Bolus infusion scheme for the adjustment of steady state [11C]Flumazenil levels in the grey matter and in the blood plasma for neuroreceptor imaging - Mauler, Jörg; Heinzel, Alexander; Matusch, Andreas; Herzog, Hans; Neuner, Irene; Scheins, Jürgen; Wyss, Christine; Dammers, Jürgen; Lang, Markus; Ermert, Johannes; Neumaier, Bernd; Langen, Karl-Josef; et al. (NeuroImage (Orlando, Fla.), 2020)
Keywords: [11C]flumazenil; Adult; Binding sites; Blood flow; Bolus infusion scheme; Brain; Carbon Radioisotopes - administration & dosage; Decomposition; Experiments; Flumazenil; Flumazenil - administration & dosage; Flumazenil - blood; Flumazenil - pharmacokinetics; GABA Modulators - administration & dosage; GABA Modulators - blood; GABA Modulators - pharmacokinetics; Gray Matter - diagnostic imaging; Gray Matter - drug effects; Gray Matter - metabolism; Humans; Ligands; Magnetic Resonance Imaging; Male; Metabolic rate; Metabolite analysis; Metabolites; Multimodal Imaging; Neuroimaging; Partial volume correction; PET/MR; Plasma; Positron emission tomography; Sensory Receptor Cells - drug effects; Sensory Receptor Cells - metabolism; Signal processing; Steady state; Substantia alba; Substantia grisea; Volunteers; White Matter - diagnostic imaging; White Matter - drug effects; White Matter - metabolism; Young Adult; [11C]flumazenil; Partial volume correction; PET/MR; Bolus infusion scheme; Metabolite analysis; Steady state; [C]flumazenil