Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer

γδ T cells are a distinct subgroup of T cells that bridge the innate and adaptive immune system and can attack cancer cells in an MHC-unrestricted manner. Trials of adoptive γδ T cell transfer in solid tumors have had limited success. Here, we show that DNA methyltransferase inhibitors (DNMTis) upre...

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Published inNature communications Vol. 12; no. 1; pp. 2163 - 18
Main Authors Weng, Rueyhung R., Lu, Hsuan-Hsuan, Lin, Chien-Ting, Fan, Chia-Chi, Lin, Rong-Shan, Huang, Tai-Chung, Lin, Shu-Yung, Huang, Yi-Jhen, Juan, Yi-Hsiu, Wu, Yi-Chieh, Hung, Zheng-Ci, Liu, Chi, Lin, Xuan-Hui, Hsieh, Wan-Chen, Chiu, Tzu-Yuan, Liao, Jung-Chi, Chiu, Yen-Ling, Chen, Shih-Yu, Yu, Chong-Jen, Tsai, Hsing-Chen
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 12.04.2021
Nature Publishing Group
Nature Portfolio
Subjects
13/2
13/21
13/31
14/19
38/39
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631/250/1619/554/2509
631/337/176
631/67/580
64/60
692/4028/67/1612
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Actin
Actin Cytoskeleton - drug effects
Actin Cytoskeleton - metabolism
Adaptive systems
Adhesion
Animals
Cell activation
Cell adhesion molecules
Cell Line, Tumor
Chromatin
Clinical trials
Combinatorial analysis
Cytoskeleton
Cytoskeleton - drug effects
Cytoskeleton - metabolism
Cytotoxicity
Cytotoxicity, Immunologic - drug effects
Cytotoxicity, Immunologic - genetics
Decitabine - pharmacology
Deoxyribonucleic acid
Depletion
DNA
DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors
DNA (Cytosine-5-)-Methyltransferases - metabolism
DNA methylation
DNA methyltransferase
Enzyme Inhibitors - pharmacology
Epigenesis, Genetic - drug effects
Epigenetics
Gene Expression Regulation, Neoplastic - drug effects
Humanities and Social Sciences
Humans
Immune system
Immunological Synapses - drug effects
Immunological Synapses - genetics
Immunotherapy
Inhibitors
Isotope Labeling
Lung cancer
Lung Neoplasms - genetics
Lung Neoplasms - immunology
Lymphocyte Activation - drug effects
Lymphocyte Activation - genetics
Lymphocyte Subsets - drug effects
Lymphocyte Subsets - metabolism
Lymphocytes
Lymphocytes T
Lysis
Major histocompatibility complex
Male
Mice
Mice, Inbred NOD
multidisciplinary
Phosphotyrosine - metabolism
Proteomics
Receptors, Antigen, T-Cell, gamma-delta - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Science
Science (multidisciplinary)
Solid tumors
Subgroups
Survival Analysis
Synapses
Toxicity
Tumor Suppressor Protein p53 - metabolism
Tumors
Up-Regulation - drug effects
Xenograft Model Antitumor Assays
Online AccessGet full text
ISSN2041-1723
2041-1723
DOI10.1038/s41467-021-22433-4

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Abstract γδ T cells are a distinct subgroup of T cells that bridge the innate and adaptive immune system and can attack cancer cells in an MHC-unrestricted manner. Trials of adoptive γδ T cell transfer in solid tumors have had limited success. Here, we show that DNA methyltransferase inhibitors (DNMTis) upregulate surface molecules on cancer cells related to γδ T cell activation using quantitative surface proteomics. DNMTi treatment of human lung cancer potentiates tumor lysis by ex vivo-expanded Vδ1-enriched γδ T cells. Mechanistically, DNMTi enhances immune synapse formation and mediates cytoskeletal reorganization via coordinated alterations of DNA methylation and chromatin accessibility. Genetic depletion of adhesion molecules or pharmacological inhibition of actin polymerization abolishes the potentiating effect of DNMTi. Clinically, the DNMTi-associated cytoskeleton signature stratifies lung cancer patients prognostically. These results support a combinatorial strategy of DNMTis and γδ T cell-based immunotherapy in lung cancer management. Gamma delta (γδ) T cells have potential for use in immunotherapy against tumours. Here, the authors demonstrate that treatment of tumours with DNA methyltransferase inhibitors modulates cytoskeleton arrangements, upregulates adhesion molecules and increases tumour killing by γδ T cells.
AbstractList γδ T cells are a distinct subgroup of T cells that bridge the innate and adaptive immune system and can attack cancer cells in an MHC-unrestricted manner. Trials of adoptive γδ T cell transfer in solid tumors have had limited success. Here, we show that DNA methyltransferase inhibitors (DNMTis) upregulate surface molecules on cancer cells related to γδ T cell activation using quantitative surface proteomics. DNMTi treatment of human lung cancer potentiates tumor lysis by ex vivo-expanded Vδ1-enriched γδ T cells. Mechanistically, DNMTi enhances immune synapse formation and mediates cytoskeletal reorganization via coordinated alterations of DNA methylation and chromatin accessibility. Genetic depletion of adhesion molecules or pharmacological inhibition of actin polymerization abolishes the potentiating effect of DNMTi. Clinically, the DNMTi-associated cytoskeleton signature stratifies lung cancer patients prognostically. These results support a combinatorial strategy of DNMTis and γδ T cell-based immunotherapy in lung cancer management.Gamma delta (γδ) T cells have potential for use in immunotherapy against tumours. Here, the authors demonstrate that treatment of tumours with DNA methyltransferase inhibitors modulates cytoskeleton arrangements, upregulates adhesion molecules and increases tumour killing by γδ T cells.
γδ T cells are a distinct subgroup of T cells that bridge the innate and adaptive immune system and can attack cancer cells in an MHC-unrestricted manner. Trials of adoptive γδ T cell transfer in solid tumors have had limited success. Here, we show that DNA methyltransferase inhibitors (DNMTis) upregulate surface molecules on cancer cells related to γδ T cell activation using quantitative surface proteomics. DNMTi treatment of human lung cancer potentiates tumor lysis by ex vivo-expanded Vδ1-enriched γδ T cells. Mechanistically, DNMTi enhances immune synapse formation and mediates cytoskeletal reorganization via coordinated alterations of DNA methylation and chromatin accessibility. Genetic depletion of adhesion molecules or pharmacological inhibition of actin polymerization abolishes the potentiating effect of DNMTi. Clinically, the DNMTi-associated cytoskeleton signature stratifies lung cancer patients prognostically. These results support a combinatorial strategy of DNMTis and γδ T cell-based immunotherapy in lung cancer management. Gamma delta (γδ) T cells have potential for use in immunotherapy against tumours. Here, the authors demonstrate that treatment of tumours with DNA methyltransferase inhibitors modulates cytoskeleton arrangements, upregulates adhesion molecules and increases tumour killing by γδ T cells.
