Reciprocal Influences of HIV and Cannabinoids on the Brain and Cognitive Function

Globally, cannabis is the most commonly used illicit drug, with disproportionately high use among persons with HIV. Despite advances in HIV care, nearly half of persons living with HIV continue to experience neurocognitive deficits or impairments that may have negative impacts on their daily functio...

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Published inJournal of neuroimmune pharmacology Vol. 15; no. 4; pp. 765 - 779
Main Authors Towe, Sheri L., Meade, Christina S., Cloak, Christine C., Bell, Ryan P., Baptiste, Julian, Chang, Linda
Format Journal Article
LanguageEnglish
Published New York Springer US 01.12.2020
Springer Nature B.V
Subjects
Animals
Biomedical and Life Sciences
Biomedicine
Brain - drug effects
Brain - metabolism
Cannabinoids - administration & dosage
Cannabinoids - metabolism
Cell Biology
Cognition - drug effects
Cognition - physiology
HIV
HIV Infections - drug therapy
HIV Infections - epidemiology
HIV Infections - metabolism
Human immunodeficiency virus
Humans
Immunology
Invited Review
Marijuana
Marijuana Use - epidemiology
Marijuana Use - metabolism
Neurosciences
Pharmacology/Toxicology
Virology
Neuropathogenesis
Endocannabinoid system
Cannabis
HIV
Online AccessGet full text
ISSN1557-1890
1557-1904
1557-1904
DOI10.1007/s11481-020-09921-y

