Suppression of host gene expression is associated with latent TB infection: a possible diagnostic biomarker
The World Health Organization End TB strategy aims for a 90% reduction of tuberculosis (TB) incidence by 2035. Systematic testing and treatment of latent TB infection (LTBI) among contacts of active TB patients is recommended as one of the ways to curtail TB incidence. However, there is a shortage o...
Saved in:
| Published in | Scientific reports Vol. 14; no. 1; pp. 15621 - 11 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
07.07.2024
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2045-2322 2045-2322 |
| DOI | 10.1038/s41598-024-66486-z |
Cover
| Abstract | The World Health Organization End TB strategy aims for a 90% reduction of tuberculosis (TB) incidence by 2035. Systematic testing and treatment of latent TB infection (LTBI) among contacts of active TB patients is recommended as one of the ways to curtail TB incidence. However, there is a shortage of tools to accurately diagnose LTBI. We assessed the appropriateness of whole blood host transcriptomic markers (TM) to diagnose LTBI among household contacts of bacteriologically confirmed index cases compared to HIV negative healthy controls (HC). QuantiFERON-TB Gold Plus Interferon gamma release assay (IGRA) and reverse-transcriptase quantitative PCR were used to determine LTBI and quantify TM expression respectively. Association between TM expression and LTBI was evaluated by logistic regression modelling. A total of 100 participants, 49 TB exposed (TBEx) household contacts and 51 HC, were enrolled. Twenty-five (51%) TBEx individuals tested positive by IGRA, and were denoted as LTBI individuals, and 37 (72.5%) HC were IGRA-negative. Expression of 11 evaluated TM was significantly suppressed among LTBI compared to HC. Out of the 11 TM,
ZNF296
and
KLF2
expression were strongly associated with LTBI and successfully differentiated LTBI from HC. Paradoxically, 21 (49%) TBEx participants who tested IGRA negative exhibited the same pattern of suppressed TM expression as IGRA positive (LTBI-confirmed individuals). Results suggest that suppression of gene expression underlies LTBI and may be a more sensitive diagnostic biomarker than standard-of-care IGRA. |
|---|---|
| AbstractList | The World Health Organization End TB strategy aims for a 90% reduction of tuberculosis (TB) incidence by 2035. Systematic testing and treatment of latent TB infection (LTBI) among contacts of active TB patients is recommended as one of the ways to curtail TB incidence. However, there is a shortage of tools to accurately diagnose LTBI. We assessed the appropriateness of whole blood host transcriptomic markers (TM) to diagnose LTBI among household contacts of bacteriologically confirmed index cases compared to HIV negative healthy controls (HC). QuantiFERON-TB Gold Plus Interferon gamma release assay (IGRA) and reverse-transcriptase quantitative PCR were used to determine LTBI and quantify TM expression respectively. Association between TM expression and LTBI was evaluated by logistic regression modelling. A total of 100 participants, 49 TB exposed (TBEx) household contacts and 51 HC, were enrolled. Twenty-five (51%) TBEx individuals tested positive by IGRA, and were denoted as LTBI individuals, and 37 (72.5%) HC were IGRA-negative. Expression of 11 evaluated TM was significantly suppressed among LTBI compared to HC. Out of the 11 TM,
ZNF296
and
KLF2
expression were strongly associated with LTBI and successfully differentiated LTBI from HC. Paradoxically, 21 (49%) TBEx participants who tested IGRA negative exhibited the same pattern of suppressed TM expression as IGRA positive (LTBI-confirmed individuals). Results suggest that suppression of gene expression underlies LTBI and may be a more sensitive diagnostic biomarker than standard-of-care IGRA. The World Health Organization End TB strategy aims for a 90% reduction of tuberculosis (TB) incidence by 2035. Systematic testing and treatment of latent TB infection (LTBI) among contacts of active TB patients is recommended as one of the ways to curtail TB incidence. However, there is a shortage of tools to accurately diagnose LTBI. We assessed the appropriateness of whole blood host transcriptomic markers (TM) to diagnose LTBI among household contacts of bacteriologically confirmed index cases compared to HIV negative healthy controls (HC). QuantiFERON-TB Gold Plus Interferon gamma release assay (IGRA) and reverse-transcriptase quantitative PCR were used to determine LTBI and quantify TM expression respectively. Association between TM expression and LTBI was evaluated by logistic regression modelling. A total of 100 participants, 49 TB exposed (TBEx) household contacts and 51 HC, were enrolled. Twenty-five (51%) TBEx individuals tested positive by IGRA, and were denoted as LTBI individuals, and 37 (72.5%) HC were IGRA-negative. Expression of 11 evaluated TM was significantly suppressed among LTBI compared to HC. Out of the 11 TM, ZNF296 and KLF2 expression