γδ T cells are a distinct subgroup of T cells that bridge the innate and adaptive immune system and can attack cancer cells in an MHC-unrestricted manner. Trials of adoptive γδ T cell transfer in solid tumors have had limited success. Here, we show that DNA methyltransferase inhibitors (DNMTis) upregulate surface molecules on cancer cells related to γδ T cell activation using quantitative surface proteomics. DNMTi treatment of human lung cancer potentiates tumor lysis by ex vivo-expanded Vδ1-enriched γδ T cells. Mechanistically, DNMTi enhances immune synapse formation and mediates cytoskeletal reorganization via coordinated alterations of DNA methylation and chromatin accessibility. Genetic depletion of adhesion molecules or pharmacological inhibition of actin polymerization abolishes the potentiating effect of DNMTi. Clinically, the DNMTi-associated cytoskeleton signature stratifies lung cancer patients prognostically. These results support a combinatorial strategy of DNMTis and γδ T cell-based immunotherapy in lung cancer management.
Gamma delta (γδ) T cells have potential for use in immunotherapy against tumours. Here, the authors demonstrate that treatment of tumours with DNA methyltransferase inhibitors modulates cytoskeleton arrangements, upregulates adhesion molecules and increases tumour killing by γδ T cells.
γδ T cells are a distinct subgroup of T cells that bridge the innate and adaptive immune system and can attack cancer cells in an MHC-unrestricted manner. Trials of adoptive γδ T cell transfer in solid tumors have had limited success. Here, we show that DNA methyltransferase inhibitors (DNMTis) upregulate surface molecules on cancer cells related to γδ T cell activation using quantitative surface proteomics. DNMTi treatment of human lung cancer potentiates tumor lysis by ex vivo-expanded Vδ1-enriched γδ T cells. Mechanistically, DNMTi enhances immune synapse formation and mediates cytoskeletal reorganization via coordinated alterations of DNA methylation and chromatin accessibility. Genetic depletion of adhesion molecules or pharmacological inhibition of actin polymerization abolishes the potentiating effect of DNMTi. Clinically, the DNMTi-associated cytoskeleton signature stratifies lung cancer patients prognostically. These results support a combinatorial strategy of DNMTis and γδ T cell-based immunotherapy in lung cancer management.γδ T cells are a distinct subgroup of T cells that bridge the innate and adaptive immune system and can attack cancer cells in an MHC-unrestricted manner. Trials of adoptive γδ T cell transfer in solid tumors have had limited success. Here, we show that DNA methyltransferase inhibitors (DNMTis) upregulate surface molecules on cancer cells related to γδ T cell activation using quantitative surface proteomics. DNMTi treatment of human lung cancer potentiates tumor lysis by ex vivo-expanded Vδ1-enriched γδ T cells. Mechanistically, DNMTi enhances immune synapse formation and mediates cytoskeletal reorganization via coordinated alterations of DNA methylation and chromatin accessibility. Genetic depletion of adhesion molecules or pharmacological inhibition of actin polymerization abolishes the potentiating effect of DNMTi. Clinically, the DNMTi-associated cytoskeleton signature stratifies lung cancer patients prognostically. These results support a combinatorial strategy of DNMTis and γδ T cell-based immunotherapy in lung cancer management.
ArticleNumber 2163
Author Tsai, Hsing-Chen
Lin, Xuan-Hui
Chiu, Yen-Ling
Huang, Yi-Jhen
Lu, Hsuan-Hsuan
Lin, Chien-Ting
Wu, Yi-Chieh
Juan, Yi-Hsiu
Hung, Zheng-Ci
Huang, Tai-Chung
Lin, Shu-Yung
Chen, Shih-Yu
Chiu, Tzu-Yuan
Liu, Chi
Lin, Rong-Shan
Weng, Rueyhung R.
Liao, Jung-Chi
Fan, Chia-Chi
Yu, Chong-Jen
Hsieh, Wan-Chen
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/33846331$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1158/2326-6066.CIR-19-0404
10.3389/fimmu.2019.02836
10.1101/gr.208108.116
10.3389/fimmu.2018.01239
10.1002/cyto.a.23283
10.1186/1471-2105-12-323
10.1093/bioinformatics/btp324
10.1186/s13059-016-1066-1
10.1016/j.cell.2017.06.007
10.1093/bioinformatics/btu049
10.1158/2326-6066.CIR-18-0647
10.1093/bioinformatics/btu170
10.1158/1078-0432.CCR-16-0597
10.1186/s13059-014-0550-8
10.1016/j.ccr.2011.12.029
10.3389/fimmu.2019.00661
10.1002/eji.201243150
10.4161/2162402X.2014.973808
10.1080/2162402X.2015.1006088
10.1016/j.iotech.2019.06.002
10.1074/mcp.M112.025205
10.1016/j.ymthe.2017.12.001
10.3389/fimmu.2018.00851
10.1016/j.cell.2017.10.022
10.1016/j.cell.2015.07.056
10.1016/j.clim.2016.07.012
10.1158/1078-0432.CCR-13-3451
10.1080/2162402X.2017.1284723
10.1038/sj.onc.1207232
10.4049/jimmunol.1102165
10.1016/j.jprot.2012.07.009
10.1080/2162402X.2019.1648170
10.1158/2159-8290.CD-11-0214
10.1182/blood-2011-12-398321
10.1038/nprot.2015.020
10.3389/fimmu.2018.01808
10.1186/gb-2008-9-9-r137
10.1146/annurev-med-062315-120245
10.1093/nar/gks1147
10.1182/blood-2011-02-339135
10.1016/j.cell.2015.07.011
10.1038/nmeth.1923
10.1016/j.cell.2018.12.040
10.1371/journal.pcbi.1003118
10.1038/nmeth.3863
10.1186/s12864-018-4559-3
10.1038/s41571-019-0266-5
10.18632/oncotarget.1542
10.1038/nmeth.4396
10.1016/j.intimp.2011.01.001
10.1093/bioinformatics/btv145
