Generation of inner ear hair cells by direct lineage conversion of primary somatic cells
The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to numerous genetic and environmental insults. In mammals, hair cells lack regenerative capacity, and their death leads to permanent hearing loss and vestibular dysfunction. Their paucity and inaccessibility has limi...
Saved in:
| Published in | eLife Vol. 9 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
eLife Sciences Publications Ltd
30.06.2020
eLife Sciences Publications, Ltd |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2050-084X 2050-084X |
| DOI | 10.7554/eLife.55249 |
Cover
| Abstract | The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to numerous genetic and environmental insults. In mammals, hair cells lack regenerative capacity, and their death leads to permanent hearing loss and vestibular dysfunction. Their paucity and inaccessibility has limited the search for otoprotective and regenerative strategies. Growing hair cells in vitro would provide a route to overcome this experimental bottleneck. We report a combination of four transcription factors (Six1, Atoh1, Pou4f3, and Gfi1) that can convert mouse embryonic fibroblasts, adult tail-tip fibroblasts and postnatal supporting cells into induced hair cell-like cells (iHCs). iHCs exhibit hair cell-like morphology, transcriptomic and epigenetic profiles, electrophysiological properties, mechanosensory channel expression, and vulnerability to ototoxin in a high-content phenotypic screening system. Thus, direct reprogramming provides a platform to identify causes and treatments for hair cell loss, and may help identify future gene therapy approaches for restoring hearing.
Worldwide, hearing loss is the most common loss of sensation. Most cases of hearing loss are due to the death of specialized hair cells found deep inside the ear. These hair cells convert sounds into nerve impulses which can be understood by the brain. Hair cells naturally degrade as part of aging and can be damaged by other factors including loud noises, and otherwise therapeutic drugs, such as those used in chemotherapy for cancer. In humans and other mammals, once hair cells are lost they cannot be replaced.
Hair cells have often been studied using mice, but the small number of hair cells in their ears, and their location deep inside the skull, makes it particularly difficult to study them in this way. Scientists are seeking ways to grow hair cells in the laboratory to make it easier to understand how they work and the factors that contribute to their damage and loss. Different cell types in the body are formed in response to specific combinations of biological signals. Currently, scientists do not have an efficient way to grow hair cells in the laboratory, because the correct signals needed to create them are not known.
Menendez et al. have now identified four proteins which, when activated, convert fibroblasts, a common type of cell, into hair cells similar to those in the ear. These proteins are called Six1, Atoh1, Pou4f3 and Gfi1. Menendez et al. termed the resulting cells induced hair cells, or iHCs for short, and analyzed these cells to identify those characteristics that are similar to normal hair cells, as well as their differences. Importantly, the iHCs were found to be damaged by the same chemicals that specifically harm normal hair cells, suggesting they are useful test subjects.
The ability to create hair cells in the laboratory using more easily available cells has many uses. These cells can help to understand the normal function of hair cells and how they become damaged. They can also be used to test new drugs to assess their success in preventing or reversing hearing loss. These findings may also lead to genetic solutions to curing hearing loss. |
|---|---|
| AbstractList | The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to numerous genetic and environmental insults. In mammals, hair cells lack regenerative capacity, and their death leads to permanent hearing loss and vestibular dysfunction. Their paucity and inaccessibility has limited the search for otoprotective and regenerative strategies. Growing hair cells in vitro would provide a route to overcome this experimental bottleneck. We report a combination of four transcription factors (Six1, Atoh1, Pou4f3, and Gfi1) that can convert mouse embryonic fibroblasts, adult tail-tip fibroblasts and postnatal supporting cells into induced hair cell-like cells (iHCs). iHCs exhibit hair cell-like morphology, transcriptomic and epigenetic profiles, electrophysiological properties, mechanosensory channel expression, and vulnerability to ototoxin in a high-content phenotypic screening system. Thus, direct reprogramming provides a platform to identify causes and treatments for hair cell loss, and may help identify future gene therapy approaches for restoring hearing. The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to numerous genetic and environmental insults. In mammals, hair cells lack regenerative capacity, and their death leads to permanent hearing loss and vestibular dysfunction. Their paucity and inaccessibility has limited the search for otoprotective and regenerative strategies. Growing hair cells in vitro would provide a route to overcome this experimental bottleneck. We report a combination of four transcription factors (Six1, Atoh1, Pou4f3, and Gfi1) that can convert mouse embryonic fibroblasts, adult tail-tip fibroblasts and postnatal supporting cells into induced hair cell-like cells (iHCs). iHCs exhibit hair cell-like morphology, transcriptomic and epigenetic profiles, electrophysiological properties, mechanosensory channel expression, and vulnerability to ototoxin in a high-content phenotypic screening system. Thus, direct reprogramming provides a platform to identify causes and treatments for hair cell loss, and may help identify future gene therapy approaches for restoring hearing. Worldwide, hearing loss is the most common loss of sensation. Most cases of hearing loss are due to the death of specialized hair cells found deep inside the ear. These hair cells convert sounds into nerve impulses which can be understood by the brain. Hair cells naturally degrade as part of aging and can be damaged by other factors including loud noises, and otherwise therapeutic drugs, such as those used in chemotherapy for cancer. In humans and other mammals, once hair cells are lost they cannot be replaced. Hair cells have often been studied using mice, but the small number of hair cells in their ears, and their location deep inside the skull, makes it particularly difficult to study them in this way. Scientists are seeking ways to grow hair cells in the laboratory to make it easier to understand how they work and the factors that contribute to their damage and loss. Different cell types in the body are formed in response to specific combinations of biological signals. Currently, scientists do not have an efficient way to grow hair cells in the laboratory, because the correct signals needed to create them are not known. Menendez et al. have now identified four proteins which, when activated, convert fibroblasts, a common type of cell, into hair cells similar to those in the ear. These proteins are called Six1, Atoh1, Pou4f3 and Gfi1. Menendez et al. termed the resulting cells induced hair cells, or iHCs for short, and analyzed these cells to identify those characteristics that are similar to normal hair cells, as well as their differences. Importantly, the iHCs were found to be damaged by the same chemicals that specifically harm normal hair cells, suggesting they are useful test subjects. The ability to create hair cells in the laboratory using more easily available cells has many uses. These cells can help to understand the normal function of hair cells and how they become damaged. They can also be used to test new drugs to assess their success in preventing or reversing hearing loss. These findings may also lead to genetic solutions to curing hearing loss. The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to numerous genetic and environmental insults. In mammals, hair cells lack regenerative capacity, and their death leads to permanent hearing loss and vestibular dysfunction. Their paucity and inaccessibility has limited the search for otoprotective and regenerative strategies. Growing hair cells in vitro would provide a route to overcome this experimental bottleneck. We report a combination of four transcription factors (Six1, Atoh1, Pou4f3, and Gfi1) that can convert mouse embryonic fibroblasts, adult tail-tip fibroblasts and postnatal supporting cells into induced hair cell-like cells (iHCs). iHCs exhibit hair cell-like morphology, transcriptomic and epigenetic profiles, electrophysiological properties, mechanosensory channel expression, and vulnerability to ototoxin in a high-content phenotypic screening system. Thus, direct reprogramming provides a platform to identify causes and treatments for hair cell loss, and may help identify future gene therapy approaches for restoring hearing.The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to numerous genetic and environmental insults. In mammals, hair cells lack regenerative capacity, and their death leads to permanent hearing loss and vestibular dysfunction. Their paucity and inaccessibility has limited the search for otoprotective and regenerative strategies. Growing hair cells in vitro would provide a route to overcome this experimental bottleneck. We report a combination of four transcription factors (Six1, Atoh1, Pou4f3, and Gfi1) that can convert mouse embryonic fibroblasts, adult tail-tip fibroblasts and postnatal supporting cells into induced hair cell-like cells (iHCs). iHCs exhibit hair cell-like morphology, transcriptomic and epigenetic profiles, electrophysiological properties, mechanosensory