Volume rendered 3D OCTA assessment of macular ischemia in patients with type 1 diabetes and without diabetic retinopathy
The aim of this study was to measure macular perfusion in patients with type 1 diabetes and no signs of diabetic retinopathy (DR) using volume rendered three-dimensional (3D) optical coherence tomography angiography (OCTA). We collected data from 35 patients with diabetes and no DR who had OCTA obta...
Saved in:
| Published in | Scientific reports Vol. 11; no. 1; pp. 19793 - 7 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
05.10.2021
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2045-2322 2045-2322 |
| DOI | 10.1038/s41598-021-99297-7 |
Cover
| Abstract | The aim of this study was to measure macular perfusion in patients with type 1 diabetes and no signs of diabetic retinopathy (DR) using volume rendered three-dimensional (3D) optical coherence tomography angiography (OCTA). We collected data from 35 patients with diabetes and no DR who had OCTA obtained. An additional control group of 35 eyes from 35 healthy subjects was included for comparison. OCTA volume data were processed with a previously presented algorithm in order to obtain the 3D vascular volume and 3D perfusion density. In order to weigh the contribution of different plexuses’ impairment to volume rendered vascular perfusion, OCTA
en face
images were binarized in order to obtain two-dimensional (2D) perfusion density metrics. Mean ± SD age was 27.2 ± 10.2 years [range 19–64 years] in the diabetic group and 31.0 ± 11.4 years [range 19–61 years] in the control group (p = 0.145). The 3D vascular volume was 0.27 ± 0.05 mm
3
in the diabetic group and 0.29 ± 0.04 mm
3
in the control group (p = 0.020). The 3D perfusion density was 9.3 ± 1.6% and 10.3 ± 1.6% in diabetic patients and controls, respectively (p = 0.005). Using a 2D visualization, the perfusion density was lower in diabetic patients, but only at the deep vascular complex (DVC) level (38.9 ± 3.7% in diabetes and 41.0 ± 3.1% in controls, p = 0.001), while no differences were detected at the superficial capillary plexus (SCP) level (34.4 ± 3.1% and 34.3 ± 3.8% in the diabetic and healthy subjects, respectively, p = 0.899). In conclusion, eyes without signs of DR of patients with diabetes have a reduced volume rendered macular perfusion compared to control healthy eyes. |
|---|---|
| AbstractList | The aim of this study was to measure macular perfusion in patients with type 1 diabetes and no signs of diabetic retinopathy (DR) using volume rendered three-dimensional (3D) optical coherence tomography angiography (OCTA). We collected data from 35 patients with diabetes and no DR who had OCTA obtained. An additional control group of 35 eyes from 35 healthy subjects was included for comparison. OCTA volume data were processed with a previously presented algorithm in order to obtain the 3D vascular volume and 3D perfusion density. In order to weigh the contribution of different plexuses’ impairment to volume rendered vascular perfusion, OCTA en face images were binarized in order to obtain two-dimensional (2D) perfusion density metrics. Mean ± SD age was 27.2 ± 10.2 years [range 19–64 years] in the diabetic group and 31.0 ± 11.4 years [range 19–61 years] in the control group (p = 0.145). The 3D vascular volume was 0.27 ± 0.05 mm3 in the diabetic group and 0.29 ± 0.04 mm3 in the control group (p = 0.020). The 3D perfusion density was 9.3 ± 1.6% and 10.3 ± 1.6% in diabetic patients and controls, respectively (p = 0.005). Using a 2D visualization, the perfusion density was lower in diabetic patients, but only at the deep vascular complex (DVC) level (38.9 ± 3.7% in diabetes and 41.0 ± 3.1% in controls, p = 0.001), while no differences were detected at the superficial capillary plexus (SCP) level (34.4 ± 3.1% and 34.3 ± 3.8% in the diabetic and healthy subjects, respectively, p = 0.899). In conclusion, eyes without signs of DR of patients with diabetes have a reduced volume rendered macular perfusion compared to control healthy eyes. Abstract The aim of this study was to measure macular perfusion in patients with type 1 diabetes and no signs of diabetic retinopathy (DR) using volume rendered three-dimensional (3D) optical coherence tomography angiography (OCTA). We collected data from 35 patients with diabetes and no DR who had OCTA obtained. An additional control group of 35 eyes from 35 healthy subjects was included for comparison. OCTA volume data were processed with a previously presented algorithm in order to obtain the 3D vascular volume and 3D perfusion density. In order to weigh the contribution of different plexuses’ impairment to volume rendered vascular perfusion, OCTA en face images were binarized in order to obtain two-dimensional (2D) perfusion density metrics. Mean ± SD age was 27.2 ± 10.2 years [range 19–64 years] in the diabetic group and 31.0 ± 11.4 years [range 19–61 years] in the control group (p = 0.145). The 3D vascular volume was 0.27 ± 0.05 mm3 in the diabetic group and 0.29 ± 0.04 mm3 in the control group (p = 0.020). The 3D perfusion density was 9.3 ± 1.6% and 10.3 ± 1.6% in diabetic patients and controls, respectively (p = 0.005). Using a 2D visualization, the perfusion density was lower in diabetic patients, but only at the deep vascular complex (DVC) level (38.9 ± 3.7% in diabetes and 41.0 ± 3.1% in controls, p = 0.001), while no differences were detected at the superficial capillary plexus (SCP) level (34.4 ± 3.1% and 34.3 ± 3.8% in the diabetic and healthy