10.1016/j.immuni.2020.02.014
10.1038/nri3384
10.1038/s41596-019-0128-8
10.18632/oncotarget.1782
10.2741/3961
10.1165/ajrcmb.17.3.2837
10.1038/nprot.2016.136
10.4161/onci.27572
10.1016/S1074-7613(01)00095-4
10.3389/fimmu.2018.01601
10.4161/epi.23470
10.1128/MCB.25.11.4727-4741.2005
10.3389/fimmu.2018.00929
10.1080/2162402X.2016.1237328
10.1038/s41577-019-0218-4
10.3389/fimmu.2018.00377
10.1038/s41573-019-0038-z
10.1002/cyto.a.22271
10.1124/mol.65.1.18
10.3389/fimmu.2018.00512
10.1002/pmic.201300309
10.1038/s41590-018-0304-y
10.1016/j.immuni.2019.09.006
10.3389/fimmu.2018.00617
10.1093/nar/gkw257
10.1158/0008-5472.CAN-15-2125
10.1038/ni.3518
10.1126/science.285.5428.727
10.3389/fimmu.2018.01409
10.4161/2162402X.2014.992749
10.1074/mcp.M200025-MCP200
10.1073/pnas.1314975111
10.1371/journal.pone.0179501
10.4049/jimmunol.170.6.2862
10.1038/s41568-019-0153-5
10.1126/scisignal.aai9062
10.13172/2052-9295-1-1-432
10.12688/f1000research.7796.1
10.14806/ej.17.1.200
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References Woan, Miller (CR1) 2019; 7
Wrangle (CR12) 2013; 4
Han (CR78) 2017; 91
Siebenkas (CR10) 2017; 12
Ghoneim (CR53) 2017; 170
Markoutsa (CR73) 2014; 14
Corces (CR43) 2017; 14
Craig (CR41) 2012; 17
CR34
Li, Dewey (CR81) 2011; 12
Ong (CR14) 2002; 1
CR31
CR75
Mi (CR24) 2019; 14
Vantourout, Hayday (CR4) 2013; 13
Karhemo (CR70) 2012; 77
Guillerey, Huntington, Smyth (CR25) 2016; 17
Lawrence (CR83) 2013; 9
Ding (CR45) 2012; 120
Minetto (CR55) 2019; 10
Ou (CR90) 2018; 19
Philipsen (CR32) 2013; 12
Deniger (CR59) 2014; 20
Samusik, Good, Spitzer, Davis, Nolan (CR79) 2016; 13
Niu (CR68) 2018; 9
Roulois (CR51) 2015; 162
Langmead, Salzberg (CR82) 2012; 9
Pidsley (CR87) 2016; 17
Correia (CR27) 2011; 118
Karpf (CR50) 2004; 65
Bauer (CR16) 1999; 285
Willcox, Willcox (CR36) 2019; 20
Di Lorenzo (CR28) 2019; 7
CR88
Li, Durbin (CR89) 2009; 25
Silva-Santos, Mensurado, Coffelt (CR7) 2019; 19
Zunder (CR76) 2015; 10
CR40
Chiappinelli (CR9) 2015; 162
Tsai (CR15) 2012; 21
Topper (CR52) 2017; 171
Li (CR29) 2011; 11
Juergens (CR49) 2011; 1
Wang, El-Deiry (CR22) 2003; 22
Blazquez, Benyamine, Pasero, Olive (CR35) 2018; 9
Aryee (CR85) 2014; 30
Wilde (CR44) 2012; 189
Tyanova, Temu, Cox (CR72) 2016; 11
Sebestyen, Prinz, Dechanet-Merville, Silva-Santos, Kuball (CR3) 2020; 19
Fisher, Heuijerjans, Yan, Gustafsson, Anderson (CR5) 2014; 3
Mondragon, Kroemer, Galluzzi (CR60) 2016; 5
McCann (CR38) 2003; 170
Wu (CR58) 2015; 4
Almeida (CR26) 2016; 22
Kabelitz (CR6) 2016; 172
Finck (CR77) 2013; 83
Li (CR11) 2014; 5
Ghoshal (CR13) 2005; 25
Jin (CR61) 2019; 176
Dokouhaki (CR30) 2013; 43
Fisher, Anderson (CR62) 2018; 9
Kalbasi, Ribas (CR54) 2020; 20
Zhang (CR91) 2008; 9
Chiappinelli, Zahnow, Ahuja, Baylin (CR48) 2016; 76
Wang (CR64) 2018; 9
Bhat, Kabelitz (CR65) 2015; 4
CR94
Topper, Vaz, Marrone, Brahmer, Baylin (CR8) 2020; 17
Lin, Crockett, Lim, Elenitoba-Johnson (CR71) 2003; 14
Fisher, Kramer, Gustafsson, Anderson (CR57) 2015; 4
Tosolini (CR47) 2017; 6
Simoes, Di Lorenzo, Silva-Santos (CR20) 2018; 9
Karunakaran (CR33) 2020; 52
Bolger, Lohse, Usadel (CR80) 2014; 30
Frazao (CR21) 2019; 10
De Groot (CR46) 2019; 8
Bhat, Kouakanou, Peters, Yin, Kabelitz (CR66) 2018; 9
Yu, Wang, He (CR92) 2015; 31
Chen (CR86) 2013; 8
Si, Lv, Zhou, Hu (CR74) 2015; 8
Love, Huber, Anders (CR84) 2014; 15
Newick, O’Brien, Moon, Albelda (CR2) 2017; 68
Cai (CR42) 2017; 27
Ramirez (CR93) 2016; 44
Chu (CR69) 1997; 17
Nussbaumer, Koslowski (CR56) 2019; 1
Sheppard, Ferry, Guedes, Guerra (CR19) 2018; 9
Mace, Orange (CR39) 2014; 111
Wang (CR67) 2018; 9
Capsomidis (CR63) 2018; 26
Breuer (CR23) 2013; 41
Silva-Santos, Strid (CR17) 2018; 9
Willcox (CR37) 2019; 51
Cosman (CR18) 2001; 14
S Wilde (22433_CR44) 2012; 189
A Capsomidis (22433_CR63) 2018; 26
B Langmead (22433_CR82) 2012; 9
22433_CR40
HE Ghoneim (22433_CR53) 2017; 170
22433_CR88
H Li (22433_CR89) 2009; 25
K Ghoshal (22433_CR13) 2005; 25
SE Ong (22433_CR14) 2002; 1
R De Groot (22433_CR46) 2019; 8
J Bhat (22433_CR66) 2018; 9
Z Sebestyen (22433_CR3) 2020; 19
N Samusik (22433_CR79) 2016; 13
AR Almeida (22433_CR26) 2016; 22
C Guillerey (22433_CR25) 2016; 17
JL Blazquez (22433_CR35) 2018; 9
M Tosolini (22433_CR47) 2017; 6
G Han (22433_CR78) 2017; 91
PR Karhemo (22433_CR70) 2012; 77
B Silva-Santos (22433_CR17) 2018; 9
FE McCann (22433_CR38) 2003; 170
KV Woan (22433_CR1) 2019; 7
KB Chiappinelli (22433_CR48) 2016; 76
YW Chu (22433_CR69) 1997; 17
C Jin (22433_CR61) 2019; 176
S Wang (22433_CR22) 2003; 22
Z Wang (22433_CR64) 2018; 9
R Pidsley (22433_CR87) 2016; 17
S Sheppard (22433_CR19) 2018; 9
LL Si (22433_CR74) 2015; 8
D Kabelitz (22433_CR6) 2016; 172
MJ Topper (22433_CR52) 2017; 171
22433_CR34
22433_CR31
22433_CR75
MM Karunakaran (22433_CR33) 2020; 52
DV Correia (22433_CR27) 2011; 118
D Cosman (22433_CR18) 2001; 14
F Ramirez (22433_CR93) 2016; 44
HC Tsai (22433_CR15) 2012; 21
EM Mace (22433_CR39) 2014; 111
DC Deniger (22433_CR59) 2014; 20
Z Lin (22433_CR71) 2003; 14
MI Love (22433_CR84) 2014; 15
K Breuer (22433_CR23) 2013; 41
D Wu (22433_CR58) 2015; 4
J Fisher (22433_CR62) 2018; 9
Y Cai (22433_CR42) 2017; 27
D Roulois (22433_CR51) 2015; 162
RA Juergens (22433_CR49) 2011; 1
AM Bolger (22433_CR80) 2014; 30
O Nussbaumer (22433_CR56) 2019; 1
