Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites - Breda, Carlo; Sathyasaikumar, Korrapati V.; Idrissi, Shama Sograte; Notarangelo, Francesca M.; Estranero, Jasper G.; Moore, Gareth G. L.; Green, Edward W.; Kyriacou, Charalambos P.; Schwarcz, Robert; Giorgini, Flaviano (Proceedings of the National Academy of Sciences - PNAS, 2016)
Keywords: Animals; Biological Sciences; Dose-Response Relationship, Drug; Drosophila; Enzymes; Huntingtons disease; Kynurenine - metabolism; Metabolites; Neurodegeneration; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Neurodegenerative Diseases - prevention & control; Neurology; Neuroprotective Agents - administration & dosage; Neuropsychology; Parkinson's disease; Pathogenesis; Signal Transduction - drug effects; Treatment Outcome; Tryptophan Oxygenase - antagonists & inhibitors; neurodegeneration; Alzheimer’s disease; KMO; Parkinson’s disease; TDO