQ-DJMhDQ2z4UBMRU8T5OUG2mSnNnYBiLnQsNKSEoGz10ndzgLJeqB-PCvjJIoaFtXMQQAapowgpMRNQ0jWbzvxnujcbEHvhqrEF-WBnE910VrHB7MtANG5RXCxnUu8D_h29IqHj8iD2t3lh5U8veYrNlph3hHIzunb2jdc3RCB03L_w6526-D-R3SWbqsQFzCrbsn5Bf2y2pQuGiR0yvrsEpsAhOFYpjB0dGUwglqf9RJvCUZzBQQ7qsyacAvK3RsRms0IbyjqFAMqM5Gs8JZOi8lDu8sUgu_3SLFLSn3lAxvhaHPyMa0mNpNQjMtteimUgeB4ZkVSVdzAQebACHn1iN-wypl6hbqiOQxUWUon8XKjRWwVtWs9cjbln5WNQ-5kXITOK_0F9Dsavg5xHgytmqMAu6RXRQHVdXFtgpJHZSuHBoseE1JgSoJhmN0XVkBfwqbe61Qbq9QgioxK5d3VkSuHTR6iUww5pGtRgZVreucamcmjLS9ik_G9L2pLRZOcVjUMvDlb6ZAVICE8dAjzyvRXn4wsIBSBoFH3jWyvnz39V_zxX-HuUvu9c77Z-rsZHC6Re5XCUC4p7ZNNubfFvYleJnzdKec25Rc3rYy-QP9XIvK |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELe2IU1ICEH5WNjY_MDXS9YkduzmAaGJUm2MVUhQqW_GcRzUqmsKbgU88Xfx33GXr6pi421PUZNL4ubOd2ffx4-QZ0kvT6TmxtfgjPqIceWnoUn9MBNa2JhHNsV9yIuhOB3x9-N4vEX-NLUwmFbZ6MRSUWeFwT3yboQrBSZl3M3rrIiP_cGbxTcfAaQw0NqgaVQScm5__YDVm3t91gdWP4-iwbvPb0_9GmDANzFnS5_xWGqd2jDLe4FJbCZFgCCYUSKksXkuDIis4HmapNxIk-TM9mwgci40rIqkZPDcbXJLMpZgNqEcy3V2SRy0bawYggE1DRnB4Yib5pGs13XT48m0OAa_jVXoL2vjuJ3rojUUdxbaAdPyCm3jKnf4n1BuaSEH98jd2rWlJ5Us3idbdt4hXn9il_QFrfuPzuiwaf_fIbsXdWC_Qzpr9xWIS-h194D8xt5ZDSIXLXJ6aR1WjM1g0lAMOTg6mVM4Qe3POqG3JINZA4J-WSYQ-GW1js1ojSyEdxQVogHV2WRROEuXpfThnUVq4bdbpbg95R6S0Y0w9BHZmRdzu0dopqUWYSp1EBieWZGEmgs42AQIObce8RtWKVO3U0dUj5kqw_qsp9xUAWtVzVqPvGzpF1UjkWsp94DzSn8FLa9GnyKMLWPbxjjgHjlCcVBVjWyrnNRJ6dah8YLXlBSonmA4RtdVFvCnsNHXBuXBBiWoFbNx-XBD5NpBo8fIBGMe2W9kUNV6z6l2lsJI26v4ZEzlm9ti5RSHBS7Ml_B6CkQISBiPPPK4Eu31BwNrKGUQeORVI-vrd1_9NZ_8d5hHZBfUiPpwNjzfJ7erXCDcXjsgO8vvK_sUHM5lelhObUq-3LQu-QtVEpA5 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Contribution+of+mesothelial+cells+in+the+expression+of+inflammatory-related+factors+in+omental+adipose+tissue+of+obese+subjects&rft.jtitle=International+journal+of+obesity+%282005%29&rft.au=Darimont%2C+C&rft.au=Avanti%2C+O&rft.au=Blancher%2C+F&rft.au=Wagniere%2C+S&rft.date=2008-01-01&rft.issn=1476-5497&rft.eissn=1476-5497&rft.volume=32&rft.issue=1&rft.spage=112&rft_id=info:doi/10.1038%2Fsj.ijo.0803688&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0307-0565&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0307-0565&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0307-0565&client=summon |