channel expression, and vulnerability to ototoxin in a high-content phenotypic screening system. Thus, direct reprogramming provides a platform to identify causes and treatments for hair cell loss, and may help identify future gene therapy approaches for restoring hearing. The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to numerous genetic and environmental insults. In mammals, hair cells lack regenerative capacity, and their death leads to permanent hearing loss and vestibular dysfunction. Their paucity and inaccessibility has limited the search for otoprotective and regenerative strategies. Growing hair cells in vitro would provide a route to overcome this experimental bottleneck. We report a combination of four transcription factors (Six1, Atoh1, Pou4f3, and Gfi1) that can convert mouse embryonic fibroblasts, adult tail-tip fibroblasts and postnatal supporting cells into induced hair cell-like cells (iHCs). iHCs exhibit hair cell-like morphology, transcriptomic and epigenetic profiles, electrophysiological properties, mechanosensory channel expression, and vulnerability to ototoxin in a high-content phenotypic screening system. Thus, direct reprogramming provides a platform to identify causes and treatments for hair cell loss, and may help identify future gene therapy approaches for restoring hearing. Worldwide, hearing loss is the most common loss of sensation. Most cases of hearing loss are due to the death of specialized hair cells found deep inside the ear. These hair cells convert sounds into nerve impulses which can be understood by the brain. Hair cells naturally degrade as part of aging and can be damaged by other factors including loud noises, and otherwise therapeutic drugs, such as those used in chemotherapy for cancer. In humans and other mammals, once hair cells are lost they cannot be replaced. Hair cells have often been studied using mice, but the small number of hair cells in their ears, and their location deep inside the skull, makes it particularly difficult to study them in this way. Scientists are seeking ways to grow hair cells in the laboratory to make it easier to understand how they work and the factors that contribute to their damage and loss. Different cell types in the body are formed in response to specific combinations of biological signals. Currently, scientists do not have an efficient way to grow hair cells in the laboratory, because the correct signals needed to create them are not known. Menendez et al. have now identified four proteins which, when activated, convert fibroblasts, a common type of cell, into hair cells similar to those in the ear. These proteins are called Six1, Atoh1, Pou4f3 and Gfi1. Menendez et al. termed the resulting cells induced hair cells, or iHCs for short, and analyzed these cells to identify those characteristics that are similar to normal hair cells, as well as their differences. Importantly, the iHCs were found to be damaged by the same chemicals that specifically harm normal hair cells, suggesting they are useful test subjects. The ability to create hair cells in the laboratory using more easily available cells has many uses. These cells can help to understand the normal function of hair cells and how they become damaged. They can also be used to test new drugs to assess their success in preventing or reversing hearing loss. These findings may also lead to genetic solutions to curing hearing loss. The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to numerous genetic and environmental insults. In mammals, hair cells lack regenerative capacity, and their death leads to permanent hearing loss and vestibular dysfunction. Their paucity and inaccessibility has limited the search for otoprotective and regenerative strategies. Growing hair cells in vitro would provide a route to overcome this experimental bottleneck. We report a combination of four transcription factors ( , and ) that can convert mouse embryonic fibroblasts, adult tail-tip fibroblasts and postnatal supporting cells into induced hair cell-like cells (iHCs). iHCs exhibit hair cell-like morphology, transcriptomic and epigenetic profiles, electrophysiological properties, mechanosensory channel expression, and vulnerability to ototoxin in a high-content phenotypic screening system. Thus, direct reprogramming provides a platform to identify causes and treatments for hair cell loss, and may help identify future gene therapy approaches for restoring hearing. |
| Author | Llamas, Juan Segil, Neil Yu, Haoze V Markowitz, Alexander L Huang, Chichou Kalluri, Radha Ichida, Justin Lee, James Gopalakrishnan, Suhasni Tao, Litao Menendez, Louise Trecek, Talon Wang, Xizi |
| Author_xml | – sequence: 1 givenname: Louise orcidid: 0000-0001-6830-0358 surname: Menendez fullname: Menendez, Louise organization: Department of Stem Cell and Regenerative Medicine, University of Southern California, Los Angeles, United States, Eli and Edythe Broad Center, University of Southern California, Los Angeles, United States, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, United States – sequence: 2 givenname: Talon surname: Trecek fullname: Trecek, Talon organization: Department of Stem Cell and Regenerative Medicine, University of Southern California, Los Angeles, United States, Eli and Edythe Broad Center, University of Southern California, Los Angeles, United States – sequence: 3 givenname: Suhasni surname: Gopalakrishnan fullname: Gopalakrishnan, Suhasni organization: Department of Stem Cell and Regenerative Medicine, University of Southern California, Los Angeles, United States, Eli and Edythe Broad Center, University of Southern California, Los Angeles, United States, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, United States – sequence: 4 givenname: Litao surname: Tao fullname: Tao, Litao organization: Department of Stem Cell and Regenerative Medicine, University of Southern California, Los Angeles, United States, Eli and Edythe Broad Center, University of Southern California, Los Angeles, United States – sequence: 5 givenname: Alexander L surname: Markowitz fullname: Markowitz, Alexander L organization: Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, United States, USC Caruso Department of Otolaryngology – Head and Neck Surgery, University of Southern California, Los Angeles, United States – sequence: 6 givenname: Haoze V surname: Yu fullname: Yu, Haoze V organization: Department of Stem Cell and Regenerative Medicine, University of Southern California, Los Angeles, United States, Eli and Edythe Broad Center, University of Southern California, Los Angeles, United States – sequence: 7 givenname: Xizi surname: Wang fullname: Wang, Xizi organization: Department of Stem Cell and Regenerative Medicine, University of Southern California, Los Angeles, United States, Eli and Edythe Broad Center, University of Southern California, Los Angeles, United States – sequence: 8 givenname: Juan surname: Llamas fullname: Llamas, Juan organization: Department of Stem Cell and Regenerative Medicine, University of Southern California, Los Angeles, United States, Eli and Edythe Broad Center, University of Southern California, Los Angeles, United States – sequence: 9 givenname: Chichou surname: Huang fullname: Huang, Chichou organization: DRVision Technologies, Bellevue, United States – sequence: 10 givenname: James surname: Lee fullname: Lee, James organization: DRVision Technologies, Bellevue, United States – sequence: 11 givenname: Radha orcidid: 0000-0002-0360-8965 surname: Kalluri fullname: Kalluri, Radha organization: Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, United States, USC Caruso Department of Otolaryngology – Head and Neck Surgery, University of Southern California, Los Angeles, United States – sequence: 12 givenname: Justin surname: Ichida fullname: Ichida, Justin organization: Department of Stem Cell and Regenerative Medicine, University of Southern California, Los Angeles, United States, Eli and Edythe Broad Center, University of Southern California, Los Angeles, United States, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, United States – sequence: 13 givenname: Neil orcidid: 0000-0002-0441-2067 surname: Segil fullname: Segil, Neil organization: Department of Stem Cell and Regenerative Medicine, University of Southern California, Los Angeles, United States, Eli and Edythe Broad Center, University of Southern California, Los Angeles, United States, USC Caruso Department of Otolaryngology – Head and Neck Surgery, University of Southern California, Los Angeles, United States |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32602462$$D View this record in MEDLINE/PubMed |
| BookMark | eNptUs1vFCEcJabG1rUn74bEi4luZRgYmIuJabQ22cSLJr0RBn5s2bCwwkzN_vfS3bXZVrnw9d7Lew9eopOYIiD0uiEXgnP2ERbewQXnlPXP0BklnMyJZDcnR-tTdF7KitQhmJRN_wKdtrQjlHX0DN1cQYSsR58iTg77WHcYdMa32mdsIISChy22PoMZcfAR9BKwSfEOcjmQNtmvdd7iktZVyOxZr9Bzp0OB88M8Qz-_fvlx-W2--H51ffl5MTecNePcEG2MHaygttFi4MZaaTghVjvXS7CDE4w7qgdrWCcJa3jbdp0QpBe861rZztD1XtcmvVIHKyppr3YHKS-VztVVANUZ2RFj-p61A3O1C6dZa4lzkkhOoK1aH_ZaU9zo7W8dwoNgQ9R93wpC7Vvt-q7wT3v4ZhrWYA3EMevwyMPjm-hv1TLdKVH7r_wq8O4gkNOvCcqo1r7ct6cjpKkoypqe9JLWoDP09gl0laYca7MVRXtGBG1FRb05dvRg5e97V8D7PcDkVEoG92_AxXHA5gna-HH3V2ocH_7L-QNGf85x |