were strongly associated with LTBI and successfully differentiated LTBI from HC. Paradoxically, 21 (49%) TBEx participants who tested IGRA negative exhibited the same pattern of suppressed TM expression as IGRA positive (LTBI-confirmed individuals). Results suggest that suppression of gene expression underlies LTBI and may be a more sensitive diagnostic biomarker than standard-of-care IGRA.The World Health Organization End TB strategy aims for a 90% reduction of tuberculosis (TB) incidence by 2035. Systematic testing and treatment of latent TB infection (LTBI) among contacts of active TB patients is recommended as one of the ways to curtail TB incidence. However, there is a shortage of tools to accurately diagnose LTBI. We assessed the appropriateness of whole blood host transcriptomic markers (TM) to diagnose LTBI among household contacts of bacteriologically confirmed index cases compared to HIV negative healthy controls (HC). QuantiFERON-TB Gold Plus Interferon gamma release assay (IGRA) and reverse-transcriptase quantitative PCR were used to determine LTBI and quantify TM expression respectively. Association between TM expression and LTBI was evaluated by logistic regression modelling. A total of 100 participants, 49 TB exposed (TBEx) household contacts and 51 HC, were enrolled. Twenty-five (51%) TBEx individuals tested positive by IGRA, and were denoted as LTBI individuals, and 37 (72.5%) HC were IGRA-negative. Expression of 11 evaluated TM was significantly suppressed among LTBI compared to HC. Out of the 11 TM, ZNF296 and KLF2 expression were strongly associated with LTBI and successfully differentiated LTBI from HC. Paradoxically, 21 (49%) TBEx participants who tested IGRA negative exhibited the same pattern of suppressed TM expression as IGRA positive (LTBI-confirmed individuals). Results suggest that suppression of gene expression underlies LTBI and may be a more sensitive diagnostic biomarker than standard-of-care IGRA. The World Health Organization End TB strategy aims for a 90% reduction of tuberculosis (TB) incidence by 2035. Systematic testing and treatment of latent TB infection (LTBI) among contacts of active TB patients is recommended as one of the ways to curtail TB incidence. However, there is a shortage of tools to accurately diagnose LTBI. We assessed the appropriateness of whole blood host transcriptomic markers (TM) to diagnose LTBI among household contacts of bacteriologically confirmed index cases compared to HIV negative healthy controls (HC). QuantiFERON-TB Gold Plus Interferon gamma release assay (IGRA) and reverse-transcriptase quantitative PCR were used to determine LTBI and quantify TM expression respectively. Association between TM expression and LTBI was evaluated by logistic regression modelling. A total of 100 participants, 49 TB exposed (TBEx) household contacts and 51 HC, were enrolled. Twenty-five (51%) TBEx individuals tested positive by IGRA, and were denoted as LTBI individuals, and 37 (72.5%) HC were IGRA-negative. Expression of 11 evaluated TM was significantly suppressed among LTBI compared to HC. Out of the 11 TM, ZNF296 and KLF2 expression were strongly associated with LTBI and successfully differentiated LTBI from HC. Paradoxically, 21 (49%) TBEx participants who tested IGRA negative exhibited the same pattern of suppressed TM expression as IGRA positive (LTBI-confirmed individuals). Results suggest that suppression of gene expression underlies LTBI and may be a more sensitive diagnostic biomarker than standard-of-care IGRA. The World Health Organization End TB strategy aims for a 90% reduction of tuberculosis (TB) incidence by 2035. Systematic testing and treatment of latent TB infection (LTBI) among contacts of active TB patients is recommended as one of the ways to curtail TB incidence. However, there is a shortage of tools to accurately diagnose LTBI. We assessed the appropriateness of whole blood host transcriptomic markers (TM) to diagnose LTBI among household contacts of bacteriologically confirmed index cases compared to HIV negative healthy controls (HC). QuantiFERON-TB Gold Plus Interferon gamma release assay (IGRA) and reverse-transcriptase quantitative PCR were used to determine LTBI and quantify TM expression respectively. Association between TM expression and LTBI was evaluated by logistic regression modelling. A total of 100 participants, 49 TB exposed (TBEx) household contacts and 51 HC, were enrolled. Twenty-five (51%) TBEx individuals tested positive by IGRA, and were denoted as LTBI individuals, and 37 (72.5%) HC were IGRA-negative. Expression of 11 evaluated TM was significantly suppressed among LTBI compared to HC. Out of the 11 TM, ZNF296 and KLF2 expression were strongly associated with LTBI and successfully differentiated LTBI from HC. Paradoxically, 21 (49%) TBEx participants who tested IGRA negative exhibited the same pattern of suppressed TM expression as IGRA positive (LTBI-confirmed individuals). Results suggest that suppression of gene expression underlies LTBI and