Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa

The lamina cribrosa is a primary site of damage in glaucoma. While mechanical distortion is hypothesized to cause reduction of axoplasmic flow, little is known about how the pores, which contains the retinal ganglion cell axons, traverse the lamina cribrosa. We investigated lamina cribrosa pore path...

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Published inScientific reports Vol. 8; no. 1; pp. 7281 - 7
Main Authors Wang, Bo, Lucy, Katie A., Schuman, Joel S., Sigal, Ian A., Bilonick, Richard A., Lu, Chen, Liu, Jonathan, Grulkowski, Ireneusz, Nadler, Zachary, Ishikawa, Hiroshi, Kagemann, Larry, Fujimoto, James G., Wollstein, Gadi
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 08.05.2018
Nature Publishing Group
Nature Portfolio
Subjects
59
692/308/53
692/698/1688/512/2613
Aged
Axonal Transport - physiology
Axons
Axons - pathology
Eye
Female
Glaucoma
Glaucoma, Open-Angle - physiopathology
Humanities and Social Sciences
Humans
Image processing
Intraocular Pressure - physiology
Male
Middle Aged
multidisciplinary
Nerve Fibers - pathology
Nerve Fibers - physiology
Ocular Hypertension - physiopathology
Optic Disk - diagnostic imaging
Optic Disk - physiopathology
Optic nerve
Optic Nerve - diagnostic imaging
Optic Nerve - physiopathology
Pores
Retina
Retinal Ganglion Cells - pathology
Science
Science (multidisciplinary)
Segmentation
Tomography, Optical Coherence
Online AccessGet full text
ISSN2045-2322
2045-2322
DOI10.1038/s41598-018-25645-9

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Abstract The lamina cribrosa is a primary site of damage in glaucoma. While mechanical distortion is hypothesized to cause reduction of axoplasmic flow, little is known about how the pores, which contains the retinal ganglion cell axons, traverse the lamina cribrosa. We investigated lamina cribrosa pore paths in vivo to quantify differences in tortuosity of pore paths between healthy and glaucomatous eyes. We imaged 16 healthy, 23 glaucoma suspect and 48 glaucomatous eyes from 70 subjects using a swept source optical coherence tomography system. The lamina cribrosa pores were automatically segmented using a previously described segmentation algorithm. Individual pore paths were automatically tracked through the depth of the lamina cribrosa using custom software. Pore path convergence to the optic nerve center and tortuosity was quantified for each eye. We found that lamina cribrosa pore pathways traverse the lamina cribrosa closer to the optic nerve center along the depth of the lamina cribrosa regardless of disease severity or diagnostic category. In addition, pores of glaucoma eyes take a more tortuous path through the lamina cribrosa compared to those of healthy eyes, suggesting a potential mechanism for reduction of axoplasmic flow in glaucoma.
AbstractList The lamina cribrosa is a primary site of damage in glaucoma. While mechanical distortion is hypothesized to cause reduction of axoplasmic flow, little is known about how the pores, which contains the retinal ganglion cell axons, traverse the lamina cribrosa. We investigated lamina cribrosa pore paths in vivo to quantify differences in tortuosity of pore paths between healthy and glaucomatous eyes. We imaged 16 healthy, 23 glaucoma suspect and 48 glaucomatous eyes from 70 subjects using a swept source optical coherence tomography system. The lamina cribrosa pores were automatically segmented using a previously described segmentation algorithm. Individual pore paths were automatically tracked through the depth of the lamina cribrosa using custom software. Pore path convergence to the optic nerve center and tortuosity was quantified for each eye. We found that lamina cribrosa pore pathways traverse the lamina cribrosa closer to the optic nerve center along the depth of the lamina cribrosa regardless of disease severity or diagnostic category. In addition, pores of glaucoma eyes take a more tortuous path through the lamina cribrosa compared to those of healthy eyes, suggesting a potential mechanism for reduction of axoplasmic flow in glaucoma.The lamina cribrosa is a primary site of damage in glaucoma. While mechanical distortion is hypothesized to cause reduction of axoplasmic flow, little is known about how the pores, which contains the retinal ganglion cell axons, traverse the lamina cribrosa. We investigated lamina cribrosa pore paths in vivo to quantify differences in tortuosity of pore paths between healthy and glaucomatous eyes. We imaged 16 healthy, 23 glaucoma suspect and 48 glaucomatous eyes from 70 subjects using a swept source optical coherence tomography system. The lamina cribrosa pores were automatically segmented using a previously described segmentation algorithm. Individual pore paths were automatically tracked through the depth of the lamina cribrosa using custom software. Pore path convergence to the optic nerve center and tortuosity was quantified for each eye. We found that lamina cribrosa pore pathways traverse the lamina cribrosa closer to the optic nerve center along the depth of the lamina cribrosa regardless of disease severity or diagnostic category. In addition, pores of glaucoma eyes take a more tortuous path through the lamina cribrosa compared to those of healthy eyes, suggesting a potential mechanism for reduction of axoplasmic flow in glaucoma.
The lamina cribrosa is a primary site of damage in glaucoma. While mechanical distortion is hypothesized to cause reduction of axoplasmic flow, little is known about how the pores, which contains the retinal ganglion cell axons, traverse the lamina cribrosa. We investigated lamina cribrosa pore paths in vivo to quantify differences in tortuosity of pore paths between healthy and glaucomatous eyes. We imaged 16 healthy, 23 glaucoma suspect and 48 glaucomatous eyes from 70 subjects using a swept source optical coherence tomography system. The lamina cribrosa pores were automatically segmented using a previously described segmentation algorithm. Individual pore paths were automatically tracked through the depth of the lamina cribrosa using custom software. Pore path convergence to the optic nerve center and tortuosity was quantified for each eye. We found that lamina cribrosa pore pathways traverse the lamina cribrosa closer to the optic nerve center along the depth of the lamina cribrosa regardless of disease severity or diagnostic category. In addition, pores of glaucoma eyes take a more tortuous path through the lamina cribrosa compared to those of healthy eyes, suggesting a potential mechanism for reduction of axoplasmic flow in glaucoma.
The lamina cribrosa is a primary site of damage in glaucoma. While mechanical distortion is hypothesized to cause reduction of axoplasmic flow, little is known about how the pores, which contains the retinal ganglion cell axons, traverse the lamina cribrosa. We investigated lamina cribrosa pore paths in vivo to quantify differences in tortuosity of pore paths between healthy and glaucomatous eyes. We imaged 16 healthy, 23 glaucoma suspect and 48 glaucomatous eyes from 70 subjects using a swept source optical coherence tomography system. The lamina cribrosa pores were automatically segmented using a previously described segmentation algorithm. Individual pore paths were automatically tracked through the depth of the lamina cribrosa using custom software. Pore path convergence to the optic nerve center and tortuosity was quantified for each eye. We found that lamina cribrosa pore pathways traverse the lamina cribrosa closer to the optic nerve center along the depth of the lamina cribrosa regardless of disease severity or diagnostic category. In addition, pores of glaucoma eyes take a more tortuous path through the lamina cribrosa compared to those of healthy eyes, suggesting a potential mechanism for reduction of axoplasmic flow in glaucoma.
Abstract The lamina cribrosa is a primary site of damage in glaucoma. While mechanical distortion is hypothesized to cause reduction of axoplasmic flow, little is known about how the pores, which contains the retinal ganglion cell axons, traverse the lamina cribrosa. We investigated lamina cribrosa pore paths in vivo to quantify differences in tortuosity of pore paths between healthy and glaucomatous eyes. We imaged 16 healthy, 23 glaucoma suspect and 48 glaucomatous eyes from 70 subjects using a swept source optical coherence tomography system. The lamina cribrosa pores were automatically segmented using a previously described segmentation algorithm. Individual pore paths were automatically tracked through the depth of the lamina cribrosa using custom software. Pore path convergence to the optic nerve center and tortuosity was quantified for each eye. We found that lamina cribrosa pore pathways traverse the lamina cribrosa closer to the optic nerve center along the depth of the lamina cribrosa regardless of disease severity or diagnostic category. In addition, pores of glaucoma eyes take a more tortuous path through the lamina cribrosa compared to those of healthy eyes, suggesting a potential mechanism for reduction of axoplasmic flow in glaucoma.
ArticleNumber 7281
Author Lu, Chen
Sigal, Ian A.
Schuman, Joel S.
Bilonick, Richard A.
Liu, Jonathan
Grulkowski, Ireneusz
Lucy, Katie A.
Ishikawa, Hiroshi
Kagemann, Larry
Wang, Bo
Fujimoto, James G.
Nadler, Zachary
Wollstein, Gadi
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Snippet The lamina cribrosa is a primary site of damage in glaucoma. While mechanical distortion is hypothesized to cause reduction of axoplasmic flow, little is known...
Abstract The lamina cribrosa is a primary site of damage in glaucoma. While mechanical distortion is hypothesized to cause reduction of axoplasmic flow, little...
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SubjectTerms 59
692/308/53
692/698/1688/512/2613
Aged
Axonal Transport - physiology
Axons
Axons - pathology
Eye
Female
Glaucoma
Glaucoma, Open-Angle - physiopathology
Humanities and Social Sciences
Humans
Image processing
Intraocular Pressure - physiology
Male
Middle Aged
multidisciplinary
Nerve Fibers - pathology
Nerve Fibers - physiology
Ocular Hypertension - physiopathology
Optic Disk - diagnostic imaging
Optic Disk - physiopathology
Optic nerve
Optic Nerve - diagnostic imaging
Optic Nerve - physiopathology
Pores
Retina
Retinal Ganglion Cells - pathology
Science
Science (multidisciplinary)
Segmentation
Tomography, Optical Coherence
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Title Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa
URI https://link.springer.com/article/10.1038/s41598-018-25645-9
https://www.ncbi.nlm.nih.gov/pubmed/29740064
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https://www.proquest.com/docview/2036788157
https://pubmed.ncbi.nlm.nih.gov/PMC5940889
https://www.nature.com/articles/s41598-018-25645-9.pdf
https://doaj.org/article/59f39a05013d4683b1993c1562a34630
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