| CitedBy_id | crossref_primary_10_1073_pnas_2300839120 crossref_primary_10_1002_SMMD_20230028 crossref_primary_10_1016_j_joto_2024_07_007 crossref_primary_10_3390_ijms21165764 crossref_primary_10_1073_pnas_2304680121 crossref_primary_10_1016_j_isci_2023_107769 crossref_primary_10_1186_s40779_022_00372_5 crossref_primary_10_3389_fncel_2021_732507 crossref_primary_10_1002_advs_202410494 crossref_primary_10_1242_dmm_049593 crossref_primary_10_1016_j_heares_2023_108813 crossref_primary_10_34172_bi_2022_23900 crossref_primary_10_1242_dev_201865 crossref_primary_10_1093_hmg_ddac096 crossref_primary_10_3390_bioengineering11050425 crossref_primary_10_1101_gr_271080_120 crossref_primary_10_3389_fnmol_2022_1020803 crossref_primary_10_1002_cmdc_202400038 crossref_primary_10_1080_1061186X_2023_2216900 crossref_primary_10_1002_advs_202304551 crossref_primary_10_1016_j_reth_2022_04_008 crossref_primary_10_3389_fcell_2021_730042 crossref_primary_10_1016_j_devcel_2021_07_003 crossref_primary_10_3390_cells11203331 crossref_primary_10_1073_pnas_2301301120 crossref_primary_10_1016_j_celrep_2023_113421 crossref_primary_10_1016_j_mcn_2022_103736 crossref_primary_10_1002_stem_3315 crossref_primary_10_1016_j_gde_2022_101954 crossref_primary_10_1038_s41598_020_78167_8 crossref_primary_10_1093_nargab_lqac023 crossref_primary_10_1152_ajpcell_00453_2021 crossref_primary_10_1007_s12264_023_01130_w crossref_primary_10_7554_eLife_66547 crossref_primary_10_1016_j_heares_2022_108515 crossref_primary_10_3389_fncel_2021_660748 crossref_primary_10_1016_j_heares_2023_108916 crossref_primary_10_1002_stem_3346 crossref_primary_10_3389_fgene_2020_591099 crossref_primary_10_1016_j_devcel_2021_08_013 crossref_primary_10_7554_eLife_79712 crossref_primary_10_7554_eLife_61849 crossref_primary_10_1038_s41598_022_11931_0 crossref_primary_10_1002_cphc_202200766 crossref_primary_10_1016_j_conb_2023_102745 crossref_primary_10_3389_fnmol_2022_854635 crossref_primary_10_1016_j_heares_2025_109256 crossref_primary_10_61186_phypha_27_4_331 crossref_primary_10_1093_pnasnexus_pgae445 crossref_primary_10_1126_sciadv_abj7651 crossref_primary_10_1016_j_neulet_2025_138136 crossref_primary_10_1007_s00439_022_02445_w crossref_primary_10_3389_fnins_2023_1177791 crossref_primary_10_3389_fcell_2024_1359207 crossref_primary_10_1038_s41598_023_44259_4 crossref_primary_10_1073_pnas_2105137118 crossref_primary_10_1002_dvdy_772 crossref_primary_10_3390_ijms23010066 |
| Cites_doi | 10.1097/01.moo.0000186799.45377.63 10.1126/science.3381100 10.1002/(SICI)1096-9861(19980720)397:1<69::AID-CNE6>3.0.CO;2-G 10.1371/journal.pone.0089377 10.4414/smw.2008.12260 10.1038/nature14590 10.1016/j.cell.2013.09.028 10.1073/pnas.1100230108 10.1242/dev.114926 10.1073/pnas.2334503100 10.1242/dev.139089 10.1016/j.brainres.2009.02.028 10.1016/j.ydbio.2007.04.035 10.1172/JCI60405 10.1038/ng1622 10.1113/jphysiol.1992.sp019030 10.1016/j.devcel.2011.12.006 10.1523/JNEUROSCI.17-24-09506.1997 10.1016/j.heares.2015.12.001 10.1016/j.neuron.2012.10.032 10.1242/dev.129320 10.1113/JP277997 10.1038/nature01763 10.1093/nar/gkx692 10.1016/j.ydbio.2013.01.005 10.1371/journal.pgen.1006967 10.1016/j.heares.2014.12.013 10.1242/jcs.113.9.1565 10.1038/ncomms9557 10.1038/nrn1987 10.1038/nature18323 10.1038/srep17886 10.1001/archotol.1967.00760050034007 10.1016/j.stem.2011.09.002 10.1016/j.bpj.2018.05.005 10.1016/0378-5955(91)90027-7 10.1523/JNEUROSCI.5420-11.2012 10.1007/s10162-009-0183-x 10.1523/JNEUROSCI.05-06-01609.1985 10.1016/j.stem.2015.05.015 10.1038/s41467-019-11687-8 10.1016/S0896-6273(03)00365-9 10.1016/j.ydbio.2004.05.013 10.1152/jn.00136.2009 10.1016/j.ymthe.2018.12.014 10.1016/j.semcdb.2016.08.017 10.1002/dvdy.20736 10.1016/0378-5955(95)00173-5 10.1002/dvdy.20551 10.1002/sctm.18-0267 10.1242/dev.103036 10.1038/nm.4490 10.1016/j.stem.2009.09.012 10.3109/00016488109108196 10.1038/nn.4449 10.1126/science.7839151 10.1242/dev.137976 10.1523/JNEUROSCI.5083-14.2015 10.1111/tpj.13882 10.1073/pnas.96.7.4084 10.1089/scd.2014.0033 10.1073/pnas.0506580102 10.1038/nature10671 10.1016/S1567-133X(03)00089-9 10.1038/s41592-018-0255-0 10.1007/978-1-4939-8961-4_9 10.1016/j.neuron.2013.06.019 10.1101/gad.831000 10.1038/nn1120 10.1242/dev.02453 10.1242/dev.129.10.2495 10.1242/dev.123141 10.1016/j.semcdb.2016.10.003 10.1038/nature11279 10.1038/nm1193 10.1016/j.cell.2010.07.002 10.1016/j.tips.2013.05.006 10.1038/nmeth.4031 10.1016/j.stem.2015.12.001 10.1007/BF00314545 10.1038/nature04849 10.1242/dev.00628 10.1016/j.stem.2015.01.013 10.1101/gad.5.9.1524 10.1242/dev.126.8.1581 10.1073/pnas.1016071107 10.1523/JNEUROSCI.21-18-07013.2001 10.1242/dev.00943 10.2337/db10-1540 10.1016/j.ydbio.2013.06.022 10.1038/ncb3437 10.1128/MCB.00208-07 10.1038/nature12903 10.1523/JNEUROSCI.0818-12.2012 10.1242/dev.00190 10.1523/JNEUROSCI.5606-12.2013 10.1089/hum.2017.120 10.3389/fnmol.2020.00013 10.1016/j.bbamcr.2019.02.010 10.1186/jbiol16 10.1073/pnas.1522401112 10.1002/neu.20054 10.1186/s40360-015-0036-7 10.1038/srep45524 10.1038/nn1349 10.1016/j.cell.2007.11.019 10.1186/s13024-016-0075-6 10.1016/j.stem.2011.07.014 10.1038/ng1966 10.14573/altex.1405271 10.1523/JNEUROSCI.18-19-07811.1998 10.1517/14712598.2015.1009889 10.1200/JCO.2016.69.2319 10.1016/j.brainres.2015.10.012 10.1038/nature12298 10.18632/oncotarget.12812 10.1242/dev.168617 10.1016/j.heares.2004.12.002 10.1002/0471142727.mb2129s109 10.1016/j.heares.2008.02.007 10.1016/j.cell.2006.07.024 10.1016/j.modgep.2007.05.002 10.3389/fncel.2015.00110 10.1016/j.heares.2014.01.001 10.1038/75753 10.1523/JNEUROSCI.23-06-02141.2003 10.1126/science.3381101 10.1016/j.mbs.2015.03.001 10.1093/emboj/cdf689 10.1016/j.stem.2019.08.005 10.1387/ijdb.072408js 10.1038/nbt.1754 10.1126/science.284.5421.1837 10.1016/j.stemcr.2014.01.008 10.1007/s11626-016-0106-1 10.1371/journal.pone.0022347 10.1016/j.drudis.2012.10.003 10.1093/nar/gkaa012 10.7554/eLife.50777 10.1016/j.devcel.2008.11.008 10.1083/jcb.137.6.1287 10.1038/nature01059 10.15283/ijsc19075 10.1016/j.cell.2010.03.035 10.3389/fnagi.2015.00058 10.1111/j.1469-7793.1999.00653.x 10.1007/s00412-002-0210-8 10.1097/00005537-200110000-00025 10.1016/j.neulet.2013.04.053 10.1242/dev.119149 10.1002/dvdy.23754 10.1523/JNEUROSCI.1690-14.2014 10.1523/JNEUROSCI.5126-14.2015 10.1016/j.otc.2018.03.002 10.1016/j.jcf.2014.07.009 10.1016/j.celrep.2017.09.011 10.1126/science.1241062 10.1258/ebm.2009.009281 10.1007/s004290050088 10.1016/0378-5955(94)90157-0 |
| ContentType | Journal Article |
| Copyright | 2020, Menendez et al. 2020, Menendez et al. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2020, Menendez et al 2020 Menendez et al |
| Copyright_xml | – notice: 2020, Menendez et al. – notice: 2020, Menendez et al. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2020, Menendez et al 2020 Menendez et al |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U 7X8 5PM ADTOC UNPAY DOA |
| DOI | 10.7554/eLife.55249 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection (Proquest) ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni Edition) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Natural Science Collection ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) Medical Database Science Database Biological Science Database ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic CrossRef Publicly Available Content Database MEDLINE |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository – sequence: 5 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2050-084X |
| ExternalDocumentID | oai_doaj_org_article_6c860cc9943b4f488fa43d0ff80850e3 10.7554/elife.55249 PMC7326493 32602462 10_7554_eLife_55249 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NINDS NIH HHS grantid: R01 NS097850 – fundername: NIDCD NIH HHS grantid: R01 DC015530 – fundername: NINDS NIH HHS grantid: R00 NS077435 – fundername: NIDCD NIH HHS grantid: T32 DC009975 – fundername: ; – fundername: ; grantid: Tau Consortium – fundername: ; grantid: Richard N. Merkin Assistant Professor of Stem Cell Biology and Regenerative Medicine at USC – fundername: ; grantid: R01NS097850 – fundername: ; grantid: R01DC015530 – fundername: ; grantid: New York Stem Cell Foundation-Robertson Investigator – fundername: ; grantid: R00NS077435 |
| GroupedDBID | 53G 5VS 7X7 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAKDD AAYXX ABUWG ACGFO ACGOD ACPRK ADBBV ADRAZ AENEX AFKRA AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI CCPQU CITATION DIK DWQXO EMOBN FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HMCUK HYE IAO IEA IHR INH INR ISR ITC KQ8 LK8 M1P M2P M48 M7P M~E NQS OK1 PGMZT PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PUEGO RHI RNS RPM UKHRP ALIPV CGR CUY CVF ECM EIF NPM 3V. 7XB 8FK K9. PKEHL PQEST PQUKI PRINS Q9U 7X8 5PM ADTOC H13 UNPAY |
| ID | FETCH-LOGICAL-c541t-c0accdbd72d1a7b5cdd8c500daff98edbf745f2abdc4680415336677097566383 |
| IEDL.DBID | M48 |
| ISSN | 2050-084X |
| IngestDate | Tue Oct 14 19:03:32 EDT 2025 Sun Oct 26 04:15:13 EDT 2025 Tue Sep 30 16:47:13 EDT 2025 Thu Sep 04 15:54:09 EDT 2025 Tue Oct 07 07:09:25 EDT 2025 Mon Jul 21 06:00:19 EDT 2025 Thu Apr 24 23:08:54 EDT 2025 Wed Oct 01 04:51:04 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | reprogramming mouse stem cells screening sensory hair cell regeneration developmental biology regenerative medicine inner ear ototoxin |
| Language | English |
| License | 2020, Menendez et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. cc-by |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c541t-c0accdbd72d1a7b5cdd8c500daff98edbf745f2abdc4680415336677097566383 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-0360-8965 0000-0001-6830-0358 0000-0002-0441-2067 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.7554/eLife.55249 |
| PMID | 32602462 |
| PQID | 2429407237 |
| PQPubID | 2045579 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_6c860cc9943b4f488fa43d0ff80850e3 unpaywall_primary_10_7554_elife_55249 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7326493 proquest_miscellaneous_2419098266 proquest_journals_2429407237 pubmed_primary_32602462 crossref_primary_10_7554_eLife_55249 crossref_citationtrail_10_7554_eLife_55249 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2020-06-30 |
| PublicationDateYYYYMMDD | 2020-06-30 |
| PublicationDate_xml | – month: 06 year: 2020 text: 2020-06-30 day: 30 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: Cambridge |
| PublicationTitle | eLife |
| PublicationTitleAlternate | Elife |
| PublicationYear | 2020 |
| Publisher | eLife Sciences Publications Ltd eLife Sciences Publications, Ltd |
