Quinolinate promotes macrophage-induced immune tolerance in glioblastoma through the NMDAR/PPARγ signaling axis - Kesarwani, Pravin; Kant, Shiva; Zhao, Yi; Prabhu, Antony; Buelow, Katie L.; Miller, C. Ryan; Chinnaiyan, Prakash (Nature communications, 2023)
Keywords: 13/1; 13/105; 13/106; 13/31; 13/51; 13/89; 38; 49/15; 59; 631/67/1922; 631/67/2327; 631/67/580; 64; 64/60; Accumulation; Animals; Biological Products - metabolism; Brain; Brain cancer; Brain Neoplasms - pathology; Brain tumors; Cell activation; FOXO1 protein; Genetic engineering; Glioblastoma; Glioblastoma - genetics; Glutamate receptors; Glutamic acid receptors (ionotropic); Humanities and Social Sciences; Immune Tolerance; Immunological tolerance; Macrophages; Macrophages - metabolism; Metabolism; Metabolomics; Mice; Microenvironments; multidisciplinary; N-Methyl-D-aspartic acid receptors; Neurodegenerative diseases; Neurodegenerative Diseases - metabolism; Peroxisome proliferator-activated receptors; Phenotypes; PPAR gamma - metabolism; Quinolinic Acid - metabolism; Receptor mechanisms; Receptors, N-Methyl-D-Aspartate - metabolism; Science; Science (multidisciplinary); Signaling; Therapeutic targets; Tryptophan; Tryptophan - metabolism; Tumor Microenvironment; Tumorigenesis; Tumors; Upstream