may be a more sensitive diagnostic biomarker than standard-of-care IGRA. Abstract The World Health Organization End TB strategy aims for a 90% reduction of tuberculosis (TB) incidence by 2035. Systematic testing and treatment of latent TB infection (LTBI) among contacts of active TB patients is recommended as one of the ways to curtail TB incidence. However, there is a shortage of tools to accurately diagnose LTBI. We assessed the appropriateness of whole blood host transcriptomic markers (TM) to diagnose LTBI among household contacts of bacteriologically confirmed index cases compared to HIV negative healthy controls (HC). QuantiFERON-TB Gold Plus Interferon gamma release assay (IGRA) and reverse-transcriptase quantitative PCR were used to determine LTBI and quantify TM expression respectively. Association between TM expression and LTBI was evaluated by logistic regression modelling. A total of 100 participants, 49 TB exposed (TBEx) household contacts and 51 HC, were enrolled. Twenty-five (51%) TBEx individuals tested positive by IGRA, and were denoted as LTBI individuals, and 37 (72.5%) HC were IGRA-negative. Expression of 11 evaluated TM was significantly suppressed among LTBI compared to HC. Out of the 11 TM, ZNF296 and KLF2 expression were strongly associated with LTBI and successfully differentiated LTBI from HC. Paradoxically, 21 (49%) TBEx participants who tested IGRA negative exhibited the same pattern of suppressed TM expression as IGRA positive (LTBI-confirmed individuals). Results suggest that suppression of gene expression underlies LTBI and may be a more sensitive diagnostic biomarker than standard-of-care IGRA. |
| ArticleNumber | 15621 |
| Author | Walbaum, Natasha Tionge, Sikwese Nliwasa, Marriott Margaritella, Nicolò Sabiiti, Wilber Musisi, Emmanuel Chaima, David Msosa, Takondwa Nakiboneka, Ritah Msefula, Chisomo L. Sloan, Derek Nyirenda, Tonney |
| Author_xml | – sequence: 1 givenname: Ritah surname: Nakiboneka fullname: Nakiboneka, Ritah organization: Division of Infection and Global Health, School of Medicine, University of St Andrews, Department of Pathology, Kamuzu University of Health Sciences, Pathology Department, Helse Nord Tuberculosis Initiative (HNTI), Kamuzu University of Health Sciences, Africa Centre for Public Health and Herbal Medicines (ACEPHEM), Kamuzu University of Health Sciences, Uganda Virus Research Institute – sequence: 2 givenname: Nicolò surname: Margaritella fullname: Margaritella, Nicolò organization: School of Mathematics and Statistics, University of St Andrews – sequence: 3 givenname: Tonney surname: Nyirenda fullname: Nyirenda, Tonney organization: Department of Pathology, Kamuzu University of Health Sciences – sequence: 4 givenname: David surname: Chaima fullname: Chaima, David organization: Department of Pathology, Kamuzu University of Health Sciences – sequence: 5 givenname: Natasha surname: Walbaum fullname: Walbaum, Natasha organization: Division of Infection and Global Health, School of Medicine, University of St Andrews – sequence: 6 givenname: Emmanuel surname: Musisi fullname: Musisi, Emmanuel organization: Division of Infection and Global Health, School of Medicine, University of St Andrews, Adroit Biomedical and Bioentrepreneurship Research Service – sequence: 7 givenname: Sikwese surname: Tionge fullname: Tionge, Sikwese organization: Pathology Department, Helse Nord Tuberculosis Initiative (HNTI), Kamuzu University of Health Sciences – sequence: 8 givenname: Takondwa surname: Msosa fullname: Msosa, Takondwa organization: Pathology Department, Helse Nord Tuberculosis Initiative (HNTI), Kamuzu University of Health Sciences – sequence: 9 givenname: Marriott surname: Nliwasa fullname: Nliwasa, Marriott organization: Department of Pathology, Kamuzu University of Health Sciences, Pathology Department, Helse Nord Tuberculosis Initiative (HNTI), Kamuzu University of Health Sciences – sequence: 10 givenname: Chisomo L. surname: Msefula fullname: Msefula, Chisomo L. organization: Department of Pathology, Kamuzu University of Health Sciences, Pathology Department, Helse Nord Tuberculosis Initiative (HNTI), Kamuzu University of Health Sciences, Africa Centre for Public Health and Herbal Medicines (ACEPHEM), Kamuzu University of Health Sciences – sequence: 11 givenname: Derek surname: Sloan fullname: Sloan, Derek organization: Division of Infection and Global Health, School of Medicine, University of St Andrews – sequence: 12 givenname: Wilber surname: Sabiiti fullname: Sabiiti, Wilber email: ws31@st-andrews.ac.uk organization: Division of Infection and Global Health, School of Medicine, University of St Andrews |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38972907$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kktv3CAUhVGVqknT_IEuKqRuunELGAPupmqjPiJF6qKzRxiwh4kHpmD3kV_fm3GSJlmEDQjO-Thw73N0EFP0CL2k5C0ltXpXOG1aVRHGKyG4EtXlE3TECG8qVjN2cGd9iE5K2RAYDWs5bZ-hw1q1krVEHqGLH_Nul30pIUWcerxOZcKDjx77P7f7oWBTSrLBTN7h32Fa4xGWccKrTzjE3tsJZO-xwbsEjm702AUzRGAFi7uQtiZf-PwCPe3NWPzJ9XyMVl8-r06_Veffv56dfjyvbMPpVCnlFZOKGVqThpKuNrVjxHqmLLfcKWJb0XU9UUo5Q7vG0V4yS6kXnXWO1sfobMG6ZDZ6lwPc_lcnE_R-I-VBmwzBRq8dk7YjSjLVApn2RkriGqoIAz7hDFgfFtZu7rbeWXhzNuM96P2TGNZ6SL80pYwpUksgvLkm5PRz9mXS21CsH0cTfZqLrokUUnBOBEhfP5Bu0pwjfNVexYUSnIDq1d1It1luagoCtQhshmpk32sbJnNVIUgYRk2JvuogvXSQhg7S-w7Sl2BlD6w39EdN9WIqII6Dz_9jP-L6B6f82iM |