subjects, respectively, p = 0.899). In conclusion, eyes without signs of DR of patients with diabetes have a reduced volume rendered macular perfusion compared to control healthy eyes. The aim of this study was to measure macular perfusion in patients with type 1 diabetes and no signs of diabetic retinopathy (DR) using volume rendered three-dimensional (3D) optical coherence tomography angiography (OCTA). We collected data from 35 patients with diabetes and no DR who had OCTA obtained. An additional control group of 35 eyes from 35 healthy subjects was included for comparison. OCTA volume data were processed with a previously presented algorithm in order to obtain the 3D vascular volume and 3D perfusion density. In order to weigh the contribution of different plexuses’ impairment to volume rendered vascular perfusion, OCTA en face images were binarized in order to obtain two-dimensional (2D) perfusion density metrics. Mean ± SD age was 27.2 ± 10.2 years [range 19–64 years] in the diabetic group and 31.0 ± 11.4 years [range 19–61 years] in the control group (p = 0.145). The 3D vascular volume was 0.27 ± 0.05 mm 3 in the diabetic group and 0.29 ± 0.04 mm 3 in the control group (p = 0.020). The 3D perfusion density was 9.3 ± 1.6% and 10.3 ± 1.6% in diabetic patients and controls, respectively (p = 0.005). Using a 2D visualization, the perfusion density was lower in diabetic patients, but only at the deep vascular complex (DVC) level (38.9 ± 3.7% in diabetes and 41.0 ± 3.1% in controls, p = 0.001), while no differences were detected at the superficial capillary plexus (SCP) level (34.4 ± 3.1% and 34.3 ± 3.8% in the diabetic and healthy subjects, respectively, p = 0.899). In conclusion, eyes without signs of DR of patients with diabetes have a reduced volume rendered macular perfusion compared to control healthy eyes. The aim of this study was to measure macular perfusion in patients with type 1 diabetes and no signs of diabetic retinopathy (DR) using volume rendered three-dimensional (3D) optical coherence tomography angiography (OCTA). We collected data from 35 patients with diabetes and no DR who had OCTA obtained. An additional control group of 35 eyes from 35 healthy subjects was included for comparison. OCTA volume data were processed with a previously presented algorithm in order to obtain the 3D vascular volume and 3D perfusion density. In order to weigh the contribution of different plexuses’ impairment to volume rendered vascular perfusion, OCTA en face images were binarized in order to obtain two-dimensional (2D) perfusion density metrics. Mean ± SD age was 27.2 ± 10.2 years [range 19–64 years] in the diabetic group and 31.0 ± 11.4 years [range 19–61 years] in the control group (p = 0.145). The 3D vascular volume was 0.27 ± 0.05 mm3 in the diabetic group and 0.29 ± 0.04 mm3 in the control group (p = 0.020). The 3D perfusion density was 9.3 ± 1.6% and 10.3 ± 1.6% in diabetic patients and controls, respectively (p = 0.005). Using a 2D visualization, the perfusion density was lower in diabetic patients, but only at the deep vascular complex (DVC) level (38.9 ± 3.7% in diabetes and 41.0 ± 3.1% in controls, p = 0.001), while no differences were detected at the superficial capillary plexus (SCP) level (34.4 ± 3.1% and 34.3 ± 3.8% in the diabetic and healthy subjects, respectively, p = 0.899). In conclusion, eyes without signs of DR of patients with diabetes have a reduced volume rendered macular perfusion compared to control healthy eyes. The aim of this study was to measure macular perfusion in patients with type 1 diabetes and no signs of diabetic retinopathy (DR) using volume rendered three-dimensional (3D) optical coherence tomography angiography (OCTA). We collected data from 35 patients with diabetes and no DR who had OCTA obtained. An additional control group of 35 eyes from 35 healthy subjects was included for comparison. OCTA volume data were processed with a previously presented algorithm in order to obtain the 3D vascular volume and 3D perfusion density. In order to weigh the contribution of different plexuses' impairment to volume rendered vascular perfusion, OCTA en face images were binarized in order to obtain two-dimensional (2D) perfusion density metrics. Mean ± SD age was 27.2 ± 10.2 years [range 19-64 years] in the diabetic group and 31.0 ± 11.4 years [range 19-61 years] in the control group (p = 0.145). The 3D vascular volume was 0.27 ± 0.05 mm3 in the diabetic group and 0.29 ± 0.04 mm3 in the control group (p = 0.020). The 3D perfusion density was 9.3 ± 1.6% and 10.3 ± 1.6% in diabetic patients and controls, respectively (p = 0.005). Using a 2D visualization, the perfusion density was lower in diabetic patients, but only at the deep vascular complex (DVC) level (38.9 ± 3.7% in diabetes and 41.0 ± 3.1% in controls, p = 0.001), while no differences were detected at the superficial capillary plexus (SCP) level (34.4 ± 3.1% and 34.3 ± 3.8% in the diabetic and healthy subjects, respectively, p = 0.899). In conclusion, eyes without signs of DR of patients with diabetes have a reduced volume rendered macular perfusion compared to control healthy eyes.The aim of this study was to measure macular perfusion in patients with type 1 diabetes and no signs of diabetic retinopathy (DR) using volume rendered three-dimensional (3D) optical coherence tomography angiography (OCTA). We collected data from 35 patients with diabetes and no DR who had OCTA obtained. An additional control group of 35 eyes from 35 healthy