CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia

Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be associated with CNS-infiltration and –relapse in B-...

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Published inCommunications biology Vol. 4; no. 1; pp. 73 - 6
Main Authors Lenk, Lennart, Carlet, Michela, Vogiatzi, Fotini, Spory, Lea, Winterberg, Dorothee, Cousins, Antony, Vossen-Gajcy, Michaela, Ibruli, Olta, Vokuhl, Christian, Cario, Gunnar, El Ayoubi, Omar, Kramer, Lisa, Ritgen, Matthias, Brüggemann, Monika, Häsler, Robert, Schrappe, Martin, Fuhrmann, Stephan, Halsey, Christina, Jeremias, Irmela, Hobeika, Elias, Jumaa, Hassan, Alsadeq, Ameera, Schewe, Denis M.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 15.01.2021
Nature Publishing Group
Nature Portfolio
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13
13/31
38/89
42/35
45/77
59
64
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692/308/1426
692/308/2778
692/53/2421
692/699/67/1990/283/2125
82
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Acute lymphoblastic leukemia
Animal models
Biology
Biomedical and Life Sciences
Central nervous system
Infiltration
Leukemia
Life Sciences
Lymphatic leukemia
Lymphocytes B
Nervous system
Xenografts
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ISSN2399-3642
2399-3642
DOI10.1038/s42003-020-01591-z

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Abstract Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be associated with CNS-infiltration and –relapse in B-cell precursor (BCP)-ALL patients. Furthermore, we show that downregulation of CD79a hampers the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS. Lenk et al find that the preB cell receptor (preBCR) is associated with infiltration and relapse of acute lymphoblastic leukemia in the central nervous system (CNS). They also show that downregulation of preBCR component CD79a reduces the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.
AbstractList Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be associated with CNS-infiltration and –relapse in B-cell precursor (BCP)-ALL patients. Furthermore, we show that downregulation of CD79a hampers the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.Lenk et al find that the preB cell receptor (preBCR) is associated with infiltration and relapse of acute lymphoblastic leukemia in the central nervous system (CNS). They also show that downregulation of preBCR component CD79a reduces the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.
Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be associated with CNS-infiltration and –relapse in B-cell precursor (BCP)-ALL patients. Furthermore, we show that downregulation of CD79a hampers the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS. Lenk et al find that the preB cell receptor (preBCR) is associated with infiltration and relapse of acute lymphoblastic leukemia in the central nervous system (CNS). They also show that downregulation of preBCR component CD79a reduces the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.
Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be associated with CNS-infiltration and -relapse in B-cell precursor (BCP)-ALL patients. Furthermore, we show that downregulation of CD79a hampers the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.
Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be associated with CNS-infiltration and -relapse in B-cell precursor (BCP)-ALL patients. Furthermore, we show that downregulation of CD79a hampers the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be associated with CNS-infiltration and -relapse in B-cell precursor (BCP)-ALL patients. Furthermore, we show that downregulation of CD79a hampers the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.
Lenk et al find that the preB cell receptor (preBCR) is associated with infiltration and relapse of acute lymphoblastic leukemia in the central nervous system (CNS). They also show that downregulation of preBCR component CD79a reduces the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.
ArticleNumber 73
Author Vossen-Gajcy, Michaela
Cousins, Antony
Winterberg, Dorothee
Spory, Lea
Carlet, Michela
El Ayoubi, Omar
Cario, Gunnar
Vogiatzi, Fotini
Brüggemann, Monika
Alsadeq, Ameera
Jumaa, Hassan
Kramer, Lisa
Ibruli, Olta
Schrappe, Martin
Hobeika, Elias
Lenk, Lennart
Vokuhl, Christian
Halsey, Christina
Häsler, Robert
Schewe, Denis M.
Fuhrmann, Stephan
Ritgen, Matthias
Jeremias, Irmela
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  organization: Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Center for Environmental Health (HMGU), German Cancer Consortium (DKTK), Partnering Site Munich, Department of Pediatrics, Dr. von Hauner Children’s Hospital, University Hospital, LMU Munich
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  surname: Schewe
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  email: denis.schewe@uksh.de
  organization: Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein
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Snippet Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify...
Lenk et al find that the preB cell receptor (preBCR) is associated with infiltration and relapse of acute lymphoblastic leukemia in the central nervous system...
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Acute lymphoblastic leukemia
Animal models
Biology
Biomedical and Life Sciences
Central nervous system
Infiltration
Leukemia
Life Sciences
Lymphatic leukemia
Lymphocytes B
Nervous system
Xenografts
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Title CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia
URI https://link.springer.com/article/10.1038/s42003-020-01591-z
https://www.ncbi.nlm.nih.gov/pubmed/33452446
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https://pubmed.ncbi.nlm.nih.gov/PMC7810877
https://doaj.org/article/45d481a21f3e44e49b4f84076c7e9181
Volume 4
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