| CitedBy_id | crossref_primary_10_1038_s41598_024_77164_5 crossref_primary_10_2147_IDR_S485099 |
| Cites_doi | 10.12688/f1000research.19805.1 10.1186/s13098-021-00743-3 10.1038/s41598-017-12772-y 10.1091/mbc.e12-07-0558 10.1038/ni.3096 10.3389/fimmu.2021.668060 10.1183/09031936.00120908 10.1086/382030 10.1038/nature09247 10.1016/j.molcel.2022.03.038 10.1038/s41598-017-18547-9 10.1038/73208 10.1093/oxfordjournals.aje.a121593 10.1016/S0959-440X(00)00167-6 10.3390/ijms18112383 10.1371/journal.pone.0070630 10.1038/gene.2010.51 10.1128/JCM.00547-11 10.1016/j.tube.2021.102127 10.1038/s41423-020-0502-z 10.1016/S1473-3099(18)30355-4 10.1016/j.molcel.2014.12.015 10.1111/ajt.15841 10.1183/09031936.00196608 10.1016/j.biocel.2007.07.018 10.1016/S0955-0674(99)00075-7 10.3389/fimmu.2019.00221 10.1016/j.jinf.2017.09.012 10.1128/spectrum.02445-21 10.3389/fimmu.2019.02948 10.1186/s12859-015-0848-x 10.1073/pnas.1109201108 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2024 2024. The Author(s). The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s) 2024 – notice: 2024. The Author(s). – notice: The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI Q9U 7X8 5PM DOA |
| DOI | 10.1038/s41598-024-66486-z |
| DatabaseName | SpringerOpen Free (Free internet resource, activated by CARLI) CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Science Database Biological Science Database ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Open Access Full Text |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE - Academic MEDLINE Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature OA Free Journals (WRLC) url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 5 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2045-2322 |
| EndPage | 11 |
| ExternalDocumentID | oai_doaj_org_article_d27cb087289c4d1fa770d51802bf0042 PMC11228037 38972907 10_1038_s41598_024_66486_z |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: Helse Nord Tuberculosis Initiative (HNTI), Pathology Department, Kamuzu University of Health Sciences – fundername: Uganda Virus Research Institute, Entebbe, Uganda – fundername: School of Mathematics and Statistics, University of St Andrews, UK – fundername: Department of Pathology, Kamuzu University of Health Sciences – fundername: Adroit Biomedical and Bioentrepreneurship Research Service – fundername: Wellcome Trust Institutional Strategic Support fund of the University of St Andrews grantid: 204821/Z/16/Z; 204821/Z/16/Z – fundername: School of Medicine, University of St Andrews, UK – fundername: Africa Centre for Public Health and Herbal Medicines (ACEPHEM), Kamuzu University of Health Sciences – fundername: Wellcome Trust Institutional Strategic Support fund of the University of St Andrews grantid: 204821/Z/16/Z |
| GroupedDBID | 0R~ 3V. 4.4 53G 5VS 7X7 88A 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD ABDBF ABUWG ACGFS ACSMW ACUHS ADBBV ADRAZ AENEX AEUYN AFKRA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M0L M1P M2P M48 M7P M~E NAO OK1 PIMPY PQQKQ PROAC PSQYO RNT RNTTT RPM SNYQT UKHRP AASML AAYXX AFPKN CITATION PHGZM PHGZT CGR CUY CVF ECM EIF NPM PJZUB PPXIY PQGLB 7XB 8FK AARCD K9. PKEHL PQEST PQUKI Q9U 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c541t-88e82782a130510b3a3d20ce28c4c4d80c96bbf0888da1b5d1f72c11e6bcdd13 |
| IEDL.DBID | M48 |
| ISSN | 2045-2322 |
| IngestDate | Wed Aug 27 01:32:05 EDT 2025 Thu Aug 21 18:32:29 EDT 2025 Thu Sep 04 22:30:42 EDT 2025 Wed Aug 13 11:00:20 EDT 2025 Mon Jul 21 06:00:19 EDT 2025 Tue Jul 01 01:02:05 EDT 2025 Thu Apr 24 23:12:49 EDT 2025 Fri Feb 21 02:38:54 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | 2024. The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c541t-88e82782a130510b3a3d20ce28c4c4d80c96bbf0888da1b5d1f72c11e6bcdd13 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/s41598-024-66486-z |
| PMID | 38972907 |
| PQID | 3076468640 |
| PQPubID | 2041939 |
| PageCount | 11 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_d27cb087289c4d1fa770d51802bf0042 pubmedcentral_primary_oai_pubmedcentral_nih_gov_11228037 proquest_miscellaneous_3076764406 proquest_journals_3076468640 pubmed_primary_38972907 crossref_citationtrail_10_1038_s41598_024_66486_z crossref_primary_10_1038_s41598_024_66486_z springer_journals_10_1038_s41598_024_66486_z |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2024-07-07 |
| PublicationDateYYYYMMDD | 2024-07-07 |
| PublicationDate_xml | – month: 07 year: 2024 text: 2024-07-07 day: 07 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Scientific reports |
| PublicationTitleAbbrev | Sci Rep |
| PublicationTitleAlternate | Sci Rep |