subjects was included for comparison. OCTA volume data were processed with a previously presented algorithm in order to obtain the 3D vascular volume and 3D perfusion density. In order to weigh the contribution of different plexuses' impairment to volume rendered vascular perfusion, OCTA en face images were binarized in order to obtain two-dimensional (2D) perfusion density metrics. Mean ± SD age was 27.2 ± 10.2 years [range 19-64 years] in the diabetic group and 31.0 ± 11.4 years [range 19-61 years] in the control group (p = 0.145). The 3D vascular volume was 0.27 ± 0.05 mm3 in the diabetic group and 0.29 ± 0.04 mm3 in the control group (p = 0.020). The 3D perfusion density was 9.3 ± 1.6% and 10.3 ± 1.6% in diabetic patients and controls, respectively (p = 0.005). Using a 2D visualization, the perfusion density was lower in diabetic patients, but only at the deep vascular complex (DVC) level (38.9 ± 3.7% in diabetes and 41.0 ± 3.1% in controls, p = 0.001), while no differences were detected at the superficial capillary plexus (SCP) level (34.4 ± 3.1% and 34.3 ± 3.8% in the diabetic and healthy subjects, respectively, p = 0.899). In conclusion, eyes without signs of DR of patients with diabetes have a reduced volume rendered macular perfusion compared to control healthy eyes. The aim of this study was to measure macular perfusion in patients with type 1 diabetes and no signs of diabetic retinopathy (DR) using volume rendered three-dimensional (3D) optical coherence tomography angiography (OCTA). We collected data from 35 patients with diabetes and no DR who had OCTA obtained. An additional control group of 35 eyes from 35 healthy subjects was included for comparison. OCTA volume data were processed with a previously presented algorithm in order to obtain the 3D vascular volume and 3D perfusion density. In order to weigh the contribution of different plexuses' impairment to volume rendered vascular perfusion, OCTA en face images were binarized in order to obtain two-dimensional (2D) perfusion density metrics. Mean ± SD age was 27.2 ± 10.2 years [range 19-64 years] in the diabetic group and 31.0 ± 11.4 years [range 19-61 years] in the control group (p = 0.145). The 3D vascular volume was 0.27 ± 0.05 mm in the diabetic group and 0.29 ± 0.04 mm in the control group (p = 0.020). The 3D perfusion density was 9.3 ± 1.6% and 10.3 ± 1.6% in diabetic patients and controls, respectively (p = 0.005). Using a 2D visualization, the perfusion density was lower in diabetic patients, but only at the deep vascular complex (DVC) level (38.9 ± 3.7% in diabetes and 41.0 ± 3.1% in controls, p = 0.001), while no differences were detected at the superficial capillary plexus (SCP) level (34.4 ± 3.1% and 34.3 ± 3.8% in the diabetic and healthy subjects, respectively, p = 0.899). In conclusion, eyes without signs of DR of patients with diabetes have a reduced volume rendered macular perfusion compared to control healthy eyes. |
| ArticleNumber | 19793 |
| Author | Querques, Lea Grosso, Domenico Brambati, Maria Sacconi, Riccardo Querques, Giuseppe Borrelli, Enrico Parravano, Mariacristina Costanzo, Eliana Pina, Adelaide De Geronimo, Daniele Bandello, Francesco Viganò, Chiara |
| Author_xml | – sequence: 1 givenname: Enrico surname: Borrelli fullname: Borrelli, Enrico organization: Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele – sequence: 2 givenname: Domenico surname: Grosso fullname: Grosso, Domenico organization: Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele – sequence: 3 givenname: Mariacristina surname: Parravano fullname: Parravano, Mariacristina organization: IRCCS - Fondazione Bietti – sequence: 4 givenname: Eliana surname: Costanzo fullname: Costanzo, Eliana organization: IRCCS - Fondazione Bietti – sequence: 5 givenname: Maria surname: Brambati fullname: Brambati, Maria organization: Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele – sequence: 6 givenname: Chiara surname: Viganò fullname: Viganò, Chiara organization: Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele – sequence: 7 givenname: Riccardo surname: Sacconi fullname: Sacconi, Riccardo organization: Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele – sequence: 8 givenname: Lea surname: Querques fullname: Querques, Lea organization: Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele – sequence: 9 givenname: Adelaide surname: Pina fullname: Pina, Adelaide organization: Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele – sequence: 10 givenname: Daniele surname: De Geronimo fullname: De Geronimo, Daniele organization: IRCCS - Fondazione Bietti – sequence: 11 givenname: Francesco surname: Bandello fullname: Bandello, Francesco organization: Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele – sequence: 12 givenname: Giuseppe surname: Querques fullname: Querques, Giuseppe email: querques.giuseppe@unisr.it organization: Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34611239$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNUk1v1DAUjFARLaV_gAOyxIVLIP6IE1-QquWrUqVeClfrxXne9SqxFzuh7L_H3V1K20OFL7bemxmP3_hlceSDx6J4Tav3tOLthyRordqyYrRUiqmmbJ4VJ6wSdck4Y0f3zsfFWUrrKq-aKUHVi-KYC0kp4-qk-P0jDPOIJKLvMWJP-Cdytbg-J5ASpjSin0iwZAQzDxCJS2aFowPiPNnA5HI7kRs3rci03SChpHfQ4YSJgO93jTBPh6Iz-ZbJ-ZCJq-2r4rmFIeHZYT8tvn_5fL34Vl5efb1YnF-WphbVVHaVUBQNCouypgIMWClaJRtorTIKuGUNIEhDOeuBK2pN3VEuBUfVWQH8tLjY6_YB1noT3QhxqwM4vSuEuNQQs7cBda-k5KaVBioQrFHQ2c6y3tbYQ0NNm7X4Xmv2G9jewDDcCdJK38ai97HoHIvexaKbzPq4Z23mbsTe5JlFGB5YedjxbqWX4ZduhWINr7LAu4NADD9nTJMecw44DOAxzEmzulGSKclFhr59BF2HOfo84B2KVS3nNKPe3Hd0Z-Xvt8iAdg8wMaQU0Wrjphx3uDXohqdfyx5R_2tEh8GmDPZLjP9sP8H6A4lF7s8 |