P Vantourout (22433_CR4) 2013; 13
G Yu (22433_CR92) 2015; 31
YA Chen (22433_CR86) 2013; 8
L Philipsen (22433_CR32) 2013; 12
B Silva-Santos (22433_CR7) 2019; 19
MJ Topper (22433_CR8) 2020; 17
H Li (22433_CR11) 2014; 5
KB Chiappinelli (22433_CR9) 2015; 162
B Li (22433_CR81) 2011; 12
ER Zunder (22433_CR76) 2015; 10
AW Craig (22433_CR41) 2012; 17
C Siebenkas (22433_CR10) 2017; 12
K Newick (22433_CR2) 2017; 68
CR Willcox (22433_CR37) 2019; 51
H Mi (22433_CR24) 2019; 14
J Wrangle (22433_CR12) 2013; 4
S Tyanova (22433_CR72) 2016; 11
J Fisher (22433_CR57) 2015; 4
A Frazao (22433_CR21) 2019; 10
A Kalbasi (22433_CR54) 2020; 20
22433_CR94
AR Karpf (22433_CR50) 2004; 65
Y Zhang (22433_CR91) 2008; 9
JP Fisher (22433_CR5) 2014; 3
S Bauer (22433_CR16) 1999; 285
ZC Ding (22433_CR45) 2012; 120
L Mondragon (22433_CR60) 2016; 5
B Di Lorenzo (22433_CR28) 2019; 7
P Dokouhaki (22433_CR30) 2013; 43
AE Simoes (22433_CR20) 2018; 9
MR Corces (22433_CR43) 2017; 14
J Ou (22433_CR90) 2018; 19
BE Willcox (22433_CR36) 2019; 20
C Niu (22433_CR68) 2018; 9
M Lawrence (22433_CR83) 2013; 9
S Wang (22433_CR67) 2018; 9
S Markoutsa (22433_CR73) 2014; 14
J Bhat (22433_CR65) 2015; 4
MJ Aryee (22433_CR85) 2014; 30
Z Li (22433_CR29) 2011; 11
R Finck (22433_CR77) 2013; 83
P Minetto (22433_CR55) 2019; 10
References_xml – volume: 7
  start-page: 1742
  year: 2019
  end-page: 1747
  ident: CR1
  article-title: Harnessing natural killer cell antitumor immunity: from the bench to bedside
  publication-title: Cancer Immunol. Res.
  doi: 10.1158/2326-6066.CIR-19-0404
– volume: 10
  start-page: 2836
  year: 2019
  ident: CR55
  article-title: Harnessing NK cells for cancer treatment
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2019.02836
– volume: 27
  start-page: 533
  year: 2017
  end-page: 544
  ident: CR42
  article-title: Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells
  publication-title: Genome Res.
  doi: 10.1101/gr.208108.116
– volume: 9
  start-page: 1239
  year: 2018
  ident: CR64
  article-title: Decitabine enhances Vgamma9Vdelta2 T cell-mediated cytotoxic effects on osteosarcoma cells via the NKG2DL-NKG2D axis
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.01239
– volume: 91
  start-page: 1150
  year: 2017
  end-page: 1163
  ident: CR78
  article-title: Atomic mass tag of bismuth-209 for increasing the immunoassay multiplexing capacity of mass cytometry
  publication-title: Cytometry A
  doi: 10.1002/cyto.a.23283
– volume: 12
  year: 2011
  ident: CR81
  article-title: RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
  publication-title: BMC Bioinformatics
  doi: 10.1186/1471-2105-12-323
– volume: 25
  start-page: 1754
  year: 2009
  end-page: 1760
  ident: CR89
  article-title: Fast and accurate short read alignment with Burrows-Wheeler transform
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp324
– volume: 17
  year: 2016
  ident: CR87
  article-title: Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-1066-1
– volume: 170
  start-page: 142
  year: 2017
  end-page: 157
  ident: CR53
  article-title: De novo epigenetic programs inhibit PD-1 blockade-mediated T cell rejuvenation
  publication-title: Cell
  doi: 10.1016/j.cell.2017.06.007
– volume: 30
  start-page: 1363
  year: 2014
  end-page: 1369
  ident: CR85
  article-title: Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu049
– volume: 7
  start-page: 552
  year: 2019
  end-page: 558
  ident: CR28
  article-title: Broad cytotoxic targeting of acute myeloid leukemia by polyclonal delta one T cells
  publication-title: Cancer Immunol. Res.
  doi: 10.1158/2326-6066.CIR-18-0647
– volume: 30
  start-page: 2114
  year: 2014
  end-page: 2120
  ident: CR80
  article-title: Trimmomatic: a flexible trimmer for Illumina sequence data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu170
– volume: 22
  start-page: 5795
  year: 2016
  end-page: 5804
  ident: CR26
  article-title: Delta One T cells for immunotherapy of chronic lymphocytic leukemia: clinical-grade expansion/differentiation and preclinical proof of concept
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-16-0597
– volume: 15
  year: 2014
  ident: CR84
  article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0550-8
– volume: 21
  start-page: 430
  year: 2012
  end-page: 446
  ident: CR15
  article-title: Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2011.12.029
– volume: 10
  start-page: 661
  year: 2019
  ident: CR21
  article-title: NKG2D/NKG2-ligand pathway offers new opportunities in cancer treatment
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2019.00661
– volume: 43
  start-page: 3175
  year: 2013
  end-page: 3182
  ident: CR30
  article-title: NKG2D regulates production of soluble TRAIL by ex vivo expanded human gammadelta T cells
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.201243150
– volume: 4
  start-page: e973808
  year: 2015
  ident: CR57
  article-title: Non-V delta 2 gamma delta T lymphocytes as effectors of cancer immunotherapy
  publication-title: Oncoimmunology
  doi: 10.4161/2162402X.2014.973808
– volume: 4
  start-page: e1006088
  year: 2015
  ident: CR65
  article-title: gammadelta T cells and epigenetic drugs: A useful merger in cancer immunotherapy?
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2015.1006088
– volume: 1
  start-page: 3
  year: 2019
  end-page: 10
  ident: CR56
  article-title: The emerging role of γδ T cells in cancer immunotherapy
  publication-title: Immuno-Oncol. Technol.
  doi: 10.1016/j.iotech.2019.06.002
– volume: 12
  start-page: 2551
  year: 2013
  end-page: 2567
  ident: CR32
  article-title: Multimolecular analysis of stable immunological synapses reveals sustained recruitment and sequential assembly of signaling clusters
  publication-title: Mol. Cell Proteomics
  doi: 10.1074/mcp.M112.025205
– volume: 26
  start-page: 354
  year: 2018
  end-page: 365
  ident: CR63
  article-title: Chimeric antigen receptor-engineered human gamma delta T cells: enhanced cytotoxicity with retention of cross presentation
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2017.12.001
– volume: 9
  start-page: 851
  year: 2018
  ident: CR17
  article-title: Working in “NK Mode”: natural killer group 2 member D and natural cytotoxicity receptors in stress-surveillance by gammadelta T cells
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.00851
– volume: 171
  start-page: 1284
  year: 2017
  end-page: 1300
  ident: CR52
  article-title: Epigenetic therapy ties MYC depletion to reversing immune evasion and treating lung cancer
  publication-title: Cell
  doi: 10.1016/j.cell.2017.10.022
– ident: CR75
– volume: 162
  start-page: 961
  year: 2015
  end-page: 973
  ident: CR51
  article-title: DNA-demethylating agents target colorectal cancer cells by inducing viral mimicry by endogenous transcripts
  publication-title: Cell
  doi: 10.1016/j.cell.2015.07.056
– ident: CR88
– volume: 172
  start-page: 90
  year: 2016
  end-page: 97
  ident: CR6
  article-title: Human gammadelta T cells: from a neglected lymphocyte population to cellular immunotherapy: a personal reflection of 30years of gammadelta T cell research
  publication-title: Clin. Immunol.
  doi: 10.1016/j.clim.2016.07.012
– volume: 20
  start-page: 5708
  year: 2014
  end-page: 5719
  ident: CR59
  article-title: Activating and propagating polyclonal gamma delta T cells with broad specificity for malignancies
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-13-3451
– volume: 6
  start-page: e1284723
  year: 2017
  ident: CR47
  article-title: Assessment of tumor-infiltrating TCRVgamma9Vdelta2 gammadelta lymphocyte abundance by deconvolution of human cancers microarrays
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2017.1284723
– volume: 22
  start-page: 8628
  year: 2003
  end-page: 8633
  ident: CR22
  article-title: TRAIL and apoptosis induction by TNF-family death receptors
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1207232
– volume: 189
  start-page: 598
  year: 2012
  end-page: 605
  ident: CR44
  article-title: Human antitumor CD8+ T cells producing Th1 polycytokines show superior antigen sensitivity and tumor recognition
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1102165
– volume: 77
  start-page: 87
  year: 2012
  end-page: 100
  ident: CR70
  article-title: An optimized isolation of biotinylated cell surface proteins reveals novel players in cancer metastasis
  publication-title: J. Proteom.
  doi: 10.1016/j.jprot.2012.07.009
– volume: 8
  start-page: e1648170
  year: 2019
  ident: CR46
  article-title: Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2019.1648170
– volume: 1
  start-page: 598
  year: 2011
  end-page: 607
  ident: CR49
  article-title: Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-11-0214
– volume: 120
  start-page: 2229
  year: 2012
  end-page: 2239
  ident: CR45
  article-title: Polyfunctional CD4(+) T cells are essential for eradicating advanced B-cell lymphoma after chemotherapy
  publication-title: Blood
  doi: 10.1182/blood-2011-12-398321
– volume: 10
  start-page: 316
  year: 2015
  end-page: 333
  ident: CR76
  article-title: Palladium-based mass tag cell barcoding with a doublet-filtering scheme and single-cell deconvolution algorithm
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2015.020
– volume: 9
  start-page: 1808
  year: 2018
  ident: CR19
  article-title: The paradoxical role of NKG2D in cancer immunity
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.01808
– volume: 9
  year: 2008
  ident: CR91
  article-title: Model-based analysis of ChIP-Seq (MACS)
  publication-title: Genome Biol.
  doi: 10.1186/gb-2008-9-9-r137
– volume: 68
  start-page: 139
  year: 2017
  end-page: 152
  ident: CR2
  article-title: CAR T cell therapy for solid tumors
  publication-title: Annu. Rev. Med.
  doi: 10.1146/annurev-med-062315-120245
– volume: 41
  start-page: D1228
  year: 2013
  end-page: D1233
  ident: CR23
  article-title: InnateDB: systems biology of innate immunity and beyond-recent updates and continuing curation
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gks1147
– volume: 118
  start-page: 992
  year: 2011
  end-page: 1001
  ident: CR27
  article-title: Differentiation of human peripheral blood Vdelta1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells
  publication-title: Blood
  doi: 10.1182/blood-2011-02-339135
– volume: 162
  start-page: 974
  year: 2015
  end-page: 986
  ident: CR9
  article-title: Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses
  publication-title: Cell
  doi: 10.1016/j.cell.2015.07.011
– volume: 9
  start-page: 357
  year: 2012
  end-page: 359
  ident: CR82
  article-title: Fast gapped-read alignment with Bowtie 2
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1923
– volume: 176
  start-page: 998
  year: 2019
  end-page: 1013
  ident: CR61
  article-title: Commensal microbiota promote lung cancer development via gammadelta T cells
  publication-title: Cell
  doi: 10.1016/j.cell.2018.12.040
– volume: 8
  start-page: 6540
  year: 2015
  end-page: 6546
  ident: CR74
  article-title: Establishment and identification of human primary lung cancer cell culture in vitro
  publication-title: Int J. Clin. Exp. Pathol.
– volume: 9
  start-page: e1003118
  year: 2013
  ident: CR83
  article-title: Software for computing and annotating genomic ranges
  publication-title: PLoS Comput. Biol.
  doi: 10.1371/journal.pcbi.1003118
– volume: 13
  start-page: 493
  year: 2016
  end-page: 496
  ident: CR79
  article-title: Automated mapping of phenotype space with single-cell data
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3863
– volume: 19
  year: 2018
  ident: CR90
  article-title: ATACseqQC: a Bioconductor package for post-alignment quality assessment of ATAC-seq data
  publication-title: BMC Genomics
  doi: 10.1186/s12864-018-4559-3
– volume: 17
  start-page: 75
  year: 2020
  end-page: 90
  ident: CR8
  article-title: The emerging role of epigenetic therapeutics in immuno-oncology
  publication-title: Nat. Rev. Clin. Oncol.
  doi: 10.1038/s41571-019-0266-5
– volume: 4
  start-page: 2067
  year: 2013
  end-page: 2079
  ident: CR12
  article-title: Alterations of immune response of non-small cell lung cancer with azacytidine
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.1542
– volume: 14
  start-page: 959
  year: 2017
  end-page: 962
  ident: CR43
  article-title: An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.4396
– volume: 11
  start-page: 496
  year: 2011
  end-page: 503
  ident: CR29
  article-title: IFN-gamma enhances HOS and U2OS cell lines susceptibility to gammadelta T cell-mediated killing through the Fas/Fas ligand pathway
  publication-title: Int. Immunopharmacol.