| PublicationYear | 2024 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | Matsuura, Miyazaki, Miyazaki, Tashiro, Miyazaki (CR32) 2017; 7 Jodoin (CR39) 2012; 23 Pearson, Fleetwood, Eaton, Crossley, Bao (CR30) 2008; 40 Keyse (CR35) 2000; 12 CR19 Berry (CR17) 2010; 466 CR18 Burel (CR14) 2019; 10 CR12 Kung (CR36) 2000; 6 Filbeck, Cerullo, Pfeffer, Claudio (CR38) 2022; 82 Jha, Das (CR31) 2017; 18 Bade (CR40) 2021; 12 Burel (CR34) 2021; 131 Mack (CR1) 2009; 33 Maertzdorf (CR16) 2011; 12 Bloom (CR15) 2013 Chai, Wang, Liu, Ge (CR10) 2020; 17 Louie (CR4) 2004; 189 Batten, Mccune (CR5) 1957; 38 Zellweger, Sotgiu, Corradi, Durando (CR6) 2020; 111 Comstock, Livesay, Woolpert (CR2) 1974; 99 CR7 CR29 Laity, Lee, Wright (CR33) 2001; 11 Wang (CR9) 2015; 16 CR28 CR26 Francisco (CR25) 2017 Latorre (CR13) 2010; 35 CR24 CR23 CR22 CR21 Shao, Brown, Santhanam, Hegde (CR37) 2015; 57 CR20 CR42 Honeyborne (CR27) 2011; 49 Li (CR3) 2021; 13 Wong (CR41) 2018; 8 Sterling (CR8) 2020 Kaipilyawar, Salgame (CR43) 2019; 8 Abubakar (CR11) 2018; 18 66486_CR19 66486_CR18 SM Keyse (66486_CR35) 2000; 12 C Kung (66486_CR36) 2000; 6 I Abubakar (66486_CR11) 2018; 18 S Filbeck (66486_CR38) 2022; 82 GW Comstock (66486_CR2) 1974; 99 Q Chai (66486_CR10) 2020; 17 J Wang (66486_CR9) 2015; 16 U Mack (66486_CR1) 2009; 33 R Pearson (66486_CR30) 2008; 40 I Honeyborne (66486_CR27) 2011; 49 JC Batten (66486_CR5) 1957; 38 JN Jodoin (66486_CR39) 2012; 23 CI Bloom (66486_CR15) 2013 66486_CR24 66486_CR23 66486_CR22 66486_CR21 MPR Berry (66486_CR17) 2010; 466 66486_CR20 66486_CR42 NM Francisco (66486_CR25) 2017 T Matsuura (66486_CR32) 2017; 7 S Shao (66486_CR37) 2015; 57 66486_CR29 66486_CR28 JH Laity (66486_CR33) 2001; 11 J Maertzdorf (66486_CR16) 2011; 12 66486_CR26 P Jha (66486_CR31) 2017; 18 V Kaipilyawar (66486_CR43) 2019; 8 TR Sterling (66486_CR8) 2020 D Wong (66486_CR41) 2018; 8 LG Louie (66486_CR4) 2004; 189 I Latorre (66486_CR13) 2010; 35 JG Burel (66486_CR34) 2021; 131 JP Zellweger (66486_CR6) 2020; 111 M Li (66486_CR3) 2021; 13 66486_CR12 JG Burel (66486_CR14) 2019; 10 66486_CR7 P Bade (66486_CR40) 2021; 12 |
| References_xml | – volume: 8 start-page: 1 year: 2019 end-page: 13 ident: CR43 article-title: Infection resisters: Targets of new research for uncovering natural protective immunity against Mycobacterium tuberculosis publication-title: F1000Research doi: 10.12688/f1000research.19805.1 – ident: CR22 – volume: 13 start-page: 1 year: 2021 end-page: 8 ident: CR3 article-title: Global, regional, and national prevalence of diabetes mellitus in patients with pulmonary tuberculosis: A systematic review and meta-analysis publication-title: Diabetol. Metab. Syndr. doi: 10.1186/s13098-021-00743-3 – volume: 7 start-page: 1 year: 2017 end-page: 12 ident: CR32 article-title: Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin publication-title: Sci. Rep. doi: 10.1038/s41598-017-12772-y – volume: 23 start-page: 4713 year: 2012 end-page: 4724 ident: CR39 article-title: Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry publication-title: Mol. Biol. Cell doi: 10.1091/mbc.e12-07-0558 – ident: CR18 – volume: 16 start-page: 237 year: 2015 end-page: 245 ident: CR9 article-title: Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system publication-title: Nat. Immunol. doi: 10.1038/ni.3096 – volume: 12 start-page: 1 year: 2021 end-page: 14 ident: CR40 article-title: Integrative analysis of human macrophage inflammatory response related to mycobacterium tuberculosis virulence publication-title: Front. Immunol. doi: 10.3389/fimmu.2021.668060 – volume: 33 start-page: 956 year: 2009 end-page: 973 ident: CR1 article-title: LTBI Latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement publication-title: Eur. Respir. J. doi: 10.1183/09031936.00120908 – ident: CR12 – volume: 189 start-page: 1084 year: 2004 end-page: 1090 ident: CR4 article-title: Mycobacterium tuberculosis/HIV-1 coinfection and disease: Role of human leukocyte antigen variation publication-title: J. Infect. Dis. doi: 10.1086/382030 – volume: 466 start-page: 973 year: 2010 end-page: 977 ident: CR17 article-title: An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis publication-title: Nature doi: 10.1038/nature09247 – ident: CR29 – volume: 82 start-page: 1451 year: 2022 end-page: 1466 ident: CR38 article-title: Review mechanisms from bacteria to humans publication-title: Mol. Cell doi: 10.1016/j.molcel.2022.03.038 – volume: 8 start-page: 155 year: 2018 ident: CR41 article-title: Protein tyrosine kinase, PtkA, is required for Mycobacterium tuberculosis growth in macrophages publication-title: Sci Rep. doi: 10.1038/s41598-017-18547-9 – volume: 6 start-page: 343 year: 2000 end-page: 345 ident: CR36 article-title: Table 1 peripheral blood lymphocyte subpopulations publication-title: Nat. Med. doi: 10.1038/73208 – volume: 99 start-page: 131 year: 1974 end-page: 138 ident: CR2 article-title: The prognosis of a positive tuberculin reaction in childhood and adolescence publication-title: Am. J. Epidemiol. doi: 10.1093/oxfordjournals.aje.a121593 – ident: CR42 – ident: CR23 – volume: 11 start-page: 39 