Genetic and Epigenetic Defects at the GNAS Locus Lead to Distinct Patterns of Skeletal Growth but Similar Early‐Onset Obesity - Hanna, Patrick; Grybek, Virginie; Perez de Nanclares, Guiomar; Tran, Léa C; de Sanctis, Luisa; Elli, Francesca; Errea, Javier; Francou, Bruno; Kamenicky, Peter; Linglart, Léa; Pereda, Arrate; Rothenbuhler, Anya; et al. (Journal of bone and mineral research, 2018)
Keywords: Adult; Age of Onset; Birth; Body height; Body Mass Index; Body weight; Bone Development; Bone Development - genetics; Chromogranins; Chromogranins - genetics; DNA methylation; EARLY‐ONSET OBESITY; Epigenesis, Genetic; Female; Fetuses; Genetic Loci; Genetic Predisposition to Disease; Genetics; GNAS; GROWTH; Growth plate; GTP-Binding Protein alpha Subunits, Gs; GTP-Binding Protein alpha Subunits, Gs - genetics; Haploinsufficiency; Human genetics; Humans; Infant, Newborn; Life Sciences; Male; Obesity; Obesity - genetics; Overweight; Parathyroid; Parathyroid hormone; Pregnancy; PSEUDOHYPOPARATHYROIDISM; Pseudohypoparathyroidism - genetics; PSEUDOPSEUDOHYPOPARATHYROIDISM; Transcription; Velocity; Weight Gain; Weight Gain - genetics; GNAS; EARLY-ONSET OBESITY; PSEUDOHYPOPARATHYROIDISM; PSEUDOPSEUDOHYPOPARATHYROIDISM; GROWTH