  doi: 10.1016/j.intimp.2011.01.001
– volume: 31
  start-page: 2382
  year: 2015
  end-page: 2383
  ident: CR92
  article-title: ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btv145
– volume: 52
  start-page: 487
  year: 2020
  end-page: 498
  ident: CR33
  article-title: Butyrophilin-2A1 directly binds germline-encoded regions of the Vgamma9Vdelta2 TCR and is essential for phosphoantigen sensing
  publication-title: Immunity
  doi: 10.1016/j.immuni.2020.02.014
– volume: 13
  start-page: 88
  year: 2013
  end-page: 100
  ident: CR4
  article-title: Six-of-the-best: unique contributions of gammadelta T cells to immunology
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3384
– volume: 14
  start-page: 703
  year: 2019
  end-page: 721
  ident: CR24
  article-title: Protocol Update for large-scale genome and gene function analysis with the PANTHER classification system (v.14.0)
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-019-0128-8
– volume: 5
  start-page: 587
  year: 2014
  end-page: 598
  ident: CR11
  article-title: Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.1782
– ident: CR40
– volume: 17
  start-page: 861
  year: 2012
  end-page: 875
  ident: CR41
  article-title: FES/FER kinase signaling in hematopoietic cells and leukemias
  publication-title: Front. Biosci.
  doi: 10.2741/3961
– volume: 17
  start-page: 353
  year: 1997
  end-page: 360
  ident: CR69
  article-title: Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/ajrcmb.17.3.2837
– volume: 11
  start-page: 2301
  year: 2016
  end-page: 2319
  ident: CR72
  article-title: The MaxQuant computational platform for mass spectrometry-based shotgun proteomics
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2016.136
– volume: 19
  start-page: 392
  year: 2019
  end-page: 404
  ident: CR7
  article-title: gammadelta T cells: pleiotropic immune effectors with therapeutic potential in cancer
  publication-title: Nat. Rev. Cancer
– ident: CR94
– volume: 3
  start-page: e27572
  year: 2014
  ident: CR5
  article-title: gammadelta T cells for cancer immunotherapy: A systematic review of clinical trials
  publication-title: Oncoimmunology
  doi: 10.4161/onci.27572
– volume: 14
  start-page: 123
  year: 2001
  end-page: 133
  ident: CR18
  article-title: ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor
  publication-title: Immunity
  doi: 10.1016/S1074-7613(01)00095-4
– volume: 9
  start-page: 1601
  year: 2018
  ident: CR35
  article-title: New insights into the regulation of gammadelta T cells by BTN3A and other BTN/BTNL in tumor immunity
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.01601
– volume: 8
  start-page: 203
  year: 2013
  end-page: 209
  ident: CR86
  article-title: Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray
  publication-title: Epigenetics
  doi: 10.4161/epi.23470
– volume: 25
  start-page: 4727
  year: 2005
  end-page: 4741
  ident: CR13
  article-title: 5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.25.11.4727-4741.2005
– volume: 9
  start-page: 929
  year: 2018
  ident: CR20
  article-title: Molecular determinants of target cell recognition by human gammadelta T cells
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.00929
– volume: 5
  start-page: e1237328
  year: 2016
  ident: CR60
  article-title: Immunosuppressive gammadelta T cells foster pancreatic carcinogenesis
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2016.1237328
– ident: CR31
– volume: 20
  start-page: 25
  year: 2020
  end-page: 39
  ident: CR54
  article-title: Tumour-intrinsic resistance to immune checkpoint blockade
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/s41577-019-0218-4
– volume: 9
  start-page: 377
  year: 2018
  ident: CR67
  article-title: Valproic acid combined with zoledronate enhance gammadelta T cell-mediated cytotoxicity against osteosarcoma cells via the accumulation of mevalonate pathway intermediates
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.00377
– volume: 14
  start-page: 149
  year: 2003
  end-page: 155
  ident: CR71
  article-title: High-throughput analysis of protein/peptide complexes by immunoprecipitation and automated LC-MS/MS
  publication-title: J. Biomol. Tech.
– volume: 19
  start-page: 169
  year: 2020
  end-page: 184
  ident: CR3
  article-title: Translating gammadelta (gammadelta) T cells and their receptors into cancer cell therapies
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/s41573-019-0038-z
– volume: 83
  start-page: 483
  year: 2013
  end-page: 494
  ident: CR77
  article-title: Normalization of mass cytometry data with bead standards
  publication-title: Cytometry A
  doi: 10.1002/cyto.a.22271
– volume: 65
  start-page: 18
  year: 2004
  end-page: 27
  ident: CR50
  article-title: Limited gene activation in tumor and normal epithelial cells treated with the DNA methyltransferase inhibitor 5-aza-2’-deoxycytidine
  publication-title: Mol. Pharmacol.
  doi: 10.1124/mol.65.1.18
– volume: 9
  start-page: 512
  year: 2018
  ident: CR66
  article-title: Immunotherapy with human gamma delta T cells-synergistic potential of epigenetic drugs?
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.00512
– volume: 14
  start-page: 659
  year: 2014
  end-page: 667
  ident: CR73
  article-title: Sulfo-NHS-SS-biotin derivatization: a versatile tool for MALDI mass analysis of PTMs in lysine-rich proteins
  publication-title: Proteomics
  doi: 10.1002/pmic.201300309
– ident: CR34
– volume: 20
  start-page: 121
  year: 2019
  end-page: 128
  ident: CR36
  article-title: gammadelta TCR ligands: the quest to solve a 500-million-year-old mystery
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-018-0304-y
– volume: 51
  start-page: 813
  year: 2019
  end-page: 825
  ident: CR37
  article-title: Butyrophilin-like 3 directly binds a human Vgamma4(+) T cell receptor using a modality distinct from clonally-restricted antigen
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.09.006
– volume: 9
  start-page: 617
  year: 2018
  ident: CR68
  article-title: Decitabine inhibits gamma delta T cell cytotoxicity by promoting KIR2DL2/3 expression
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.00617
– volume: 44
  start-page: W160
  year: 2016
  end-page: W165
  ident: CR93
  article-title: deepTools2: a next generation web server for deep-sequencing data analysis
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkw257
– volume: 76
  start-page: 1683
  year: 2016
  end-page: 1689
  ident: CR48
  article-title: Combining epigenetic and immunotherapy to combat cancer
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-15-2125
– volume: 17
  start-page: 1025
  year: 2016
  end-page: 1036
  ident: CR25
  article-title: Targeting natural killer cells in cancer immunotherapy
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3518
– volume: 285
  start-page: 727
  year: 1999
  end-page: 729
  ident: CR16
  article-title: Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
  publication-title: Science
  doi: 10.1126/science.285.5428.727
– volume: 9
  start-page: 1409
  year: 2018
  ident: CR62
  article-title: Engineering approaches in human gamma delta T cells for cancer immunotherapy
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.01409
– volume: 4
  start-page: e992749
  year: 2015
  ident: CR58
  article-title: Ex vivo expanded human circulating Vdelta1 gammadeltaT cells exhibit favorable therapeutic potential for colon cancer
  publication-title: Oncoimmunology
  doi: 10.4161/2162402X.2014.992749
– volume: 1
  start-page: 376
  year: 2002
  end-page: 386
  ident: CR14
  article-title: Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics
  publication-title: Mol. Cell Proteomics
  doi: 10.1074/mcp.M200025-MCP200
– volume: 111
  start-page: 6708
  year: 2014
  end-page: 6713
  ident: CR39
  article-title: Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1314975111
– volume: 12
  start-page: e0179501
  year: 2017
  ident: CR10
  article-title: Inhibiting DNA methylation activates cancer testis antigens and expression of the antigen processing and presentation machinery in colon and ovarian cancer cells
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0179501
– volume: 170
  start-page: 2862
  year: 2003
  end-page: 2870
  ident: CR38
  article-title: The size of the synaptic cleft and distinct distributions of filamentous actin, ezrin, CD43, and CD45 at activating and inhibitory human NK cell immune synapses
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.170.6.2862
– volume: 118
  start-page: 992
  year: 2011
  ident: 22433_CR27
  publication-title: Blood
  doi: 10.1182/blood-2011-02-339135
– volume: 19
  start-page: 392
  year: 2019
  ident: 22433_CR7
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-019-0153-5
– volume: 285
  start-page: 727
  year: 1999
  ident: 22433_CR16
  publication-title: Science
  doi: 10.1126/science.285.5428.727
– volume: 14
  start-page: 123
  year: 2001
  ident: 22433_CR18
  publication-title: Immunity
  doi: 10.1016/S1074-7613(01)00095-4
– volume: 9
  start-page: 617
  year: 2018
  ident: 22433_CR68
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.00617
– volume: 44
  start-page: W160
  year: 2016
  ident: 22433_CR93
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkw257
– ident: 22433_CR75
  doi: 10.1126/scisignal.aai9062
– volume: 83
  start-page: 483
  year: 2013
  ident: 22433_CR77
  publication-title: Cytometry A
  doi: 10.1002/cyto.a.22271
– volume: 17
  start-page: 75
  year: 2020
  ident: 22433_CR8
  publication-title: Nat. Rev. Clin. Oncol.