year: 2001 end-page: 46 ident: CR33 article-title: Zinc finger proteins: New insights into structural and functional diversity publication-title: Curr. Opin. Struct. Biol. doi: 10.1016/S0959-440X(00)00167-6 – volume: 18 start-page: 2383 year: 2017 ident: CR31 article-title: KLF2 in regulation of NF-κB-mediated immune cell function and inflammation publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms18112383 – year: 2013 ident: CR15 article-title: Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, Pneumonias and lung cancers publication-title: PLoS One doi: 10.1371/journal.pone.0070630 – ident: CR21 – volume: 12 start-page: 15 year: 2011 end-page: 22 ident: CR16 article-title: Human gene expression profiles of susceptibility and resistance in tuberculosis publication-title: Genes Immun. doi: 10.1038/gene.2010.51 – ident: CR19 – volume: 49 start-page: 3905 year: 2011 end-page: 3911 ident: CR27 article-title: Molecular bacterial load assay, a culture-free biomarker for rapid and accurate quantification of sputum Mycobacterium tuberculosis bacillary load during treatment publication-title: J. Clin. Microbiol. doi: 10.1128/JCM.00547-11 – volume: 131 start-page: 102127 year: 2021 ident: CR34 article-title: Distinct blood transcriptomic signature of treatment in latent tuberculosis infected individuals at risk of developing active disease publication-title: Tuberculosis doi: 10.1016/j.tube.2021.102127 – volume: 38 start-page: 424 year: 1957 end-page: 437 ident: CR5 article-title: The influence of corticotrophin and cortisone with antituberculous drugs on population of in tissues of mice publication-title: Br. J. Exp. Pathol. – volume: 111 start-page: 170 year: 2020 end-page: 183 ident: CR6 article-title: The diagnosis of latent tuberculosis infection (Ltbi): Currently available tests, future developments, and perspectives to eliminate tuberculosis (tb) publication-title: Med. del Lav. – volume: 17 start-page: 901 year: 2020 end-page: 913 ident: CR10 article-title: New insights into the evasion of host innate immunity by Mycobacterium tuberculosis publication-title: Cell. Mol. Immunol. doi: 10.1038/s41423-020-0502-z – volume: 18 start-page: 1077 year: 2018 end-page: 1087 ident: CR11 article-title: Prognostic value of interferon-γ release assays and tuberculin skin test in predicting the development of active tuberculosis (UK PREDICT TB): A prospective cohort study publication-title: Lancet Infect. Dis. doi: 10.1016/S1473-3099(18)30355-4 – volume: 57 start-page: 433 year: 2015 end-page: 444 ident: CR37 article-title: Structure and assembly pathway of the ribosome quality control complex publication-title: Mol. Cell doi: 10.1016/j.molcel.2014.12.015 – year: 2020 ident: CR8 article-title: Guidelines for the treatment of latent tuberculosis infection: Recommendations from the national tuberculosis controllers association and CDC, 2020 publication-title: Am. J. Transplant. doi: 10.1111/ajt.15841 – volume: 35 start-page: 338 year: 2010 end-page: 342 ident: CR13 article-title: Evaluating the non-tuberculous mycobacteria effect in the tuberculosis infection diagnosis publication-title: Eur. Respir. J. doi: 10.1183/09031936.00196608 – volume: 40 start-page: 1996 year: 2008 end-page: 2001 ident: CR30 article-title: Krüppel-like transcription factors: A functional family publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/j.biocel.2007.07.018 – ident: CR7 – volume: 12 start-page: 186 year: 2000 end-page: 192 ident: CR35 article-title: Protein phosphatases and the regulation of mitogen-activated protein kinase signalling publication-title: Curr. Opin. Cell Biol. doi: 10.1016/S0955-0674(99)00075-7 – volume: 10 start-page: 1 year: 2019 end-page: 12 ident: CR14 article-title: Host transcriptomics as a tool to identify diagnostic and mechanistic immune signatures of tuberculosis publication-title: Front. Immunol. doi: 10.3389/fimmu.2019.00221 – ident: CR28 – ident: CR26 – ident: CR24 – year: 2017 ident: CR25 article-title: Diagnostic accuracy of a selected signature gene set that discriminates active pulmonary tuberculosis and other pulmonary diseases publication-title: J. Infect. doi: 10.1016/j.jinf.2017.09.012 – ident: CR20 – volume: 189 start-page: 1084 year: 2004 ident: 66486_CR4 publication-title: J. Infect. Dis. doi: 10.1086/382030 – ident: 66486_CR20 doi: 10.1128/spectrum.02445-21 – volume: 131 start-page: 102127 year: 2021 ident: 66486_CR34 publication-title: Tuberculosis doi: 10.1016/j.tube.2021.102127 – ident: 66486_CR19 doi: 10.3389/fimmu.2019.02948 – volume: 23 start-page: 4713 year: 2012 ident: 66486_CR39 publication-title: Mol. Biol. Cell doi: 10.1091/mbc.e12-07-0558 – ident: 66486_CR24 – ident: 66486_CR26 – ident: 66486_CR28 – volume: 12 start-page: 15 year: 2011 ident: 66486_CR16 publication-title: Genes Immun. doi: 10.1038/gene.2010.51 – volume: 49 start-page: 3905 year: 2011 ident: 66486_CR27 publication-title: J. Clin. Microbiol. doi: 10.1128/JCM.00547-11 – volume: 33 start-page: 956 year: 2009 ident: 66486_CR1 publication-title: Eur. Respir. J. doi: 10.1183/09031936.00120908 – volume: 111 start-page: 170 year: 2020 ident: 66486_CR6 publication-title: Med. del Lav. – ident: 66486_CR22 – volume: 18 start-page: 2383 year: 2017 ident: 66486_CR31 publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms18112383 – volume: 7 start-page: 1 year: 2017 ident: 66486_CR32 publication-title: Sci. Rep. doi: 10.1038/s41598-017-12772-y – year: 2013 ident: 66486_CR15 publication-title: PLoS One doi: 10.1371/journal.pone.0070630 – volume: 57 start-page: 433 year: 2015 ident: 66486_CR37 publication-title: Mol. Cell doi: 10.1016/j.molcel.2014.12.015 – volume: 12 start-page: 1 year: 2021 ident: 66486_CR40 publication-title: Front. Immunol. doi: 10.3389/fimmu.2021.668060 – volume: 8 start-page: 155 year: 2018 ident: 66486_CR41 publication-title: Sci Rep. doi: 10.1038/s41598-017-18547-9 – volume: 11 start-page: 39 year: 2001 ident: 66486_CR33 publication-title: Curr. Opin. Struct. Biol. doi: 10.1016/S0959-440X(00)00167-6 – volume: 8 start-page: 1 year: 2019 ident: 66486_CR43 publication-title: F1000Research doi: 10.12688/f1000research.19805.1 – ident: 66486_CR29 – volume: 6 start-page: 343 year: 2000 ident: 66486_CR36 publication-title: Nat. Med. doi: 10.1038/73208 – ident: 66486_CR12 – volume: 18 start-page: 1077 year: 2018 ident: 66486_CR11 publication-title: Lancet Infect. Dis. doi: 10.1016/S1473-3099(18)30355-4 – ident: 66486_CR18 doi: 10.1186/s12859-015-0848-x – ident: 66486_CR42 doi: 10.1073/pnas.1109201108 – volume: 13 start-page: 1 year: 2021 ident: 66486_CR3 publication-title: Diabetol. Metab. Syndr. doi: 10.1186/s13098-021-00743-3 – volume: 466 start-page: 973 year: 2010 ident: 66486_CR17 publication-title: Nature doi: 10.1038/nature09247 – volume: 38 start-page: 424 year: 1957 ident: 66486_CR5 publication-title: Br. J. Exp. Pathol. – volume: 35 start-page: 338 year: 2010 ident: 66486_CR13 publication-title: Eur. Respir. J. doi: 10.1183/09031936.00196608 – volume: 12 start-page: 186 year: 2000 ident: 66486_CR35 publication-title: Curr. Opin. Cell Biol. doi: 10.1016/S0955-0674(99)00075-7 – volume: 82 start-page: 1451 year: 2022 ident: 66486_CR38 publication-title: Mol. Cell doi: 10.1016/j.molcel.2022.03.038 – volume: 10 start-page: 1 year: 2019 ident: 66486_CR14 publication-title: Front. Immunol. doi: 10.3389/fimmu.2019.00221 – volume: 16 start-page: 237 year: 2015 ident: 66486_CR9 publication-title: Nat. Immunol. doi: 10.1038/ni.3096 – ident: 66486_CR23 – ident: 66486_CR21 – ident: 66486_CR7 – year: 2020 ident: 66486_CR8 publication-title: Am. J. Transplant. doi: 10.1111/ajt.15841 – volume: 99 start-page: 131 year: 1974 ident: 66486_CR2 publication-title: Am. J. Epidemiol. doi: 10.1093/oxfordjournals.aje.a121593 – volume: 17 start-page: 901 year: 2020 ident: 66486_CR10 publication-title: Cell. Mol. Immunol. doi: 10.1038/s41423-020-0502-z – volume: 40 start-page: 1996 year: 2008 ident: 66486_CR30 publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/j.biocel.2007.07.018 – year: 2017 ident: 66486_CR25 publication-title: J. Infect. doi: 10.1016/j.jinf.2017.09.012 |
| SSID | ssj0000529419 |
| Score | 2.443968 |
| Snippet | The World Health Organization End TB strategy aims for a 90% reduction of tuberculosis (TB) incidence by 2035. Systematic testing and treatment of latent TB... Abstract The World Health Organization End TB strategy aims for a 90% reduction of tuberculosis (TB) incidence by 2035. Systematic testing and treatment of... |
| SourceID | doaj pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 15621 |
| SubjectTerms | 631/337/2019 692/53/2421 692/699/255/1856 Adolescent Adult Biomarkers Biomarkers - blood Case-Control Studies Female Gene expression Humanities and Social Sciences Humans Interferon-gamma Release Tests - methods Krueppel-like factor Latent Tuberculosis - blood Latent Tuberculosis - diagnosis Latent Tuberculosis - genetics Male Middle Aged multidisciplinary Science Science (multidisciplinary) Transcriptome Transcriptomics Tuberculosis Young Adult |
| SummonAdditionalLinks | – databaseName: DOAJ Open Access Full Text dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrR3LihQxsJAFwYv4ttdVInjTZpN0Og9vrrgsgp5G2FvIq3Fx6Fl2ZkH3660kPe2Oz4u3JqnQoR6pqqQeAC9QwEzvnWlD7_tWdCq1LtKulVz0xic_sNIb8MNHefJJvD_tT6-1-soxYbU8cEXcYeQqeKoVOgZBRDY4pWjsc90yP2SOy6cvNfSaM1WrenMjmJmyZGinD9eoqXI2GRetlELL9mpHE5WC_b-zMn8NlvzpxbQoouM7cHuyIMmbuvO7cCON9-Bm7Sn57T58yX06a3DrSFYDyVkcBLkkkfR1Hj9bEzfRJUWS72LJEj_HDVkckW181viaOHK-ykKzTCTWmDz8Kckp-zmq5-IBLI7fLd6etFNHBSSFYJtW66Q52gQONRcKo-9cFzkNiesgELuaBiM94hXd4uiY7xHfigfGkvQhRtY9hL1xNabHQIxQygT0dQRS1XnuqOkojU4l9IDcMDTAtsi1Yao2npteLG159e60rQSxSBBbCGKvGng5rzmvtTb-Cn2UaTZD5jrZZQC5x07cY__FPQ0cbCluJ-FdWzz2pJBaCtrA83kaxS6_pbgxrS4rDEKhOdTAo8og807QBkSXhaoG9A7r7Gx1d2Y8-1xKe6P1m9uF4dJXWy77sa8_42L_f-DiCdziWTzK3fUB7G0uLtNTtLg2_lkRru8l4Cay priority: 102 providerName: Directory of Open Access Journals – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3di9QwEA96Ivgifls9JYJvWi5p0yT1RTzxOAR9WmHfQr6qh0u77u6B3l_vTJr2WD_urbQpTfqbSSYzk_kR8hIUrG2cbUvfuKYUtYqlDawuZSWa1kXX8cQN-OmzPP0iPi6bZXa4bXNa5TQnpok6DB595Ecgi1JILQV7u_5RImsURlczhcZ1coODJYLUDWqpZh8LRrEEb_NZGVbroy2sV3imrBKllELL8mJvPUpl-_9la_6dMvlH3DQtRyd3yO1sR9J3I_B3ybXY3yM3R2bJX_fJd2TrHFNcezp0FM9yUJCVSOPP-f7ZltqMTgwUPbJ0BZf9ji6O6ZSl1b-hlq4HVJ1VpGHMzIOPUjy4j7k9mwdkcfJh8f60zLwKAIjgu1LrqCuwDCysX6CSrrZ1qJiPlfbCi6CZb6VzHcw_OljumsA7VXnOo3Q-BF4_JAf90MfHhLZCqdbDjkcAttZVlgEILFgVYR9ku64gfPq5xuea40h9sTIp9l1rMwJiABCTADEXBXk1v7MeK25c2foYMZtbYrXsdGPYfDVZ-UyolHdMK9hcwvh4Z5ViocHadzBKmLUKcjghbrIKb82lwBXkxfwYlA8jKraPw_nYBlqBUVSQR6OAzD0BSxA2LkwVRO-Jzl5X95_0Z99SgW-wgZE0DF59PUnZZb_-_y-eXD2Mp-RWhYKffNOH5GC3OY_PwKLauedJbX4DeSoe7g priority: 102 providerName: ProQuest – databaseName: Springer Nature HAS Fully OA dbid: AAJSJ link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlR3LihQxsFhnEbyIb1tXieBNG5N0Okl7mxWXZUAvjrC3kFfr4tCzzMyC7tdbST9kdBW8NUmFTlKPVCX1AHiJDNbUzjalr11dikrF0gZalZKLunHRtSzXBvzwUZ5-Fouz-uwA-BgLk532c0rLLKZH77A3WzxoUjAYF6WUQsvy6gYcaoXidwaH8_ni02K6WUlvV4I1Q4QMrfQ1g_dOoZys_zoN809Hyd9eS_MhdHIHbg_aI5n3870LB7G7Bzf7epI_7sO3VKOzd2ztyLolKYKDIIVEEr9P7edbYgecxEDSPSxZ4We3I8tjMvpmdW-JJRfrxDCrSELvj4c_JSlcP3n0bB7A8uT98t1pOVRTQDQItiu1jpqjPmDx1EJGdJWtAqc-cu2FF0FT30jnWpQ6Oljm6sBaxT1jUTofAqsewqxbd_ExkEYo1Xi0cwRi1DpuaVNRGqyKaP3Yti2AjZtr_JBpPBW8WJn84l1p0yPEIEJMRoi5KuDVNOaiz7PxT-jjhLMJMuXIzg3rzRcz0IwJXHlHtUKTEtfHWqsUDXXKeIerRFlVwNGIcTMw7tagyJNCailoAS-mbmS59I5iu7i-7GEQClWhAh71BDLNBPU_NFeoKkDvkc7eVPd7uvOvOa03ar6pVBgOfT1S2a95_X0vnvwf-FO4xRMj5BvqI5jtNpfxGepVO_d8YKSfslYewQ priority: 102 providerName: Springer Nature |
| Title | Suppression of host gene expression is associated with latent TB infection: a possible diagnostic biomarker |
| URI | https://link.springer.com/article/10.1038/s41598-024-66486-z https://www.ncbi.nlm.nih.gov/pubmed/38972907 https://www.proquest.com/docview/3076468640 https://www.proquest.com/docview/3076764406 https://pubmed.ncbi.nlm.nih.gov/PMC11228037 https://doaj.org/article/d27cb087289c4d1fa770d51802bf0042 |
| Volume | 14 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrR1db9Mw8LQPIfGC-CbbqIzEGwQSx7EdJITaatNUiQlBJ_UtsmMHJqpktJ207ddztpOiQuGJp0TOWbHvw76z7wPgJQpYkWtVxFWu85hlwsbKJFnMKcsLbXWd-tqAH8_46TmbzPLZDvTljjoELreadq6e1Pli_ub6x80HFPj3IWRcvl3iJuQCxSiLOWeSx7e7sO_vi5wrX6fuh1zftGBp0cXObO-6sT_5NP7bdM8_XSh_u0f129PJfbjX6ZVkGBjhAezY5iHcCZUmbx7Bd1e9M7i8NqStiYvtIMg7ltjrdfvFkqiOWtYQd0JL5vjarMh0RHqvreYdUeSydaI0t8QETz38KXGB_M7XZ_EYpifH0_Fp3NVZQAKxdBVLaSVFTUEhxlBEdaYyQ5PKUlmxihmZVAXXusb1SBqV6tyktaBVmlquK2PS7AnsNW1jnwEpmBBFhRYQQ1orTVVSZElilLBoF6m6jiDtkVtWXQ5yVwpjXvq78EyWgSAlEqT0BClvI3i17nMZMnD8E3rkaLaGdNmzfUO7-Fp2wlgaKiqdSIHGJs4vrZUQicldLjycJa5iERz1FC97jixxMeSMS86SCF6sP6MwuhsW1dj2KsAgFCpJETwNDLIeCWqGaMgkIgK5wTobQ9380lx88wm_USd2RcSw6-uey36N6--4OPgfuDiEu9SJhz_RPoK91eLKPkc9bKUHsCtmYgD7w-HkywSfo-OzT5-xdczHA3-2MfDi9xM2kjTw |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3JbtQw9KlMheCC2AkUMBKcIKrjOImDVCEGWk1pO0JokHqzvIVWHSXDzFTQ_hv_xnO2alh66y1KnMT2W_z2B_ASCSxPtMpDk-gk5HHmQmVpHKaMJ7l2uojq3oAH43T0lX86TA7X4FeXC-PDKjueWDNqWxlvI99EXEx5KlJO382-h75rlPeudi00VNtawW7VJcbaxI49d_YDVbjF1u5HhPcrxna2Jx9GYdtlAKfHo2UohBMMz0mF3BwRVMcqtowax4ThhltBTZ5qXSA1CqsindioyJiJIpdqY20U42evwTr39pMBrA-3x5-_9EYe70bjUd4m69BYbC7wwPRJbYyHacpFGp6vHIh134B_Cbt_x2z-4bitz8Od23CrFWTJ-wbz7sCaK-_C9aa15dk9OPHtQpsY25JUBfHJJASR1RH3s79_vCCqRQ9niTcJkylelksyGZIuTKx8SxSZVZ52p47YJjQQf0p85QAfXDS_D5Or2PIHMCir0j0CkvMsyw2qXByRS2mmaB5TalXmUBFTRRFA1G2uNG3Rc997Yypr53ssZAMQiQCRNUDkeQCv-3dmTcmPS0cPPcz6kb5cd32jmn-TLfVLyzKjqchQu8X1RYXKMmoTX3wPV4lsM4CNDuKy5SELeYHxAbzoHyP1e5eOKl112ozBUSiVBfCwQZB-JiiKouZEswDECuqsTHX1SXl8VFcYRyHcdy3DV990WHYxr__vxePLl_EcbowmB_tyf3e89wRuMk8EtaF8AwbL-al7iuLdUj9riYiAvGKy_Q3T92Hy |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3bbtMw1BqbQLwg7gQGGAmeIKrjOLGDNCHKVm0MqgkVaW-Wb2HTqqS0nWD7Q_6K48TJVC5721uUOIntc_e5IfQSCKzItCpik-ksZil3sbIkjXPKskI7XSZNb8DP43z3K_t4mB2uoV9dLowPq-x4YsOobW38GfkAcDFnucgZGZQhLOJge_Ru9j32HaS8p7Vrp6FCmwW71ZQbC0ke--7sB5hzi629bYD9K0pHO5MPu3HoOABTZckyFsIJCjJTAWcHZNWpSi0lxlFhmGFWEFPkWpdAmcKqRGc2KTk1SeJybaxNUvjsNbTBQeiDHbgx3BkffOkPfLxLjSVFSNwhqRgsQHj6BDfK4jxnIo_PV4Rj00PgX4rv3_GbfzhxG9k4uo1uBaUWv2-x8A5ac9VddL1tc3l2D5341qFtvG2F6xL7xBIMiOuw-9nfP15gFVDFWeyPh_EULqslngxxFzJWvcUKz2pPx1OHbRsmCD_FvoqADzSa30eTq9jyB2i9qiv3COGCcV4YML8YIJrSVJEiJcQq7sAoU2UZoaTbXGlCAXTfh2MqG0d8KmQLEAkAkQ1A5HmEXvfvzNryH5eOHnqY9SN96e7mRj3_JgMnkJZyo4ngYOnC-pJScU5s5gvxwSqBhUZos4O4DPxkIS-wP0Iv-sfACbx7R1WuPm3HwCjQ0CL0sEWQfiagloIVRXiExArqrEx19Ul1fNRUGweF3Hcwg1ffdFh2Ma__78Xjy5fxHN0A8pWf9sb7T9BN6mmgOTPfROvL-al7CpreUj8LNISRvGKq_Q2SumY2 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Suppression+of+host+gene+expression+is+associated+with+latent+TB+infection%3A+a+possible+diagnostic+biomarker&rft.jtitle=Scientific+reports&rft.au=Ritah+Nakiboneka&rft.au=Nicol%C3%B2+Margaritella&rft.au=Tonney+Nyirenda&rft.au=David+Chaima&rft.date=2024-07-07&rft.pub=Nature+Portfolio&rft.eissn=2045-2322&rft.volume=14&rft.issue=1&rft.spage=1&rft.epage=11&rft_id=info:doi/10.1038%2Fs41598-024-66486-z&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_d27cb087289c4d1fa770d51802bf0042 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon |