Chitosan@Puerarin hydrogel for accelerated wound healing in diabetic subjects by miR-29ab1 mediated inflammatory axis suppression

Wound healing is one of the major global health concerns in patients with diabetes. Overactivation of pro-inflammatory M1 macrophages is associated with delayed wound healing in diabetes. miR-29ab1 plays a critical role in diabetes-related macrophage inflammation. Hence, inhibition of inflammation a...

Full description

Saved in:
Bibliographic Details
Published inBioactive materials Vol. 19; pp. 653 - 665
Main Authors Zeng, Xiaoling, Chen, Baohui, Wang, Luping, Sun, Yingxiao, Jin, Zhao, Liu, Xuanyong, Ouyang, Liping, Liao, Yun
Format Journal Article
LanguageEnglish
Published China Elsevier B.V 01.01.2023
KeAi Publishing
KeAi Communications Co., Ltd
Subjects
Diabetic skin wound healing
Hydrogel
Macrophages
miR-29ab1
miR-29ab1
Hydrogel
Macrophages
Diabetic skin wound healing
Online AccessGet full text
ISSN2452-199X
2452-199X
DOI10.1016/j.bioactmat.2022.04.032

Cover

Abstract Wound healing is one of the major global health concerns in patients with diabetes. Overactivation of pro-inflammatory M1 macrophages is associated with delayed wound healing in diabetes. miR-29ab1 plays a critical role in diabetes-related macrophage inflammation. Hence, inhibition of inflammation and regulation of miR-29 expression have been implicated as new points for skin wound healing. In this study, the traditional Chinese medicine, puerarin, was introduced to construct an injectable and self-healing chitosan@puerarin (C@P) hydrogel. The C@P hydrogel promoted diabetic wound healing and accelerated angiogenesis, which were related to the inhibition of the miR-29 mediated inflammation response. Compared to healthy subjects, miR-29a and miR-29b1 were ectopically increased in the skin wound of the diabetic model, accompanied by upregulated M1-polarization, and elevated levels of IL-1β and TNF-α. Further evaluations by miR-29ab1 knockout mice exhibited superior wound healing and attenuated inflammation. The present results suggested that miR-29ab1 is essential for diabetic wound healing by regulating the inflammatory response. Suppression of miR-29ab1 by the C@P hydrogel has the potential for improving medical approaches for wound repair. [Display omitted] •A chitosan based hydrogel containing puerarin was constructed for promoting diabetic wound healing.•Chitosan@Puerarin hydrogel accelerated skin repair through inhibiting M1-polarization and reducing IL-1β and TNF-α.•miR-29 a/b1 was found to be ectopic increased in the skin-wound of diabetic model.•miR-29 a/b1 was inhibited by Chitosan@Puerarin in diabetic wound healing.
AbstractList Wound healing is one of the major global health concerns in patients with diabetes. Overactivation of pro-inflammatory M1 macrophages is associated with delayed wound healing in diabetes. miR-29ab1 plays a critical role in diabetes-related macrophage inflammation. Hence, inhibition of inflammation and regulation of miR-29 expression have been implicated as new points for skin wound healing. In this study, the traditional Chinese medicine, puerarin, was introduced to construct an injectable and self-healing chitosan@puerarin (C@P) hydrogel. The C@P hydrogel promoted diabetic wound healing and accelerated angiogenesis, which were related to the inhibition of the miR-29 mediated inflammation response. Compared to healthy subjects, miR-29a and miR-29b1 were ectopically increased in the skin wound of the diabetic model, accompanied by upregulated M1-polarization, and elevated levels of IL-1β and TNF-α. Further evaluations by miR-29ab1 knockout mice exhibited superior wound healing and attenuated inflammation. The present results suggested that miR-29ab1 is essential for diabetic wound healing by regulating the inflammatory response. Suppression of miR-29ab1 by the C@P hydrogel has the potential for improving medical approaches for wound repair.
Wound healing is one of the major global health concerns in patients with diabetes. Overactivation of pro-inflammatory M1 macrophages is associated with delayed wound healing in diabetes. miR-29ab1 plays a critical role in diabetes-related macrophage inflammation. Hence, inhibition of inflammation and regulation of miR-29 expression have been implicated as new points for skin wound healing. In this study, the traditional Chinese medicine, puerarin, was introduced to construct an injectable and self-healing chitosan@puerarin (C@P) hydrogel. The C@P hydrogel promoted diabetic wound healing and accelerated angiogenesis, which were related to the inhibition of the miR-29 mediated inflammation response. Compared to healthy subjects, miR-29a and miR-29b1 were ectopically increased in the skin wound of the diabetic model, accompanied by upregulated M1-polarization, and elevated levels of IL-1β and TNF-α. Further evaluations by miR-29ab1 knockout mice exhibited superior wound healing and attenuated inflammation. The present results suggested that miR-29ab1 is essential for diabetic wound healing by regulating the inflammatory response. Suppression of miR-29ab1 by the C@P hydrogel has the potential for improving medical approaches for wound repair. Image 1 • A chitosan based hydrogel containing puerarin was constructed for promoting diabetic wound healing. • Chitosan@Puerarin hydrogel accelerated skin repair through inhibiting M1-polarization and reducing IL-1β and TNF-α. • miR-29 a/b1 was found to be ectopic increased in the skin-wound of diabetic model. • miR-29 a/b1 was inhibited by Chitosan@Puerarin in diabetic wound healing.
Wound healing is one of the major global health concerns in patients with diabetes. Overactivation of pro-inflammatory M1 macrophages is associated with delayed wound healing in diabetes. miR-29ab1 plays a critical role in diabetes-related macrophage inflammation. Hence, inhibition of inflammation and regulation of miR-29 expression have been implicated as new points for skin wound healing. In this study, the traditional Chinese medicine, puerarin, was introduced to construct an injectable and self-healing chitosan@puerarin (C@P) hydrogel. The C@P hydrogel promoted diabetic wound healing and accelerated angiogenesis, which were related to the inhibition of the miR-29 mediated inflammation response. Compared to healthy subjects, miR-29a and miR-29b1 were ectopically increased in the skin wound of the diabetic model, accompanied by upregulated M1-polarization, and elevated levels of IL-1β and TNF-α. Further evaluations by miR-29ab1 knockout mice exhibited superior wound healing and attenuated inflammation. The present results suggested that miR-29ab1 is essential for diabetic wound healing by regulating the inflammatory response. Suppression of miR-29ab1 by the C@P hydrogel has the potential for improving medical approaches for wound repair.Wound healing is one of the major global health concerns in patients with diabetes. Overactivation of pro-inflammatory M1 macrophages is associated with delayed wound healing in diabetes. miR-29ab1 plays a critical role in diabetes-related macrophage inflammation. Hence, inhibition of inflammation and regulation of miR-29 expression have been implicated as new points for skin wound healing. In this study, the traditional Chinese medicine, puerarin, was introduced to construct an injectable and self-healing chitosan@puerarin (C@P) hydrogel. The C@P hydrogel promoted diabetic wound healing and accelerated angiogenesis, which were related to the inhibition of the miR-29 mediated inflammation response. Compared to healthy subjects, miR-29a and miR-29b1 were ectopically increased in the skin wound of the diabetic model, accompanied by upregulated M1-polarization, and elevated levels of IL-1β and TNF-α. Further evaluations by miR-29ab1 knockout mice exhibited superior wound healing and attenuated inflammation. The present results suggested that miR-29ab1 is essential for diabetic wound healing by regulating the inflammatory response. Suppression of miR-29ab1 by the C@P hydrogel has the potential for improving medical approaches for wound repair.
Wound healing is one of the major global health concerns in patients with diabetes. Overactivation of pro-inflammatory M1 macrophages is associated with delayed wound healing in diabetes. miR-29ab1 plays a critical role in diabetes-related macrophage inflammation. Hence, inhibition of inflammation and regulation of miR-29 expression have been implicated as new points for skin wound healing. In this study, the traditional Chinese medicine, puerarin, was introduced to construct an injectable and self-healing chitosan@puerarin (C@P) hydrogel. The C@P hydrogel promoted diabetic wound healing and accelerated angiogenesis, which were related to the inhibition of the miR-29 mediated inflammation response. Compared to healthy subjects, miR-29a and miR-29b1 were ectopically increased in the skin wound of the diabetic model, accompanied by upregulated M1-polarization, and elevated levels of IL-1β and TNF-α. Further evaluations by miR-29ab1 knockout mice exhibited superior wound healing and attenuated inflammation. The present results suggested that miR-29ab1 is essential for diabetic wound healing by regulating the inflammatory response. Suppression of miR-29ab1 by the C@P hydrogel has the potential for improving medical approaches for wound repair. [Display omitted] •A chitosan based hydrogel containing puerarin was constructed for promoting diabetic wound healing.•Chitosan@Puerarin hydrogel accelerated skin repair through inhibiting M1-polarization and reducing IL-1β and TNF-α.•miR-29 a/b1 was found to be ectopic increased in the skin-wound of diabetic model.•miR-29 a/b1 was inhibited by Chitosan@Puerarin in diabetic wound healing.