  doi: 10.1038/s41571-019-0266-5
– volume: 13
  start-page: 88
  year: 2013
  ident: 22433_CR4
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3384
– volume: 41
  start-page: D1228
  year: 2013
  ident: 22433_CR23
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gks1147
– volume: 1
  start-page: 376
  year: 2002
  ident: 22433_CR14
  publication-title: Mol. Cell Proteomics
  doi: 10.1074/mcp.M200025-MCP200
– volume: 21
  start-page: 430
  year: 2012
  ident: 22433_CR15
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2011.12.029
– volume: 25
  start-page: 4727
  year: 2005
  ident: 22433_CR13
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.25.11.4727-4741.2005
– volume: 5
  start-page: e1237328
  year: 2016
  ident: 22433_CR60
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2016.1237328
– volume: 26
  start-page: 354
  year: 2018
  ident: 22433_CR63
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2017.12.001
– volume: 9
  start-page: e1003118
  year: 2013
  ident: 22433_CR83
  publication-title: PLoS Comput. Biol.
  doi: 10.1371/journal.pcbi.1003118
– volume: 11
  start-page: 496
  year: 2011
  ident: 22433_CR29
  publication-title: Int. Immunopharmacol.
  doi: 10.1016/j.intimp.2011.01.001
– volume: 9
  start-page: 1409
  year: 2018
  ident: 22433_CR62
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.01409
– volume: 65
  start-page: 18
  year: 2004
  ident: 22433_CR50
  publication-title: Mol. Pharmacol.
  doi: 10.1124/mol.65.1.18
– volume: 162
  start-page: 961
  year: 2015
  ident: 22433_CR51
  publication-title: Cell
  doi: 10.1016/j.cell.2015.07.056
– ident: 22433_CR94
– volume: 22
  start-page: 8628
  year: 2003
  ident: 22433_CR22
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1207232
– volume: 30
  start-page: 1363
  year: 2014
  ident: 22433_CR85
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu049
– volume: 14
  start-page: 959
  year: 2017
  ident: 22433_CR43
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.4396
– volume: 9
  start-page: 377
  year: 2018
  ident: 22433_CR67
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.00377
– volume: 9
  start-page: 357
  year: 2012
  ident: 22433_CR82
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1923
– volume: 170
  start-page: 2862
  year: 2003
  ident: 22433_CR38
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.170.6.2862
– volume: 4
  start-page: 2067
  year: 2013
  ident: 22433_CR12
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.1542
– volume: 20
  start-page: 121
  year: 2019
  ident: 22433_CR36
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-018-0304-y
– volume: 17
  year: 2016
  ident: 22433_CR87
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-1066-1
– volume: 77
  start-page: 87
  year: 2012
  ident: 22433_CR70
  publication-title: J. Proteom.
  doi: 10.1016/j.jprot.2012.07.009
– volume: 4
  start-page: e973808
  year: 2015
  ident: 22433_CR57
  publication-title: Oncoimmunology
  doi: 10.4161/2162402X.2014.973808
– volume: 6
  start-page: e1284723
  year: 2017
  ident: 22433_CR47
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2017.1284723
– ident: 22433_CR40
  doi: 10.13172/2052-9295-1-1-432
– volume: 10
  start-page: 661
  year: 2019
  ident: 22433_CR21
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2019.00661
– volume: 31
  start-page: 2382
  year: 2015
  ident: 22433_CR92
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btv145
– volume: 8
  start-page: 6540
  year: 2015
  ident: 22433_CR74
  publication-title: Int J. Clin. Exp. Pathol.
– volume: 5
  start-page: 587
  year: 2014
  ident: 22433_CR11
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.1782
– volume: 52
  start-page: 487
  year: 2020
  ident: 22433_CR33
  publication-title: Immunity
  doi: 10.1016/j.immuni.2020.02.014
– volume: 19
  start-page: 169
  year: 2020
  ident: 22433_CR3
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/s41573-019-0038-z
– volume: 17
  start-page: 1025
  year: 2016
  ident: 22433_CR25
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3518
– volume: 8
  start-page: e1648170
  year: 2019
  ident: 22433_CR46
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2019.1648170
– volume: 25
  start-page: 1754
  year: 2009
  ident: 22433_CR89
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp324
– volume: 4
  start-page: e992749
  year: 2015
  ident: 22433_CR58
  publication-title: Oncoimmunology
  doi: 10.4161/2162402X.2014.992749
– volume: 7
  start-page: 1742
  year: 2019
  ident: 22433_CR1
  publication-title: Cancer Immunol. Res.
  doi: 10.1158/2326-6066.CIR-19-0404
– volume: 172
  start-page: 90
  year: 2016
  ident: 22433_CR6
  publication-title: Clin. Immunol.
