Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic and targetable tissue states
Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic brain cells, including astrocytes, neurons and microglia/myeloid cells. This complex mixture of cell types forms the biological context for therapeutic response and tumor recurrence. We used single-nucleus RNA se...
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| Published in | Nature communications Vol. 14; no. 1; pp. 2586 - 18 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
04.05.2023
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2041-1723 2041-1723 |
| DOI | 10.1038/s41467-023-38186-1 |
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| Abstract | Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic brain cells, including astrocytes, neurons and microglia/myeloid cells. This complex mixture of cell types forms the biological context for therapeutic response and tumor recurrence. We used single-nucleus RNA sequencing and spatial transcriptomics to determine the cellular composition and transcriptional states in primary and recurrent glioma and identified three compositional ‘tissue-states’ defined by cohabitation patterns between specific subpopulations of neoplastic and non-neoplastic brain cells. These tissue-states correlated with radiographic, histopathologic, and prognostic features and were enriched in distinct metabolic pathways. Fatty acid biosynthesis was enriched in the tissue-state defined by the cohabitation of astrocyte-like/mesenchymal glioma cells, reactive astrocytes, and macrophages, and was associated with recurrent GBM and shorter survival. Treating acute slices of GBM with a fatty acid synthesis inhibitor depleted the transcriptional signature of this pernicious tissue-state. These findings point to therapies that target interdependencies in the GBM microenvironment.
Glioblastoma (GBM) cells can infiltrate into the tumour microenvironment (TME) and contribute to recurrence. Here, the authors analyse primary and recurrent GBMs and their TME using single-nucleus and spatial transcriptomics, revealing tissue states defined by the combinations of neoplastic and non-neoplastic cells, which could be therapeutic targets. |
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| AbstractList | Abstract Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic brain cells, including astrocytes, neurons and microglia/myeloid cells. This complex mixture of cell types forms the biological context for therapeutic response and tumor recurrence. We used single-nucleus RNA sequencing and spatial transcriptomics to determine the cellular composition and transcriptional states in primary and recurrent glioma and identified three compositional ‘tissue-states’ defined by cohabitation patterns between specific subpopulations of neoplastic and non-neoplastic brain cells. These tissue-states correlated with radiographic, histopathologic, and prognostic features and were enriched in distinct metabolic pathways. Fatty acid biosynthesis was enriched in the tissue-state defined by the cohabitation of astrocyte-like/mesenchymal glioma cells, reactive astrocytes, and macrophages, and was associated with recurrent GBM and shorter survival. Treating acute slices of GBM with a fatty acid synthesis inhibitor depleted the transcriptional signature of this pernicious tissue-state. These findings point to therapies that target interdependencies in the GBM microenvironment. Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic brain cells, including astrocytes, neurons and microglia/myeloid cells. This complex mixture of cell types forms the biological context for therapeutic response and tumor recurrence. We used single-nucleus RNA sequencing and spatial transcriptomics to determine the cellular composition and transcriptional states in primary and recurrent glioma and identified three compositional ‘tissue-states’ defined by cohabitation patterns between specific subpopulations of neoplastic and non-neoplastic brain cells. These tissue-states correlated with radiographic, histopathologic, and prognostic features and were enriched in distinct metabolic pathways. Fatty acid biosynthesis was enriched in the tissue-state defined by the cohabitation of astrocyte-like/mesenchymal glioma cells, reactive astrocytes, and macrophages, and was associated with recurrent GBM and shorter survival. Treating acute slices of GBM with a fatty acid synthesis inhibitor depleted the transcriptional signature of this pernicious tissue-state. These findings point to therapies that target interdependencies in the GBM microenvironment.Glioblastoma (GBM) cells can infiltrate into the tumour microenvironment (TME) and contribute to recurrence. Here, the authors analyse primary and recurrent GBMs and their TME using single-nucleus and spatial transcriptomics, revealing tissue states defined by the combinations of neoplastic and non-neoplastic cells, which could be therapeutic targets. Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic brain cells, including astrocytes, neurons and microglia/myeloid cells. This complex mixture of cell types forms the biological context for therapeutic response and tumor recurrence. We used single-nucleus RNA sequencing and spatial transcriptomics to determine the cellular composition and transcriptional states in primary and recurrent glioma and identified three compositional 'tissue-states' defined by cohabitation patterns between specific subpopulations of neoplastic and non-neoplastic brain cells. These tissue-states correlated with radiographic, histopathologic, and prognostic features and were enriched in distinct metabolic pathways. Fatty acid biosynthesis was enriched in the tissue-state defined by the cohabitation of astrocyte-like/mesenchymal glioma cells, reactive astrocytes, and macrophages, and was associated with recurrent GBM and shorter survival. Treating acute slices of GBM with a fatty acid synthesis inhibitor depleted the transcriptional signature of this pernicious tissue-state. These findings point to therapies that target interdependencies in the GBM microenvironment.Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic brain cells, including astrocytes, neurons and microglia/myeloid cells. This complex mixture of cell types forms the biological context for therapeutic response and tumor recurrence. We used single-nucleus RNA sequencing and spatial transcriptomics to determine the cellular composition and transcriptional states in primary and recurrent glioma and identified three compositional 'tissue-states' defined by cohabitation patterns between specific subpopulations of neoplastic and non-neoplastic brain cells. These tissue-states correlated with radiographic, histopathologic, and prognostic features and were enriched in distinct metabolic pathways. Fatty acid biosynthesis was enriched in the tissue-state defined by the cohabitation of astrocyte-like/mesenchymal glioma cells, reactive astrocytes, and macrophages, and was associated with recurrent GBM and shorter survival. Treating acute slices of GBM with a fatty acid synthesis inhibitor depleted the transcriptional signature of this pernicious tissue-state. These findings point to therapies that target interdependencies in the GBM microenvironment. Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic brain cells, including astrocytes, neurons and microglia/myeloid cells. This complex mixture of cell types forms the biological context for therapeutic response and tumor recurrence. We used single-nucleus RNA sequencing and spatial transcriptomics to determine the cellular composition and transcriptional states in primary and recurrent glioma and identified three compositional ‘tissue-states’ defined by cohabitation patterns between specific subpopulations of neoplastic and non-neoplastic brain cells. These tissue-states correlated with radiographic, histopathologic, and prognostic features and were enriched in distinct metabolic pathways. Fatty acid biosynthesis was enriched in the tissue-state defined by the cohabitation of astrocyte-like/mesenchymal glioma cells, reactive astrocytes, and macrophages, and was associated with recurrent GBM and shorter survival. Treating acute slices of GBM with a fatty acid synthesis inhibitor depleted the transcriptional signature of this pernicious tissue-state. These findings point to therapies that target interdependencies in the GBM microenvironment. Glioblastoma (GBM) cells can infiltrate into the tumour microenvironment (TME) and contribute to recurrence. Here, the authors analyse primary and recurrent GBMs and their TME using single-nucleus and spatial transcriptomics, revealing tissue states defined by the combinations of neoplastic and non-neoplastic cells, which could be therapeutic targets. Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic brain cells, including astrocytes, neurons and microglia/myeloid cells. This complex mixture of cell types forms the biological context for therapeutic response and tumor recurrence. We used single-nucleus RNA sequencing and spatial transcriptomics to determine the cellular composition and transcriptional states in primary and recurrent glioma and identified three compositional ‘tissue-states’ defined by cohabitation patterns between specific subpopulations of neoplastic and non-neoplastic brain cells. These tissue-states correlated with radiographic, histopathologic, and prognostic features and were enriched in distinct metabolic pathways. Fatty acid biosynthesis was enriched in the tissue-state defined by the cohabitation of astrocyte-like/mesenchymal glioma cells, reactive astrocytes, and macrophages, and was associated with recurrent GBM and shorter survival. Treating acute slices of GBM with a fatty acid synthesis inhibitor depleted the transcriptional signature of this pernicious tissue-state. These findings point to therapies that target interdependencies in the GBM microenvironment. |