| Publisher_xml | – name: eLife Sciences Publications Ltd – name: eLife Sciences Publications, Ltd |
| References | Cai (bib18) 2013; 33 Koch (bib69) 2011; 480 Pak (bib107) 1995; 91 Bohne (bib11) 2000; 21 Singhal (bib129) 2016; 113 Zheng (bib164) 2000; 3 Hume (bib54) 2007; 7 Liu (bib89) 2014; 34 Wu (bib156) 2017; 20 Cheng (bib24) 2005; 13 Forge (bib39) 1998; 397 Knight (bib68) 2017; 35 Villanueva-Paz (bib146) 2019; 1866 Brignull (bib14) 2009; 1277 Shi (bib127) 2018; 24 Cox (bib30) 2014; 141 Wallis (bib148) 2003; 130 Stojanova (bib131) 2016; 143 Suzuki (bib134) 2017; 7 Groves (bib45) 2010; 235 Zhang (bib161) 2004; 3 Jiang (bib60) 2016; 332 Ostrowski (bib105) 2015; 142 Maass (bib93) 2015; 9 Ieda (bib57) 2010; 142 Hinojosa (bib49) 2001; 111 Tan (bib138) 2019; 10 Demêmes (bib33) 1993; 274 Sanyal (bib125) 2012; 489 Matei (bib96) 2005; 234 Chonko (bib25) 2013; 381 Buenrostro (bib15) 2015; 109 Lim (bib84) 2016; 11 Holt (bib51) 2014; 311 Takebayashi (bib137) 2007; 307 Roberson (bib115) 1994; 15 Liberman (bib82) 2002; 419 Hasson (bib46) 1997; 137 Koehler (bib70) 2013; 500 Bermingham (bib8) 1999; 284 Takahashi (bib135) 2007; 131 Al-Malky (bib3) 2015; 14 Vaisbuch (bib143) 2018; 51 Oesterle (bib102) 2009; 10 Boëda (bib10) 2002; 21 Lee (bib75) 2019; 12 Robinson (bib116) 2011; 29 Phan (bib109) 2015; 264 Sahly (bib124) 1997; 196 Sagwa (bib123) 2015; 16 Heintzman (bib47) 2007; 39 Johnsson (bib61) 1981; 383 Lowenheim (bib91) 1999; 96 Marcotti (bib94) 1999; 520 Pt 3 Chen (bib23) 1999; 126 Gopalakrishnan (bib44) 2017; 1656 Lumpkin (bib92) 2003; 3 Ozaki (bib106) 2004; 131 Bardhan (bib7) 2019; 597 Cai (bib19) 2015; 35 Dallos (bib32) 1985; 5 Burns (bib17) 2015; 6 White (bib152) 2006; 441 Ronaghi (bib118) 2014; 23 Géléoc (bib41) 2003; 6 Breslin (bib13) 2013; 18 Kelly (bib65) 2012; 32 Lemon (bib78) 2000; 14 Cotanche (bib29) 1991; 52 Woods (bib155) 2004; 7 Babos (bib6) 2019; 25 Buenrostro (bib16) 2015; 523 Marro (bib95) 2011; 9 Yoon (bib159) 2019; 16 Ahmed (bib2) 2012; 22 Li (bib81) 2020; 48 Mellough (bib99) 2019; 8 Mistry (bib100) 2018; 114 Ryan (bib122) 2015; 329 Lee (bib74) 2006; 133 Subramanian (bib133) 2005; 102 Wang (bib149) 2005; 37 Bodmer (bib9) 2008; 138 Ryals (bib121) 1988; 240 Leibovici (bib76) 2005; 203 Chen (bib22) 2016; 13 Oshima (bib104) 2010; 141 Pan (bib108) 2013; 79 Gale (bib40) 2001; 21 Géléoc (bib42) 2014; 344 Lim (bib83) 2016; 7 Wapinski (bib151) 2017; 20 Qian (bib110) 2006; 235 Roccio (bib117) 2015; 5 Zhang (bib162) 2017; 13 Wong (bib154) 2015; 7 Goetze (bib43) 2007; 27 Lelli (bib77) 2009; 101 Lo (bib90) 1991; 5 Rhee (bib111) 2017; 45 Mizutari (bib101) 2013; 77 Zhu (bib165) 2019; 8 Langer (bib73) 2013; 34 Richardson (bib112) 1997; 17 Zheng (bib163) 2003; 130 Lalit (bib72) 2016; 18 Alharazneh (bib4) 2011; 6 Kaminski (bib62) 2016; 18 Yoshimura (bib160) 2019; 27 Doetzlhofer (bib34) 2004; 272 Kelley (bib64) 2006; 7 Fekete (bib38) 1998; 18 Klisch (bib67) 2011; 108 Hoa (bib50) 2020; 13 WHO (bib153) 2019 Takahashi (bib136) 2006; 126 Atkinson (bib5) 2015; 142 Troutt (bib142) 1994; 81 Doetzlhofer (bib35) 2009; 16 Richardson (bib114) 2015; 15 Liu (bib85) 2011; 60 Liu (bib87) 2012; 32 Driver (bib36) 2013; 376 Kozubek (bib71) 2002; 111 Costa (bib27) 2015; 142 Ichida (bib55) 2009; 5 Tao (bib139) 2018; 29 Abdolazimi (bib1) 2016; 143 Corwin (bib26) 1988; 240 McGrath (bib98) 2017; 65 Housley (bib52) 1992; 448 Li (bib80) 2003; 100 Wapinski (bib150) 2013; 155 Bramhall (bib12) 2014; 2 Levine (bib79) 2003; 424 Creyghton (bib31) 2010; 107 Izumikawa (bib59) 2008; 240 Stone (bib132) 2007; 51 Liu (bib88) 2014; 9 Richardson (bib113) 1999; 884 Tarchini (bib140) 2016; 143 Xu (bib157) 2015; 16 Ichida (bib56) 2018; 145 Liu (bib86) 2012; 241 Treutlein (bib141) 2016; 534 van Vliet (bib145) 2014; 31 Chen (bib21) 2002; 129 Kim (bib66) 2014; 506 Ruben (bib120) 1967; 86 Eybalin (bib37) 1990; 310 Hiler (bib48) 2015; 17 Izumikawa (bib58) 2005; 11 Oliver (bib103) 2003; 23 Kawashima (bib63) 2011; 121 Van Pham (bib144) 2017; 53 Scheffer (bib126) 2015; 35 Costa (bib28) 2017; 65 Yang (bib158) 2013; 549 Sijacic (bib128) 2018; 94 Ross (bib119) 2003; 39 Volpi (bib147) 2000; 113 ( Pt 9 Chardin (bib20) 1995; 267 Matsui (bib97) 2004; 61 Son (bib130) 2011; 9 Huang (bib53) 2019; 1905 |
| References_xml | – volume: 13 start-page: 343 year: 2005 ident: bib24 article-title: Mechanisms of hair cell death and protection publication-title: Current Opinion in Otolaryngology & Head and Neck Surgery doi: 10.1097/01.moo.0000186799.45377.63 – volume: 240 start-page: 1772 year: 1988 ident: bib26 article-title: Regeneration of sensory hair cells after acoustic trauma publication-title: Science doi: 10.1126/science.3381100 – volume: 397 start-page: 69 year: 1998 ident: bib39 article-title: Hair cell recovery in the vestibular sensory epithelia of mature guinea pigs publication-title: The Journal of Comparative Neurology doi: 10.1002/(SICI)1096-9861(19980720)397:1<69::AID-CNE6>3.0.CO;2-G – volume: 9 year: 2014 ident: bib88 article-title: In vivo generation of immature inner hair cells in neonatal mouse cochleae by ectopic Atoh1 expression publication-title: PLOS ONE doi: 10.1371/journal.pone.0089377 – volume: 138 start-page: 708 year: 2008 ident: bib9 article-title: Protection, regeneration and replacement of hair cells in the cochlea: implications for the future treatment of sensorineural hearing loss publication-title: Swiss Medical Weekly doi: 10.4414/smw.2008.12260 – volume: 523 start-page: 486 year: 2015 ident: bib16 article-title: Single-cell chromatin accessibility reveals principles of regulatory variation publication-title: Nature doi: 10.1038/nature14590 – volume: 155 start-page: 621 year: 2013 ident: bib150 article-title: Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons publication-title: Cell doi: 10.1016/j.cell.2013.09.028 – volume: 108 start-page: 3288 year: 2011 ident: bib67 article-title: In vivo Atoh1 targetome reveals how a proneural transcription factor regulates cerebellar development publication-title: PNAS doi: 10.1073/pnas.1100230108 – volume: 142 start-page: 1561 year: 2015 ident: bib5 article-title: Sensory hair cell development and regeneration: similarities and differences publication-title: Development doi: 10.1242/dev.114926 – volume: 100 start-page: 13495 year: 2003 ident: bib80 article-title: Generation of hair cells by stepwise differentiation of embryonic stem cells publication-title: PNAS doi: 10.1073/pnas.2334503100 – volume: 143 start-page: 3926 year: 2016 ident: bib140 article-title: A link between planar polarity and staircase-like bundle architecture in hair cells publication-title: Development doi: 10.1242/dev.139089 – volume: 1277 start-page: 12 year: 2009 ident: bib14 article-title: Feathers and fins: non-mammalian models for hair cell regeneration publication-title: Brain Research doi: 10.1016/j.brainres.2009.02.028 – volume: 307 start-page: 165 year: 2007 ident: bib137 article-title: Multiple roles of notch signaling in cochlear development publication-title: Developmental Biology doi: 10.1016/j.ydbio.2007.04.035 – year: 2019 ident: bib153 article-title: World health organization – volume: 121 start-page: 4796 year: 2011 ident: bib63 article-title: Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes publication-title: Journal of Clinical Investigation doi: 10.1172/JCI60405 – volume: 37 start-page: 980 year: 2005 ident: bib149 article-title: Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway publication-title: Nature Genetics doi: 10.1038/ng1622 – volume: 448 start-page: 73 year: 1992 ident: bib52 article-title: Ionic currents of outer hair cells isolated from the guinea-pig cochlea publication-title: The Journal of Physiology doi: 10.1113/jphysiol.1992.sp019030 – volume: 22 start-page: 377 year: 2012 ident: bib2 article-title: Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2 publication-title: Developmental Cell doi: 10.1016/j.devcel.2011.12.006 – volume: 17 start-page: 9506 year: 1997 ident: bib112 article-title: Myosin VIIA is required for aminoglycoside accumulation in cochlear hair cells publication-title: The Journal of Neuroscience doi: 10.1523/JNEUROSCI.17-24-09506.1997 – volume: 332 start-page: 17 year: 2016 ident: bib60 article-title: Hair cell regeneration or the expression of related factors that regulate the fate specification of supporting cells in the cochlear ducts of embryonic and posthatch chickens publication-title: Hearing Research doi: 10.1016/j.heares.2015.12.001 – volume: 77 start-page: 58 year: 2013 ident: bib101 article-title: Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma publication-title: Neuron doi: 10.1016/j.neuron.2012.10.032 – volume: 143 start-page: 841 year: 2016 ident: bib1 article-title: Selection of cell fate in the organ of Corti involves the integration of hes/Hey signaling at the Atoh1 promoter publication-title: Development doi: 10.1242/dev.129320 – volume: 597 start-page: 3389 year: 2019 ident: bib7 article-title: Gata3 is required for the functional maturation of inner hair cells and their innervation in the mouse cochlea publication-title: The Journal of Physiology doi: 10.1113/JP277997 – volume: 424 start-page: 147 year: 2003 ident: bib79 article-title: Transcription regulation and animal diversity publication-title: Nature doi: 10.1038/nature01763 – volume: 45 start-page: 10103 year: 2017 ident: bib111 article-title: Mechanisms of transcription factor-mediated direct reprogramming of mouse embryonic stem cells to trophoblast stem-like cells publication-title: Nucleic Acids Research doi: 10.1093/nar/gkx692 – volume: 376 start-page: 86 year: 2013 ident: bib36 article-title: The Atoh1-lineage gives rise to hair cells and supporting cells within the mammalian cochlea publication-title: Developmental Biology doi: 10.1016/j.ydbio.2013.01.005 – volume: 13 year: 2017 ident: bib162 article-title: Six1 is essential for differentiation and patterning of the mammalian auditory sensory epithelium publication-title: PLOS Genetics doi: 10.1371/journal.pgen.1006967 – volume: 329 start-page: 33 year: 2015 ident: bib122 article-title: The regulation of gene expression in hair cells publication-title: Hearing Research doi: 10.1016/j.heares.2014.12.013 – volume: 113 ( Pt 9 start-page: 1565 year: 2000 ident: bib147 article-title: Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei publication-title: Journal of Cell Science doi: 10.1242/jcs.113.9.1565 – volume: 6 year: 2015 ident: bib17 article-title: Single-cell RNA-Seq resolves cellular complexity in sensory organs from the neonatal inner ear publication-title: Nature Communications doi: 10.1038/ncomms9557 – volume: 7 start-page: 837 year: 2006 ident: bib64 article-title: Regulation of cell fate in the sensory epithelia of the inner ear publication-title: Nature Reviews Neuroscience doi: 10.1038/nrn1987 – volume: 534 start-page: 391 year: 2016 ident: bib141 article-title: Dissecting direct reprogramming from fibroblast to neuron using single-cell RNA-seq publication-title: Nature doi: 10.1038/nature18323 – volume: 5 year: 2015 ident: bib117 article-title: Cell cycle reactivation of cochlear progenitor cells in neonatal FUCCI mice by a GSK3 small molecule inhibitor publication-title: Scientific Reports doi: 10.1038/srep17886 – volume: 86 start-page: 32 year: 1967 ident: bib120 article-title: Serial section radioautography of the inner ear: histological technique publication-title: Archives of Otolaryngology - Head and Neck Surgery doi: 10.1001/archotol.1967.00760050034007 – volume: 9 start-page: 374 year: 2011 ident: bib95 article-title: Direct lineage conversion of terminally differentiated hepatocytes to functional neurons publication-title: Cell Stem Cell doi: 10.1016/j.stem.2011.09.002 – volume: 114 start-page: 2974 year: 2018 ident: bib100 article-title: The effects of statistical multiplicity of infection on virus quantification and infectivity assays publication-title: Biophysical Journal doi: 10.1016/j.bpj.2018.05.005 – volume: 52 start-page: 379 year: 1991 ident: bib29 article-title: Stereociliary bundles reorient during hair cell development and regeneration in the chick cochlea publication-title: Hearing Research doi: 10.1016/0378-5955(91)90027-7 – volume: 32 start-page: 6699 year: 2012 ident: bib65 article-title: Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.5420-11.2012 – volume: 10 start-page: 525 year: 2009 ident: bib102 article-title: Supporting cell characteristics in long-deafened aged mouse ears publication-title: Journal of the Association for Research in Otolaryngology doi: 10.1007/s10162-009-0183-x – volume: 5 start-page: 1609 year: 1985 ident: bib32 article-title: Membrane potential and response changes in mammalian cochlear hair cells during intracellular recording publication-title: The Journal of Neuroscience doi: 10.1523/JNEUROSCI.05-06-01609.1985 – volume: 17 start-page: 101 year: 2015 ident: bib48 article-title: Quantification of retinogenesis in 3D cultures reveals epigenetic memory and higher efficiency in iPSCs derived from rod photoreceptors publication-title: Cell Stem Cell doi: 10.1016/j.stem.2015.05.015 – volume: 10 year: 2019 ident: bib138 article-title: AAV-ie enables safe and efficient gene transfer to inner ear cells publication-title: Nature Communications doi: 10.1038/s41467-019-11687-8 – volume: 39 start-page: 13 year: 2003 ident: bib119 article-title: Basic helix-loop-helix factors in cortical development publication-title: Neuron doi: 10.1016/S0896-6273(03)00365-9 – volume: 272 start-page: 432 year: 2004 ident: bib34 article-title: In vitro growth and differentiation of mammalian sensory hair cell progenitors: a requirement for EGF and periotic mesenchyme publication-title: Developmental Biology doi: 10.1016/j.ydbio.2004.05.013 – volume: 101 start-page: 2961 year: 2009 ident: bib77 article-title: Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea publication-title: Journal of Neurophysiology doi: 10.1152/jn.00136.2009 – volume: 27 start-page: 681 year: 2019 ident: bib160 article-title: Targeted allele suppression prevents progressive hearing loss in the mature murine model of human TMC1 deafness publication-title: Molecular Therapy doi: 10.1016/j.ymthe.2018.12.014 – volume: 65 start-page: 88 year: 2017 ident: bib98 article-title: Stereocilia morphogenesis and maintenance through regulation of actin stability publication-title: Seminars in Cell & Developmental Biology doi: 10.1016/j.semcdb.2016.08.017 – volume: 235 start-page: 1689 year: 2006 ident: bib110 article-title: Basic helix-loop-helix gene Hes6 delineates the sensory hair cell lineage in the inner ear publication-title: Developmental Dynamics doi: 10.1002/dvdy.20736 – volume: 91 start-page: 119 year: 1995 ident: bib107 article-title: Cytoskeletal and calcium-binding proteins in the mammalian organ of Corti: cell type-specific proteins displaying longitudinal and radial gradients publication-title: Hearing Research doi: 10.1016/0378-5955(95)00173-5 – volume: 234 start-page: 633 year: 2005 ident: bib96 article-title: Smaller inner ear sensory epithelia in neurog 1 null mice are related to earlier hair cell cycle exit publication-title: Developmental Dynamics doi: 10.1002/dvdy.20551 – volume: 8 start-page: 694 year: 2019 ident: bib99 article-title: Systematic comparison of retinal organoid differentiation from human pluripotent stem cells reveals stage specific, cell line, and methodological differences publication-title: STEM CELLS Translational Medicine doi: 10.1002/sctm.18-0267 – volume: 141 start-page: 816 year: 2014 ident: bib30 article-title: Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo publication-title: Development doi: 10.1242/dev.103036 – volume: 24 start-page: 313 year: 2018 ident: bib127 article-title: Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons publication-title: Nature Medicine doi: 10.1038/nm.4490 – volume: 5 start-page: 491 year: 2009 ident: bib55 article-title: A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog publication-title: Cell Stem Cell doi: 10.1016/j.stem.2009.09.012 – volume: 383 start-page: 1 year: 1981 ident: bib61 article-title: Aminoglycoside-induced cochlear pathology in man publication-title: Acta Oto-Laryngologica doi: 10.3109/00016488109108196 – volume: 20 start-page: 24 year: 2017 ident: bib156 article-title: Mechanosensory hair cells express two molecularly distinct mechanotransduction channels publication-title: Nature Neuroscience doi: 10.1038/nn.4449 – volume: 267 start-page: 707 year: 1995 ident: bib20 article-title: Regeneration and mammalian auditory hair cells publication-title: Science doi: 10.1126/science.7839151 – volume: 143 year: 2016 ident: bib131 article-title: Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea publication-title: Development doi: 10.1242/dev.137976 – volume: 35 start-page: 5870 year: 2015 ident: bib19 article-title: Characterization of the transcriptome of nascent hair cells and identification of direct targets of the Atoh1 transcription factor publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.5083-14.2015 – volume: 94 start-page: 215 year: 2018 ident: bib128 article-title: Changes in chromatin accessibility between Arabidopsis stem cells and mesophyll cells illuminate cell type-specific transcription factor networks publication-title: The Plant Journal doi: 10.1111/tpj.13882 – volume: 96 start-page: 4084 year: 1999 ident: bib91 article-title: Gene disruption of p27Kip1 allows cell proliferation in the postnatal and adult organ of corti publication-title: PNAS doi: 10.1073/pnas.96.7.4084 – volume: 23 start-page: 1275 year: 2014 ident: bib118 article-title: Inner ear hair cell-like cells from human embryonic stem cells publication-title: Stem Cells and Development doi: 10.1089/scd.2014.0033 – volume: 102 start-page: 15545 year: 2005 ident: bib133 article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles publication-title: PNAS doi: 10.1073/pnas.0506580102 – volume: 480 start-page: 543 year: 2011 ident: bib69 article-title: Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease publication-title: Nature doi: 10.1038/nature10671 – volume: 3 start-page: 389 year: 2003 ident: bib92 article-title: Math1-driven GFP expression in the developing nervous system of transgenic mice publication-title: Gene Expression Patterns doi: 10.1016/S1567-133X(03)00089-9 – volume: 16 start-page: 75 year: 2019 ident: bib159 article-title: Reliability of human cortical organoid generation publication-title: Nature Methods doi: 10.1038/s41592-018-0255-0 – volume: 1905 start-page: 93 year: 2019 ident: bib53 article-title: Conversion of fibroblasts to hepatocytes in vitro publication-title: Methods in Molecular Biology doi: 10.1007/978-1-4939-8961-4_9 – volume: 79 start-page: 504 year: 2013 ident: bib108 article-title: TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear publication-title: Neuron doi: 10.1016/j.neuron.2013.06.019 – volume: 14 start-page: 2551 year: 2000 ident: bib78 article-title: Orchestrated response: a symphony of transcription factors for gene control publication-title: Genes & Development doi: 10.1101/gad.831000 – volume: 6 start-page: 1019 year: 2003 ident: bib41 article-title: Developmental acquisition of sensory transduction in hair cells of the mouse inner ear publication-title: Nature Neuroscience doi: 10.1038/nn1120 – volume: 133 start-page: 2817 year: 2006 ident: bib74 article-title: A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of corti development publication-title: Development doi: 10.1242/dev.02453 – volume: 129 start-page: 2495 year: 2002 ident: bib21 article-title: The role of Math1 in inner ear development: uncoupling the establishment of the sensory primordium from hair cell fate determination publication-title: Development doi: 10.1242/dev.129.10.2495 – volume: 142 start-page: 2533 year: 2015 ident: bib105 article-title: Ectopic Atoh1 expression drives merkel cell production in embryonic, postnatal and adult mouse epidermis publication-title: Development doi: 10.1242/dev.123141 – volume: 65 start-page: 60 year: 2017 ident: bib28 article-title: Atoh1 in sensory hair cell development: constraints and cofactors publication-title: Seminars in Cell & Developmental Biology doi: 10.1016/j.semcdb.2016.10.003 – volume: 489 start-page: 109 year: 2012 ident: bib125 article-title: The long-range interaction landscape of gene promoters publication-title: Nature doi: 10.1038/nature11279 – volume: 11 start-page: 271 year: 2005 ident: bib58 article-title: Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals publication-title: Nature Medicine doi: 10.1038/nm1193 – volume: 142 start-page: 375 year: 2010 ident: bib57 article-title: Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors publication-title: Cell doi: 10.1016/j.cell.2010.07.002 – volume: 34 start-page: 458 year: 2013 ident: bib73 article-title: Understanding platinum-induced ototoxicity publication-title: Trends in Pharmacological Sciences doi: 10.1016/j.tips.2013.05.006 – volume: 13 start-page: 1013 year: 2016 ident: bib22 article-title: ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing publication-title: Nature Methods doi: 10.1038/nmeth.4031 – volume: 18 start-page: 354 year: 2016 ident: bib72 article-title: Lineage reprogramming of fibroblasts into proliferative induced cardiac progenitor cells by defined factors publication-title: Cell Stem Cell doi: 10.1016/j.stem.2015.12.001 – volume: 274 start-page: 487 year: 1993 ident: bib33 article-title: Cellular distribution of parvalbumin immunoreactivity in the peripheral vestibular system of three rodents publication-title: Cell and Tissue Research doi: 10.1007/BF00314545 – volume: 441 start-page: 984 year: 2006 ident: bib152 article-title: Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells publication-title: Nature doi: 10.1038/nature04849 – volume: 130 start-page: 3989 year: 2003 ident: bib163 article-title: The role of Six1 in mammalian auditory system development publication-title: Development doi: 10.1242/dev.00628 – volume: 16 start-page: 119 year: 2015 ident: bib157 article-title: Direct lineage reprogramming: strategies, mechanisms, and applications publication-title: Cell Stem Cell doi: 10.1016/j.stem.2015.01.013 – volume: 5 start-page: 1524 year: 1991 ident: bib90 article-title: Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells publication-title: Genes & Development doi: 10.1101/gad.5.9.1524 – volume: 126 start-page: 1581 year: 1999 ident: bib23 article-title: p27(Kip1) links cell proliferation to morphogenesis in the developing organ of corti publication-title: Development doi: 10.1242/dev.126.8.1581 – volume: 107 start-page: 21931 year: 2010 ident: bib31 article-title: Histone H3K27ac separates active from poised enhancers and predicts developmental state publication-title: PNAS doi: 10.1073/pnas.1016071107 – volume: 21 start-page: 7013 year: 2001 ident: bib40 article-title: FM1-43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel publication-title: The Journal of Neuroscience doi: 10.1523/JNEUROSCI.21-18-07013.2001 – volume: 131 start-page: 551 year: 2004 ident: bib106 article-title: Six1 controls patterning of the mouse otic vesicle publication-title: Development doi: 10.1242/dev.00943 – volume: 21 start-page: 505 year: 2000 ident: bib11 article-title: Degeneration in the cochlea after noise damage: primary versus secondary events publication-title: The American Journal of Otology – volume: 60 start-page: 1393 year: 2011 ident: bib85 article-title: Generation of stable pluripotent stem cells from NOD mouse tail-tip fibroblasts publication-title: Diabetes doi: 10.2337/db10-1540 – volume: 381 start-page: 401 year: 2013 ident: bib25 article-title: Atoh1 directs hair cell differentiation and survival in the late embryonic mouse inner ear publication-title: Developmental Biology doi: 10.1016/j.ydbio.2013.06.022 – volume: 18 start-page: 1269 year: 2016 ident: bib62 article-title: Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors publication-title: Nature Cell Biology doi: 10.1038/ncb3437 – volume: 27 start-page: 4475 year: 2007 ident: bib43 article-title: The three-dimensional structure of human interphase chromosomes is related to the transcriptome map publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.00208-07 – volume: 506 start-page: 511 year: 2014 ident: bib66 article-title: Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity publication-title: Nature doi: 10.1038/nature12903 – volume: 32 start-page: 6600 year: 2012 ident: bib87 article-title: Age-dependent in vivo conversion of mouse cochlear pillar and deiters' cells to immature hair cells by Atoh1 ectopic expression publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.0818-12.2012 – volume: 130 start-page: 221 year: 2003 ident: bib148 article-title: The zinc finger transcription factor Gfi1, implicated in Lymphomagenesis, is required for inner ear hair cell differentiation and survival publication-title: Development doi: 10.1242/dev.00190 – volume: 33 start-page: 10110 year: 2013 ident: bib18 article-title: Conditional deletion of Atoh1 reveals distinct critical periods for survival and function of hair cells in the organ of corti publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.5606-12.2013 – volume: 29 start-page: 492 year: 2018 ident: bib139 article-title: Delivery of Adeno-Associated virus vectors in adult mammalian Inner-Ear cell subtypes without auditory dysfunction publication-title: Human Gene Therapy doi: 10.1089/hum.2017.120 – volume: 13 year: 2020 ident: bib50 article-title: Characterizing adult cochlear supporting cell transcriptional diversity using Single-Cell RNA-Seq: validation in the adult mouse and translational implications for the adult human cochlea publication-title: Frontiers in Molecular Neuroscience doi: 10.3389/fnmol.2020.00013 – volume: 1866 start-page: 861 year: 2019 ident: bib146 article-title: Pathophysiological characterization of MERRF patient-specific induced neurons generated by direct reprogramming publication-title: Biochimica Et Biophysica Acta (BBA) - Molecular Cell Research doi: 10.1016/j.bbamcr.2019.02.010 – volume: 3 year: 2004 ident: bib161 article-title: The functional landscape of mouse gene expression publication-title: Journal of Biology doi: 10.1186/jbiol16 – volume: 113 start-page: 122 year: 2016 ident: bib129 article-title: Mouse embryonic fibroblasts exhibit extensive developmental and phenotypic diversity publication-title: PNAS doi: 10.1073/pnas.1522401112 – volume: 61 start-page: 250 year: 2004 ident: bib97 article-title: Critical signaling events during the aminoglycoside-induced death of sensory hair cells in vitro publication-title: Journal of Neurobiology doi: 10.1002/neu.20054 – volume: 16 year: 2015 ident: bib123 article-title: Comparing amikacin and kanamycin-induced hearing loss in multidrug-resistant tuberculosis treatment under programmatic conditions in a namibian retrospective cohort publication-title: BMC Pharmacology and Toxicology doi: 10.1186/s40360-015-0036-7 – volume: 7 year: 2017 ident: bib134 article-title: Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction publication-title: Scientific Reports doi: 10.1038/srep45524 – volume: 7 start-page: 1310 year: 2004 ident: bib155 article-title: Math1 regulates development of the sensory epithelium in the mammalian cochlea publication-title: Nature Neuroscience doi: 10.1038/nn1349 – volume: 131 start-page: 861 year: 2007 ident: bib135 article-title: Induction of pluripotent stem cells from adult human fibroblasts by defined factors publication-title: Cell doi: 10.1016/j.cell.2007.11.019 – volume: 11 year: 2016 ident: bib84 article-title: Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis publication-title: Molecular Neurodegeneration doi: 10.1186/s13024-016-0075-6 – volume: 9 start-page: 205 year: 2011 ident: bib130 article-title: Conversion of mouse and human fibroblasts into functional spinal motor neurons publication-title: Cell Stem Cell doi: 10.1016/j.stem.2011.07.014 – volume: 15 start-page: 28 year: 1994 ident: bib115 article-title: Cell division in the gerbil cochlea after acoustic trauma publication-title: The American Journal of Otology – volume: 39 start-page: 311 year: 2007 ident: bib47 article-title: Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome publication-title: Nature Genetics doi: 10.1038/ng1966 – volume: 310 start-page: 639 year: 1990 ident: bib37 article-title: Immunolocalization of parvalbumin in two glutamatergic cell types of the guinea pig cochlea: inner hair cells and spinal ganglion neurons] publication-title: Comptes Rendus De l'Academie Des Sciences. Serie III, Sciences De La Vie – volume: 31 start-page: 479 year: 2014 ident: bib145 article-title: Current approaches and future role of high content imaging in safety sciences and drug discovery publication-title: ALTEX doi: 10.14573/altex.1405271 – volume: 18 start-page: 7811 year: 1998 ident: bib38 article-title: Hair cells and supporting cells share a common progenitor in the avian inner ear publication-title: The Journal of Neuroscience doi: 10.1523/JNEUROSCI.18-19-07811.1998 – volume: 15 start-page: 417 year: 2015 ident: bib114 article-title: Atoh1 gene therapy in the cochlea for hair cell regeneration publication-title: Expert Opinion on Biological Therapy doi: 10.1517/14712598.2015.1009889 – volume: 35 start-page: 440 year: 2017 ident: bib68 article-title: Group-Wide, prospective study of ototoxicity assessment in children receiving cisplatin chemotherapy (ACCL05C1): A report from the children's Oncology Group publication-title: Journal of Clinical Oncology doi: 10.1200/JCO.2016.69.2319 – volume: 1656 start-page: 2 year: 2017 ident: bib44 article-title: New approaches for direct conversion of patient fibroblasts into neural cells publication-title: Brain Research doi: 10.1016/j.brainres.2015.10.012 – volume: 500 start-page: 217 year: 2013 ident: bib70 article-title: Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture publication-title: Nature doi: 10.1038/nature12298 – volume: 7 start-page: 74496 year: 2016 ident: bib83 article-title: Patient fibroblasts-derived induced neurons demonstrate autonomous neuronal defects in adult-onset Krabbe disease publication-title: Oncotarget doi: 10.18632/oncotarget.12812 – volume: 145 year: 2018 ident: bib56 article-title: Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons publication-title: Development doi: 10.1242/dev.168617 – volume: 203 start-page: 144 year: 2005 ident: bib76 article-title: Initial characterization of Kinocilin, a protein of the hair cell kinocilium publication-title: Hearing Research doi: 10.1016/j.heares.2004.12.002 – volume: 109 start-page: 1 year: 2015 ident: bib15 article-title: Atac‐seq: a method for assaying chromatin accessibility genome‐wide publication-title: Current Protocols in Molecular Biology doi: 10.1002/0471142727.mb2129s109 – volume: 240 start-page: 52 year: 2008 ident: bib59 article-title: Response of the flat cochlear epithelium to forced expression of Atoh1 publication-title: Hearing Research doi: 10.1016/j.heares.2008.02.007 – volume: 126 start-page: 663 year: 2006 ident: bib136 article-title: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors publication-title: Cell doi: 10.1016/j.cell.2006.07.024 – volume: 7 start-page: 798 year: 2007 ident: bib54 article-title: Expression of LHX3 and SOX2 during mouse inner ear development publication-title: Gene Expression Patterns doi: 10.1016/j.modgep.2007.05.002 – volume: 9 year: 2015 ident: bib93 article-title: Changes in the regulation of the notch signaling pathway are temporally correlated with regenerative failure in the mouse cochlea publication-title: Frontiers in Cellular Neuroscience doi: 10.3389/fncel.2015.00110 – volume: 311 start-page: 17 year: 2014 ident: bib51 article-title: TMC function in hair cell transduction publication-title: Hearing Research doi: 10.1016/j.heares.2014.01.001 – volume: 3 start-page: 580 year: 2000 ident: bib164 article-title: Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears publication-title: Nature Neuroscience doi: 10.1038/75753 – volume: 23 start-page: 2141 year: 2003 ident: bib103 article-title: Resting potential and submembrane calcium concentration of inner hair cells in the isolated mouse cochlea are set by KCNQ-type potassium channels publication-title: The Journal of Neuroscience doi: 10.1523/JNEUROSCI.23-06-02141.2003 – volume: 240 start-page: 1774 year: 1988 ident: bib121 article-title: Hair cell regeneration after acoustic trauma in adult Coturnix quail publication-title: Science doi: 10.1126/science.3381101 – volume: 264 start-page: 21 year: 2015 ident: bib109 article-title: Modeling multiple infection of cells by viruses: challenges and insights publication-title: Mathematical Biosciences doi: 10.1016/j.mbs.2015.03.001 – volume: 21 start-page: 6689 year: 2002 ident: bib10 article-title: Myosin VIIa, harmonin and cadherin 23, three usher I gene products that cooperate to shape the sensory hair cell bundle publication-title: The EMBO Journal doi: 10.1093/emboj/cdf689 – volume: 25 start-page: 486 year: 2019 ident: bib6 article-title: Mitigating antagonism between transcription and proliferation allows Near-Deterministic cellular reprogramming publication-title: Cell Stem Cell doi: 10.1016/j.stem.2019.08.005 – volume: 51 start-page: 633 year: 2007 ident: bib132 article-title: Hair cell regeneration in the avian auditory epithelium publication-title: The International Journal of Developmental Biology doi: 10.1387/ijdb.072408js – volume: 29 start-page: 24 year: 2011 ident: bib116 article-title: Integrative genomics viewer publication-title: Nature Biotechnology doi: 10.1038/nbt.1754 – volume: 284 start-page: 1837 year: 1999 ident: bib8 article-title: Math1: an essential gene for the generation of inner ear hair cells publication-title: Science doi: 10.1126/science.284.5421.1837 – volume: 2 start-page: 311 year: 2014 ident: bib12 article-title: Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea publication-title: Stem Cell Reports doi: 10.1016/j.stemcr.2014.01.008 – volume: 53 start-page: 207 year: 2017 ident: bib144 article-title: Production of endothelial progenitor cells from skin fibroblasts by direct reprogramming for clinical usages publication-title: In Vitro Cellular & Developmental Biology - Animal doi: 10.1007/s11626-016-0106-1 – volume: 6 year: 2011 ident: bib4 article-title: Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicity publication-title: PLOS ONE doi: 10.1371/journal.pone.0022347 – volume: 18 start-page: 240 year: 2013 ident: bib13 article-title: Three-dimensional cell culture: the missing link in drug discovery publication-title: Drug Discovery Today doi: 10.1016/j.drudis.2012.10.003 – volume: 48 start-page: 2880 year: 2020 ident: bib81 article-title: Dynamic changes in cis-regulatory occupancy by Six1 and its cooperative interactions with distinct cofactors drive lineage-specific gene expression programs during progressive differentiation of the auditory sensory epithelium publication-title: Nucleic Acids Research doi: 10.1093/nar/gkaa012 – volume: 8 year: 2019 ident: bib165 article-title: Single-cell proteomics reveals changes in expression during hair-cell development publication-title: eLife doi: 10.7554/eLife.50777 – volume: 16 start-page: 58 year: 2009 ident: bib35 article-title: Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of corti publication-title: Developmental Cell doi: 10.1016/j.devcel.2008.11.008 – volume: 137 start-page: 1287 year: 1997 ident: bib46 article-title: Unconventional myosins in inner-ear sensory epithelia publication-title: Journal of Cell Biology doi: 10.1083/jcb.137.6.1287 – volume: 419 start-page: 300 year: 2002 ident: bib82 article-title: Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier publication-title: Nature doi: 10.1038/nature01059 – volume: 884 start-page: 110 year: 1999 ident: bib113 article-title: A missense mutation in myosin VIIA prevents aminoglycoside accumulation in early postnatal cochlear hair cells publication-title: Annals of the New York Academy of Sciences – volume: 12 start-page: 474 year: 2019 ident: bib75 article-title: Direct reprogramming to human induced neuronal progenitors from fibroblasts of familial and sporadic parkinson's Disease Patients publication-title: International Journal of Stem Cells doi: 10.15283/ijsc19075 – volume: 141 start-page: 704 year: 2010 ident: bib104 article-title: Mechanosensitive hair cell-like cells from embryonic and induced pluripotent stem cells publication-title: Cell doi: 10.1016/j.cell.2010.03.035 – volume: 7 year: 2015 ident: bib154 article-title: Mechanisms of sensorineural cell damage, death and survival in the cochlea publication-title: Frontiers in Aging Neuroscience doi: 10.3389/fnagi.2015.00058 – volume: 520 Pt 3 start-page: 653 year: 1999 ident: bib94 article-title: Developmental expression of the potassium current IK,n contributes to maturation of mouse outer hair cells publication-title: The Journal of Physiology doi: 10.1111/j.1469-7793.1999.00653.x – volume: 111 start-page: 321 year: 2002 ident: bib71 article-title: 3d structure of the human genome: order in randomness publication-title: Chromosoma doi: 10.1007/s00412-002-0210-8 – volume: 111 start-page: 1797 year: 2001 ident: bib49 article-title: Aminoglycoside ototoxicity: a human temporal bone study publication-title: The Laryngoscope doi: 10.1097/00005537-200110000-00025 – volume: 549 start-page: 7 year: 2013 ident: bib158 article-title: Ectopic hair cell-like cell induction by Math1 mainly involves direct transdifferentiation in neonatal mammalian cochlea publication-title: Neuroscience Letters doi: 10.1016/j.neulet.2013.04.053 – volume: 142 start-page: 1948 year: 2015 ident: bib27 article-title: Generation of sensory hair cells by genetic programming with a combination of transcription factors publication-title: Development doi: 10.1242/dev.119149 – volume: 241 start-page: 684 year: 2012 ident: bib86 article-title: In vivo notch reactivation in differentiating cochlear hair cells induces Sox2 and Prox1 expression but does not disrupt hair cell maturation publication-title: Developmental Dynamics doi: 10.1002/dvdy.23754 – volume: 34 start-page: 11085 year: 2014 ident: bib89 article-title: Characterization of transcriptomes of cochlear inner and outer hair cells publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.1690-14.2014 – volume: 35 start-page: 6366 year: 2015 ident: bib126 article-title: Gene expression by mouse inner ear hair cells during development publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.5126-14.2015 – volume: 51 start-page: 705 year: 2018 ident: bib143 article-title: Age-Related hearing loss: innovations in hearing augmentation publication-title: Otolaryngologic Clinics of North America doi: 10.1016/j.otc.2018.03.002 – volume: 14 start-page: 248 year: 2015 ident: bib3 article-title: High-frequency audiometry reveals high prevalence of aminoglycoside ototoxicity in children with cystic fibrosis publication-title: Journal of Cystic Fibrosis doi: 10.1016/j.jcf.2014.07.009 – volume: 20 start-page: 3236 year: 2017 ident: bib151 article-title: Rapid chromatin switch in the direct reprogramming of fibroblasts to neurons publication-title: Cell Reports doi: 10.1016/j.celrep.2017.09.011 – volume: 344 year: 2014 ident: bib42 article-title: Sound strategies for hearing restoration publication-title: Science doi: 10.1126/science.1241062 – volume: 235 start-page: 434 year: 2010 ident: bib45 article-title: The challenge of hair cell regeneration publication-title: Experimental Biology and Medicine doi: 10.1258/ebm.2009.009281 – volume: 196 start-page: 159 year: 1997 ident: bib124 article-title: Expression of myosin VIIA during mouse embryogenesis publication-title: Anatomy and Embryology doi: 10.1007/s004290050088 – volume: 81 start-page: 100 year: 1994 ident: bib142 article-title: The changing microtubule arrangements in developing hair cells of the chick cochlea publication-title: Hearing Research doi: 10.1016/0378-5955(94)90157-0 |