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Abstract Globally, cannabis is the most commonly used illicit drug, with disproportionately high use among persons with HIV. Despite advances in HIV care, nearly half of persons living with HIV continue to experience neurocognitive deficits or impairments that may have negative impacts on their daily function. Chronic cannabis use may play a role in the development or exacerbation of these impairments. Here we present a review summarizing existing research detailing the effect of cannabis use associated with the neuropathogenesis of HIV. We examine evidence for possible additive or synergistic effects of HIV infection and cannabis use on neuroHIV in both the preclinical and adult human literatures, including in vitro studies, animal models, clinical neuroimaging research, and studies examining the cognitive effects of cannabis. We discuss the limitations of existing research, including methodological challenges involved with clinical research with human subjects. We identify gaps in the field and propose critical research questions to advance our understanding of how cannabis use affects neuroHIV. Graphical Abstract
AbstractList Globally, cannabis is the most commonly used illicit drug, with disproportionately high use among persons with HIV. Despite advances in HIV care, nearly half of persons living with HIV continue to experience neurocognitive deficits or impairments that may have negative impacts on their daily function. Chronic cannabis use may play a role in the development or exacerbation of these impairments. Here we present a review summarizing existing research detailing the effect of cannabis use associated with the neuropathogenesis of HIV. We examine evidence for possible additive or synergistic effects of HIV infection and cannabis use on neuroHIV in both the preclinical and adult human literatures, including in vitro studies, animal models, clinical neuroimaging research, and studies examining the cognitive effects of cannabis. We discuss the limitations of existing research, including methodological challenges involved with clinical research with human subjects. We identify gaps in the field and propose critical research questions to advance our understanding of how cannabis use affects neuroHIV. Graphical Abstract
Globally, cannabis is the most commonly used illicitdrug, with disproportionately high use among persons with HIV. Despite advances in HIV care, nearly half of persons with HIV continue to experience neurocognitive deficits or impairments that may have negative impacts on their daily function. Chronic cannabis use may play a role in the development or exacerbation of these impairments. Here we present a review summarizing existing research detailing the effect of cannabis use associated with the neuropathogenesis of HIV. We examine evidence for possible additive or synergistic effects of HIV infection and cannabis use on neuroHIV in both the preclinical and adult human literatures, including in vitro studies, animal models, clinical neuroimaging research, and studies examining the cognitive effects of cannabis. We discuss the limitations of existing research, including methodological challenges involved with clinical research with human subjects. We identify gaps in the field and propose critical research questions to advance our understanding of how cannabis use affects neuroHIV.
Globally, cannabis is the most commonly used illicit drug, with disproportionately high use among persons with HIV. Despite advances in HIV care, nearly half of persons living with HIV continue to experience neurocognitive deficits or impairments that may have negative impacts on their daily function. Chronic cannabis use may play a role in the development or exacerbation of these impairments. Here we present a review summarizing existing research detailing the effect of cannabis use associated with the neuropathogenesis of HIV. We examine evidence for possible additive or synergistic effects of HIV infection and cannabis use on neuroHIV in both the preclinical and adult human literatures, including in vitro studies, animal models, clinical neuroimaging research, and studies examining the cognitive effects of cannabis. We discuss the limitations of existing research, including methodological challenges involved with clinical research with human subjects. We identify gaps in the field and propose critical research questions to advance our understanding of how cannabis use affects neuroHIV. Graphical Abstract.Globally, cannabis is the most commonly used illicit drug, with disproportionately high use among persons with HIV. Despite advances in HIV care, nearly half of persons living with HIV continue to experience neurocognitive deficits or impairments that may have negative impacts on their daily function. Chronic cannabis use may play a role in the development or exacerbation of these impairments. Here we present a review summarizing existing research detailing the effect of cannabis use associated with the neuropathogenesis of HIV. We examine evidence for possible additive or synergistic effects of HIV infection and cannabis use on neuroHIV in both the preclinical and adult human literatures, including in vitro studies, animal models, clinical neuroimaging research, and studies examining the cognitive effects of cannabis. We discuss the limitations of existing research, including methodological challenges involved with clinical research with human subjects. We identify gaps in the field and propose critical research questions to advance our understanding of how cannabis use affects neuroHIV. Graphical Abstract.
Globally, cannabis is the most commonly used illicit drug, with disproportionately high use among persons with HIV. Despite advances in HIV care, nearly half of persons living with HIV continue to experience neurocognitive deficits or impairments that may have negative impacts on their daily function. Chronic cannabis use may play a role in the development or exacerbation of these impairments. Here we present a review summarizing existing research detailing the effect of cannabis use associated with the neuropathogenesis of HIV. We examine evidence for possible additive or synergistic effects of HIV infection and cannabis use on neuroHIV in both the preclinical and adult human literatures, including in vitro studies, animal models, clinical neuroimaging research, and studies examining the cognitive effects of cannabis. We discuss the limitations of existing research, including methodological challenges involved with clinical research with human subjects. We identify gaps in the field and propose critical research questions to advance our understanding of how cannabis use affects neuroHIV.
Globally, cannabis is the most commonly used illicit drug, with disproportionately high use among persons with HIV. Despite advances in HIV care, nearly half of persons living with HIV continue to experience neurocognitive deficits or impairments that may have negative impacts on their daily function. Chronic cannabis use may play a role in the development or exacerbation of these impairments. Here we present a review summarizing existing research detailing the effect of cannabis use associated with the neuropathogenesis of HIV. We examine evidence for possible additive or synergistic effects of HIV infection and cannabis use on neuroHIV in both the preclinical and adult human literatures, including in vitro studies, animal models, clinical neuroimaging research, and studies examining the cognitive effects of cannabis. We discuss the limitations of existing research, including methodological challenges involved with clinical research with human subjects. We identify gaps in the field and propose critical research questions to advance our understanding of how cannabis use affects neuroHIV. Graphical Abstract.
Author Cloak, Christine C.
Towe, Sheri L.
Bell, Ryan P.
Chang, Linda
Baptiste, Julian
Meade, Christina S.
AuthorAffiliation a Duke University School of Medicine, Department of Psychiatry & Behavioral Sciences, Durham, NC, 27705, USA
b University of Maryland School of Medicine, Diagnostic Radiology and Nuclear Medicine Baltimore, MD, 21201, USA
d University of Hawaii at Manoa, John A Burns School of Medicine, Honolulu, HI 96813
c Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, 21205
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  surname: Chang
  fullname: Chang, Linda
  email: lchang@som.umaryland.edu
  organization: Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Department of Neurology, Johns Hopkins University School of Medicine, John A Burns School of Medicine, University of Hawaii at Manoa
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32445005$$D View this record in MEDLINE/PubMed
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PublicationDate 2020-12-01
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PublicationDate_xml – month: 12
  year: 2020
  text: 2020-12-01
  day: 01
PublicationDecade 2020
PublicationPlace New York
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PublicationTitle Journal of neuroimmune pharmacology
PublicationTitleAbbrev J Neuroimmune Pharmacol
PublicationTitleAlternate J Neuroimmune Pharmacol
PublicationYear 2020
Publisher Springer US
Springer Nature B.V
Publisher_xml – name: Springer US
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Snippet Globally, cannabis is the most commonly used illicit drug, with disproportionately high use among persons with HIV. Despite advances in HIV care, nearly half...
Globally, cannabis is the most commonly used illicitdrug, with disproportionately high use among persons with HIV. Despite advances in HIV care, nearly half of...
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SubjectTerms Animals
Biomedical and Life Sciences
Biomedicine
Brain - drug effects
Brain - metabolism
Cannabinoids - administration & dosage
Cannabinoids - metabolism
Cell Biology
Cognition - drug effects
Cognition - physiology
HIV
HIV Infections - drug therapy
HIV Infections - epidemiology
HIV Infections - metabolism
Human immunodeficiency virus
Humans
Immunology
Invited Review
Marijuana
Marijuana Use - epidemiology
Marijuana Use - metabolism
Neurosciences
Pharmacology/Toxicology
Virology
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Title Reciprocal Influences of HIV and Cannabinoids on the Brain and Cognitive Function
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