Evaluation of different treatment modalities on the efficacy of hydroxypropyl Guar (HP-Guar) formulation on tear film stability (TFS) in subjects exposed to adverse environmental conditions

• Published in: BMC ophthalmology Vol. 23; no. 1; pp. 226 - 11
• Main Authors: Abusharha, Ali, Pearce, Ian E., Afsar, Tayyaba, Alsaqr, Ali, Fagehi, Raied, Razak, Suhail
• Format: Journal Article
• Language: English
• Published: London BioMed Central 22.05.2023; BMC
• Subjects: Controlled environment chamber; Cyamopsis; Desiccating environment; Dry eye; Dry Eye Syndromes; Efficiency; Electrolytes; Environmental conditions; Evaporation; Humans; Humidity; Hydroxypropyl guar; Laboratories; Lacerations; Lipids; Lubricants & lubrication; Medicine; Medicine & Public Health; Ophthalmic Solutions; Ophthalmology; Polysaccharides; Relative humidity; Tear evaporation rate; Tear film stability; Tears; Fort Worth Texas; United States > US; Texas; Tear film stability; Tear evaporation rate; Dry eye; Desiccating environment; Hydroxypropyl guar; Treatment modalities; Controlled environment chamber
• ISSN: 1471-2415; 1471-2415
• DOI: 10.1186/s12886-023-02977-3

The study aimed to assess the efficacy of hydroxypropyl guar (HP) formulation (Systane) to protect tear film parameters under desiccating environment using protection and relief treatment modalities. The subjects were exposed to adverse environmental conditions using a Controlled Environment Chamber (CEC) where the relative humidity (RH) was 5% and the ambient temperature was 21 °C and screened for Tear break-up time (TBUT), Tear film evaporation rate (TFER) and lipid layer thickness (LLT) using the HIRCAL grid, Servomed EP3 Evaporimeter and Keeler’s TearScope-Plus respectively. Significant improvement in LLT was noticed in the protection modality. The mean tear film evaporation rate doubled after exposure to the humidity of 5% to a value of 105.37 g/m 2 /h (0.29 µl/min). All subjects displayed a significant reduction in non-invasive tear break-up time (NITBUT) with a mean NITBUT of 7.7 s after exposure to a desiccating environment for 15 min. A significant increase in NITBUT after the instillation of the drops was recorded in both methods. The results obtained from this study showed that a solution containing HP-Guar significantly improves tear film parameters under a desiccating environment. Apart from the tear evaporation rate, all tear parameters showed improvement after the use of HP-Guar eye drops. It is evident that tear film parameters respond differently to the management modalities and using CEC has the potential to provide researchers with a readily available method to evaluate the efficiency of tear supplementation.