| SSID | ssj0000748819 |
| Score | 2.502358 |
| Snippet | The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to numerous genetic and environmental insults. In mammals, hair cells lack... |
| SourceID | doaj unpaywall pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| SubjectTerms | Animals Cell Lineage Cytology Developmental Biology Ears & hearing Efficiency Embryo fibroblasts Epigenetics Fibroblasts Fibroblasts - physiology Gene expression Gene therapy Hair cells Hair Cells, Auditory, Inner - physiology Hearing loss Hearing protection Inner ear Labyrinth Supporting Cells - physiology Mammals Math1 protein Mice - physiology Mice, Transgenic Morphology ototoxin regeneration reprogramming screening sensory hair cell SIX gene family Somatic cells Stem cells Stem Cells and Regenerative Medicine Tail Transcription factors Transcription Factors - metabolism Vestibular system |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Na9wwEBUlUJJLaZukdZsEBdJLwI1s68M6tiEhlNBTA3sz-iQLizdkdwn77zsjOWaXBHop-GSPQH4aSW_k8RtCznQwIcJVVhiiwOpXlxq_FErrom9q7RufEmR_y5s7_msiJhulvjAnLMsDZ-AupGslc05r3lgewd2i4Y1nMbYothaSzidr9UYwldZgBZaVzj_kKdgyL8LtNIbvQtSomrmxBSWl_tfo5cssyd1V_2DWT2Y229iCrt-TdwN3pD9ynz-QN6H_SN7mapLrfTLJEtKINJ1HmopqUXBkem-mjxRP6BfUrmnexCjSS1hLaEo7T2dm2Oghi0_QxTxJueZWB-Tu-urP5U05FE4oneDVsnTMOOetV7WvjLLCed86wZg3Meo2eBsVF7E21jsukwBR00ipFNMK2B3ErIdkp5_34TOhtfKh4sG2HrhWBYPRCt9E5kQVfGuZLsj5M5adG1TFsbjFrIPoAoHvEvBdAr4gZ6Px8D6vm_3EQRlNUAE73QC_6Aa_6P7lFwU5eh7SbpiWiw74iEZFuEYV5HR8DBMK0TR9mK_QBjiShqhLFuRT9oCxJ8B1gdPIuiBqyze2urr9pJ_eJ9FuBW25hm59G73oJQazEYMv_wODr2SvxuOBlN54RHaWj6twDBxqaU_SdPkL8xYcnw priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3di9QwEB_OPURfxG-rp0Q4X4R6bdM2zYOIJ3ccIouIB_tW8uktLO26H8j-986kH95yh9CnNoHpZJL5ZTL5DcCxdMp5fOKUtii4-mWxpJPCUhtveSYttyFBdlpeXOZfZ8XsAKbDXRhKqxzWxLBQ29ZQjPwEXYkkMi8uPi1_x1Q1ik5XhxIaqi-tYD8GirE7cJgRM9YEDk_Ppt9_jFEXdJgV-sDuop5AV3rivs29-1AUGbFpXnNNgcH_Nth5M3vy3rZZqt0ftVhcc03nD-FBjynZ584IHsGBax7D3a7K5O4JzDpqaRoB1noWim0xNHB2peYrRpH7NdM71jk3RrAT1xgW0tFDLI06LTtSCrZuA8Vr1-spXJ6f_fxyEfcFFWJT5OkmNgnqyWorMpsqoQtjbWWKJLHKe1k5q73IC58pbU1eBmIizstSiEQKRH24l30Gk6Zt3AtgmbAuzZ2uLGKwtDRVVVjuE1OkzlY6kRG8H3RZm55tnIpeLGrcdZDi66D4Oig-guOxcf8_tzc7pUEZmxAzdnjRrn7V_USrUZQyMUbKnOvc42h7lXObeF8ROZ_jERwNQ1r303Vd_zOuCN6On3GikTZV49ottUHsJHE3VkbwvLOAURLEwIh1yiwCsWcbe6Luf2nmV4HMW2DfXKJY70YruqmDxaiDl_8X_xXczyggEBIaj2CyWW3da0RNG_2mnwp_Ad8rGsY priority: 102 providerName: ProQuest – databaseName: Unpaywall dbid: UNPAY link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1La9wwEB7SDaW99P1wkhaVppeCt37oYR3TtCGUEnrowvZk9CRLjTdkdynbX9-R7DXZJNCAT9YIRqOR9I08_gbgUDrlPD5pHkIU3P2KVIYvhVwbb8tC2tLGBNkzfjqh36ZsugPvN__CXPl-L_Ck--SamXdjxjBKuAe7nCHgHsHu5OzH0a9QNi5jkZl02v15d73H1lkTKflvw5E30yEfrNoLtf6jmubKWXPyGL5stOxSTH6PV0s9Nn-vETj-ZxhP4FGPNclR5xxPYce1z-B-V31y_RymHeV0mBky9yQW4SLo-ORczS5JuNFfEL0m3aFHAhzFvYfENPV4xxY6XXRkFWQxj9SvXa8XMDn5-vP4NO0LLaSG0XyZmkwZY7UVhc2V0MxYWxmWZVZ5LytntReU-UJpayiPhEVlybkQmRSIBjHGfQmjdt6610AKYV1Ona4sYrOcm6pitvSZYbmzlc5kAh83U1KbnoU8FMNoaoxGgqlq9x1NVUdTJXA4CPfjuV3sc5jbQSQwZscXOAN1vwBrVIVnxkhJS009blte0dJm3leBtM-VCRxsPKPul_GiRvwiA4NcKRJ4NzTjAgzWVK2br4IMYiqJURpP4FXnSIMmiI0RA_EiAbHlYluqbre0s_NI8i2wL5Wo1ofBGW_aoBlssHdHuX14WIQbg5jxeACj5eXKvUFYtdRv-2X1DwHpIxM priority: 102 providerName: Unpaywall |
| Title | Generation of inner ear hair cells by direct lineage conversion of primary somatic cells |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/32602462 https://www.proquest.com/docview/2429407237 https://www.proquest.com/docview/2419098266 https://pubmed.ncbi.nlm.nih.gov/PMC7326493 https://doi.org/10.7554/elife.55249 https://doaj.org/article/6c860cc9943b4f488fa43d0ff80850e3 |
| UnpaywallVersion | publishedVersion |
| Volume | 9 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 2050-084X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000748819 issn: 2050-084X databaseCode: KQ8 dateStart: 20120101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 2050-084X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000748819 issn: 2050-084X databaseCode: KQ8 dateStart: 20130101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2050-084X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000748819 issn: 2050-084X databaseCode: DOA dateStart: 20130101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 2050-084X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000748819 issn: 2050-084X databaseCode: DIK dateStart: 20120101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 2050-084X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000748819 issn: 2050-084X databaseCode: GX1 dateStart: 0 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2050-084X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000748819 issn: 2050-084X databaseCode: M~E dateStart: 20120101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 2050-084X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000748819 issn: 2050-084X databaseCode: RPM dateStart: 20120101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVPQU databaseName: Health & Medical Collection (Proquest) customDbUrl: eissn: 2050-084X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000748819 issn: 2050-084X databaseCode: 7X7 dateStart: 20120101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 2050-084X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000748819 issn: 2050-084X databaseCode: BENPR dateStart: 20120101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVFZP databaseName: Scholars Portal Journals: Open Access customDbUrl: eissn: 2050-084X dateEnd: 20250131 omitProxy: true ssIdentifier: ssj0000748819 issn: 2050-084X databaseCode: M48 dateStart: 20121201 isFulltext: true titleUrlDefault: http://journals.scholarsportal.info providerName: Scholars Portal |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Ja9wwFH5kobSX0r1u00GF9FLw1Jss61SSkhBKO4TSAfdktCYDxk5nIZl_3yfZYzrNHAo-aQH505Pe92T5ewDH3Ahj8QljF6Lg7peE3H0pzKWyOk24TrW_IDvJL6bZ15KWe7BJxtkDuNgZ2rl8UtN5Pb77vf6MCx7565ihN_xkvs2sGVOKkcQ-HKKL4i6Hw_ee5_stmaGd-iQfSUS9lmnZ_av3b_8t7-RF_Hcxz_sXKB-umhuxvhV1_Zd3On8Cj3taSU46O3gKe6Z5Bg-6RJPr51B26tJuEkhric-3RdDGybWYzYk7vF8QuSadfyOOeeI2Q_yNdH-c5jrddLoUZNF6ldeu1wuYnp_9_HIR9jkVQkWzeBmqSCilpWaJjgWTVGldKBpFWljLC6OlZRm1iZBaZbnXJkrTPGcs4gyJH4azL-GgaRvzGkjCtIkzIwuNNCzOVVFQndpI0djoQkY8gI8bLCvVC467vBd1hYGHA77ywFce-ACOh8b9--xuduomZWjixLF9QTu_qvq1VuFQ8kgpzrNUZhZn3oos1ZG1hdPnM2kAR5sprTYGVyFV4U4sLmUBvB-qca05NEVj2pVrg_SJY0CWB_Cqs4BhJEiDke7kSQBsyza2hrpd08yuvZ43w74Zx2F9GKzoPgb1gMGb_4PqLTxK3NmAv9t4BAfL-cq8QwK1lCPYZyUbweHp2eTyx8gfQ4z8gsGy6eTy5NcfbeoglQ |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VVqhcEG8CBYzUXpBC83Di-FAhCq22dFkh1Ep7S_2kK62SZR-q9s_x2xg72dBVK26VctrY0ezMeB72-BuAXW6EsfiEsUtR0PolIXcnhblUVqcJ16n2BbKDvHdOvw2z4Qb8Wd2FcWWVK5voDbWuldsj30dXwh2YV8o-TX6HrmuUO11dtdAQbWsFfeAhxtqLHadmeYUp3Ozg5CvKey9Jjo_OvvTCtstAqDIaz0MV4WQtNUt0LJjMlNaFyqJIC2t5YbS0jGY2EVIrmnu0njTNc8YizjAUwgQPv3sPtmhKOSZ_W4dHgx8_u10edNAF-tzmYiBD171v-iNrPmZZ4tA7r7lC3zHgtjD3ZrXm9qKaiOWVGI-vucLjR_CwjWHJ50bpHsOGqZ7A_aar5fIpDBsoaydxUlvim3sR5BS5FKMpcScFMyKXpHGmxIW5aNOIL3_3e3du0qQBwSCz2kPKNrOewfmdsPY5bFZ1ZV4CSZg2MTWy0BjzxbkqikynNlJZbHQhIx7AhxUvS9Wim7smG-MSsxzH-NIzvvSMD2C3G9z-n9uHHTqhdEMcErf_oZ7-KtuFXSIpeaQU5zSV1KK0raCpjqwtHBigSQPYWYm0bM3DrPynzAG8717jwnbcFJWpF24Mxmocs788gBeNBnSUYMyNsVWeBMDWdGON1PU31ejSg4cznEs5krXXadFNHow7Hrz6P_nvYLt39r1f9k8Gp6_hQeI2I3wx5Q5szqcL8wYjtrl82y4LAhd3vRL_AueAWKg |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEB6VIh4XxBtDgUVqL0hubK_t9R4QAkrU0qriQKXcjPdFI0V2yENV_hq_jpm1Yxq14lYpp3g3msx7dsffAOxKW1mHnzCmEgW9XxJKuinMlXaGJ9Jw4xtkT_PDs_TbKBttwZ_1uzDUVrn2id5Rm0bTGfkAQ4kkMC8uBq5ri_h-MPw4_R3SBCm6aV2P02hV5NiuLrB8m384OkBZ7yXJ8OuPL4dhN2Eg1FkaL0IdVVobZURi4kqoTBtT6CyKTOWcLKxRTqSZSypldJp7pB7O81yISApMg7C4w9-9BbcF55LaCcVI9Oc7GJoLjLbtK4ECg_bAnoyd3c-yhHA7LwVBPyvgugT3ap_mvWU9rVYX1WRyKQgOH8KDLntln1p1ewRbtn4Md9p5lqsnMGpBrEnWrHHMj_ViyCd2Xo1njO4I5kytWBtGGSW46M2Yb3z3p3a0adrCX7B548Fk211P4exGGPsMtuumti-AJcLYOLWqMJjtxbkuisxwF-kstqZQkQzg_ZqXpe5wzWm8xqTE-oYYX3rGl57xAez2i7v_c_2yzySUfglhcPsvmtmvsjPpEknJI62lTLlKHUrbVSk3kXMFwQBaHsDOWqRl5xjm5T81DuBd_xhNmrhZ1bZZ0hrM0iTWfXkAz1sN6CnBbBuzqjwJQGzoxgapm0_q8bmHDRe4N5VI1l6vRVd5MOl58PL_5L-Fu2h_5cnR6fEruJ_QKYTvotyB7cVsaV9jqrZQb7xNMPh500b4F4v9VkI |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1La9wwEB7SDaW99P1wkhaVppeCt37oYR3TtCGUEnrowvZk9CRLjTdkdynbX9-R7DXZJNCAT9YIRqOR9I08_gbgUDrlPD5pHkIU3P2KVIYvhVwbb8tC2tLGBNkzfjqh36ZsugPvN__CXPl-L_Ck--SamXdjxjBKuAe7nCHgHsHu5OzH0a9QNi5jkZl02v15d73H1lkTKflvw5E30yEfrNoLtf6jmubKWXPyGL5stOxSTH6PV0s9Nn-vETj-ZxhP4FGPNclR5xxPYce1z-B-V31y_RymHeV0mBky9yQW4SLo-ORczS5JuNFfEL0m3aFHAhzFvYfENPV4xxY6XXRkFWQxj9SvXa8XMDn5-vP4NO0LLaSG0XyZmkwZY7UVhc2V0MxYWxmWZVZ5LytntReU-UJpayiPhEVlybkQmRSIBjHGfQmjdt6610AKYV1Ona4sYrOcm6pitvSZYbmzlc5kAh83U1KbnoU8FMNoaoxGgqlq9x1NVUdTJXA4CPfjuV3sc5jbQSQwZscXOAN1vwBrVIVnxkhJS009blte0dJm3leBtM-VCRxsPKPul_GiRvwiA4NcKRJ4NzTjAgzWVK2br4IMYiqJURpP4FXnSIMmiI0RA_EiAbHlYluqbre0s_NI8i2wL5Wo1ofBGW_aoBlssHdHuX14WIQbg5jxeACj5eXKvUFYtdRv-2X1DwHpIxM |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Generation+of+inner+ear+hair+cells+by+direct+lineage+conversion+of+primary+somatic+cells&rft.jtitle=eLife&rft.au=Menendez%2C+Louise&rft.au=Trecek%2C+Talon&rft.au=Gopalakrishnan%2C+Suhasni&rft.au=Tao%2C+Litao&rft.date=2020-06-30&rft.issn=2050-084X&rft.eissn=2050-084X&rft.volume=9&rft_id=info:doi/10.7554%2FeLife.55249&rft.externalDBID=n%2Fa&rft.externalDocID=10_7554_eLife_55249 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2050-084X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2050-084X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2050-084X&client=summon |