| CitedBy_id | crossref_primary_10_1007_s00592_021_01844_1 crossref_primary_10_1186_s12886_024_03752_8 crossref_primary_10_1016_j_ajo_2023_04_005 crossref_primary_10_1038_s41598_024_53000_8 crossref_primary_10_3390_jcm12051973 crossref_primary_10_1016_j_preteyeres_2022_101134 crossref_primary_10_1007_s00592_024_02354_6 crossref_primary_10_3390_diagnostics13020232 crossref_primary_10_1364_OE_485619 |
| Cites_doi | 10.1097/IAE.0000000000001344 10.1136/bjophthalmol-2018-311942 10.1038/nmeth.2089 10.1002/jbio.202000152 10.1038/s41598-020-57680-w 10.1007/s40123-019-0178-6 10.1136/bjophthalmol-2020-317890 10.1097/IAE.0000000000001250 10.1007/s00592-017-0996-8 10.1016/j.ophtha.2019.06.016 10.1097/IAE.0000000000003077 10.1016/j.preteyeres.2017.11.003 10.1167/iovs.17-22359 10.1097/IAE.0000000000000882 10.1111/aos.13404 10.1016/j.preteyeres.2018.07.002 10.1136/bjophthalmol-2019-314018 10.1167/iovs.16-20531 10.1016/j.ajo.2013.05.033 10.2174/09298673113209990022 10.1167/iovs.17-23304 10.1038/s41598-019-53307-x 10.1109/tmi.2019.2948867 10.1111/aos.13510 10.1038/s41598-019-53357-1 10.1167/iovs.16-19776 10.1167/iovs.61.10.53 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2021 2021. The Author(s). The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s) 2021 – notice: 2021. The Author(s). – notice: The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U 7X8 5PM ADTOC UNPAY DOA |
| DOI | 10.1038/s41598-021-99297-7 |
| DatabaseName | Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Journals Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) Medical Database Science Database Biological science database ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall Openly Available Collection - DOAJ |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database CrossRef MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 5 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository – sequence: 6 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2045-2322 |
| EndPage | 7 |
| ExternalDocumentID | oai_doaj_org_article_d9663c86ca0a4279abfbf2df5eda71c8 10.1038/s41598-021-99297-7 PMC8492730 34611239 10_1038_s41598_021_99297_7 |
| Genre | Research Support, Non-U.S. Gov't Multicenter Study Journal Article |
| GroupedDBID | 0R~ 3V. 4.4 53G 5VS 7X7 88A 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD ABDBF ABUWG ACGFS ACSMW ACUHS ADBBV ADRAZ AENEX AEUYN AFKRA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M0L M1P M2P M48 M7P M~E NAO OK1 PIMPY PQQKQ PROAC PSQYO RNT RNTTT RPM SNYQT UKHRP AASML AAYXX AFPKN CITATION PHGZM PHGZT PJZUB PPXIY PQGLB PUEGO CGR CUY CVF ECM EIF NPM 7XB 8FK K9. PKEHL PQEST PQUKI PRINS Q9U 7X8 5PM ADTOC EJD IPNFZ RIG UNPAY |
| ID | FETCH-LOGICAL-c540t-b0491ece4fe6514acaf648967a8f9c9a3f27aea6c132da391fc5b13643e9bf4a3 |
| IEDL.DBID | M48 |
| ISSN | 2045-2322 |
| IngestDate | Tue Oct 14 19:02:06 EDT 2025 Sun Oct 26 04:12:55 EDT 2025 Tue Sep 30 16:53:29 EDT 2025 Fri Sep 05 08:03:06 EDT 2025 Tue Oct 07 09:17:35 EDT 2025 Thu Jan 02 22:55:34 EST 2025 Wed Oct 01 02:17:15 EDT 2025 Thu Apr 24 22:51:39 EDT 2025 Fri Feb 21 02:39:27 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | 2021. The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. cc-by |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c540t-b0491ece4fe6514acaf648967a8f9c9a3f27aea6c132da391fc5b13643e9bf4a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/s41598-021-99297-7 |
| PMID | 34611239 |
| PQID | 2579208331 |
| PQPubID | 2041939 |
| PageCount | 7 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_d9663c86ca0a4279abfbf2df5eda71c8 unpaywall_primary_10_1038_s41598_021_99297_7 pubmedcentral_primary_oai_pubmedcentral_nih_gov_8492730 proquest_miscellaneous_2579629634 proquest_journals_2579208331 pubmed_primary_34611239 crossref_citationtrail_10_1038_s41598_021_99297_7 crossref_primary_10_1038_s41598_021_99297_7 springer_journals_10_1038_s41598_021_99297_7 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2021-10-05 |
| PublicationDateYYYYMMDD | 2021-10-05 |
| PublicationDate_xml | – month: 10 year: 2021 text: 2021-10-05 day: 05 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Scientific reports |
| PublicationTitleAbbrev | Sci Rep |
| PublicationTitleAlternate | Sci Rep |
| PublicationYear | 2021 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | Scarinci, Picconi, Giorno (CR26) 2018 Onishi, Nesper, Roberts (CR27) 2018 Schneider, Rasband, Eliceiri (CR22) 2012; 9 Borrelli, Sadda, Uji, Querques (CR9) 2019 Spaide, Fujimoto, Waheed, Sadda, Staurenghi (CR11) 2017; 64 Borrelli, Parravano, Costanzo (CR21) 2020; 41 Dimitrova, Chihara, Takahashi, Amano, Okazaki (CR3) 2017 Simonett, Scarinci, Picconi (CR6) 2017 Borrelli, Sacconi, Klose, de Sisternes, Bandello, Querques (CR15) 2019 Ghasemi Falavarjani, Habibi, Anvari (CR20) 2020 Santos, Warren, Santos (CR13) 2020 Zhang, Hwang, Dongye, Wilson, Huang, Jia (CR28) 2016; 57 Borrelli, Sacconi, Querques, Battista, Bandello, Querques (CR18) 2020; 13 Carnevali, Sacconi, Corbelli (CR4) 2017; 54 Rabiolo, Gelormini, Marchese (CR24) 2018 Ashraf, Sampani, Clermont (CR5) 2020 Sim, Keane, Zarranz-Ventura (CR1) 2013 Sun, Tang, Wong (CR12) 2019 Borrelli, Sarraf, Freund, Sadda (CR10) 2018 Choi, Waheed, Moult (CR7) 2017; 37 Borrelli, Sacconi, Brambati, Bandello, Querques (CR16) 2019 Hirano, Kitahara, Toriyama, Kasamatsu, Murata, Sadda (CR25) 2019 Spaide, Suzuki, Yannuzzi, Matet, Behar-Cohen (CR14) 