Author Chen, Baohui
Sun, Yingxiao
Zeng, Xiaoling
Liu, Xuanyong
Ouyang, Liping
Wang, Luping
Jin, Zhao
Liao, Yun
Author_xml – sequence: 1
  givenname: Xiaoling
  surname: Zeng
  fullname: Zeng, Xiaoling
  organization: Department of Pharmacy, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China
– sequence: 2
  givenname: Baohui
  surname: Chen
  fullname: Chen, Baohui
  organization: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China
– sequence: 3
  givenname: Luping
  surname: Wang
  fullname: Wang, Luping
  organization: Department of Pharmacy, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China
– sequence: 4
  givenname: Yingxiao
  surname: Sun
  fullname: Sun, Yingxiao
  organization: Department of Pharmacy, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China
– sequence: 5
  givenname: Zhao
  surname: Jin
  fullname: Jin, Zhao
  organization: Department of Pharmacy, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China
– sequence: 6
  givenname: Xuanyong
  surname: Liu
  fullname: Liu, Xuanyong
  email: xyliu@mail.sic.ac.cn
  organization: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China
– sequence: 7
  givenname: Liping
  surname: Ouyang
  fullname: Ouyang, Liping
  email: lpouyang@shsmu.edu.cn
  organization: Department of Pharmacy, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China
– sequence: 8
  givenname: Yun
  orcidid: 0000-0002-0389-9379
  surname: Liao
  fullname: Liao, Yun
  email: libra_ly@shsmu.edu.cn
  organization: Department of Pharmacy, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35600974$$D View this record in MEDLINE/PubMed
BookMark eNqFUk1vEzEQXaEiWkr_AuyRS4Lt_XB8AFFFfFSqBEIgcbPG3tnE0a4dbG9LjvxzJqStWi69-Gvee-OZec-LIx88FsUrzuac8fbNZm5cAJtHyHPBhJizes4q8aQ4EXUjZlypn0f3zsfFWUobxhiXtDD5rDiumpYxJeuT4s9y7XJI4N9_nTBCdL5c77oYVjiUfYglWIsDBTJ25XWYfFeuEQbnVyUhOwcGs7NlmswGbU6l2ZWj-zYTCgwvRyTAnuh8P8BI3w1xV8Jvl4iw3UZMyQX_onjaw5Dw7GY_LX58_PB9-Xl2-eXTxfL8cmabmucZcCbbXrTWILC6511VyYWEhURAVhuLwrCeNw2XaHpgFVdgRQ9WVR0Yo2R1WlwcdLsAG72NboS40wGc_vcQ4kpDpGIG1Fb2VW2UqgzW9V6Ftwpt07WSbi0D0np30NpOhqq06HOE4YHow4h3a70KV1pxprhQJPD6RiCGXxOmrEeXqNMDeAxT0qJtF4LLpm0I-vJ-rrsktzMkwNsDwMaQUsReW5chU2sptRs0Z3pvG73Rd7bRe9toVmuyDfHlf_zbFI8zzw9MpLldOYw6WYfe0twj2YEa6x7V-AuSrOZA
CitedBy_id crossref_primary_10_1002_adfm_202211323
crossref_primary_10_1002_ptr_7906
crossref_primary_10_1002_adma_202405002
crossref_primary_10_1016_j_carbpol_2024_122568
crossref_primary_10_1016_j_ijbiomac_2024_132048
crossref_primary_10_3389_fchem_2024_1402870
crossref_primary_10_1016_j_addr_2023_114764
crossref_primary_10_1002_adfm_202304353
crossref_primary_10_1002_adhm_202401490
crossref_primary_10_1002_smll_202406441
crossref_primary_10_1002_pol_20240904
crossref_primary_10_1002_adhm_202500734
crossref_primary_10_1002_mco2_741
crossref_primary_10_1021_acsami_4c05435
crossref_primary_10_1016_j_ijbiomac_2023_127223
crossref_primary_10_1111_1750_3841_17628
crossref_primary_10_1016_j_carbpol_2023_121580
crossref_primary_10_1166_jbt_2023_3339
crossref_primary_10_1166_mex_2024_2637
crossref_primary_10_1016_j_carbpol_2024_122233
crossref_primary_10_1063_5_0200159
crossref_primary_10_1021_acsami_2c07732
crossref_primary_10_1002_slct_202404438
crossref_primary_10_1002_admt_202300669
crossref_primary_10_3390_gels9070594
crossref_primary_10_1002_adhm_202404525
crossref_primary_10_1016_j_carbpol_2024_122731
crossref_primary_10_1186_s40824_023_00379_6
crossref_primary_10_1016_j_envres_2023_115912
crossref_primary_10_1021_acsami_4c01265
crossref_primary_10_1111_1753_0407_13474
crossref_primary_10_1177_20417314241253290
crossref_primary_10_1002_adma_202415550
crossref_primary_10_2174_0118715303287050240223073217
Cites_doi 10.1038/s41467-019-09601-3
10.15252/emmm.201708046
10.1186/s12950-018-0201-z
10.1007/s00125-011-2399-7
10.3390/ijms21228748
10.1038/jid.2015.30
10.1016/j.addr.2009.07.019
10.1016/j.mser.2014.10.001
10.1096/fj.201700773R
10.1016/j.biomaterials.2019.119398
10.1016/j.jconrel.2020.03.030
10.7150/thno.27385
10.1016/j.cbi.2015.11.017
10.1007/s00018-016-2268-0
10.1039/D0FO02761H
10.1021/acsami.7b09395
10.1016/j.actbio.2021.01.046
10.1016/j.actbio.2018.05.039
10.1016/j.jconrel.2016.01.026
10.1002/adma.202105667
10.1161/CIRCULATIONAHA.117.031942
10.1016/j.bbrc.2007.12.052
10.3390/ijms19082198
10.1002/eji.202048690
10.1016/j.biomaterials.2018.06.004
10.1177/2041731420947242
10.1152/physiolgenomics.00141.2011
10.1186/s12951-021-01062-5
10.1142/S0192415X18500891
10.1016/j.biomaterials.2020.119769
10.2337/db18-0981
10.1186/s12951-021-00973-7
10.1136/bmjdrc-2019-001009
10.1002/adfm.201901474
10.1016/j.celrep.2020.108576
10.1016/j.biomaterials.2021.120838
10.1111/j.1349-7006.2009.01385.x
10.1016/j.jgr.2017.11.005
10.1146/annurev-bioeng-060418-052422
10.1016/j.biomaterials.2019.02.027
10.1016/j.biomaterials.2020.120286
10.1016/j.biomaterials.2019.119477
10.1126/scitranslmed.3009337
10.3390/pharmaceutics12030216
10.1016/j.ijpharm.2020.119543
10.1016/j.ejphar.2017.10.033
10.1016/j.pharmthera.2019.107452
10.1007/s00109-015-1374-z
10.1016/j.immuni.2016.02.015
10.1002/adma.202100176
10.1016/j.bone.2015.04.048
10.1016/j.biomaterials.2014.02.012
10.4049/jimmunol.1103171
10.1016/j.biopha.2020.110734
10.1016/j.biomaterials.2018.08.044
10.1016/j.biomaterials.2013.02.021
10.1016/j.intimp.2021.108001
10.1039/C9BM00991D
10.1093/humupd/dmaa039
10.1172/JCI92035
10.1002/advs.202003627
10.1038/ncomms13393
10.1002/smll.201902232
10.1016/j.biopha.2019.01.031
10.1021/jz5000269
10.1038/jid.2013.164
10.1126/sciadv.aba0942
10.1016/j.biomaterials.2013.02.065
10.1016/j.semcancer.2015.02.007
10.3390/ijms18071545
10.1080/17425247.2019.1580691
10.1016/j.isci.2021.103604
10.1002/hep.31050
10.1016/j.tem.2020.05.005
ContentType Journal Article
Copyright 2022 The Authors
2022 The Authors.
2022 The Authors 2022
Copyright_xml – notice: 2022 The Authors
– notice: 2022 The Authors.
– notice: 2022 The Authors 2022
DBID 6I.
AAFTH
AAYXX
CITATION
NPM
7X8
5PM
DOA
DOI 10.1016/j.bioactmat.2022.04.032
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
CrossRef
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList PubMed


MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
EISSN 2452-199X
EndPage 665
ExternalDocumentID oai_doaj_org_article_c7f34b993be44c2fa169ec5d674c260a
PMC9109129
35600974
10_1016_j_bioactmat_2022_04_032
S2452199X22002092
Genre Journal Article
GroupedDBID 0SF
6I.
AACTN
AAEDW
AAFTH
AALRI
AAXUO
ABMAC
ACGFS
ADBBV
AEXQZ
AFTJW
AITUG
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
AOIJS
BCNDV
EBS
EJD
FDB
GROUPED_DOAJ
HYE
M41
NCXOZ
OK1
ROL
RPM
SSZ
0R~
AAYWO
AAYXX
ABJCF
ACVFH
ADCNI
ADMLS
ADVLN
AEUPX
AFKRA
AFPUW
AIGII
AKBMS
AKRWK
AKYEP
BBNVY
BENPR
BGLVJ
BHPHI
CCPQU
CITATION
HCIFZ
KB.
