International Society for Heart and Lung Transplantation working formulation of a standardized nomenclature for cardiac allograft vasculopathy—2010

• Published in: The Journal of heart and lung transplantation Vol. 29; no. 7; pp. 717 - 727
• Main Authors: Mehra, Mandeep R., Crespo-Leiro, Maria G., Dipchand, Anne, Ensminger, Stephan M., Hiemann, Nicola E., Kobashigawa, Jon A., Madsen, Joren, Parameshwar, Jayan, Starling, Randall C., Uber, Patricia A.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2010; Elsevier
• Subjects: angiography; Biological and medical sciences; biomarkers; cardiac allograft function; cardiac allograft vasculopathy; Cardiology. Vascular system; Graft Rejection - pathology; Heart Transplantation - pathology; Humans; International Cooperation; intravascular ultrasound; Medical sciences; pediatric considerations; restrictive physiology; Societies, Medical; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the heart; Terminology as Topic; Transplantation, Homologous; Vascular Diseases - pathology; Vascular Diseases - surgery; cardiac allograft vasculopathy; intravascular ultrasound; restrictive physiology; biomarkers; cardiac allograft function; pediatric considerations; angiography; Heart; Nomenclature; Lung; Cardiovascular disease; Transplantation; Homotransplantation; Phlebology; Vascular disease; Treatment; Surgery; Formulation; Dosage form; Graft; Circulatory system; Society; Cardiology; International
• ISSN: 1053-2498; 1557-3117; 1557-3117
• DOI: 10.1016/j.healun.2010.05.017

The development of cardiac allograft vasculopathy remains the Achilles heel of cardiac transplantation. Unfortunately, the definitions of cardiac allograft vasculopathy are diverse, and there are no uniform international standards for the nomenclature of this entity. This consensus document, commissioned by the International Society of Heart and Lung Transplantation Board, is based on best evidence and clinical consensus derived from critical analysis of available information pertaining to angiography, intravascular ultrasound imaging, microvascular function, cardiac allograft histology, circulating immune markers, non-invasive imaging tests, and gene-based and protein-based biomarkers. This document represents a working formulation for an international nomenclature of cardiac allograft vasculopathy, similar to the development of the system for adjudication of cardiac allograft rejection by histology.