  doi: 10.1016/j.clim.2016.07.012
– volume: 17
  start-page: 353
  year: 1997
  ident: 22433_CR69
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/ajrcmb.17.3.2837
– volume: 162
  start-page: 974
  year: 2015
  ident: 22433_CR9
  publication-title: Cell
  doi: 10.1016/j.cell.2015.07.011
– volume: 12
  start-page: e0179501
  year: 2017
  ident: 22433_CR10
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0179501
– volume: 14
  start-page: 659
  year: 2014
  ident: 22433_CR73
  publication-title: Proteomics
  doi: 10.1002/pmic.201300309
– ident: 22433_CR31
  doi: 10.12688/f1000research.7796.1
– volume: 9
  start-page: 512
  year: 2018
  ident: 22433_CR66
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.00512
– volume: 111
  start-page: 6708
  year: 2014
  ident: 22433_CR39
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1314975111
– volume: 9
  start-page: 929
  year: 2018
  ident: 22433_CR20
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.00929
– volume: 1
  start-page: 598
  year: 2011
  ident: 22433_CR49
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-11-0214
– volume: 10
  start-page: 2836
  year: 2019
  ident: 22433_CR55
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2019.02836
– volume: 22
  start-page: 5795
  year: 2016
  ident: 22433_CR26
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-16-0597
– volume: 12
  start-page: 2551
  year: 2013
  ident: 22433_CR32
  publication-title: Mol. Cell Proteomics
  doi: 10.1074/mcp.M112.025205
– volume: 27
  start-page: 533
  year: 2017
  ident: 22433_CR42
  publication-title: Genome Res.
  doi: 10.1101/gr.208108.116
– volume: 3
  start-page: e27572
  year: 2014
  ident: 22433_CR5
  publication-title: Oncoimmunology
  doi: 10.4161/onci.27572
– volume: 9
  start-page: 851
  year: 2018
  ident: 22433_CR17
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.00851
– volume: 20
  start-page: 25
  year: 2020
  ident: 22433_CR54
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/s41577-019-0218-4
– volume: 14
  start-page: 149
  year: 2003
  ident: 22433_CR71
  publication-title: J. Biomol. Tech.
– volume: 8
  start-page: 203
  year: 2013
  ident: 22433_CR86
  publication-title: Epigenetics
  doi: 10.4161/epi.23470
– volume: 9
  start-page: 1239
  year: 2018
  ident: 22433_CR64
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.01239
– volume: 91
  start-page: 1150
  year: 2017
  ident: 22433_CR78
  publication-title: Cytometry A
  doi: 10.1002/cyto.a.23283
– volume: 51
  start-page: 813
  year: 2019
  ident: 22433_CR37
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.09.006
– volume: 171
  start-page: 1284
  year: 2017
  ident: 22433_CR52
  publication-title: Cell
  doi: 10.1016/j.cell.2017.10.022
– volume: 4
  start-page: e1006088
  year: 2015
  ident: 22433_CR65
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2015.1006088
– volume: 10
  start-page: 316
  year: 2015
  ident: 22433_CR76
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2015.020
– volume: 17
  start-page: 861
  year: 2012
  ident: 22433_CR41
  publication-title: Front. Biosci.
  doi: 10.2741/3961
– volume: 12
  year: 2011
  ident: 22433_CR81
  publication-title: BMC Bioinformatics
  doi: 10.1186/1471-2105-12-323
– volume: 11
  start-page: 2301
  year: 2016
  ident: 22433_CR72
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2016.136
– volume: 14
  start-page: 703
  year: 2019
  ident: 22433_CR24
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-019-0128-8
– volume: 120
  start-page: 2229
  year: 2012
  ident: 22433_CR45
  publication-title: Blood
  doi: 10.1182/blood-2011-12-398321
– volume: 19
  year: 2018
  ident: 22433_CR90
  publication-title: BMC Genomics
  doi: 10.1186/s12864-018-4559-3
– volume: 13
  start-page: 493
  year: 2016
  ident: 22433_CR79
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3863
– volume: 1
  start-page: 3
  year: 2019
  ident: 22433_CR56
  publication-title: Immuno-Oncol. Technol.
  doi: 10.1016/j.iotech.2019.06.002
– volume: 30
  start-page: 2114
  year: 2014
  ident: 22433_CR80
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu170
– ident: 22433_CR34
– volume: 15
  year: 2014
  ident: 22433_CR84
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0550-8
– volume: 43
  start-page: 3175
  year: 2013
  ident: 22433_CR30
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.201243150
– ident: 22433_CR88
  doi: 10.14806/ej.17.1.200
– volume: 68
  start-page: 139
  year: 2017
  ident: 22433_CR2
  publication-title: Annu. Rev. Med.
  doi: 10.1146/annurev-med-062315-120245
– volume: 9
  start-page: 1601
  year: 2018
  ident: 22433_CR35
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.01601
– volume: 9
  year: 2008
  ident: 22433_CR91
  publication-title: Genome Biol.
  doi: 10.1186/gb-2008-9-9-r137
– volume: 7
  start-page: 552
  year: 2019
  ident: 22433_CR28
  publication-title: Cancer Immunol. Res.
  doi: 10.1158/2326-6066.CIR-18-0647
– volume: 76
  start-page: 1683
  year: 2016
  ident: 22433_CR48
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-15-2125
– volume: 189
  start-page: 598
  year: 2012
  ident: 22433_CR44
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1102165
– volume: 170
  start-page: 142
  year: 2017
  ident: 22433_CR53
  publication-title: Cell
  doi: 10.1016/j.cell.2017.06.007
– volume: 20
  start-page: 5708
  year: 2014
  ident: 22433_CR59
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-13-3451
– volume: 176
  start-page: 998
  year: 2019
  ident: 22433_CR61
  publication-title: Cell
  doi: 10.1016/j.cell.2018.12.040
– volume: 9
  start-page: 1808
  year: 2018
  ident: 22433_CR19
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.01808
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Snippet γδ T cells are a distinct subgroup of T cells that bridge the innate and adaptive immune system and can attack cancer cells in an MHC-unrestricted manner....
Gamma delta (γδ) T cells have potential for use in immunotherapy against tumours. Here, the authors demonstrate that treatment of tumours with DNA...
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Cytoskeleton
Cytoskeleton - drug effects
Cytoskeleton - metabolism
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Cytotoxicity, Immunologic - genetics
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Deoxyribonucleic acid
Depletion
DNA
DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors
DNA (Cytosine-5-)-Methyltransferases - metabolism
DNA methylation
DNA methyltransferase
Enzyme Inhibitors - pharmacology
Epigenesis, Genetic - drug effects
Epigenetics
Gene Expression Regulation, Neoplastic - drug effects
Humanities and Social Sciences
Humans
Immune system
Immunological Synapses - drug effects
Immunological Synapses - genetics
Immunotherapy
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Isotope Labeling
Lung cancer
Lung Neoplasms - genetics
Lung Neoplasms - immunology
Lymphocyte Activation - drug effects
Lymphocyte Activation - genetics
Lymphocyte Subsets - drug effects
Lymphocyte Subsets - metabolism
Lymphocytes
Lymphocytes T
Lysis
Major histocompatibility complex
Male
Mice
Mice, Inbred NOD
multidisciplinary
Phosphotyrosine - metabolism
Proteomics
Receptors, Antigen, T-Cell, gamma-delta - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Science
Science (multidisciplinary)
Solid tumors
Subgroups
Survival Analysis
Synapses
Toxicity
Tumor Suppressor Protein p53 - metabolism
Tumors
Up-Regulation - drug effects
Xenograft Model Antitumor Assays
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Title Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer
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