2017 Parravano, Costanzo, Borrelli (CR23) 2020 Zhang, Qiao, Sarabi (CR17) 2019 Borrelli, Parravano, Costanzo (CR19) 2020 De Carlo, Chin, Bonini Filho (CR8) 2015 Beltramo, Porta (CR2) 2013 DA Sim (99297_CR1) 2013 K Ghasemi Falavarjani (99297_CR20) 2020 E Borrelli (99297_CR9) 2019 E Borrelli (99297_CR10) 2018 JM Simonett (99297_CR6) 2017 T Hirano (99297_CR25) 2019 M Parravano (99297_CR23) 2020 AC Onishi (99297_CR27) 2018 E Borrelli (99297_CR19) 2020 TE De Carlo (99297_CR8) 2015 T Santos (99297_CR13) 2020 A Rabiolo (99297_CR24) 2018 E Beltramo (99297_CR2) 2013 A Carnevali (99297_CR4) 2017; 54 E Borrelli (99297_CR15) 2019 E Borrelli (99297_CR18) 2020; 13 J Zhang (99297_CR17) 2019 W Choi (99297_CR7) 2017; 37 F Scarinci (99297_CR26) 2018 RF Spaide (99297_CR14) 2017 M Zhang (99297_CR28) 2016; 57 RRF Spaide (99297_CR11) 2017; 64 M Ashraf (99297_CR5) 2020 E Borrelli (99297_CR21) 2020; 41 E Borrelli (99297_CR16) 2019 CA Schneider (99297_CR22) 2012; 9 G Dimitrova (99297_CR3) 2017 Z Sun (99297_CR12) 2019 |
| References_xml | – year: 2017 ident: CR14 article-title: Volume-rendered angiographic and structural optical coherence tomography angiography of macular telangiectasia type 2 publication-title: Retina doi: 10.1097/IAE.0000000000001344 – year: 2019 ident: CR25 article-title: Quantifying vascular density and morphology using different swept-source optical coherence tomography angiographic scan patterns in diabetic retinopathy publication-title: Br. J. Ophthalmol. doi: 10.1136/bjophthalmol-2018-311942 – volume: 9 start-page: 671 year: 2012 end-page: 675 ident: CR22 article-title: NIH image to ImageJ: 25 Years of image analysis publication-title: Nat. Methods doi: 10.1038/nmeth.2089 – volume: 13 start-page: e202000152 year: 2020 ident: CR18 article-title: Quantification of diabetic macular ischemia using novel three-dimensional optical coherence tomography angiography metrics publication-title: J. Biophotonics. doi: 10.1002/jbio.202000152 – year: 2020 ident: CR23 article-title: Appearance of cysts and capillary non perfusion areas in diabetic macular edema using two different OCTA devices publication-title: Sci. Rep. doi: 10.1038/s41598-020-57680-w – year: 2019 ident: CR9 article-title: Pearls and pitfalls of optical coherence tomography angiography imaging: A review publication-title: Ophthalmol. Ther. doi: 10.1007/s40123-019-0178-6 – year: 2020 ident: CR13 article-title: Swept-source OCTA quantification of capillary closure predicts ETDRS severity staging of NPDR publication-title: Br. J. Ophthalmol. doi: 10.1136/bjophthalmol-2020-317890 – volume: 37 start-page: 11 issue: 1 year: 2017 end-page: 21 ident: CR7 article-title: Ultrahigh speed swept source optical coherence tomography angiography of retinal and choriocapillaris alterations in diabetic patients with and without retinopathy publication-title: Retina doi: 10.1097/IAE.0000000000001250 – volume: 54 start-page: 695 issue: 7 year: 2017 end-page: 702 ident: CR4 article-title: Optical coherence tomography angiography analysis of retinal vascular plexuses and choriocapillaris in patients with type 1 diabetes without diabetic retinopathy publication-title: Acta Diabetol. doi: 10.1007/s00592-017-0996-8 – year: 2019 ident: CR12 article-title: OCT angiography metrics predict progression of diabetic retinopathy and development of diabetic macular edema: A prospective study publication-title: Ophthalmology doi: 10.1016/j.ophtha.2019.06.016 – year: 2020 ident: CR19 article-title: Using three-dimensional OCTA metrics improves repeatability on quantification of ischemia in eyes with diabetic macular edema publication-title: Retina doi: 10.1097/IAE.0000000000003077 – volume: 64 start-page: 1 year: 2017 end-page: 55 ident: CR11 article-title: Optical coherence tomography angiography publication-title: Prog. Retina Eye Res. doi: 10.1016/j.preteyeres.2017.11.003 – year: 2018 ident: CR24 article-title: Macular perfusion parameters in different angiocube sizes: Does the size matter in quantitative optical coherence tomography angiography? publication-title: Investig. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.17-22359 – year: 2015 ident: CR8 article-title: Detection of microvascular changes in eyes of patients with diabetes but not clinical diabetic retinopathy using optical coherence tomography angiography publication-title: Retina doi: 10.1097/IAE.0000000000000882 – year: 2017 ident: CR6 article-title: Early microvascular retinal changes in optical coherence tomography angiography in patients with type 1 diabetes mellitus publication-title: Acta Ophthalmol. doi: 10.1111/aos.13404 – year: 2018 ident: CR10 article-title: OCT angiography and evaluation of the choroid and choroidal vascular disorders publication-title: Prog. Retina Eye Res. doi: 10.1016/j.preteyeres.2018.07.002 – year: 2020 ident: CR20 article-title: Effect of segmentation error correction on optical coherence tomography angiography measurements in healthy subjects and diabetic macular oedema publication-title: Br. J. Ophthalmol. doi: 10.1136/bjophthalmol-2019-314018 – year: 2017 ident: CR3 article-title: Quantitative retinal optical coherence tomography angiography in patients with diabetes without diabetic retinopathy publication-title: Investig. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.16-20531 – volume: 41 start-page: 1660 year: 2020 end-page: 1667 ident: CR21 article-title: Using three-dimensional OCTA metrics improves repeatability on quantification of ischemia in eyes with diabetic macular edema publication-title: Retina doi: 10.1097/IAE.0000000000003077 – year: 2013 ident: CR1 article-title: Predictive factors for the progression of diabetic macular ischemia publication-title: Am. J. Ophthalmol. doi: 10.1016/j.ajo.2013.05.033 – year: 2013 ident: CR2 article-title: Pericyte loss in diabetic retinopathy: Mechanisms and consequences publication-title: Curr. Med. Chem. doi: 10.2174/09298673113209990022 – year: 2018 ident: CR27 article-title: Importance of considering the middle capillary plexus on OCT angiography in diabetic retinopathy publication-title: Investig. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.17-23304 – year: 2019 ident: CR15 article-title: Rotational Three-dimensional OCTA: A notable new imaging tool to characterize type 3 macular neovascularization publication-title: Sci. Rep. doi: 10.1038/s41598-019-53307-x – year: 2019 ident: CR17 article-title: 3D shape modeling and analysis of retinal microvasculature in OCT-angiography images publication-title: IEEE Trans. Med. Imaging doi: 10.1109/tmi.2019.2948867 – year: 2018 ident: CR26 article-title: Deep capillary plexus impairment in patients with type 1 diabetes mellitus with no signs of diabetic retinopathy revealed using optical coherence tomography angiography publication-title: Acta Ophthalmol. doi: 10.1111/aos.13510 – year: 2019 ident: CR16 article-title: In vivo rotational three-dimensional OCTA analysis of microaneurysms in the human diabetic retina publication-title: Sci. Rep. doi: 10.1038/s41598-019-53357-1 – volume: 57 start-page: 5101 issue: 13 year: 2016 end-page: 5106 ident: CR28 article-title: Automated quantification of nonperfusion in three retinal plexuses using projection-resolved optical coherence tomography angiography in diabetic retinopathy publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.16-19776 – year: 2020 ident: CR5 article-title: Vascular density of deep, intermediate and superficial vascular plexuses are differentially affected by diabetic retinopathy severity publication-title: Investig. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.61.10.53 – volume: 41 start-page: 1660 year: 2020 ident: 99297_CR21 publication-title: Retina doi: 10.1097/IAE.0000000000003077 – year: 2019 ident: 99297_CR9 publication-title: Ophthalmol. Ther. doi: 10.1007/s40123-019-0178-6 – volume: 37 start-page: 11 issue: 1 year: 2017 ident: 99297_CR7 publication-title: Retina doi: 10.1097/IAE.0000000000001250 – year: 2018 ident: 99297_CR27 publication-title: Investig. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.17-23304 – volume: 64 start-page: 1 year: 2017 ident: 99297_CR11 publication-title: Prog. Retina Eye Res. doi: 10.1016/j.preteyeres.2017.11.003 – year: 2017 ident: 99297_CR14 publication-title: Retina doi: 10.1097/IAE.0000000000001344 – year: 2018 ident: 99297_CR26 publication-title: Acta Ophthalmol. doi: 10.1111/aos.13510 – year: 2020 ident: 99297_CR5 publication-title: Investig. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.61.10.53 – year: 2020 ident: 99297_CR13 publication-title: Br. J. Ophthalmol. doi: 10.1136/bjophthalmol-2020-317890 – year: 2018 ident: 99297_CR10 publication-title: Prog. Retina Eye Res. doi: 10.1016/j.preteyeres.2018.07.002 – year: 2020 ident: 99297_CR19 publication-title: Retina doi: 10.1097/IAE.0000000000003077 – year: 2020 ident: 99297_CR23 publication-title: Sci. Rep. doi: 10.1038/s41598-020-57680-w – year: 2019 ident: 99297_CR12 publication-title: Ophthalmology doi: 10.1016/j.ophtha.2019.06.016 – year: 2017 ident: 99297_CR3 publication-title: Investig. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.16-20531 – year: 2018 ident: 99297_CR24 publication-title: Investig. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.17-22359 – year: 2019 ident: 99297_CR17 publication-title: IEEE Trans. Med. Imaging doi: 10.1109/tmi.2019.2948867 – year: 2013 ident: 99297_CR1 publication-title: Am. J. Ophthalmol. doi: 10.1016/j.ajo.2013.05.033 – year: 2019 ident: 99297_CR15 publication-title: Sci. Rep. doi: 10.1038/s41598-019-53307-x – year: 2019 ident: 99297_CR25 publication-title: Br. J. Ophthalmol. doi: 10.1136/bjophthalmol-2018-311942 – year: 2013 ident: 99297_CR2 publication-title: Curr. Med. Chem. doi: 10.2174/09298673113209990022 – volume: 9 start-page: 671 year: 2012 ident: 99297_CR22 publication-title: Nat. Methods doi: 10.1038/nmeth.2089 – year: 2020 ident: 99297_CR20 publication-title: Br. J. Ophthalmol. doi: 10.1136/bjophthalmol-2019-314018 – year: 2017 ident: 99297_CR6 publication-title: Acta Ophthalmol. doi: 10.1111/aos.13404 – year: 2015 ident: 99297_CR8 publication-title: Retina doi: 10.1097/IAE.0000000000000882 – year: 2019 ident: 99297_CR16 publication-title: Sci. Rep. doi: 10.1038/s41598-019-53357-1 – volume: 54 start-page: 695 issue: 7 year: 2017 ident: 99297_CR4 publication-title: Acta Diabetol. doi: 10.1007/s00592-017-0996-8 – volume: 13 start-page: e202000152 year: 2020 ident: 99297_CR18 publication-title: J. Biophotonics. doi: 10.1002/jbio.202000152 – volume: 57 start-page: 5101 issue: 13 year: 2016 ident: 99297_CR28 publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.16-19776 |
| SSID | ssj0000529419 |
| Score | 2.3972824 |
| Snippet | The aim of this study was to measure macular perfusion in patients with type 1 diabetes and no signs of diabetic retinopathy (DR) using volume rendered... Abstract The aim of this study was to measure macular perfusion in patients with type 1 diabetes and no signs of diabetic retinopathy (DR) using volume... |