M7P
M~E
PDBOC
PHGZM
PHGZT
PIMPY
NPM
7X8
5PM
ID FETCH-LOGICAL-c541t-a1076f26cbea04f1d33787a87eae04bce2b0f15517ebfa0319ac2fac93dabb973
IEDL.DBID DOA
ISSN 2452-199X
IngestDate Wed Aug 27 01:32:23 EDT 2025
Thu Aug 21 18:09:22 EDT 2025
Fri Jul 11 14:05:38 EDT 2025
Wed Feb 19 02:23:51 EST 2025
Thu Apr 24 23:02:29 EDT 2025
Tue Jul 01 02:11:30 EDT 2025
Wed May 17 00:03:39 EDT 2023
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords miR-29ab1
Hydrogel
Macrophages
Diabetic skin wound healing
Language English
License This is an open access article under the CC BY-NC-ND license.
2022 The Authors.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c541t-a1076f26cbea04f1d33787a87eae04bce2b0f15517ebfa0319ac2fac93dabb973
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
The authors contributed equally to this work.
ORCID 0000-0002-0389-9379
OpenAccessLink https://doaj.org/article/c7f34b993be44c2fa169ec5d674c260a
PMID 35600974
PQID 2668217565
PQPubID 23479
PageCount 13
ParticipantIDs doaj_primary_oai_doaj_org_article_c7f34b993be44c2fa169ec5d674c260a
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9109129
proquest_miscellaneous_2668217565
pubmed_primary_35600974
crossref_citationtrail_10_1016_j_bioactmat_2022_04_032
crossref_primary_10_1016_j_bioactmat_2022_04_032
elsevier_sciencedirect_doi_10_1016_j_bioactmat_2022_04_032
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2023-01-01
PublicationDateYYYYMMDD 2023-01-01
PublicationDate_xml – month: 01
  year: 2023
  text: 2023-01-01
  day: 01
PublicationDecade 2020
PublicationPlace China
PublicationPlace_xml – name: China
PublicationTitle Bioactive materials
PublicationTitleAlternate Bioact Mater
PublicationYear 2023
Publisher Elsevier B.V
KeAi Publishing
KeAi Communications Co., Ltd
Publisher_xml – name: Elsevier B.V
– name: KeAi Publishing
– name: KeAi Communications Co., Ltd
References Van Raemdonck, Umar, Palasiewicz (bib72) 2021; 51
Campbell, Saville, Murray (bib48) 2013; 133
Zhang, Bao, Jiang (bib35) 2021; 33
Wu, Chen, Zhou (bib13) 2019; 222
Wu, Quan, Liu (bib57) 2016; 7
Mi, Liu, Liu (bib60) 2018; 42
Cao, Qiao, Meng (bib45) 2014; 5
Kronlage, Dewenter, Grosso (bib43) 2019; 140
Chen, Yin, Chen (bib5) 2020; 6
Wynn, Vannella (bib55) 2016; 44
Chen, Wang, Fan (bib19) 2018; 818
Zhang, Wei (bib17) 2020; 207
Smith, Guerau-de-Arellano, Costinean (bib51) 2012; 189
Roggli, Gattesco, Pautz (bib68) 2012; 55
Guo, Xie, Hong (bib24) 2019; 115
Ouyang, Sun, Lv (bib70) 2022; 25
Liang, Liu, Chen (bib62) 2021; 99
Qin, Jin, Saiding (bib63) 2020; 322
Garg, Pullen, Oskeritzian (bib58) 2013; 34
Zhao, Huang, Li (bib11) 2020; 258
Saleh, Dhaliwal, Portillo-Lara (bib14) 2019; 15
Wang, Zheng, Sun (bib15) 2021; 19
Wang, Chen, Ouyang (bib40) 2021; 8
Wei, Xu, Yao (bib34) 2021; 124
Bai, Kyu-Cheol, Wang (bib65) 2020; 11
Liu, Pan, Cao (bib73) 2020; 72
Bharti, Chopra, Raut (bib21) 2020; 11
Xu, Li, Chen (bib36) 2018; 19
Yang, Yang, Chen (bib3) 2020; 8
Carleton, Sefton (bib46) 2019; 223
Kharaziha, Baidya, Annabi (bib30) 2021; 33
Le, Swingler, Crowe (bib74) 2016; 94
Hiroki, Akahira, Suzuki (bib76) 2010; 101
Zhao, Lei, Li (bib56) 2018; 178
Yi (bib50) 2019; 43
Kriegel, Liu, Fang (bib75) 2012; 44
Alvarez, Liu, Trujillo-de Santiago (bib7) 2016; 240
Yan, Guan, Zhu (bib27) 2020; 12
Liao, Ouyang, Ci (bib44) 2019; 203
Zhang, Ou, Xin (bib28) 2019; 7
Lee, Rodero, Patel (bib47) 2018; 32
Liu, Ma, Liu (bib25) 2016; 243
Ou, Zhang, Fu (bib23) 2021; 19
Widlansky, Jensen, Wang (bib77) 2018; 10
Yee, Xie, Hatsell (bib41) 2016; 82
Chen, Yu, Shi (bib18) 2018; 46
Meresman, Götte, Laschke (bib20) 2020; 27
de Oliveira, Bonfante, Bergamo (bib6) 2020; 31
Zhao, Li, Song (bib66) 2019; 29
Hesketh, Sahin, West (bib52) 2017; 18
Saltiel, Olefsky (bib53) 2017; 127
Sun, Zhou, Shi (bib39) 2021; 34
Du, Ren, Wang (bib49) 2018; 15
Wang, Zhang, Wang (bib22) 2020; 131
Chen, Thouas (bib59) 2015; 87
Mu, Li, Tong (bib37) 2019; 16
Zhang, Qi, Zhao (bib10) 2020; 586
Xu, Hu, Liu (bib26) 2020; 235
Eming, Martin, Tomic-Canic (bib2) 2014; 6
Spiller, Anfang, Spiller (bib8) 2014; 35
Zheng, Fan, Wu (bib61) 2019; 10
Landén, Li, Ståhle (bib54) 2016; 73
Zhao, Niu, Liang (bib67) 2017; 9
Casey, Amedei, Aquilano (bib16) 2015; 35
Xu, Guo, Zeng (bib64) 2021; 12
Zhang, Liu, Zhang (bib12) 2018; 8
Qu, Zhao, Liang (bib31) 2018; 183
Yang, Huang, Zheng (bib29) 2021; 8
Nassiri, Zakeri, Weingarten (bib9) 2015; 135
Xu, A, Gao (bib32) 2018; 75
da Silva, Reis, Correlo (bib1) 2019; 21
Fidler, Marti, Gerth (bib42) 2019; 68
Thiersch, Rimann, Panagiotopoulou (bib4) 2013; 34
Yuan, Shen, Fan (bib33) 2021; 276
Bravo-Egana, Rosero, Molano (bib69) 2008; 366
Bhattarai, Gunn, Zhang (bib38) 2010; 62
Kirchner, Lei, MacLeod (bib71) 2020; 21
Xu (10.1016/j.bioactmat.2022.04.032_bib32) 2018; 75
Zhang (10.1016/j.bioactmat.2022.04.032_bib10) 2020; 586
Wynn (10.1016/j.bioactmat.2022.04.032_bib55) 2016; 44
Van Raemdonck (10.1016/j.bioactmat.2022.04.032_bib72) 2021; 51
Zhang (10.1016/j.bioactmat.2022.04.032_bib17) 2020; 207
Alvarez (10.1016/j.bioactmat.2022.04.032_bib7) 2016; 240
Wu (10.1016/j.bioactmat.2022.04.032_bib13) 2019; 222
Yang (10.1016/j.bioactmat.2022.04.032_bib3) 2020; 8
Thiersch (10.1016/j.bioactmat.2022.04.032_bib4) 2013; 34
Chen (10.1016/j.bioactmat.2022.04.032_bib18) 2018; 46
Zhao (10.1016/j.bioactmat.2022.04.032_bib11) 2020; 258
Zhang (10.1016/j.bioactmat.2022.04.032_bib28) 2019; 7
Saltiel (10.1016/j.bioactmat.2022.04.032_bib53) 2017; 127
Nassiri (10.1016/j.bioactmat.2022.04.032_bib9) 2015; 135
Chen (10.1016/j.bioactmat.2022.04.032_bib5) 2020; 6
Ouyang (10.1016/j.bioactmat.2022.04.032_bib70) 2022; 25
Le (10.1016/j.bioactmat.2022.04.032_bib74) 2016; 94
Yee (10.1016/j.bioactmat.2022.04.032_bib41) 2016; 82
Wu (10.1016/j.bioactmat.2022.04.032_bib57) 2016; 7
Zheng (10.1016/j.bioactmat.2022.04.032_bib61) 2019; 10
Kirchner (10.1016/j.bioactmat.2022.04.032_bib71) 2020; 21
Liu (10.1016/j.bioactmat.2022.04.032_bib25) 2016; 243
Fidler (10.1016/j.bioactmat.2022.04.032_bib42) 2019; 68
Chen (10.1016/j.bioactmat.2022.04.032_bib19) 2018; 818
Guo (10.1016/j.bioactmat.2022.04.032_bib24) 2019; 115
Hesketh (10.1016/j.bioactmat.2022.04.032_bib52) 2017; 18
Roggli (10.1016/j.bioactmat.2022.04.032_bib68) 2012; 55
Ou (10.1016/j.bioactmat.2022.04.032_bib23) 2021; 19
Sun (10.1016/j.bioactmat.2022.04.032_bib39) 2021; 34
Zhao (10.1016/j.bioactmat.2022.04.032_bib67) 2017; 9
Garg (10.1016/j.bioactmat.2022.04.032_bib58) 2013; 34
Casey (10.1016/j.bioactmat.2022.04.032_bib16) 2015; 35
Zhao (10.1016/j.bioactmat.2022.04.032_bib56) 2018; 178
Xu (10.1016/j.bioactmat.2022.04.032_bib36) 2018; 19
Zhang (10.1016/j.bioactmat.2022.04.032_bib12) 2018; 8
Lee (10.1016/j.bioactmat.2022.04.032_bib47) 2018; 32
Mu (10.1016/j.bioactmat.2022.04.032_bib37) 2019; 16
Zhao (10.1016/j.bioactmat.2022.04.032_bib66) 2019; 29
Wang (10.1016/j.bioactmat.2022.04.032_bib22) 2020; 131
Smith (10.1016/j.bioactmat.2022.04.032_bib51) 2012; 189
Liao (10.1016/j.bioactmat.2022.04.032_bib44) 2019; 203