| ArticleNumber | 2586 |
| Author | Argenziano, Michael G. Goldberg, Alexander R. Canoll, Peter Li, Juncheng Dovas, Athanassios Bruce, Jeffrey N. Youngerman, Brett Sims, Peter A. Lassman, Andrew B. Mahajan, Aayushi Gill, Brian J. A. Sisti, Michael B. Sudhakar, Tejaswi Tuddenham, John F. Furnari, Julia Kannan, Adithya McKhann, Guy M. Banu, Matei A. Humala, Nelson Khan, Fatima Paryani, Fahad Al-Dalahmah, Osama Bush, Erin Lu, Hong Save, Akshay Sun, Yu Boyett, Deborah Menon, Vilas |
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A. surname: Gill fullname: Gill, Brian J. 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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37142563$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1155/2019/2105607 10.1093/bioinformatics/bts635 10.1186/s13059-014-0550-8 10.1038/sdata.2017.24 10.1126/science.aaf2666 10.1038/s41587-021-00830-w 10.1186/s13059-021-02259-5 10.1016/j.neuroscience.2021.11.026 10.1038/sj.bjc.6603350 10.15252/msb.20188557 10.1016/j.celrep.2020.108189 10.1371/journal.pone.0147717 10.1007/s11060-014-1452-z 10.1016/j.ccell.2017.02.009 10.1038/s41467-019-10493-6 10.1038/nprot.2016.015 10.1016/j.trecan.2018.02.003 10.1038/ng.3806 10.1038/s41467-020-17041-7 10.3389/fimmu.2020.00835 10.1186/s13024-021-00426-7 10.1016/j.stem.2019.03.006 10.1007/s00432-016-2249-6 10.1093/bib/bbab466 10.1046/j.1471-4159.2001.00598.x 10.1016/j.cell.2019.06.024 10.1016/j.stem.2019.11.015 10.1126/science.1254257 10.1038/s41598-017-17204-5 10.1186/s13059-018-1449-6 10.1038/s41586-019-1775-1 10.3389/fnins.2019.00164 10.1186/s13024-020-00416-1 10.3390/ijms22158159 10.1038/nm.4415 10.1016/j.nicl.2018.10.014 10.1016/j.ccell.2017.06.003 10.1093/nar/gkw199 10.3389/fonc.2021.611038 10.1186/s13073-018-0567-9 10.1093/bioinformatics/btp616 10.1038/s41467-019-12464-3 10.1038/s41467-017-00136-z 10.1093/bioinformatics/btw777 10.1093/bioinformatics/btw313 10.1073/pnas.0506580102 10.1158/2159-8290.CD-19-0329 10.1016/j.cell.2019.04.001 10.3390/ijms20102496 10.1038/s41593-020-00789-y 10.1016/j.cell.2017.09.021 10.1186/s13073-021-00894-y 10.1186/s40478-020-0880-6 10.1101/gr.271288.120 10.1016/j.cell.2019.05.031 10.1186/s13059-019-1874-1 10.1038/s41586-019-1195-2 10.1073/pnas.1405839111 10.18637/jss.v025.i01 10.1038/s41590-022-01215-0 10.1016/j.celrep.2017.10.030 10.1007/s00401-012-0996-2 10.1186/1471-2105-14-7 10.1007/978-1-4757-3294-8 10.1101/2020.10.20.346544 |
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| References | Thrupp (CR35) 2020; 32 Subramanian (CR63) 2005; 102 Zhao (CR57) 2017; 4 Weng (CR19) 2019; 24 Petukhov (CR45) 2018; 19 Darmanis (CR11) 2017; 21 Gu, Eils, Schlesner (CR68) 2016; 32 Quail, Joyce (CR1) 2017; 31 Ioannou (CR42) 2019; 177 Puchalski (CR4) 2018; 360 Levitin (CR10) 2019; 15 Lê, Josse, Husson (CR28) 2008; 25 Wang (CR6) 2017; 32 Szabo (CR18) 2019; 10 Lin, Peddada (CR27) 2020; 11 Miller (CR66) 2021; 31 Liu (CR24) 2021; 11 Liu (CR58) 2018; 20 Yasumoto (CR40) 2016; 11 Wojtas (CR21) 2020; 15 Cenini, Lloret, Cascella (CR26) 2019; 2019 Grube (CR32) 2014; 118 Al-Dalahmah (CR23) 2020; 8 Jin (CR5) 2017; 23 Reimand (CR62) 2016; 44 Pombo Antunes (CR15) 2021; 24 Zhao (CR41) 2006; 95 Patel (CR8) 2014; 344 Hafemeister, Satija (CR49) 2019; 20 CR53 CR52 Henrik Heiland (CR20) 2019; 10 CR50 Fu (CR16) 2020; 11 Bankhead (CR69) 2017; 7 Wei (CR34) 2022; 481 Yuan (CR2) 2018; 10 Lun, McCarthy, Marioni (CR47) 2016; 5 Wang (CR7) 2019; 9 Zhou (CR43) 2016; 142 Cable (CR29) 2022; 40 Mathys (CR36) 2019; 570 Chen (CR38) 2021; 16 McCarthy (CR46) 2017; 33 Fazi (CR25) 2019; 20 Neftel (CR9) 2019; 178 Garcia Corrales (CR31) 2021; 22 Stuart (CR48) 2019; 177 Love, Huber, Anders (CR59) 2014; 15 Barthel (CR14) 2019; 576 Krishnaswami (CR44) 2016; 11 Zhao (CR54) 2021; 13 Foster (CR37) 2019; 13 Wang (CR30) 2021; 22 Yang (CR65) 2022; 23 CR67 Robinson, McCarthy, Smyth (CR60) 2010; 26 Dobin (CR56) 2013; 29 CR64 Stockwell (CR39) 2017; 171 Schellenberg, Montine (CR22) 2012; 124 Yeo (CR17) 2022; 23 Gill (CR3) 2014; 111 Lee (CR13) 2017; 49 Tabernero (CR33) 2001; 79 Levitin, Yuan, Sims (CR51) 2018; 4 Bhaduri (CR12) 2020; 26 Bush (CR55) 2017; 8 Hanzelmann, Castelo, Guinney (CR61) 2013; 14 L Liu (38186_CR24) 2021; 11 T Stuart (38186_CR48) 2019; 177 J Yuan (38186_CR2) 2018; 10 X Jin (38186_CR5) 2017; 23 A Bhaduri (38186_CR12) 2020; 26 B Fazi (38186_CR25) 2019; 20 H Lin (38186_CR27) 2020; 11 Q Wang (38186_CR6) 2017; 32 W Zhao (38186_CR41) 2006; 95 FP Barthel (38186_CR14) 2019; 576 EM Foster (38186_CR37) 2019; 13 AP Patel (38186_CR8) 2014; 344 38186_CR52 38186_CR53 V Petukhov (38186_CR45) 2018; 19 L Wang (38186_CR7) 2019; 9 X Liu (38186_CR58) 2018; 20 Q Weng (38186_CR19) 2019; 24 GD Schellenberg (38186_CR22) 2012; 124 S Grube (38186_CR32) 2014; 118 A Dobin (38186_CR56) 2013; 29 S Lê (38186_CR28) 2008; 25 C Hafemeister (38186_CR49) 2019; 20 DJ McCarthy (38186_CR46) 2017; 33 N Thrupp (38186_CR35) 2020; 32 Y Yang (38186_CR65) 2022; 23 L Wang (38186_CR30) 2021; 22 MS Ioannou (38186_CR42) 2019; 177 RB Puchalski (38186_CR4) 2018; 360 BR Stockwell (38186_CR39) 2017; 171 AT Yeo (38186_CR17) 2022; 23 AT Lun (38186_CR47) 2016; 5 HM Levitin (38186_CR10) 2019; 15 H Wei (38186_CR34) 2022; 481 38186_CR64 A Tabernero (38186_CR33) 2001; 79 DM Cable (38186_CR29) 2022; 40 38186_CR67 Y Zhou (38186_CR43) 2016; 142 A Subramanian (38186_CR63) 2005; 102 P Bankhead (38186_CR69) 2017; 7 SR Krishnaswami (38186_CR44) 2016; 11 Z Gu (38186_CR68) 2016; 32 S Darmanis (38186_CR11) 2017; 21 D Henrik Heiland (38186_CR20) 2019; 10 AR Pombo Antunes (38186_CR15) 2021; 24 BJ Gill (38186_CR3) 2014; 111 Z Zhao (38186_CR57) 2017; 4 Y Yasumoto (38186_CR40) 2016; 11 HM Levitin (38186_CR51) 2018; 4 O Al-Dalahmah (38186_CR23) 2020; 8 W Fu (38186_CR16) 2020; 11 J Reimand (38186_CR62) 2016; 44 G Cenini (38186_CR26) 2019; 2019 H Mathys (38186_CR36) 2019; 570 AV Garcia Corrales (38186_CR31) 2021; 22 S Hanzelmann (38186_CR61) 2013; 14 DF Quail (38186_CR1) 2017; 31 EC Bush (38186_CR55) 2017; 8 MI Love (38186_CR59) 2014; 15 PA Szabo (38186_CR18) 2019; 10 W Zhao (38186_CR54) 2021; 13 JK Lee (38186_CR13) 2017; 49 AM Wojtas (38186_CR21) 2020; 15 38186_CR50 C Neftel (38186_CR9) 2019; 178 F Chen (38186_CR38) 2021; 16 BF Miller (38186_CR66) 2021; 31 MD Robinson (38186_CR60) 2010; 26 |
| References_xml | – volume: 2019 start-page: 2105607 year: 2019 ident: CR26 article-title: Oxidative stress in neurodegenerative diseases: from a mitochondrial point of view publication-title: Oxid. Med. Cell. Longev. doi: 10.1155/2019/2105607 – volume: 29 start-page: 15 year: 2013 end-page: 21 ident: CR56 article-title: STAR: ultrafast universal RNA-seq aligner publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts635 – volume: 15 year: 2014 ident: CR59 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol. doi: 10.1186/s13059-014-0550-8 – volume: 4 year: 2017 ident: CR57 article-title: Comprehensive RNA-seq transcriptomic profiling in the malignant progression of gliomas publication-title: Sci. Data doi: 10.1038/sdata.2017.24 – volume: 360 start-page: 660 year: 2018 end-page: 663 ident: CR4 article-title: An anatomic transcriptional atlas of human glioblastoma publication-title: Science doi: 10.1126/science.aaf2666 – volume: 40 start-page: 517 year: 2022 end-page: 526 ident: CR29 article-title: Robust decomposition of cell type mixtures in spatial transcriptomics publication-title: Nat. Biotechnol. doi: 10.1038/s41587-021-00830-w – volume: 22 year: 2021 ident: CR30 article-title: The evolution of alternative splicing in glioblastoma under therapy publication-title: Genome Biol. doi: 10.1186/s13059-021-02259-5 – volume: 481 start-page: 85 year: 2022 end-page: 98 ident: CR34 article-title: De novo lipogenesis in astrocytes promotes the repair of blood-brain barrier after transient cerebral ischemia through interleukin-33 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2021.11.026 – volume: 95 start-page: 869 year: 2006 end-page: 878 ident: CR41 article-title: Fatty acid synthase: a novel target for antiglioma therapy publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6603350 – volume: 15 start-page: e8557 year: 2019 ident: CR10 article-title: De novo gene signature identification from single-cell RNA-seq with hierarchical Poisson factorization publication-title: Mol. Syst. Biol. doi: 10.15252/msb.20188557 – volume: 32 start-page: 108189 year: 2020 ident: CR35 article-title: Single-nucleus RNA-Seq is not suitable for detection of microglial activation genes in humans publication-title: Cell Rep. doi: 10.1016/j.celrep.2020.108189 – volume: 11 start-page: e0147717 year: 2016 ident: CR40 article-title: Inhibition of fatty acid synthase decreases expression of stemness markers in glioma stem cells publication-title: PLoS ONE doi: 10.1371/journal.pone.0147717 – volume: 118 start-page: 277 year: 2014 end-page: 287 ident: CR32 article-title: Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis publication-title: J. Neurooncol. doi: 10.1007/s11060-014-1452-z – volume: 31 start-page: 326 year: 2017 end-page: 341 ident: CR1 article-title: The microenvironmental landscape of brain tumors publication-title: Cancer Cell doi: 10.1016/j.ccell.2017.02.009 – volume: 10 year: 2019 ident: CR20 article-title: Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma publication-title: Nat. Commun. doi: 10.1038/s41467-019-10493-6 – volume: 11 start-page: 499 year: 2016 end-page: 524 ident: CR44 article-title: Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons publication-title: Nat. Protoc. doi: 10.1038/nprot.2016.015 – volume: 4 start-page: 264 year: 2018 end-page: 268 ident: CR51 article-title: Single-cell transcriptomic analysis of tumor heterogeneity publication-title: Trends Cancer doi: 10.1016/j.trecan.2018.02.003 – volume: 49 start-page: 594 year: 2017 end-page: 599 ident: CR13 article-title: Spatiotemporal genomic architecture informs precision oncology in glioblastoma publication-title: Nat. Genet doi: 10.1038/ng.3806 – volume: 11 year: 2020 ident: CR27 article-title: Analysis of compositions of microbiomes with bias correction publication-title: Nat. Commun. doi: 10.1038/s41467-020-17041-7 – volume: 11 start-page: 835 year: 2020 ident: CR16 article-title: Single-cell atlas reveals complexity of the immunosuppressive microenvironment of initial and recurrent glioblastoma publication-title: Front. Immunol. doi: 10.3389/fimmu.2020.00835 – ident: CR67 – volume: 16 start-page: 5 year: 2021 ident: CR38 article-title: Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer’s disease neuropathology publication-title: Mol. Neurodegener. doi: 10.1186/s13024-021-00426-7 – ident: CR50 – volume: 24 start-page: 707 year: 2019 end-page: 723.e8 ident: CR19 article-title: Single-cell transcriptomics uncovers glial progenitor diversity and cell fate determinants during development and gliomagenesis publication-title: Cell Stem Cell doi: 10.1016/j.stem.2019.03.006 – volume: 142 start-page: 2447 year: 2016 end-page: 2459 ident: CR43 article-title: Inhibition of fatty acid synthase suppresses neovascularization via regulating the expression of VEGF-A in glioma publication-title: J. Cancer Res. Clin. Oncol. doi: 10.1007/s00432-016-2249-6 – volume: 23 start-page: bbab466 year: 2022 ident: CR65 article-title: SC-MEB: spatial clustering with hidden Markov random field using empirical Bayes publication-title: Brief. Bioinform doi: 10.1093/bib/bbab466 – volume: 79 start-page: 606 year: 2001 end-page: 616 ident: CR33 article-title: Neuronal differentiation is triggered by oleic acid synthesized and released by astrocytes publication-title: J. Neurochem. doi: 10.1046/j.1471-4159.2001.00598.x – volume: 178 start-page: 835 year: 2019 end-page: 849.e21 ident: CR9 article-title: An integrative model of cellular states, plasticity, and genetics for glioblastoma publication-title: Cell doi: 10.1016/j.cell.2019.06.024 – volume: 26 start-page: 48 year: 2020 end-page: 63.e6 ident: CR12 article-title: Outer radial glia-like cancer stem cells contribute to heterogeneity of glioblastoma publication-title: Cell Stem Cell doi: 10.1016/j.stem.2019.11.015 – volume: 344 start-page: 1396 year: 2014 end-page: 1401 ident: CR8 article-title: Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma publication-title: Science doi: 10.1126/science.1254257 – volume: 7 year: 2017 ident: CR69 article-title: QuPath: open source software for digital pathology image analysis publication-title: Sci. Rep. doi: 10.1038/s41598-017-17204-5 – volume: 19 year: 2018 ident: CR45 article-title: dropEst: pipeline for accurate estimation of molecular counts in droplet-based single-cell RNA-seq experiments publication-title: Genome Biol. doi: 10.1186/s13059-018-1449-6 – ident: CR64 – volume: 576 start-page: 112 year: 2019 end-page: 120 ident: CR14 article-title: Longitudinal molecular trajectories of diffuse glioma in adults publication-title: Nature doi: 10.1038/s41586-019-1775-1 – volume: 13 start-page: 164 year: 2019 ident: CR37 article-title: Clusterin in Alzheimer’s Disease: mechanisms, genetics, and lessons from other pathologies publication-title: Front. Neurosci. doi: 10.3389/fnins.2019.00164 – volume: 15 start-page: 71 year: 2020 ident: CR21 article-title: Astrocyte-derived clusterin suppresses amyloid formation in vivo publication-title: Mol. Neurodegener. doi: 10.1186/s13024-020-00416-1 – volume: 22 start-page: 8159 year: 2021 ident: CR31 article-title: Fatty acid synthesis in glial cells of the CNS publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms22158159 – volume: 23 start-page: 1352 year: 2017 end-page: 1361 ident: CR5 article-title: Targeting glioma stem cells through combined BMI1 and EZH2 inhibition publication-title: Nat. Med doi: 10.1038/nm.4415 – volume: 20 start-page: 1070 year: 2018 end-page: 1077 ident: CR58 article-title: A radiomic signature as a non-invasive predictor of progression-free survival in patients with lower-grade gliomas publication-title: Neuroimage Clin. doi: 10.1016/j.nicl.2018.10.014 – ident: CR53 – volume: 32 start-page: 42 year: 2017 end-page: 56.e6 ident: CR6 article-title: Tumor evolution of glioma-intrinsic gene expression subtypes associates with immunological changes in the microenvironment publication-title: Cancer Cell doi: 10.1016/j.ccell.2017.06.003 – volume: 44 start-page: W83 year: 2016 end-page: W89 ident: CR62 article-title: g:Profiler-a web server for functional interpretation of gene lists (2016 update) publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkw199 – volume: 11 start-page: 611038 year: 2021 ident: CR24 article-title: CHI3L2 is a novel prognostic biomarker and correlated with immune infiltrates in gliomas publication-title: Front. Oncol. doi: 10.3389/fonc.2021.611038 – volume: 10 year: 2018 ident: CR2 article-title: Single-cell transcriptome analysis of lineage diversity in high-grade glioma publication-title: Genome Med. doi: 10.1186/s13073-018-0567-9 – volume: 26 start-page: 139 year: 2010 end-page: 140 ident: CR60 article-title: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp616 – volume: 10 year: 2019 ident: CR18 article-title: Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease publication-title: Nat. Commun. doi: 10.1038/s41467-019-12464-3 – volume: 8 year: 2017 ident: CR55 article-title: PLATE-Seq for genome-wide regulatory network analysis of high-throughput screens publication-title: Nat. Commun. doi: 10.1038/s41467-017-00136-z – volume: 33 start-page: 1179 year: 2017 end-page: 1186 ident: CR46 article-title: Scater: pre-processing, quality control, normalization and visualization of single-cell RNA-seq data in R publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw777 – volume: 32 start-page: 2847 year: 2016 end-page: 2849 ident: CR68 article-title: Complex heatmaps reveal patterns and correlations in multidimensional genomic data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw313 – volume: 5 start-page: 2122 year: 2016 ident: CR47 article-title: A step-by-step workflow for low-level analysis of single-cell RNA-seq data with Bioconductor publication-title: F1000Res – volume: 102 start-page: 15545 year: 2005 end-page: 15550 ident: CR63 article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0506580102 – volume: 9 start-page: 1708 year: 2019 end-page: 1719 ident: CR7 article-title: The phenotypes of proliferating glioblastoma cells reside on a single axis of variation publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-19-0329 – volume: 177 start-page: 1522 year: 2019 end-page: 1535.e14 ident: CR42 article-title: Neuron-astrocyte metabolic coupling protects against activity-induced fatty acid toxicity publication-title: Cell doi: 10.1016/j.cell.2019.04.001 – volume: 20 start-page: 2496 year: 2019 ident: CR25 article-title: The expression of the chemokine CXCL14 correlates with several aggressive aspects of glioblastoma and promotes key properties of glioblastoma cells publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms20102496 – volume: 24 start-page: 595 year: 2021 end-page: 610 ident: CR15 article-title: Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization publication-title: Nat. Neurosci. doi: 10.1038/s41593-020-00789-y – volume: 171 start-page: 273 year: 2017 end-page: 285 ident: CR39 article-title: Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease publication-title: Cell doi: 10.1016/j.cell.2017.09.021 – volume: 13 year: 2021 ident: CR54 article-title: Deconvolution of cell type-specific drug responses in human tumor tissue with single-cell RNA-seq publication-title: Genome Med. doi: 10.1186/s13073-021-00894-y – volume: 8 start-page: 19 year: 2020 ident: CR23 article-title: Single-nucleus RNA-seq identifies Huntington disease astrocyte states publication-title: Acta Neuropathol. Commun. doi: 10.1186/s40478-020-0880-6 – volume: 31 start-page: 1843 year: 2021 end-page: 1855 ident: CR66 article-title: Characterizing spatial gene expression heterogeneity in spatially resolved single-cell transcriptomic data with nonuniform cellular densities publication-title: Genome Res doi: 10.1101/gr.271288.120 – volume: 177 start-page: 1888 year: 2019 end-page: 1902.e21 ident: CR48 article-title: ComprehensivE Integration Of Single-cell Data publication-title: Cell doi: 10.1016/j.cell.2019.05.031 – ident: CR52 – volume: 20 year: 2019 ident: CR49 article-title: Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression publication-title: Genome Biol. doi: 10.1186/s13059-019-1874-1 – volume: 570 start-page: 332 year: 2019 end-page: 337 ident: CR36 article-title: Single-cell transcriptomic analysis of Alzheimer’s disease publication-title: Nature doi: 10.1038/s41586-019-1195-2 – volume: 111 start-page: 12550 year: 2014 end-page: 12555 ident: CR3 article-title: MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1405839111 – volume: 25 start-page: 1 year: 2008 end-page: 18 ident: CR28 article-title: FactoMineR: a package for multivariate analysis publication-title: J. Stat. Softw. doi: 10.18637/jss.v025.i01 – volume: 23 start-page: 971 year: 2022 end-page: 984 ident: CR17 article-title: Single-cell RNA sequencing reveals evolution of immune landscape during glioblastoma progression publication-title: Nat. Immunol. doi: 10.1038/s41590-022-01215-0 – volume: 21 start-page: 1399 year: 2017 end-page: 1410 ident: CR11 article-title: Single-cell RNA-seq analysis of infiltrating neoplastic cells at the migrating front of human glioblastoma publication-title: Cell Rep. doi: 10.1016/j.celrep.2017.10.030 – volume: 124 start-page: 305 year: 2012 end-page: 323 ident: CR22 article-title: The genetics and neuropathology of Alzheimer’s disease publication-title: Acta Neuropathol. doi: 10.1007/s00401-012-0996-2 – volume: 14 year: 2013 ident: CR61 article-title: GSVA: gene set variation analysis for microarray and RNA-seq data publication-title: BMC Bioinform. doi: 10.1186/1471-2105-14-7 – volume: 171 start-page: 273 year: 2017 ident: 38186_CR39 publication-title: Cell doi: 10.1016/j.cell.2017.09.021 – ident: 38186_CR52 doi: 10.1007/978-1-4757-3294-8 – volume: 15 year: 2014 ident: 38186_CR59 publication-title: Genome Biol. doi: 10.1186/s13059-014-0550-8 – volume: 26 start-page: 139 year: 2010 ident: 38186_CR60 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp616 – volume: 23 start-page: 971 year: 2022 ident: 38186_CR17 publication-title: Nat. Immunol. doi: 10.1038/s41590-022-01215-0 – volume: 16 start-page: 5 year: 2021 ident: 38186_CR38 publication-title: Mol. Neurodegener. doi: 10.1186/s13024-021-00426-7 – volume: 15 start-page: 71 year: 2020 ident: 38186_CR21 publication-title: Mol. Neurodegener. doi: 10.1186/s13024-020-00416-1 – volume: 7 year: 2017 ident: 38186_CR69 publication-title: Sci. Rep. doi: 10.1038/s41598-017-17204-5 – volume: 19 year: 2018 ident: 38186_CR45 publication-title: Genome Biol. doi: 10.1186/s13059-018-1449-6 – volume: 11 start-page: 611038 year: 2021 ident: 38186_CR24 publication-title: Front. Oncol. doi: 10.3389/fonc.2021.611038 – volume: 22 year: 2021 ident: 38186_CR30 publication-title: Genome Biol. doi: 10.1186/s13059-021-02259-5 – volume: 5 start-page: 2122 year: 2016 ident: 38186_CR47 publication-title: F1000Res – volume: 360 start-page: 660 year: 2018 ident: 38186_CR4 publication-title: Science doi: 10.1126/science.aaf2666 – volume: 20 start-page: 2496 year: 2019 ident: 38186_CR25 publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms20102496 – volume: 20 year: 2019 ident: 38186_CR49 publication-title: Genome Biol. doi: 10.1186/s13059-019-1874-1 – volume: 10 year: 2019 ident: 38186_CR18 publication-title: Nat. Commun. doi: 10.1038/s41467-019-12464-3 – volume: 111 start-page: 12550 year: 2014 ident: 38186_CR3 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1405839111 – volume: 178 start-page: 835 year: 2019 ident: 38186_CR9 publication-title: Cell doi: 10.1016/j.cell.2019.06.024 – volume: 177 start-page: 1888 year: 2019 ident: 38186_CR48 publication-title: Cell doi: 10.1016/j.cell.2019.05.031 – volume: 29 start-page: 15 year: 2013 ident: 38186_CR56 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts635 – volume: 102 start-page: 15545 year: 2005 ident: 38186_CR63 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0506580102 – volume: 21 start-page: 1399 year: 2017 ident: 38186_CR11 publication-title: Cell Rep. doi: 10.1016/j.celrep.2017.10.030 – volume: 24 start-page: 595 year: 2021 ident: 38186_CR15 publication-title: Nat. Neurosci. doi: 10.1038/s41593-020-00789-y – volume: 118 start-page: 277 year: 2014 ident: 38186_CR32 publication-title: J. Neurooncol. doi: 10.1007/s11060-014-1452-z – volume: 8 year: 2017 ident: 38186_CR55 publication-title: Nat. Commun. doi: 10.1038/s41467-017-00136-z – volume: 177 start-page: 1522 year: 2019 ident: 38186_CR42 publication-title: Cell doi: 10.1016/j.cell.2019.04.001 – volume: 23 start-page: 1352 year: 2017 ident: 38186_CR5 publication-title: Nat. Med doi: 10.1038/nm.4415 – volume: 32 start-page: 108189 year: 2020 ident: 38186_CR35 publication-title: Cell Rep. doi: 10.1016/j.celrep.2020.108189 – volume: 10 year: 2018 ident: 38186_CR2 publication-title: Genome Med. doi: 10.1186/s13073-018-0567-9 – volume: 11 start-page: 835 year: 2020 ident: 38186_CR16 publication-title: Front. Immunol. doi: 10.3389/fimmu.2020.00835 – volume: 2019 start-page: 2105607 year: 2019 ident: 38186_CR26 publication-title: Oxid. Med. Cell. Longev. doi: 10.1155/2019/2105607 – volume: 31 start-page: 326 year: 2017 ident: 38186_CR1 publication-title: Cancer Cell doi: 10.1016/j.ccell.2017.02.009 – volume: 481 start-page: 85 year: 2022 ident: 38186_CR34 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2021.11.026 – volume: 95 start-page: 869 year: 2006 ident: 38186_CR41 publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6603350 – volume: 11 year: 2020 ident: 38186_CR27 publication-title: Nat. Commun. doi: 10.1038/s41467-020-17041-7 – volume: 11 start-page: e0147717 year: 2016 ident: 38186_CR40 publication-title: PLoS ONE doi: 10.1371/journal.pone.0147717 – ident: 38186_CR67 – volume: 32 start-page: 2847 year: 2016 ident: 38186_CR68 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw313 – ident: 38186_CR64 doi: 10.1101/2020.10.20.346544 – volume: 13 start-page: 164 year: 2019 ident: 38186_CR37 publication-title: Front. Neurosci. doi: 10.3389/fnins.2019.00164 – volume: 24 start-page: 707 year: 2019 ident: 38186_CR19 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2019.03.006 – volume: 8 start-page: 19 year: 2020 ident: 38186_CR23 publication-title: Acta Neuropathol. Commun. doi: 10.1186/s40478-020-0880-6 – volume: 22 start-page: 8159 year: 2021 ident: 38186_CR31 publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms22158159 – volume: 32 start-page: 42 year: 2017 ident: 38186_CR6 publication-title: Cancer Cell doi: 10.1016/j.ccell.2017.06.003 – volume: 31 start-page: 1843 year: 2021 ident: 38186_CR66 publication-title: Genome Res doi: 10.1101/gr.271288.120 – volume: 49 start-page: 594 year: 2017 ident: 38186_CR13 publication-title: Nat. Genet doi: 10.1038/ng.3806 – volume: 142 start-page: 2447 year: 2016 ident: 38186_CR43 publication-title: J. Cancer Res. Clin. Oncol. doi: 10.1007/s00432-016-2249-6 – volume: 23 start-page: bbab466 year: 2022 ident: 38186_CR65 publication-title: Brief. Bioinform doi: 10.1093/bib/bbab466 – ident: 38186_CR50 – volume: 4 start-page: 264 year: 2018 ident: 38186_CR51 publication-title: Trends Cancer doi: 10.1016/j.trecan.2018.02.003 – volume: 9 start-page: 1708 year: 2019 ident: 38186_CR7 publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-19-0329 – volume: 26 start-page: 48 year: 2020 ident: 38186_CR12 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2019.11.015 – volume: 79 start-page: 606 year: 2001 ident: 38186_CR33 publication-title: J. Neurochem. doi: 10.1046/j.1471-4159.2001.00598.x – volume: 44 start-page: W83 year: 2016 ident: 38186_CR62 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkw199 – volume: 33 start-page: 1179 year: 2017 ident: 38186_CR46 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw777 – volume: 13 year: 2021 ident: 38186_CR54 publication-title: Genome Med. doi: 10.1186/s13073-021-00894-y – volume: 14 year: 2013 ident: 38186_CR61 publication-title: BMC Bioinform. doi: 10.1186/1471-2105-14-7 – volume: 576 start-page: 112 year: 2019 ident: 38186_CR14 publication-title: Nature doi: 10.1038/s41586-019-1775-1 – volume: 15 start-page: e8557 year: 2019 ident: 38186_CR10 publication-title: Mol. Syst. Biol. doi: 10.15252/msb.20188557 – volume: 570 start-page: 332 year: 2019 ident: 38186_CR36 publication-title: Nature doi: 10.1038/s41586-019-1195-2 – volume: 20 start-page: 1070 year: 2018 ident: 38186_CR58 publication-title: Neuroimage Clin. doi: 10.1016/j.nicl.2018.10.014 – volume: 10 year: 2019 ident: 38186_CR20 publication-title: Nat. Commun. doi: 10.1038/s41467-019-10493-6 – volume: 124 start-page: 305 year: 2012 ident: 38186_CR22 publication-title: Acta Neuropathol. doi: 10.1007/s00401-012-0996-2 – volume: 25 start-page: 1 year: 2008 ident: 38186_CR28 publication-title: J. Stat. Softw. doi: 10.18637/jss.v025.i01 – volume: 11 start-page: 499 year: 2016 ident: 38186_CR44 publication-title: Nat. Protoc. doi: 10.1038/nprot.2016.015 – ident: 38186_CR53 – volume: 344 start-page: 1396 year: 2014 ident: 38186_CR8 publication-title: Science doi: 10.1126/science.1254257 – volume: 4 year: 2017 ident: 38186_CR57 publication-title: Sci. Data doi: 10.1038/sdata.2017.24 – volume: 40 start-page: 517 year: 2022 ident: 38186_CR29 publication-title: Nat. Biotechnol. doi: 10.1038/s41587-021-00830-w |
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| Snippet | Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic brain cells, including astrocytes, neurons and microglia/myeloid cells.... Abstract Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic brain cells, including astrocytes, neurons and... |
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| Title | Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic and targetable tissue states |
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