| SourceID | doaj unpaywall pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 19793 |
| SubjectTerms | 692/308/53 692/53 Adult Aged Angiography Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - complications Diabetic retinopathy Diabetic Retinopathy - diagnosis Diabetic Retinopathy - etiology Female Humanities and Social Sciences Humans Image Processing, Computer-Assisted Imaging, Three-Dimensional Ischemia Ischemia - diagnostic imaging Ischemia - etiology Macula Lutea - blood supply Macula Lutea - diagnostic imaging Male Middle Aged multidisciplinary Perfusion Retinal Vessels - diagnostic imaging Retinal Vessels - physiopathology Retinopathy Retrospective Studies Science Science (multidisciplinary) Tomography, Optical Coherence - methods Young Adult |
| SummonAdditionalLinks | – databaseName: Openly Available Collection - DOAJ dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwELVQJQQcEN9NKchI3GjUJHb8cSyFqkICLi3qzZo4toi0Taruruj-e8Z2NuwKVDhwjW3JGb-xn-3xG0Lehit1B4XPLYI353XpgwZkix4vpQDVyALCecfnL-L0nH-6qC82Un2FmLAkD5wMd9hiU2aVsFAAr6SGxje-an3tWpCljc98C6U3NlNJ1bvSvNTjK5mCqcM5rlThNVmISEBKIHO5tRJFwf4_sczfgyWnG9MH5N6yv4LVD5jNNhalk0fk4cgm6VH6i8fkjuufkLspv-TqKbn5Fuceeh3zxbmWsg_06_HZEYVJj5MOnl5CDEalHe503WUHtOvpqLc6p-GgloaDWlrS9UEthb6NBcNyMX7sLA3vIfshpDhePSPnJx_Pjk_zMdVCbpGyLfIGNwqls457J5BCgQUvuNJCgvLaamC-kuBAWNy8tsB06W3dlAzpjNON58Cek51-6N0uoY4pW-sKdGNbXCF5I52zymrlKyZaXWakXJvd2FGHPKTDmJl4H86USUNlcKhMHCojM_JuanOVVDhurf0-jOZUMyhoxw-IKzPiyvwNVxnZX2PBjG49Nzi_aUQbY_gXb6ZidMhwywK9G5apjqhwXuMZeZGgM_WEcYH8lumMyC1QbXV1u6TvvkfRb8U1Ms0iIwdr-P3q1m2mOJgg-g-W2_sflntJ7lfBzWKUxT7ZWVwv3StkbovmdXTSnxd7QC0 priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1baxQxFD7ULaI-iHdHq0TwzQ6dmWQnyYNIW1uK4CrSSt-GM7nowHZm3Qu6_94kc6mLsvg6yUI2-U7y5ZyT7wC89iF1g4mNlQNvzMap9RqQ2lk85zmKkifo_R0fJ_nZBftwOb7cgUn_FsanVfZ7YtiodaO8j_zAQUtmji_Q9N3sR-yrRvnoal9CA7vSCvptkBi7AbuZV8Yawe7RyeTzl8Hr4uNaLJXd65mEioOFO8H8KzOfqeCoAo_5xgkVhPz_xT7_TqIcIql34NaqnuH6J06nfxxWp_fgbscyyWELi_uwY-oHcLOtO7l-CL--hj2JzEMdOaMJfU8-HZ8fEhx0OkljyRWGJFVSuRuwuaqQVDXpdFgXxDtwiXfgkpT0DlyCtQ4NzWrZfawU8e8k68aXPl4_govTk_Pjs7grwRArR-WWcekuEKlRhlmTO2qFCm3OhMw5CiuVRGozjgZz5S61GqlMrRqXKXU0x8jSMqSPYVQ3tXkKxFChxjJDWSrtTk5WcmOUUFLYjOZaphGk_bQXqtMn92UypkWIk1NRtEtVuKUqwlIVPII3w29mrTrH1t5HfjWHnl5ZO3xo5t-KzlAL7aBKlcgVJsgyLrG0pc20HRuNPFUigr0eC0Vn7oviGpwRvBqanaH66AvWplm1ffLM7XcsgictdIaRUJY73ktlBHwDVBtD3Wypq-9BDFww6RhoEsF-D7_rYW2biv0Bov8xc8-2_-nncDvzBhTyKvZgtJyvzAvH1Zbly84AfwN-kjyI priority: 102 providerName: ProQuest – databaseName: Springer Nature HAS Fully OA dbid: AAJSJ link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwED-NTgh4QHwTGMhIvNGIJnZi-7EMpqkS8MCG9hZdHFuL1CXT2gr633N2PqAamuA1tivX9zvf-c7-HcBbn1K3OHOxIfDGIkuc54CsSOOlzFGVcoY-3vH5S358KhZn2dkeTIe3MDv5-0DdvSIT45-B-asEZMtlLG_BviJgqgnsz-eLb4sxpuKzViLR_dsYGv7--uAd-xNo-v_mW16_IjnmSe_BnU1zidsfuFz-YYqOHsD93odk807oD2HPNo_gdldVcvsYfn4POw67ClXibMX4R_b18GTOcGThZK1jFxiuoLKazrf2okZWN6xnWV0xH55lPjzLEjaEZxk2VWhoN-v-Y22YfwXZtL6w8fYJnB59Ojk8jvsCC7EhR20dl3Q8SKyxwtmcHCc06HKhdC5ROW00cpdKtJgbOrJWyHXiTFYmnJwYq0snkD-FSdM29jkwy5XJdIq6NBXZRVFKa40yWrmU55VOIkiGZS9Mzz7ui2Asi5AF56roRFWQqIogqkJG8G4cc9lxb9zY-4OX5tjT82aHDwSnolfDoiIgcqNygzMUqdRYutKllctshTIxKoKDAQtFr8yrgnY1nZKryulfvBmbSQ19bgUb2266PnlKu5mI4FkHnXEmXOTk1XIdgdwB1c5Ud1ua-jxQfSuhyb-cRTAd4Pd7WjctxXSE6D-s3Iv_-_WXcDf1ChVuURzAZH21sa_IM1uXr3uF_AX-1zDj priority: 102 providerName: Springer Nature – databaseName: Unpaywall dbid: UNPAY link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwED-NTgh44PsjMJCReGPpmjix48cymCYkBg8rjKfo4thQ0SXV2grKX8_Z-YDCNLHX-CLZ5_Pdz_b5dwAv3JW6wZENNRlvmKSRdRyQJa14KQVmhRyhO-94dyQOJ8nbk_RkC0T3FsYn7XtKS--mu-ywvQUFGvcYzCUUUESXoRzOS3sFtkVKGHwA25OjD-PPrpIcYZSQYELcvpAZ8eycnzeikCfrPw9h_pso2d-W3oBrq2qO6-84m_0RkA5uwaduKE0eyrfhalkM9c-_WB4vP9bbcLPFqGzcSN6BLVPdhatN1cr1Pfjx0Xs0duar0JmS8dfs_f7xmGHP8slqy07Rp7iyKe2fzekU2bRiLYvrgrnjX-aOf1nEuuNfhlXpG-rVsv041cy9sqxqVzh5fR8mB2-O9w_DtoBDqAkILsOCth-R0SaxRhAwQ41WJJkSEjOrtEJuY4kGhaYtcYlcRVanRcQJJBlV2AT5AxhUdWUeATM806mKURW6pLibFNIYnWmV2ZiLUkUBRN2E5rplN3dFNma5v2XnWd5oNSet5l6ruQzgZf_PvOH2uFD6lbOTXtLxcvsP9dmXvJ27vCRD5zoTGkeYxFJhYQsblzY1JcpIZwHsdFaWt85ikZPXVDFBYU6jeN430zJ3dzdYmXrVyIiYvGUSwMPGKPue8EQQauYqALlhrhtd3Wyppl89lXiWKMKvowB2O8P-3a2LVLHbG_9_aO7x5cSfwPXY2b7P0tiBwfJsZZ4S8lsWz9pl_gu6t1OD priority: 102 providerName: Unpaywall |
| Title | Volume rendered 3D OCTA assessment of macular ischemia in patients with type 1 diabetes and without diabetic retinopathy |
| URI | https://link.springer.com/article/10.1038/s41598-021-99297-7 https://www.ncbi.nlm.nih.gov/pubmed/34611239 https://www.proquest.com/docview/2579208331 https://www.proquest.com/docview/2579629634 https://pubmed.ncbi.nlm.nih.gov/PMC8492730 https://www.nature.com/articles/s41598-021-99297-7.pdf https://doaj.org/article/d9663c86ca0a4279abfbf2df5eda71c8 |
| UnpaywallVersion | publishedVersion |
