A potential role for the gut microbiome in substance use disorders

Pathological substance use disorders represent a major public health crisis with limited effective treatment options. While much work has been done to understand the neuronal signaling networks and intracellular signaling cascades associated with prolonged drug use, these studies have yielded few su...

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Bibliographic Details
Published inPsychopharmacology Vol. 236; no. 5; pp. 1513 - 1530
Main Authors Meckel, Katherine R., Kiraly, Drew D.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2019
Springer
Springer Nature B.V
Subjects
Addiction
Amino acids
Analgesics, Opioid - adverse effects
Animal models
Animals
Biomedical and Life Sciences
Biomedicine
Digestive system
Drug abuse
Drug addiction
Drug use
Dysbacteriosis
Dysbiosis - chemically induced
Dysbiosis - immunology
Dysbiosis - metabolism
Dysbiosis - psychology
Ethanol - adverse effects
Gastric Mucosa - drug effects
Gastric Mucosa - immunology
Gastric Mucosa - metabolism
Gastrointestinal Microbiome - drug effects
Gastrointestinal Microbiome - physiology
Gut microbiota
Health aspects
Humans
Illegal drugs
Illicit Drugs - adverse effects
Immune system
Immune System - drug effects
Immune System - immunology
Immune System - metabolism
Immunosuppressive agents
Intestinal microflora
Intracellular signalling
Metabolites
Microbiomes
Microbiota
Neurons
Neurosciences
Pharmacology/Toxicology
Psychiatry
Public health
Public health movements
Review
Substance abuse
Substance use disorder
Substance-Related Disorders - immunology
Substance-Related Disorders - metabolism
Substance-Related Disorders - psychology
Microbiota
Addiction
Metabolites
Gut-brain
Opioid
Alcohol
Cocaine
Dysbiosis
Microbiome
Online AccessGet full text
ISSN0033-3158
1432-2072
1432-2072
DOI10.1007/s00213-019-05232-0

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Abstract Pathological substance use disorders represent a major public health crisis with limited effective treatment options. While much work has been done to understand the neuronal signaling networks and intracellular signaling cascades associated with prolonged drug use, these studies have yielded few successful treatment options for substance use disorders. In recent years, there has been a growing interest to explore interactions between the peripheral immune system, the gut microbiome, and the CNS. In this review, we will present a summary of existing evidence, suggesting a potential role for gut dysbiosis in the pathogenesis of substance use disorders. Clinical evidence of gut dysbiosis in human subjects with substance use disorder and preclinical evidence of gut dysbiosis in animal models of drug addiction are discussed in detail. Additionally, we examine how changes in the gut microbiome and its metabolites may not only be a consequence of substance use disorders but may in fact play a role in mediating behavioral response to drugs of abuse. While much work still needs to be done, understanding the interplay of gut microbiome in substance use disorders may offer a promising avenue for future therapeutic development.
AbstractList Pathological substance use disorders represent a major public health crisis with limited effective treatment options. While much work has been done to understand the neuronal signaling networks and intracellular signaling cascades associated with prolonged drug use, these studies have yielded few successful treatment options for substance use disorders. In recent years, there has been a growing interest to explore interactions between the peripheral immune system, the gut microbiome, and the CNS. In this review, we will present a summary of existing evidence, suggesting a potential role for gut dysbiosis in the pathogenesis of substance use disorders. Clinical evidence of gut dysbiosis in human subjects with substance use disorder and preclinical evidence of gut dysbiosis in animal models of drug addiction are discussed in detail. Additionally, we examine how changes in the gut microbiome and its metabolites may not only be a consequence of substance use disorders but may in fact play a role in mediating behavioral response to drugs of abuse. While much work still needs to be done, understanding the interplay of gut microbiome in substance use disorders may offer a promising avenue for future therapeutic development.
Pathological substance use disorders represent a major public health crisis with limited effective treatment options. While much work has been done to understand the neuronal signaling networks and intracellular signaling cascades associated with prolonged drug use, these studies have yielded few successful treatment options for substance use disorders. In recent years, there has been a growing interest to explore interactions between the peripheral immune system, the gut microbiome and the CNS. In this review we will present a summary of existing evidence, suggesting a potential role for gut dysbiosis in the pathogenesis of substance use disorders. Clinical evidence of gut dysbiosis in human subjects with substance use disorder as well as preclinical evidence of gut dysbiosis in animal models of drug addiction are discussed in detail. Additionally, we examine how changes in the gut microbiome and its metabolites may not only be a consequence of substance use disorders but may in fact play a role in mediating behavioral response to drugs of abuse. While much work still needs to be done, understanding the interplay of gut microbiome in substance use disorders may offers a promising avenue for future therapeutic development.
Pathological substance use disorders represent a major public health crisis with limited effective treatment options. While much work has been done to understand the neuronal signaling networks and intracellular signaling cascades associated with prolonged drug use, these studies have yielded few successful treatment options for substance use disorders. In recent years, there has been a growing interest to explore interactions between the peripheral immune system, the gut microbiome, and the CNS. In this review, we will present a summary of existing evidence, suggesting a potential role for gut dysbiosis in the pathogenesis of substance use disorders. Clinical evidence of gut dysbiosis in human subjects with substance use disorder and preclinical evidence of gut dysbiosis in animal models of drug addiction are discussed in detail. Additionally, we examine how changes in the gut microbiome and its metabolites may not only be a consequence of substance use disorders but may in fact play a role in mediating behavioral response to drugs of abuse. While much work still needs to be done, understanding the interplay of gut microbiome in substance use disorders may offer a promising avenue for future therapeutic development.Pathological substance use disorders represent a major public health crisis with limited effective treatment options. While much work has been done to understand the neuronal signaling networks and intracellular signaling cascades associated with prolonged drug use, these studies have yielded few successful treatment options for substance use disorders. In recent years, there has been a growing interest to explore interactions between the peripheral immune system, the gut microbiome, and the CNS. In this review, we will present a summary of existing evidence, suggesting a potential role for gut dysbiosis in the pathogenesis of substance use disorders. Clinical evidence of gut dysbiosis in human subjects with substance use disorder and preclinical evidence of gut dysbiosis in animal models of drug addiction are discussed in detail. Additionally, we examine how changes in the gut microbiome and its metabolites may not only be a consequence of substance use disorders but may in fact play a role in mediating behavioral response to drugs of abuse. While much work still needs to be done, understanding the interplay of gut microbiome in substance use disorders may offer a promising avenue for future therapeutic development.
Audience Academic
Author Meckel, Katherine R.
Kiraly, Drew D.
AuthorAffiliation 2 Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029
3 Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York. 10029
1 Fishberg Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029
AuthorAffiliation_xml – name: 1 Fishberg Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029
– name: 3 Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York. 10029
– name: 2 Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029
Author_xml – sequence: 1
  givenname: Katherine R.
  surname: Meckel
  fullname: Meckel, Katherine R.
  organization: Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
– sequence: 2
  givenname: Drew D.
  orcidid: 0000-0002-4818-5169
  surname: Kiraly
  fullname: Kiraly, Drew D.
  email: drew.kiraly@mssm.edu
  organization: Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, Department of Psychiatry, Icahn School of Medicine at Mount Sinai
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30982128$$D View this record in MEDLINE/PubMed
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Keywords Microbiota
Addiction
Metabolites
Gut-brain
Opioid
Alcohol
Cocaine
Dysbiosis
Microbiome
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Snippet Pathological substance use disorders represent a major public health crisis with limited effective treatment options. While much work has been done to...
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StartPage 1513
SubjectTerms Addiction
Amino acids
Analgesics, Opioid - adverse effects
Animal models
Animals
Biomedical and Life Sciences
Biomedicine
Digestive system
Drug abuse
Drug addiction
Drug use
Dysbacteriosis
Dysbiosis - chemically induced
Dysbiosis - immunology
Dysbiosis - metabolism
Dysbiosis - psychology
Ethanol - adverse effects
Gastric Mucosa - drug effects
Gastric Mucosa - immunology
Gastric Mucosa - metabolism
Gastrointestinal Microbiome - drug effects
Gastrointestinal Microbiome - physiology
Gut microbiota
Health aspects
Humans
Illegal drugs
Illicit Drugs - adverse effects
Immune system
Immune System - drug effects
Immune System - immunology
Immune System - metabolism
Immunosuppressive agents
Intestinal microflora
Intracellular signalling
Metabolites
Microbiomes
Microbiota
Neurons
Neurosciences
Pharmacology/Toxicology
Psychiatry
Public health
Public health movements
Review
Substance abuse
Substance use disorder
Substance-Related Disorders - immunology
Substance-Related Disorders - metabolism
Substance-Related Disorders - psychology
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Title A potential role for the gut microbiome in substance use disorders
URI https://link.springer.com/article/10.1007/s00213-019-05232-0
https://www.ncbi.nlm.nih.gov/pubmed/30982128
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