Du (10.1016/j.bioactmat.2022.04.032_bib49) 2018; 15
Landén (10.1016/j.bioactmat.2022.04.032_bib54) 2016; 73
Xu (10.1016/j.bioactmat.2022.04.032_bib64) 2021; 12
Wei (10.1016/j.bioactmat.2022.04.032_bib34) 2021; 124
Wang (10.1016/j.bioactmat.2022.04.032_bib15) 2021; 19
Campbell (10.1016/j.bioactmat.2022.04.032_bib48) 2013; 133
Chen (10.1016/j.bioactmat.2022.04.032_bib59) 2015; 87
Eming (10.1016/j.bioactmat.2022.04.032_bib2) 2014; 6
Carleton (10.1016/j.bioactmat.2022.04.032_bib46) 2019; 223
Yuan (10.1016/j.bioactmat.2022.04.032_bib33) 2021; 276
de Oliveira (10.1016/j.bioactmat.2022.04.032_bib6) 2020; 31
Saleh (10.1016/j.bioactmat.2022.04.032_bib14) 2019; 15
Spiller (10.1016/j.bioactmat.2022.04.032_bib8) 2014; 35
Yang (10.1016/j.bioactmat.2022.04.032_bib29) 2021; 8
Yan (10.1016/j.bioactmat.2022.04.032_bib27) 2020; 12
Bharti (10.1016/j.bioactmat.2022.04.032_bib21) 2020; 11
Liu (10.1016/j.bioactmat.2022.04.032_bib73) 2020; 72
Kriegel (10.1016/j.bioactmat.2022.04.032_bib75) 2012; 44
Widlansky (10.1016/j.bioactmat.2022.04.032_bib77) 2018; 10
Kharaziha (10.1016/j.bioactmat.2022.04.032_bib30) 2021; 33
Meresman (10.1016/j.bioactmat.2022.04.032_bib20) 2020; 27
Bravo-Egana (10.1016/j.bioactmat.2022.04.032_bib69) 2008; 366
Wang (10.1016/j.bioactmat.2022.04.032_bib40) 2021; 8
da Silva (10.1016/j.bioactmat.2022.04.032_bib1) 2019; 21
Kronlage (10.1016/j.bioactmat.2022.04.032_bib43) 2019; 140
Yi (10.1016/j.bioactmat.2022.04.032_bib50) 2019; 43
Qu (10.1016/j.bioactmat.2022.04.032_bib31) 2018; 183
Bhattarai (10.1016/j.bioactmat.2022.04.032_bib38) 2010; 62
Qin (10.1016/j.bioactmat.2022.04.032_bib63) 2020; 322
Zhang (10.1016/j.bioactmat.2022.04.032_bib35) 2021; 33
Xu (10.1016/j.bioactmat.2022.04.032_bib26) 2020; 235
Cao (10.1016/j.bioactmat.2022.04.032_bib45) 2014; 5
Bai (10.1016/j.bioactmat.2022.04.032_bib65) 2020; 11
Hiroki (10.1016/j.bioactmat.2022.04.032_bib76) 2010; 101
Mi (10.1016/j.bioactmat.2022.04.032_bib60) 2018; 42
Liang (10.1016/j.bioactmat.2022.04.032_bib62) 2021; 99
References_xml – volume: 258
  start-page: 120286
  year: 2020
  ident: bib11
  article-title: ROS-scavenging hydrogel to promote healing of bacteria infected diabetic wounds
  publication-title: Biomaterials
– volume: 44
  start-page: 237
  year: 2012
  end-page: 244
  ident: bib75
  article-title: The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury
  publication-title: Physiol. Genom.
– volume: 34
  year: 2021
  ident: bib39
  article-title: Expression of miRNA-29 in pancreatic β cells promotes inflammation and diabetes via TRAF3
  publication-title: Cell Rep.
– volume: 203
  start-page: 12
  year: 2019
  end-page: 22
  ident: bib44
  article-title: Pravastatin regulates host foreign-body reaction to polyetheretherketone implants via miR-29ab1-mediated SLIT3 upregulation
  publication-title: Biomaterials
– volume: 6
  year: 2020
  ident: bib5
  article-title: Ångstrom-scale silver particle-embedded carbomer gel promotes wound healing by inhibiting bacterial colonization and inflammation
  publication-title: Sci. Adv.
– volume: 19
  start-page: 2198
  year: 2018
  ident: bib36
  article-title: Injectable and self-healing chitosan hydrogel based on imine bonds: design and therapeutic applications
  publication-title: Int. J. Mol. Sci.
– volume: 82
  start-page: 122
  year: 2016
  end-page: 134
  ident: bib41
  article-title: Sclerostin antibody treatment improves fracture outcomes in a Type I diabetic mouse model
  publication-title: Bone
– volume: 11
  year: 2020
  ident: bib65
  article-title: Regulation of inflammatory microenvironment using a self-healing hydrogel loaded with BM-MSCs for advanced wound healing in rat diabetic foot ulcers
  publication-title: J. Tissue Eng.
– volume: 101
  start-page: 241
  year: 2010
  end-page: 249
  ident: bib76
  article-title: Changes in microRNA expression levels correlate with clinicopathological features and prognoses in endometrial serous adenocarcinomas
  publication-title: Cancer Sci.
– volume: 68
  start-page: 932
  year: 2019
  end-page: 938
  ident: bib42
  article-title: Glucose metabolism is required for platelet hyperactivation in a murine model of type 1 diabetes
  publication-title: Diabetes
– volume: 5
  start-page: 743
  year: 2014
  end-page: 748
  ident: bib45
  article-title: Spacing-dependent antimicrobial efficacy of immobilized silver nanoparticles
  publication-title: J. Phys. Chem. Lett.
– volume: 322
  start-page: 375
  year: 2020
  end-page: 389
  ident: bib63
  article-title: In situ inflammatory-regulated drug-loaded hydrogels for promoting pelvic floor repair
  publication-title: J. Contr. Release
– volume: 72
  start-page: 454
  year: 2020
  end-page: 469
  ident: bib73
  article-title: Lipotoxic hepatocyte-derived exosomal MicroRNA 192-5p activates macrophages through rictor/akt/forkhead box transcription factor O1 signaling in nonalcoholic fatty liver disease
  publication-title: Hepatology
– volume: 183
  start-page: 185
  year: 2018
  end-page: 199
  ident: bib31
  article-title: Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing
  publication-title: Biomaterials
– volume: 133
  start-page: 2461
  year: 2013
  end-page: 2470
  ident: bib48
  article-title: Local arginase 1 activity is required for cutaneous wound healing
  publication-title: J. Invest. Dermatol.
– volume: 10
  start-page: 1604
  year: 2019
  ident: bib61
  article-title: Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation
  publication-title: Nat. Commun.
– volume: 19
  start-page: 322
  year: 2021
  ident: bib15
  article-title: Ginsenosides emerging as both bifunctional drugs and nanocarriers for enhanced antitumor therapies
  publication-title: J. Nanobiotechnol.
– volume: 21
  start-page: 145
  year: 2019
  end-page: 169
  ident: bib1
  article-title: Hydrogel-based strategies to advance therapies for chronic skin wounds
  publication-title: Annu. Rev. Biomed. Eng.
– volume: 127
  start-page: 1
  year: 2017
  end-page: 4
  ident: bib53
  article-title: Inflammatory mechanisms linking obesity and metabolic disease
  publication-title: J. Clin. Invest.
– volume: 8
  year: 2021
  ident: bib40
  article-title: A novel stimuli-responsive injectable Antibacterial hydrogel to achieve synergetic photothermal/gene-targeted therapy towards uveal melanoma
  publication-title: Adv. Sci.
– volume: 140
  start-page: 580
  year: 2019
  end-page: 594
  ident: bib43
  article-title: O-GlcNAcylation of histone deacetylase 4 protects the diabetic heart from failure
  publication-title: Circulation
– volume: 207
  start-page: 107452
  year: 2020
  ident: bib17
  article-title: Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony
  publication-title: Pharmacol. Ther.
– volume: 189
  start-page: 1567
  year: 2012
  end-page: 1576
  ident: bib51
  article-title: miR-29ab1 deficiency identifies a negative feedback loop controlling Th1 bias that is dysregulated in multiple sclerosis
  publication-title: J. Immunol.
– volume: 44
  start-page: 450
  year: 2016
  end-page: 462
  ident: bib55
  article-title: Macrophages in tissue repair, regeneration, and fibrosis
  publication-title: Immunity
– volume: 7
  start-page: 13393
  year: 2016
  ident: bib57
  article-title: Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes
  publication-title: Nat. Commun.
– volume: 223
  year: 2019
  ident: bib46
  article-title: Injectable and degradable methacrylic acid hydrogel alters macrophage response in skeletal muscle
  publication-title: Biomaterials
– volume: 124
  start-page: 205
  year: 2021
  end-page: 218
  ident: bib34
  article-title: A composite hydrogel with co-delivery of antimicrobial peptides and platelet-rich plasma to enhance healing of infected wounds in diabetes
  publication-title: Acta Biomater.
– volume: 21
  start-page: 8748
  year: 2020
  ident: bib71
  article-title: The cutaneous wound innate immunological microenvironment
  publication-title: Int. J. Mol. Sci.
– volume: 25
  year: 2022
  ident: bib70
  article-title: miR-29cb2 promotes angiogenesis and osteogenesis by inhibiting HIF-3α in bone
  publication-title: iScience
– volume: 27
  start-page: 367
  year: 2020
  end-page: 392
  ident: bib20
  article-title: Plants as source of new therapies for endometriosis: a review of preclinical and clinical studies
  publication-title: Hum. Reprod. Update
– volume: 33
  year: 2021
  ident: bib30
  article-title: Rational design of immunomodulatory hydrogels for chronic wound healing
  publication-title: Adv Mater
– volume: 135
  start-page: 1700
  year: 2015
  end-page: 1703
  ident: bib9
  article-title: Relative expression of proinflammatory and antiinflammatory genes reveals differences between healing and nonhealing human chronic diabetic foot ulcers
  publication-title: J. Invest. Dermatol.
– volume: 43
  start-page: 172
  year: 2019
  end-page: 178
  ident: bib50
  article-title: Roles of ginsenosides in inflammasome activation
  publication-title: J. Ginseng. Res.
– volume: 586
  year: 2020
  ident: bib10
  article-title: Study of injectable Blueberry anthocyanins-loaded hydrogel for promoting full-thickness wound healing
  publication-title: Int. J. Pharm.
– volume: 240
  start-page: 349
  year: 2016
  end-page: 363
  ident: bib7
  article-title: Delivery strategies to control inflammatory response: modulating M1-M2 polarization in tissue engineering applications
  publication-title: J. Contr. Release
– volume: 19
  start-page: 237
  year: 2021
  ident: bib23
  article-title: More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing
  publication-title: J. Nanobiotechnol.
– volume: 62
  start-page: 83
  year: 2010
  end-page: 99
  ident: bib38
  article-title: Chitosan-based hydrogels for controlled, localized drug delivery
  publication-title: Adv. Drug Deliv. Rev.
– volume: 12
  start-page: 2726
  year: 2021
  end-page: 2740
  ident: bib64
  article-title: Puerarin improves hepatic glucose and lipid homeostasis in vitro and in vivo by regulating the AMPK pathway
  publication-title: Food Funct.
– volume: 276
  year: 2021
  ident: bib33
  article-title: A physicochemical double cross-linked multifunctional hydrogel for dynamic burn wound healing: shape adaptability, injectable self-healing property and enhanced adhesion
  publication-title: Biomaterials
– volume: 8
  start-page: 5348
  year: 2018
  end-page: 5361
  ident: bib12
  article-title: Prostaglandin E(2) hydrogel improves cutaneous wound healing via M2 macrophages polarization
  publication-title: Theranostics
– volume: 8
  year: 2020
  ident: bib3
  article-title: KGF-2 and FGF-21 poloxamer 407 hydrogel coordinates inflammation and proliferation homeostasis to enhance wound repair of scalded skin in diabetic rats
  publication-title: BMJ Open Diab. Res. Care
– volume: 73
  start-page: 3861
  year: 2016
  end-page: 3885
  ident: bib54
  article-title: Transition from inflammation to proliferation: a critical step during wound healing
  publication-title: Cell. Mol. Life Sci.
– volume: 11
  year: 2020
  ident: bib21
  article-title: Pueraria tuberosa: a review on traditional uses, pharmacology, and phytochemistry
  publication-title: Front. Pharmacol.
– volume: 6
  year: 2014
  ident: bib2
  article-title: Wound repair and regeneration: mechanisms, signaling, and translation
  publication-title: Sci. Transl. Med.
– volume: 818
  start-page: 115
  year: 2018
  end-page: 123
  ident: bib19
  article-title: Puerarin acts on the skeletal muscle to improve insulin sensitivity in diabetic rats involving μ-opioid receptor
  publication-title: Eur. J. Pharmacol.
– volume: 366
  start-page: 922
  year: 2008
  end-page: 926
  ident: bib69
  article-title: Quantitative differential expression analysis reveals miR-7 as major islet microRNA
  publication-title: Biochem. Biophys. Res. Commun.
– volume: 46
  start-page: 1771
  year: 2018
  end-page: 1789
  ident: bib18
  article-title: Management of diabetes mellitus with puerarin, a natural isoflavone from Pueraria lobata
  publication-title: Am. J. Chin. Med.
– volume: 32
  start-page: 2086
  year: 2018
  end-page: 2094
  ident: bib47
  article-title: Interleukin-23 regulates interleukin-17 expression in wounds, and its inhibition accelerates diabetic wound healing through the alteration of macrophage polarization
  publication-title: Faseb. J.
– volume: 10
  year: 2018
  ident: bib77
  article-title: miR-29 contributes to normal endothelial function and can restore it in cardiometabolic disorders
  publication-title: EMBO Mol. Med.
– volume: 131
  year: 2020
  ident: bib22
  article-title: A comprehensive review on Pueraria: insights on its chemistry and medicinal value
  publication-title: Biomed. Pharmacother.
– volume: 115
  year: 2019
  ident: bib24
  article-title: Puerarin alleviates streptozotocin (STZ)-induced osteoporosis in rats through suppressing inflammation and apoptosis via HDAC1/HDAC3 signaling
  publication-title: Biomed. Pharmacother.
– volume: 99
  start-page: 108001
  year: 2021
  ident: bib62
  article-title: The natural compound puerarin alleviates inflammation and apoptosis in experimental cell and rat preeclampsia models
  publication-title: Int. Immunopharm.
– volume: 235
  year: 2020
  ident: bib26
  article-title: Nano-puerarin regulates tumor microenvironment and facilitates chemo- and immunotherapy in murine triple negative breast cancer model
  publication-title: Biomaterials
– volume: 18
  start-page: 1545
  year: 2017
  ident: bib52
  article-title: Macrophage phenotypes regulate scar formation and chronic wound healing
  publication-title: Int. J. Mol. Sci.
– volume: 87
  start-page: 1
  year: 2015
  end-page: 57
  ident: bib59
  article-title: Metallic implant biomaterials
  publication-title: Mater. Sci. Eng. R Rep.
– volume: 8
  year: 2021
  ident: bib29
  article-title: Highly stretchable, adhesive, biocompatible, and antibacterial hydrogel dressings for wound healing
  publication-title: Adv. Sci.
– volume: 75
  start-page: 63
  year: 2018
  end-page: 74
  ident: bib32
  article-title: A hybrid injectable hydrogel from hyperbranched PEG macromer as a stem cell delivery and retention platform for diabetic wound healing
  publication-title: Acta Biomater.
– volume: 35
  start-page: 4477
  year: 2014
  end-page: 4488
  ident: bib8
  article-title: The role of macrophage phenotype in vascularization of tissue engineering scaffolds
  publication-title: Biomaterials
– volume: 33
  year: 2021
  ident: bib35
  article-title: Promoting oral mucosal wound healing with a hydrogel adhesive based on a phototriggered S-nitrosylation coupling reaction
  publication-title: Adv Mater
– volume: 12
  start-page: 216
  year: 2020
  ident: bib27
  article-title: Preparation of puerarin chitosan oral nanoparticles by ionic gelation method and its related kinetics
  publication-title: Pharmaceutics
– volume: 9
  start-page: 37563
  year: 2017
  end-page: 37574
  ident: bib67
  article-title: pH and glucose dual-responsive injectable hydrogels with insulin and fibroblasts as bioactive dressings for diabetic wound healing
  publication-title: ACS Appl. Mater. Interfaces
– volume: 16
  start-page: 239
  year: 2019
  end-page: 250
  ident: bib37
  article-title: Multi-functional chitosan-based smart hydrogels mediated biomedical application
  publication-title: Expet Opin. Drug Deliv.
– volume: 15
  year: 2019
  ident: bib14
  article-title: Local immunomodulation using an adhesive hydrogel loaded with miRNA-laden nanoparticles promotes wound healing
  publication-title: Small
– volume: 15
  start-page: 25
  year: 2018
  ident: bib49
  article-title: Cannabinoid 2 receptor attenuates inflammation during skin wound healing by inhibiting M1 macrophages rather than activating M2 macrophages
  publication-title: J. Inflamm.
– volume: 34
  start-page: 4173
  year: 2013
  end-page: 4182
  ident: bib4
  article-title: The angiogenic response to PLL-g-PEG-mediated HIF-1α plasmid DNA delivery in healthy and diabetic rats
  publication-title: Biomaterials
– volume: 34
  start-page: 4439
  year: 2013
  end-page: 4451
  ident: bib58
  article-title: Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds
  publication-title: Biomaterials
– volume: 51
  start-page: 714
  year: 2021
  end-page: 720
  ident: bib72
  article-title: TLR7 endogenous ligands remodel glycolytic macrophages and trigger skin-to-joint crosstalk in psoriatic arthritis
  publication-title: Eur. J. Immunol.
– volume: 222
  start-page: 119398
  year: 2019
  ident: bib13
  article-title: Novel H(2)S-Releasing hydrogel for wound repair via in situ polarization of M2 macrophages
  publication-title: Biomaterials
– volume: 243
  start-page: 29
  year: 2016
  end-page: 34
  ident: bib25
  article-title: Puerarin protects mouse liver against nickel-induced oxidative stress and inflammation associated with the TLR4/p38/CREB pathway
  publication-title: Chem. Biol. Interact.
– volume: 42
  start-page: 831
  year: 2018
  end-page: 838
  ident: bib60
  article-title: Icariin promotes wound healing by enhancing the migration and proliferation of keratinocytes via the AKT and ERK signaling pathway
  publication-title: Int. J. Mol. Med.
– volume: 35
  start-page: S199
  year: 2015
  end-page: s223
  ident: bib16
  article-title: Cancer prevention and therapy through the modulation of the tumor microenvironment
  publication-title: Semin. Cancer Biol.
– volume: 29
  year: 2019
  ident: bib66
  article-title: Skin-inspired antibacterial conductive hydrogels for epidermal sensors and diabetic foot wound dressings
  publication-title: Adv. Funct. Mater.
– volume: 178
  start-page: 36
  year: 2018
  end-page: 47
  ident: bib56
  article-title: Promoting in vivo early angiogenesis with sub-micrometer strontium-contained bioactive microspheres through modulating macrophage phenotypes
  publication-title: Biomaterials
– volume: 31
  start-page: 596
  year: 2020
  end-page: 610
  ident: bib6
  article-title: Obesity/Metabolic syndrome and diabetes mellitus on peri-implantitis
  publication-title: Trends Endocrinol. Metabol.
– volume: 94
  start-page: 583
  year: 2016
  end-page: 596
  ident: bib74
  article-title: The microRNA-29 family in cartilage homeostasis and osteoarthritis
  publication-title: J. Mol. Med. (Berl.)
– volume: 7
  start-page: 4230
  year: 2019
  end-page: 4236
  ident: bib28
  article-title: Polydopamine/puerarin nanoparticle-incorporated hybrid hydrogels for enhanced wound healing
  publication-title: Biomater. Sci.
– volume: 55
  start-page: 1699
  year: 2012
  end-page: 1708
  ident: bib68
  article-title: Involvement of the RNA-binding protein ARE/poly(U)-binding factor 1 (AUF1) in the cytotoxic effects of proinflammatory cytokines on pancreatic beta cells
  publication-title: Diabetologia
– volume: 10
  start-page: 1604
  year: 2019
  ident: 10.1016/j.bioactmat.2022.04.032_bib61
  article-title: Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-09601-3
– volume: 10
  year: 2018
  ident: 10.1016/j.bioactmat.2022.04.032_bib77
  article-title: miR-29 contributes to normal endothelial function and can restore it in cardiometabolic disorders
  publication-title: EMBO Mol. Med.
  doi: 10.15252/emmm.201708046
– volume: 15
  start-page: 25
  year: 2018
  ident: 10.1016/j.bioactmat.2022.04.032_bib49
  article-title: Cannabinoid 2 receptor attenuates inflammation during skin wound healing by inhibiting M1 macrophages rather than activating M2 macrophages
  publication-title: J. Inflamm.
  doi: 10.1186/s12950-018-0201-z
– volume: 55
  start-page: 1699
  year: 2012
  ident: 10.1016/j.bioactmat.2022.04.032_bib68
  article-title: Involvement of the RNA-binding protein ARE/poly(U)-binding factor 1 (AUF1) in the cytotoxic effects of proinflammatory cytokines on pancreatic beta cells
  publication-title: Diabetologia
  doi: 10.1007/s00125-011-2399-7
– volume: 21
  start-page: 8748
  year: 2020
  ident: 10.1016/j.bioactmat.2022.04.032_bib71
  article-title: The cutaneous wound innate immunological microenvironment
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms21228748
– volume: 135
  start-page: 1700
  year: 2015
  ident: 10.1016/j.bioactmat.2022.04.032_bib9
  article-title: Relative expression of proinflammatory and antiinflammatory genes reveals differences between healing and nonhealing human chronic diabetic foot ulcers
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/jid.2015.30
– volume: 62
  start-page: 83
  year: 2010
  ident: 10.1016/j.bioactmat.2022.04.032_bib38
  article-title: Chitosan-based hydrogels for controlled, localized drug delivery
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2009.07.019
– volume: 87
  start-page: 1
  year: 2015
  ident: 10.1016/j.bioactmat.2022.04.032_bib59
  article-title: Metallic implant biomaterials
  publication-title: Mater. Sci. Eng. R Rep.
  doi: 10.1016/j.mser.2014.10.001
– volume: 32
  start-page: 2086
  year: 2018
  ident: 10.1016/j.bioactmat.2022.04.032_bib47
  article-title: Interleukin-23 regulates interleukin-17 expression in wounds, and its inhibition accelerates diabetic wound healing through the alteration of macrophage polarization
  publication-title: Faseb. J.
  doi: 10.1096/fj.201700773R
– volume: 222
  start-page: 119398
  year: 2019
  ident: 10.1016/j.bioactmat.2022.04.032_bib13
  article-title: Novel H(2)S-Releasing hydrogel for wound repair via in situ polarization of M2 macrophages
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2019.119398
– volume: 322
  start-page: 375
  year: 2020
  ident: 10.1016/j.bioactmat.2022.04.032_bib63
  article-title: In situ inflammatory-regulated drug-loaded hydrogels for promoting pelvic floor repair
  publication-title: J. Contr. Release
  doi: 10.1016/j.jconrel.2020.03.030
– volume: 8
  start-page: 5348
  year: 2018
  ident: 10.1016/j.bioactmat.2022.04.032_bib12
  article-title: Prostaglandin E(2) hydrogel improves cutaneous wound healing via M2 macrophages polarization
  publication-title: Theranostics
  doi: 10.7150/thno.27385
– volume: 243
  start-page: 29
  year: 2016
  ident: 10.1016/j.bioactmat.2022.04.032_bib25
  article-title: Puerarin protects mouse liver against nickel-induced oxidative stress and inflammation associated with the TLR4/p38/CREB pathway
  publication-title: Chem. Biol. Interact.
  doi: 10.1016/j.cbi.2015.11.017
– volume: 42
  start-page: 831
  year: 2018
  ident: 10.1016/j.bioactmat.2022.04.032_bib60
  article-title: Icariin promotes wound healing by enhancing the migration and proliferation of keratinocytes via the AKT and ERK signaling pathway
  publication-title: Int. J. Mol. Med.
– volume: 73
  start-page: 3861
  year: 2016
  ident: 10.1016/j.bioactmat.2022.04.032_bib54
  article-title: Transition from inflammation to proliferation: a critical step during wound healing
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-016-2268-0
– volume: 12
  start-page: 2726
  year: 2021
  ident: 10.1016/j.bioactmat.2022.04.032_bib64
  article-title: Puerarin improves hepatic glucose and lipid homeostasis in vitro and in vivo by regulating the AMPK pathway
  publication-title: Food Funct.
  doi: 10.1039/D0FO02761H
– volume: 9
  start-page: 37563
  year: 2017
  ident: 10.1016/j.bioactmat.2022.04.032_bib67
  article-title: pH and glucose dual-responsive injectable hydrogels with insulin and fibroblasts as bioactive dressings for diabetic wound healing
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.7b09395
– volume: 124
  start-page: 205
  year: 2021
  ident: 10.1016/j.bioactmat.2022.04.032_bib34
  article-title: A composite hydrogel with co-delivery of antimicrobial peptides and platelet-rich plasma to enhance healing of infected wounds in diabetes
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2021.01.046
– volume: 75
  start-page: 63
  year: 2018
  ident: 10.1016/j.bioactmat.2022.04.032_bib32
  article-title: A hybrid injectable hydrogel from hyperbranched PEG macromer as a stem cell delivery and retention platform for diabetic wound healing
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2018.05.039
– volume: 240
  start-page: 349
  year: 2016
  ident: 10.1016/j.bioactmat.2022.04.032_bib7
  article-title: Delivery strategies to control inflammatory response: modulating M1-M2 polarization in tissue engineering applications
  publication-title: J. Contr. Release
  doi: 10.1016/j.jconrel.2016.01.026
– volume: 33
  year: 2021
  ident: 10.1016/j.bioactmat.2022.04.032_bib35
  article-title: Promoting oral mucosal wound healing with a hydrogel adhesive based on a phototriggered S-nitrosylation coupling reaction
  publication-title: Adv Mater
  doi: 10.1002/adma.202105667
– volume: 140
  start-page: 580
  year: 2019
  ident: 10.1016/j.bioactmat.2022.04.032_bib43
  article-title: O-GlcNAcylation of histone deacetylase 4 protects the diabetic heart from failure
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.117.031942
– volume: 8
  year: 2021
  ident: 10.1016/j.bioactmat.2022.04.032_bib40
  article-title: A novel stimuli-responsive injectable Antibacterial hydrogel to achieve synergetic photothermal/gene-targeted therapy towards uveal melanoma
  publication-title: Adv. Sci.
– volume: 366
  start-page: 922
  year: 2008
  ident: 10.1016/j.bioactmat.2022.04.032_bib69
  article-title: Quantitative differential expression analysis reveals miR-7 as major islet microRNA
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2007.12.052
– volume: 19
  start-page: 2198
  year: 2018
  ident: 10.1016/j.bioactmat.2022.04.032_bib36
  article-title: Injectable and self-healing chitosan hydrogel based on imine bonds: design and therapeutic applications
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms19082198
– volume: 51
  start-page: 714
  year: 2021
  ident: 10.1016/j.bioactmat.2022.04.032_bib72
  article-title: TLR7 endogenous ligands remodel glycolytic macrophages and trigger skin-to-joint crosstalk in psoriatic arthritis
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.202048690
– volume: 178
  start-page: 36
  year: 2018
  ident: 10.1016/j.bioactmat.2022.04.032_bib56
  article-title: Promoting in vivo early angiogenesis with sub-micrometer strontium-contained bioactive microspheres through modulating macrophage phenotypes
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2018.06.004
– volume: 11
  year: 2020
  ident: 10.1016/j.bioactmat.2022.04.032_bib65
  article-title: Regulation of inflammatory microenvironment using a self-healing hydrogel loaded with BM-MSCs for advanced wound healing in rat diabetic foot ulcers
  publication-title: J. Tissue Eng.
  doi: 10.1177/2041731420947242
– volume: 44
  start-page: 237
  year: 2012
  ident: 10.1016/j.bioactmat.2022.04.032_bib75
  article-title: The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury
  publication-title: Physiol. Genom.
  doi: 10.1152/physiolgenomics.00141.2011
– volume: 19
  start-page: 322
  year: 2021
  ident: 10.1016/j.bioactmat.2022.04.032_bib15
  article-title: Ginsenosides emerging as both bifunctional drugs and nanocarriers for enhanced antitumor therapies
  publication-title: J. Nanobiotechnol.
  doi: 10.1186/s12951-021-01062-5
– volume: 46
  start-page: 1771
  year: 2018
  ident: 10.1016/j.bioactmat.2022.04.032_bib18
  article-title: Management of diabetes mellitus with puerarin, a natural isoflavone from Pueraria lobata
  publication-title: Am. J. Chin. Med.
  doi: 10.1142/S0192415X18500891
– volume: 235
  year: 2020
  ident: 10.1016/j.bioactmat.2022.04.032_bib26
  article-title: Nano-puerarin regulates tumor microenvironment and facilitates chemo- and immunotherapy in murine triple negative breast cancer model
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2020.119769
– volume: 68
  start-page: 932
  year: 2019
  ident: 10.1016/j.bioactmat.2022.04.032_bib42
  article-title: Glucose metabolism is required for platelet hyperactivation in a murine model of type 1 diabetes
  publication-title: Diabetes
  doi: 10.2337/db18-0981
– volume: 19
  start-page: 237
  year: 2021
  ident: 10.1016/j.bioactmat.2022.04.032_bib23
  article-title: More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing
  publication-title: J. Nanobiotechnol.
  doi: 10.1186/s12951-021-00973-7
– volume: 8
  year: 2020
  ident: 10.1016/j.bioactmat.2022.04.032_bib3
  article-title: KGF-2 and FGF-21 poloxamer 407 hydrogel coordinates inflammation and proliferation homeostasis to enhance wound repair of scalded skin in diabetic rats
  publication-title: BMJ Open Diab. Res. Care
  doi: 10.1136/bmjdrc-2019-001009
– volume: 29
  year: 2019
  ident: 10.1016/j.bioactmat.2022.04.032_bib66
  article-title: Skin-inspired antibacterial conductive hydrogels for epidermal sensors and diabetic foot wound dressings
  publication-title: Adv. Funct. Mater.
  doi: 10.1002/adfm.201901474
– volume: 34
  year: 2021
  ident: 10.1016/j.bioactmat.2022.04.032_bib39
  article-title: Expression of miRNA-29 in pancreatic β cells promotes inflammation and diabetes via TRAF3
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2020.108576
– volume: 276
  year: 2021
  ident: 10.1016/j.bioactmat.2022.04.032_bib33
  article-title: A physicochemical double cross-linked multifunctional hydrogel for dynamic burn wound healing: shape adaptability, injectable self-healing property and enhanced adhesion
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2021.120838
– volume: 101
  start-page: 241
  year: 2010
  ident: 10.1016/j.bioactmat.2022.04.032_bib76
  article-title: Changes in microRNA expression levels correlate with clinicopathological features and prognoses in endometrial serous adenocarcinomas
  publication-title: Cancer Sci.
  doi: 10.1111/j.1349-7006.2009.01385.x
– volume: 43
  start-page: 172
  year: 2019
  ident: 10.1016/j.bioactmat.2022.04.032_bib50
  article-title: Roles of ginsenosides in inflammasome activation
  publication-title: J. Ginseng. Res.
  doi: 10.1016/j.jgr.2017.11.005
– volume: 21
  start-page: 145
  year: 2019
  ident: 10.1016/j.bioactmat.2022.04.032_bib1
  article-title: Hydrogel-based strategies to advance therapies for chronic skin wounds
  publication-title: Annu. Rev. Biomed. Eng.
  doi: 10.1146/annurev-bioeng-060418-052422
– volume: 203
  start-page: 12
  year: 2019
  ident: 10.1016/j.bioactmat.2022.04.032_bib44
  article-title: Pravastatin regulates host foreign-body reaction to polyetheretherketone implants via miR-29ab1-mediated SLIT3 upregulation
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2019.02.027
– volume: 258
  start-page: 120286
  year: 2020
  ident: 10.1016/j.bioactmat.2022.04.032_bib11
  article-title: ROS-scavenging hydrogel to promote healing of bacteria infected diabetic wounds
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2020.120286
– volume: 223
  year: 2019
  ident: 10.1016/j.bioactmat.2022.04.032_bib46
  article-title: Injectable and degradable methacrylic acid hydrogel alters macrophage response in skeletal muscle
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2019.119477
– volume: 6
  year: 2014
  ident: 10.1016/j.bioactmat.2022.04.032_bib2
  article-title: Wound repair and regeneration: mechanisms, signaling, and translation
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3009337
– volume: 12
  start-page: 216
  year: 2020
  ident: 10.1016/j.bioactmat.2022.04.032_bib27
  article-title: Preparation of puerarin chitosan oral nanoparticles by ionic gelation method and its related kinetics
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics12030216
– volume: 586
  year: 2020
  ident: 10.1016/j.bioactmat.2022.04.032_bib10
  article-title: Study of injectable Blueberry anthocyanins-loaded hydrogel for promoting full-thickness wound healing
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2020.119543
– volume: 818
  start-page: 115
  year: 2018
  ident: 10.1016/j.bioactmat.2022.04.032_bib19
  article-title: Puerarin acts on the skeletal muscle to improve insulin sensitivity in diabetic rats involving μ-opioid receptor
  publication-title: Eur. J. Pharmacol.
  doi: 10.1016/j.ejphar.2017.10.033
– volume: 207
  start-page: 107452
  year: 2020
  ident: 10.1016/j.bioactmat.2022.04.032_bib17
  article-title: Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony
  publication-title: Pharmacol. Ther.
  doi: 10.1016/j.pharmthera.2019.107452
– volume: 11
  year: 2020
  ident: 10.1016/j.bioactmat.2022.04.032_bib21
  article-title: Pueraria tuberosa: a review on traditional uses, pharmacology, and phytochemistry
  publication-title: Front. Pharmacol.
– volume: 94
  start-page: 583
  year: 2016
  ident: 10.1016/j.bioactmat.2022.04.032_bib74
  article-title: The microRNA-29 family in cartilage homeostasis and osteoarthritis
  publication-title: J. Mol. Med. (Berl.)
  doi: 10.1007/s00109-015-1374-z
– volume: 44
  start-page: 450
  year: 2016
  ident: 10.1016/j.bioactmat.2022.04.032_bib55
  article-title: Macrophages in tissue repair, regeneration, and fibrosis
  publication-title: Immunity
  doi: 10.1016/j.immuni.2016.02.015
– volume: 33
  year: 2021
  ident: 10.1016/j.bioactmat.2022.04.032_bib30
  article-title: Rational design of immunomodulatory hydrogels for chronic wound healing
  publication-title: Adv Mater
  doi: 10.1002/adma.202100176
– volume: 82
  start-page: 122
  year: 2016
  ident: 10.1016/j.bioactmat.2022.04.032_bib41
  article-title: Sclerostin antibody treatment improves fracture outcomes in a Type I diabetic mouse model
  publication-title: Bone
  doi: 10.1016/j.bone.2015.04.048
– volume: 35
  start-page: 4477
  year: 2014
  ident: 10.1016/j.bioactmat.2022.04.032_bib8
  article-title: The role of macrophage phenotype in vascularization of tissue engineering scaffolds
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2014.02.012
– volume: 189
  start-page: 1567
  year: 2012
  ident: 10.1016/j.bioactmat.2022.04.032_bib51
  article-title: miR-29ab1 deficiency identifies a negative feedback loop controlling Th1 bias that is dysregulated in multiple sclerosis
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1103171
– volume: 131
  year: 2020
  ident: 10.1016/j.bioactmat.2022.04.032_bib22
  article-title: A comprehensive review on Pueraria: insights on its chemistry and medicinal value
  publication-title: Biomed. Pharmacother.
  doi: 10.1016/j.biopha.2020.110734
– volume: 183
  start-page: 185
  year: 2018
  ident: 10.1016/j.bioactmat.2022.04.032_bib31
  article-title: Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2018.08.044
– volume: 34
  start-page: 4173
  year: 2013
  ident: 10.1016/j.bioactmat.2022.04.032_bib4
  article-title: The angiogenic response to PLL-g-PEG-mediated HIF-1α plasmid DNA delivery in healthy and diabetic rats
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2013.02.021
– volume: 99
  start-page: 108001
  year: 2021
  ident: 10.1016/j.bioactmat.2022.04.032_bib62
  article-title: The natural compound puerarin alleviates inflammation and apoptosis in experimental cell and rat preeclampsia models
  publication-title: Int. Immunopharm.
  doi: 10.1016/j.intimp.2021.108001
– volume: 7
  start-page: 4230
  year: 2019
  ident: 10.1016/j.bioactmat.2022.04.032_bib28
  article-title: Polydopamine/puerarin nanoparticle-incorporated hybrid hydrogels for enhanced wound healing
  publication-title: Biomater. Sci.
  doi: 10.1039/C9BM00991D
– volume: 27
  start-page: 367
  year: 2020
  ident: 10.1016/j.bioactmat.2022.04.032_bib20
  article-title: Plants as source of new therapies for endometriosis: a review of preclinical and clinical studies
  publication-title: Hum. Reprod. Update
  doi: 10.1093/humupd/dmaa039
– volume: 127
  start-page: 1
  year: 2017
  ident: 10.1016/j.bioactmat.2022.04.032_bib53
  article-title: Inflammatory mechanisms linking obesity and metabolic disease
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI92035
– volume: 8
  year: 2021
  ident: 10.1016/j.bioactmat.2022.04.032_bib29
  article-title: Highly stretchable, adhesive, biocompatible, and antibacterial hydrogel dressings for wound healing
  publication-title: Adv. Sci.
  doi: 10.1002/advs.202003627
– volume: 7
  start-page: 13393
  year: 2016
  ident: 10.1016/j.bioactmat.2022.04.032_bib57
  article-title: Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms13393
– volume: 15
  year: 2019
  ident: 10.1016/j.bioactmat.2022.04.032_bib14
  article-title: Local immunomodulation using an adhesive hydrogel loaded with miRNA-laden nanoparticles promotes wound healing
  publication-title: Small
  doi: 10.1002/smll.201902232
– volume: 115
  year: 2019
  ident: 10.1016/j.bioactmat.2022.04.032_bib24
  article-title: Puerarin alleviates streptozotocin (STZ)-induced osteoporosis in rats through suppressing inflammation and apoptosis via HDAC1/HDAC3 signaling
  publication-title: Biomed. Pharmacother.
  doi: 10.1016/j.biopha.2019.01.031
– volume: 5
  start-page: 743
  year: 2014
  ident: 10.1016/j.bioactmat.2022.04.032_bib45
  article-title: Spacing-dependent antimicrobial efficacy of immobilized silver nanoparticles
  publication-title: J. Phys. Chem. Lett.
  doi: 10.1021/jz5000269
– volume: 133
  start-page: 2461
  year: 2013
  ident: 10.1016/j.bioactmat.2022.04.032_bib48
  article-title: Local arginase 1 activity is required for cutaneous wound healing
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/jid.2013.164
– volume: 6
  year: 2020
  ident: 10.1016/j.bioactmat.2022.04.032_bib5
  article-title: Ångstrom-scale silver particle-embedded carbomer gel promotes wound healing by inhibiting bacterial colonization and inflammation
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.aba0942
– volume: 34
  start-page: 4439
  year: 2013
  ident: 10.1016/j.bioactmat.2022.04.032_bib58
  article-title: Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2013.02.065
– volume: 35
  start-page: S199
  issue: Suppl
  year: 2015
  ident: 10.1016/j.bioactmat.2022.04.032_bib16
  article-title: Cancer prevention and therapy through the modulation of the tumor microenvironment
  publication-title: Semin. Cancer Biol.
  doi: 10.1016/j.semcancer.2015.02.007
– volume: 18
  start-page: 1545
  year: 2017
  ident: 10.1016/j.bioactmat.2022.04.032_bib52
  article-title: Macrophage phenotypes regulate scar formation and chronic wound healing
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms18071545
– volume: 16
  start-page: 239
  year: 2019
  ident: 10.1016/j.bioactmat.2022.04.032_bib37
  article-title: Multi-functional chitosan-based smart hydrogels mediated biomedical application
  publication-title: Expet Opin. Drug Deliv.
  doi: 10.1080/17425247.2019.1580691
– volume: 25
  year: 2022
  ident: 10.1016/j.bioactmat.2022.04.032_bib70
  article-title: miR-29cb2 promotes angiogenesis and osteogenesis by inhibiting HIF-3α in bone
  publication-title: iScience
  doi: 10.1016/j.isci.2021.103604
– volume: 72
  start-page: 454
  year: 2020
  ident: 10.1016/j.bioactmat.2022.04.032_bib73
  article-title: Lipotoxic hepatocyte-derived exosomal MicroRNA 192-5p activates macrophages through rictor/akt/forkhead box transcription factor O1 signaling in nonalcoholic fatty liver disease
  publication-title: Hepatology
  doi: 10.1002/hep.31050
– volume: 31
  start-page: 596
  year: 2020
  ident: 10.1016/j.bioactmat.2022.04.032_bib6
  article-title: Obesity/Metabolic syndrome and diabetes mellitus on peri-implantitis
  publication-title: Trends Endocrinol. Metabol.
  doi: 10.1016/j.tem.2020.05.005
SSID ssj0001700007
Score 2.5450172
Snippet Wound healing is one of the major global health concerns in patients with diabetes. Overactivation of pro-inflammatory M1 macrophages is associated with...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
elsevier
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 653
SubjectTerms Diabetic skin wound healing
Hydrogel
Macrophages
miR-29ab1
Title Chitosan@Puerarin hydrogel for accelerated wound healing in diabetic subjects by miR-29ab1 mediated inflammatory axis suppression
URI https://dx.doi.org/10.1016/j.bioactmat.2022.04.032
https://www.ncbi.nlm.nih.gov/pubmed/35600974
https://www.proquest.com/docview/2668217565
https://pubmed.ncbi.nlm.nih.gov/PMC9109129
https://doaj.org/article/c7f34b993be44c2fa169ec5d674c260a
Volume 19
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQe-GCQOURCpWRuEY4tvPiRClUFQKEgEp7s8aOw6Zqs1WzK-iRf86MnV1t4LAXLpHycGRnPme-cSbfMPay0ZnLqiqnhSrcYIyRVmB1mvsqhBethKD2-bk4O9cfZvlsq9QX5YRFeeD44F65slXaohe1XmsnW8iK2ru8KUrcK0SgRqIWW8HURRSFIe9HleV0LimbYjZJ7rLdAtwSOSFGiFIGsVMlJ64pKPhPPNS_DPTvRMotz3R6n90bKSU_jkN5wO74_oD9PpnjXB2gf_NlFVQxej6_bW4WP_wlR57KwTl0OKQT0fCfVFqJE2VEP8bxyrgg2zk-rCyt0wzc3vKr7msqa7AZD3-bUENEJwLqKnyo5_CrG7DB9ZhZ2z9k56fvv5-cpWO5hdTlOlumgJFg0crCWQ9Ct1mjFM5mqEoPXmjrvLSiJYZVetsC_f0EZA9XqwasrUv1iO31i94_YTzzUKLnsypv8CXR5qQALqBB9il1gwwjYcX6SRs3apFTSYxLs046uzAbExkykRHaoIkSJjYNr6Mcx-4mb8mUm8tJTzscQJSZEWVmF8oS9noNBDNSk0g58Fbd7h68WEPH4OSlLzLQ-8VqMMiOKowJkVQn7HGE0qafirgoRnsJKycgmwxkeqbv5kEgvCa1V1k__R8jP2R3cSgqrjo9Y3vLm5V_jjxsaY_Y_vG7Tx-_HYWp9wfZ3DUd
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Chitosan%40Puerarin+hydrogel+for+accelerated+wound+healing+in+diabetic+subjects+by+miR-29ab1+mediated+inflammatory+axis+suppression&rft.jtitle=Bioactive+materials&rft.au=Zeng%2C+Xiaoling&rft.au=Chen%2C+Baohui&rft.au=Wang%2C+Luping&rft.au=Sun%2C+Yingxiao&rft.date=2023-01-01&rft.eissn=2452-199X&rft.volume=19&rft.spage=653&rft_id=info:doi/10.1016%2Fj.bioactmat.2022.04.032&rft_id=info%3Apmid%2F35600974&rft.externalDocID=35600974
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2452-199X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2452-199X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2452-199X&client=summon