| Volume | 11 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVFSB databaseName: Free Full-Text Journals in Chemistry customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: HH5 dateStart: 20110101 isFulltext: true titleUrlDefault: http://abc-chemistry.org/ providerName: ABC ChemistRy – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: KQ8 dateStart: 20110101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: DOA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVEBS databaseName: Academic Search Ultimate - eBooks customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 2045-2322 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: ABDBF dateStart: 20121221 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: DIK dateStart: 20110101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: GX1 dateStart: 0 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: M~E dateStart: 20110101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: RPM dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVAQT databaseName: Springer Nature - nature.com Journals - Fully Open Access customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: NAO dateStart: 20111201 isFulltext: true titleUrlDefault: https://www.nature.com/siteindex/index.html providerName: Nature Publishing – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: 7X7 dateStart: 20110101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 2045-2322 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: BENPR dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVFZP databaseName: Scholars Portal Journals: Open Access customDbUrl: eissn: 2045-2322 dateEnd: 20250131 omitProxy: true ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: M48 dateStart: 20110801 isFulltext: true titleUrlDefault: http://journals.scholarsportal.info providerName: Scholars Portal – providerCode: PRVAVX databaseName: Springer Nature HAS Fully OA customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: AAJSJ dateStart: 20111201 isFulltext: true titleUrlDefault: https://www.springernature.com providerName: Springer Nature – providerCode: PRVAVX databaseName: Springer Nature OA Free Journals customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: C6C dateStart: 20111201 isFulltext: true titleUrlDefault: http://www.springeropen.com/ providerName: Springer Nature |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELf2IQQ8IL4JjMpIiBcWaOI0th8Q6sqmqdLKBCsqT9HFsbdKXdL1Q6z_PWfnAyqqiqdIthM55zvfz3fnO0LeWpe6hrbxFTKvH3UCY3NAZijxnMcgUt4Ga-84G8Snw6g_6ox2SB1uWxFwvvFoZ-tJDWeTD7c3q88o8J_KK-Pi4xyVkL0oZoMNUNtzn7-b3vi2sJR1wFZVNnbJPiovaas7nFUngDL9dyijQFbXaTZ_bU1lucz-m-Dov1GVjWv1Prm7zKew-gWTyV_a6-QheVDBTtot-eQR2dH5Y3KnLES5ekJuf7hNis5cYTmdUfaFfu1ddCk0iTtpYeg1uKhVOka66esx0HFOq8Ssc2otutRadGlAa4suhTxzHcVyUTWOFbUXJ_PC1kJePSXDk-OL3qlf1WTwFWK7hZ_iiSLQSkdGx4i1QIGJIyFjDsJIJYGZkIOGWOEpNwMmA6M6acAQ92iZmgjYM7KXF7l-QahmQnVkCDJVGarSKOVaK6GkMCGLMxl4JKjJnqgqYbmtmzFJnOOciaRcqgSXKnFLlXCPvG_emZbpOraOPrKr2Yy0qbZdQzG7TCrJTTLkXaZErKANUcglpCY1YWY6OgMeKOGRg5oXkpp9E9wIZYjoluFfvGm6UXKtOwZyXSzLMXGIG2Dkkecl6zQzYVGMQJhJj_A1plqb6npPPr5y2cFFJBGStj1yWLPfn2ltI8Vhw6L_QbmX23_6FbkXWgFygRYHZG8xW-rXCN4WaYvs8hFvkf1ut_-9j8-j48H5N2ztxb2WM4i0nIBiz3Bw3v35GwJjSFw |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Jb9QwFLZKK1Q4IHYCBYwEJxo1iT1xfKhQV01pOyA0rXoLL44NI02TYRaV-XP8Np6dpYxAIy69xk7k-C3-_FZC3lqXuobA-AqZ1-ed0NgakDlKvBAxJJkIwNo7Tntx94x_vOhcrJBfTS6MDatsdKJT1HmprI18C1lLRogXWPhh9MO3XaOsd7VpoQF1a4V825UYqxM7jvX8Cq9wk-2jfaT3uyg6POjvdf26y4CvEK1M_QwxcqiV5kbHiB5AgYl5ImMBiZFKAjORAA2xwntbDkyGRnWykOFJrmVmODD87i2yxhmXePlb2z3off7SWnmsH42Hss7WCViyNcET02a12cgIhCbCFwsnomsc8C-0-3fQZuu5vUvWZ8UI5lcwHP5xOB7eJ_dqVEt3KjZ8QFZ08ZDcrvpczh-Rn-dOB9Kx61unc8r26ae9_g6Fti4oLQ29BBcUSwd449aXA6CDgtZ1XyfUGoypNRjTkDYGYwpF7gbK2bR-OFDU5mUWpW21PH9Mzm6EGE_IalEW-hmhmiWqIyOQmcrxpOaZ0FolSiYmYnEuQ4-Ezbanqq6HbttyDFPnl2dJWpEqRVKljlSp8Mj79p1RVQ1k6exdS812pq3k7R6U429prRjSHEWDqSRWEACPhITMZCbKTUfnIEKVeGSj4YW0Vi-T9FoYPPKmHUbFYL09UOhyVs2JI9Sv3CNPK9ZpV8J4jDibSY-IBaZaWOriSDH47oqPJ1wi4g08stmw3_Wylm3FZsui_7Fzz5f_9Guy3u2fnqQnR73jF-ROZIXJxXRskNXpeKZfIk6cZq9qYaTk603L_2863XrK |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VIigcEG8CBYwEJxrtJs7G8QGh0mXVUigcWrS3MHHsstI2Wfahsn-NX8fYeZQVaMWl19iJHM_r88x4BuClDalr7BpfEfP6US8wtgZkThIvRIxJJrpo_R2fjuL9k-jDsDfcgF_NXRibVtnoRKeo81JZH3mHWEuGhBd40DF1WsSX_uDt5IdvO0jZSGvTTqNikUO9PKfj2-zNQZ9o_SoMB--P9_b9usOArwipzP2M8HGglY6Mjgk5oEITR4mMBSZGKonchAI1xorObDlyGRjVywJOVlzLzETI6btX4KrgXNp0QjEUrX_HRtCiQNb3dLo86czIVtr7bDYngkCJ8MWKLXQtA_6Fc_9O12xjtjdha1FMcHmO4_EfZnFwG27VeJbtVgx4BzZ0cReuVR0ul_fg51en_djUdazTOeN99nnveJdhWxGUlYadoUuHZSM6a-uzEbJRweqKrzNmXcXMuopZwBpXMcMidwPlYl4_HClmb2QWpW2yvLwPJ5dCigewWZSFfgRM80T1ZIgyUznZ6CgTWqtEycSEPM5l4EHQbHuq6krotiHHOHUReZ6kFalSIlXqSJUKD16370yqOiBrZ7-z1Gxn2hre7kE5PU1rlZDmJBRcJbHCLkahkJiZzIS56ekcRaASD7YbXkhrxTJLL8TAgxftMKkEG-fBQpeLak4ckmaNPHhYsU67Eh7FhLC59ECsMNXKUldHitF3V3Y8iSRh3a4HOw37XSxr3VbstCz6Hzv3eP1PP4frJPXpx4OjwydwI7Sy5JI5tmFzPl3opwQQ59kzJ4kMvl226P8G4BJ4ZA |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwED-NTgh44PsjMJCReGPpmjix48cymCYkBg8rjKfo4thQ0SXV2grKX8_Z-YDCNLHX-CLZ5_Pdz_b5dwAv3JW6wZENNRlvmKSRdRyQJa14KQVmhRyhO-94dyQOJ8nbk_RkC0T3FsYn7XtKS--mu-ywvQUFGvcYzCUUUESXoRzOS3sFtkVKGHwA25OjD-PPrpIcYZSQYELcvpAZ8eycnzeikCfrPw9h_pso2d-W3oBrq2qO6-84m_0RkA5uwaduKE0eyrfhalkM9c-_WB4vP9bbcLPFqGzcSN6BLVPdhatN1cr1Pfjx0Xs0duar0JmS8dfs_f7xmGHP8slqy07Rp7iyKe2fzekU2bRiLYvrgrnjX-aOf1nEuuNfhlXpG-rVsv041cy9sqxqVzh5fR8mB2-O9w_DtoBDqAkILsOCth-R0SaxRhAwQ41WJJkSEjOrtEJuY4kGhaYtcYlcRVanRcQJJBlV2AT5AxhUdWUeATM806mKURW6pLibFNIYnWmV2ZiLUkUBRN2E5rplN3dFNma5v2XnWd5oNSet5l6ruQzgZf_PvOH2uFD6lbOTXtLxcvsP9dmXvJ27vCRD5zoTGkeYxFJhYQsblzY1JcpIZwHsdFaWt85ikZPXVDFBYU6jeN430zJ3dzdYmXrVyIiYvGUSwMPGKPue8EQQauYqALlhrhtd3Wyppl89lXiWKMKvowB2O8P-3a2LVLHbG_9_aO7x5cSfwPXY2b7P0tiBwfJsZZ4S8lsWz9pl_gu6t1OD |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Volume+rendered+3D+OCTA+assessment+of+macular+ischemia+in+patients+with+type+1+diabetes+and+without+diabetic+retinopathy&rft.jtitle=Scientific+reports&rft.au=Borrelli+Enrico&rft.au=Grosso+Domenico&rft.au=Parravano+Mariacristina&rft.au=Costanzo+Eliana&rft.date=2021-10-05&rft.pub=Nature+Publishing+Group&rft.eissn=2045-2322&rft.volume=11&rft.issue=1&rft_id=info:doi/10.1038%2Fs41598-021-99297-7&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon |